John C Kash

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Applications of high-throughput genomics to antiviral research: evasion of antiviral responses and activation of inflammation during fulminant RNA virus infection
    John C Kash
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892 3203, USA
    Antiviral Res 83:10-20. 2009
  2. pmc Treatment with the reactive oxygen species scavenger EUK-207 reduces lung damage and increases survival during 1918 influenza virus infection in mice
    John C Kash
    Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA Electronic address
    Free Radic Biol Med 67:235-47. 2014
  3. pmc Lethal synergism of 2009 pandemic H1N1 influenza virus and Streptococcus pneumoniae coinfection is associated with loss of murine lung repair responses
    John C Kash
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    MBio 2:. 2011
  4. pmc Protection against a lethal H5N1 influenza challenge by intranasal immunization with virus-like particles containing 2009 pandemic H1N1 neuraminidase in mice
    Judith D Easterbrook
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3203, USA
    Virology 432:39-44. 2012
  5. pmc Analysis by single-gene reassortment demonstrates that the 1918 influenza virus is functionally compatible with a low-pathogenicity avian influenza virus in mice
    Li Qi
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:9211-20. 2012
  6. pmc Prior infection with classical swine H1N1 influenza viruses is associated with protective immunity to the 2009 pandemic H1N1 virus
    John C Kash
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Bethesda, MD 20892 3203, USA
    Influenza Other Respir Viruses 4:121-7. 2010
  7. pmc Obese mice have increased morbidity and mortality compared to non-obese mice during infection with the 2009 pandemic H1N1 influenza virus
    Judith D Easterbrook
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3203, USA
    Influenza Other Respir Viruses 5:418-25. 2011
  8. pmc The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase
    Brett W Jagger
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    MBio 1:. 2010
  9. pmc Immunization with 1976 swine H1N1- or 2009 pandemic H1N1-inactivated vaccines protects mice from a lethal 1918 influenza infection
    Judith D Easterbrook
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3203, USA
    Influenza Other Respir Viruses 5:198-205. 2011
  10. pmc High-throughput RNA sequencing of a formalin-fixed, paraffin-embedded autopsy lung tissue sample from the 1918 influenza pandemic
    Yong Li Xiao
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Pathol 229:535-45. 2013

Collaborators

Detail Information

Publications15

  1. pmc Applications of high-throughput genomics to antiviral research: evasion of antiviral responses and activation of inflammation during fulminant RNA virus infection
    John C Kash
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892 3203, USA
    Antiviral Res 83:10-20. 2009
    ....
  2. pmc Treatment with the reactive oxygen species scavenger EUK-207 reduces lung damage and increases survival during 1918 influenza virus infection in mice
    John C Kash
    Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA Electronic address
    Free Radic Biol Med 67:235-47. 2014
    ....
  3. pmc Lethal synergism of 2009 pandemic H1N1 influenza virus and Streptococcus pneumoniae coinfection is associated with loss of murine lung repair responses
    John C Kash
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    MBio 2:. 2011
    ..This study reveals that the extent of lung damage during viral infection influences the severity of secondary bacterial infections and may help explain some differences in mortality during influenza pandemics...
  4. pmc Protection against a lethal H5N1 influenza challenge by intranasal immunization with virus-like particles containing 2009 pandemic H1N1 neuraminidase in mice
    Judith D Easterbrook
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3203, USA
    Virology 432:39-44. 2012
    ..Human influenza vaccines that elicit not only HA, but also NA immunity may provide enhanced protection against the emergence of seasonal and pandemic viruses...
  5. pmc Analysis by single-gene reassortment demonstrates that the 1918 influenza virus is functionally compatible with a low-pathogenicity avian influenza virus in mice
    Li Qi
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:9211-20. 2012
    ..While the mechanisms of influenza virus host switch, and particularly mammalian host adaptation are still only partly understood, these data suggest that the 1918 virus, whatever its origin, is very similar to avian influenza virus...
  6. pmc Prior infection with classical swine H1N1 influenza viruses is associated with protective immunity to the 2009 pandemic H1N1 virus
    John C Kash
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Bethesda, MD 20892 3203, USA
    Influenza Other Respir Viruses 4:121-7. 2010
    ..Epidemiological evidence suggested that the current seasonal vaccine did not offer significant protection from the novel pandemic, and that people over the age of 50 were less susceptible to infection...
  7. pmc Obese mice have increased morbidity and mortality compared to non-obese mice during infection with the 2009 pandemic H1N1 influenza virus
    Judith D Easterbrook
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3203, USA
    Influenza Other Respir Viruses 5:418-25. 2011
    ..Obesity has been identified as an independent risk factor for severe or fatal infection with 2009 pandemic H1N1 influenza (2009 pH1N1), but was not previously recognized for previous pandemic or seasonal influenza infections...
  8. pmc The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase
    Brett W Jagger
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    MBio 1:. 2010
    ....
  9. pmc Immunization with 1976 swine H1N1- or 2009 pandemic H1N1-inactivated vaccines protects mice from a lethal 1918 influenza infection
    Judith D Easterbrook
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3203, USA
    Influenza Other Respir Viruses 5:198-205. 2011
    ..Epidemiological and laboratory animal studies show that protection from severe 2009 pH1N1 infection is conferred by vaccination or prior infection with 1976 swH1N1 or 1918...
  10. pmc High-throughput RNA sequencing of a formalin-fixed, paraffin-embedded autopsy lung tissue sample from the 1918 influenza pandemic
    Yong Li Xiao
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Pathol 229:535-45. 2013
    ..This methodological approach should assist in the analysis of FFPE tissue samples isolated over the past century from a variety of diseases...
  11. pmc The ability of pandemic influenza virus hemagglutinins to induce lower respiratory pathology is associated with decreased surfactant protein D binding
    Li Qi
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Virology 412:426-34. 2011
    ..In contrast, the virus expressing the HA of a seasonal influenza strain induced only mild disease with little lung pathology in infected mice and exhibited strong in vitro binding to SP-D...
  12. pmc Autopsy series of 68 cases dying before and during the 1918 influenza pandemic peak
    Zong Mei Sheng
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:16416-21. 2011
    ..These findings have important implications for understanding the origins and evolution of pandemic influenza viruses...
  13. pmc Insights on influenza pathogenesis from the grave
    Jeffery K Taubenberger
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 33 North Drive, Room 3E19A 2, MSC 3203, Bethesda, MD 20892 3203, USA
    Virus Res 162:2-7. 2011
    ..These studies have yielded much information about the origin and pathogenicity of the 1918 virus, but many questions still remain...
  14. pmc An early 'classical' swine H1N1 influenza virus shows similar pathogenicity to the 1918 pandemic virus in ferrets and mice
    Matthew J Memoli
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3203, USA
    Virology 393:338-45. 2009
    ....
  15. pmc Influenza virus evolution, host adaptation, and pandemic formation
    Jeffery K Taubenberger
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Host Microbe 7:440-51. 2010
    ..Here, we review the evolution of influenza A viruses in their reservoir hosts and discuss genetic changes associated with introduction of novel viruses into humans, leading to pandemics and the establishment of seasonal viruses...