Wolfgang Kastenmuller

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread
    Wolfgang Kastenmuller
    Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 150:1235-48. 2012
  2. pmc Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction
    Wolfgang Kastenmuller
    Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 187:3186-97. 2011
  3. ncbi request reprint Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues
    Tetsuya Honda
    Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 40:235-47. 2014
  4. pmc Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8+ T cell responses in the lymph node
    Wolfgang Kastenmuller
    Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 38:502-13. 2013
  5. pmc Pathogen-Related Differences in the Abundance of Presented Antigen Are Reflected in CD4+ T Cell Dynamic Behavior and Effector Function in the Lung
    Parizad Torabi-Parizi
    Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 192:1651-60. 2014
  6. pmc Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo
    Tim Lämmermann
    Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0421, USA
    Nature 498:371-5. 2013
  7. pmc Compartmentalized control of skin immunity by resident commensals
    Shruti Naik
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Science 337:1115-9. 2012
  8. ncbi request reprint Cutting edge: mucosal application of a lyophilized viral vector vaccine confers systemic and protective immunity toward intracellular pathogens
    Wolfgang Kastenmuller
    Institute of Virology, Helmholtz Center Munich, Munich, Germany
    J Immunol 182:2573-7. 2009
  9. pmc The future of immunoimaging--deeper, bigger, more precise, and definitively more colorful
    Jianyong Tang
    Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Eur J Immunol 43:1407-12. 2013
  10. pmc Histo-cytometry: a method for highly multiplex quantitative tissue imaging analysis applied to dendritic cell subset microanatomy in lymph nodes
    Michael Y Gerner
    Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 37:364-76. 2012

Collaborators

Detail Information

Publications11

  1. pmc A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread
    Wolfgang Kastenmuller
    Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 150:1235-48. 2012
    ....
  2. pmc Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction
    Wolfgang Kastenmuller
    Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 187:3186-97. 2011
    ....
  3. ncbi request reprint Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues
    Tetsuya Honda
    Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 40:235-47. 2014
    ..We speculate that the immune system employs T cell recruitment, transient activation, and rapid desensitization to allow the T cell response to rapidly adjust to changes in antigen presentation and minimize collateral injury to the host...
  4. pmc Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8+ T cell responses in the lymph node
    Wolfgang Kastenmuller
    Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 38:502-13. 2013
    ..These data reveal the distinct localization and dynamic behavior of naive versus memory T cells within LNs and how these differences contribute to host defense...
  5. pmc Pathogen-Related Differences in the Abundance of Presented Antigen Are Reflected in CD4+ T Cell Dynamic Behavior and Effector Function in the Lung
    Parizad Torabi-Parizi
    Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 192:1651-60. 2014
    ..Optimal effector function is thus constrained by the availability of TCR ligands, pointing to the value of increasing Ag stimulation rather than effector numbers in harnessing CD4(+) T cells for therapeutic purposes in such conditions. ..
  6. pmc Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo
    Tim Lämmermann
    Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0421, USA
    Nature 498:371-5. 2013
    ..They reveal how local events are propagated over large-range distances, and how auto-signalling produces coordinated, self-organized neutrophil-swarming behaviour that isolates the wound or infectious site from surrounding viable tissue...
  7. pmc Compartmentalized control of skin immunity by resident commensals
    Shruti Naik
    Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Science 337:1115-9. 2012
    ..These findings underscore the importance of the microbiota as a distinctive feature of tissue compartmentalization, and provide insight into mechanisms of immune system regulation by resident commensal niches in health and disease...
  8. ncbi request reprint Cutting edge: mucosal application of a lyophilized viral vector vaccine confers systemic and protective immunity toward intracellular pathogens
    Wolfgang Kastenmuller
    Institute of Virology, Helmholtz Center Munich, Munich, Germany
    J Immunol 182:2573-7. 2009
    ..These data clearly demonstrate the potency of a simple needle-free vaccination, combining the advantages of mucosal application with the stability and efficiency of lyophilized MVA...
  9. pmc The future of immunoimaging--deeper, bigger, more precise, and definitively more colorful
    Jianyong Tang
    Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Eur J Immunol 43:1407-12. 2013
    ..Here, we describe additional methods whose application promises to extend our vision, allowing more complete, multiscale dissection of how immune cell positioning and movement are linked to system state, host defense, and disease. ..
  10. pmc Histo-cytometry: a method for highly multiplex quantitative tissue imaging analysis applied to dendritic cell subset microanatomy in lymph nodes
    Michael Y Gerner
    Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 37:364-76. 2012
    ..Here, we employ histo-cytometry to describe the spatial segregation of resident and migratory dendritic cell subsets into specialized microanatomical domains, suggesting an unexpected LN demarcation into discrete functional compartments...
  11. pmc The in situ dynamics of dendritic cell interactions
    Wolfgang Kastenmuller
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Eur J Immunol 40:2103-6. 2010
    ..In this Viewpoint, we discuss the insights generated by direct visualization of DC-T-cell interactions and the controversies/unanswered questions that need to be addressed in future work...