Layla Kassem

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Familiality of polarity at illness onset in bipolar affective disorder
    Layla Kassem
    Genetic Basis of Mood and Anxiety Disorders, National Institutes of Health, 35 Convent Dr, Rm 1A202 MSC 3616, Bethesda, MD 20809 3616, USA
    Am J Psychiatry 163:1754-9. 2006
  2. ncbi request reprint Sequence variation in DOCK9 and heterogeneity in bipolar disorder
    Sevilla D Detera-Wadleigh
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health U S DHHS, 35 Convent Drive, Bethesda, MD 20892, USA
    Psychiatr Genet 17:274-86. 2007
  3. ncbi request reprint Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation
    Melissa A Brotman
    Emotion and Development Branch and the Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Psychiatry 164:1238-41. 2007
  4. doi request reprint Amish revisited: next-generation sequencing studies of psychiatric disorders among the Plain people
    Liping Hou
    Human Genetics Branch, National Institute of Mental Health NIMH Intramural Research Program, National Institutes of Health NIH, US Department of Health and Human Services, Bethesda, MD, USA
    Trends Genet 29:412-8. 2013
  5. pmc Race, genetic ancestry and response to antidepressant treatment for major depression
    Eleanor Murphy
    Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA
    Neuropsychopharmacology 38:2598-606. 2013
  6. ncbi request reprint Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts
    Victor A Lopez
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 61:181-6. 2007
  7. pmc The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment
    Thomas G Schulze
    Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 3719, USA
    Neuropsychobiology 62:72-8. 2010
  8. ncbi request reprint The bipolar disorder phenome database: a resource for genetic studies
    James B Potash
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:1229-37. 2007
  9. ncbi request reprint Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes
    Thomas G Schulze
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health J5, 68159 Mannheim, Germany
    Am J Psychiatry 162:2101-8. 2005
  10. pmc Whole-genome association study of bipolar disorder
    P Sklar
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Psychiatry 13:558-69. 2008

Detail Information

Publications10

  1. ncbi request reprint Familiality of polarity at illness onset in bipolar affective disorder
    Layla Kassem
    Genetic Basis of Mood and Anxiety Disorders, National Institutes of Health, 35 Convent Dr, Rm 1A202 MSC 3616, Bethesda, MD 20809 3616, USA
    Am J Psychiatry 163:1754-9. 2006
    ..The authors sought to establish whether polarity at illness onset, which is related to severity and course, is a familial feature of bipolar affective disorder...
  2. ncbi request reprint Sequence variation in DOCK9 and heterogeneity in bipolar disorder
    Sevilla D Detera-Wadleigh
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health U S DHHS, 35 Convent Drive, Bethesda, MD 20892, USA
    Psychiatr Genet 17:274-86. 2007
    ..Subsequent reports have shown that variations in the DAOA (G72) locus on 13q33 display association with bipolar disorder but these may not account for all of the linkage evidence in the region...
  3. ncbi request reprint Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation
    Melissa A Brotman
    Emotion and Development Branch and the Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Psychiatry 164:1238-41. 2007
    ..The authors compared axis I diagnoses in parents of children with narrow phenotype bipolar disorder and parents of youth with severe mood dysregulation...
  4. doi request reprint Amish revisited: next-generation sequencing studies of psychiatric disorders among the Plain people
    Liping Hou
    Human Genetics Branch, National Institute of Mental Health NIMH Intramural Research Program, National Institutes of Health NIH, US Department of Health and Human Services, Bethesda, MD, USA
    Trends Genet 29:412-8. 2013
    ..We discuss the new opportunities for NGS in these populations, with particular emphasis on investigating psychiatric disorders. We also address some of the challenges facing NGS-based studies of complex phenotypes in founder populations...
  5. pmc Race, genetic ancestry and response to antidepressant treatment for major depression
    Eleanor Murphy
    Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA
    Neuropsychopharmacology 38:2598-606. 2013
    ..Larger samples would be needed to identify the specific genetic mechanisms that may be involved, but these findings underscore the importance of including more African-American patients in drug trials...
  6. ncbi request reprint Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts
    Victor A Lopez
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 61:181-6. 2007
    ..No studies have examined TPH2 in large samples of subjects with BPAD and suicide attempts (SA). We tested for a relationship between genetic variation in TPH2 and risk for BPAD and SA in a large family sample...
  7. pmc The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment
    Thomas G Schulze
    Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 3719, USA
    Neuropsychobiology 62:72-8. 2010
    ..A stringent phenotype definition of response is one of the hallmarks of this collaboration. ConLiGen invites all lithium researchers to join its efforts...
  8. ncbi request reprint The bipolar disorder phenome database: a resource for genetic studies
    James B Potash
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:1229-37. 2007
    ..The purpose of this study was to assemble and validate a database of phenotypic variables that were collected from families with bipolar disorder as a resource for genetic and other biological studies...
  9. ncbi request reprint Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes
    Thomas G Schulze
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health J5, 68159 Mannheim, Germany
    Am J Psychiatry 162:2101-8. 2005
    ....
  10. pmc Whole-genome association study of bipolar disorder
    P Sklar
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Psychiatry 13:558-69. 2008
    ..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...