Laszlo Kari

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Generation of targeted Chlamydia trachomatis null mutants
    Laszlo Kari
    Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 108:7189-93. 2011
  2. ncbi Chlamydia trachomatis native major outer membrane protein induces partial protection in nonhuman primates: implication for a trachoma transmission-blocking vaccine
    Laszlo Kari
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Immunol 182:8063-70. 2009
  3. ncbi A live-attenuated chlamydial vaccine protects against trachoma in nonhuman primates
    Laszlo Kari
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Exp Med 208:2217-23. 2011
  4. ncbi Frameshift mutations in a single novel virulence factor alter the in vivo pathogenicity of Chlamydia trachomatis for the female murine genital tract
    Gail L Sturdevant
    Laboratory of Intracellular Parasites, Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Infect Immun 78:3660-8. 2010
  5. ncbi The Chlamydia trachomatis plasmid is a transcriptional regulator of chromosomal genes and a virulence factor
    John H Carlson
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Infect Immun 76:2273-83. 2008
  6. ncbi Pathogenic diversity among Chlamydia trachomatis ocular strains in nonhuman primates is affected by subtle genomic variations
    Laszlo Kari
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Infect Dis 197:449-56. 2008
  7. ncbi Chlamydial IFN-gamma immune evasion is linked to host infection tropism
    David E Nelson
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 102:10658-63. 2005

Collaborators

Detail Information

Publications7

  1. ncbi Generation of targeted Chlamydia trachomatis null mutants
    Laszlo Kari
    Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 108:7189-93. 2011
    ..Additionally, this strategy could be applied to other medically important bacterial pathogens with no or difficult genetic systems...
  2. ncbi Chlamydia trachomatis native major outer membrane protein induces partial protection in nonhuman primates: implication for a trachoma transmission-blocking vaccine
    Laszlo Kari
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Immunol 182:8063-70. 2009
    ..This would have a beneficial effect on the transmission between children and sensitized adults which drives blinding inflammatory disease...
  3. ncbi A live-attenuated chlamydial vaccine protects against trachoma in nonhuman primates
    Laszlo Kari
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Exp Med 208:2217-23. 2011
    ..Epidemiological models of trachoma control indicate that a vaccine with this degree of efficacy would significantly reduce the prevalence of infection and rates of reinfection, known risk factors which drive blinding disease...
  4. ncbi Frameshift mutations in a single novel virulence factor alter the in vivo pathogenicity of Chlamydia trachomatis for the female murine genital tract
    Gail L Sturdevant
    Laboratory of Intracellular Parasites, Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Infect Immun 78:3660-8. 2010
    ..Our findings provide new information about the pathogenomics of chlamydial infection and insights for improving murine models of infection using human strains...
  5. ncbi The Chlamydia trachomatis plasmid is a transcriptional regulator of chromosomal genes and a virulence factor
    John H Carlson
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Infect Immun 76:2273-83. 2008
    ..Our findings have important implications in understanding a role for the plasmid in the pathogenesis of human infection and disease...
  6. ncbi Pathogenic diversity among Chlamydia trachomatis ocular strains in nonhuman primates is affected by subtle genomic variations
    Laszlo Kari
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Infect Dis 197:449-56. 2008
    ..Our findings are the first to identify genes that correlate with differences in pathogenicity among trachoma strains...
  7. ncbi Chlamydial IFN-gamma immune evasion is linked to host infection tropism
    David E Nelson
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 102:10658-63. 2005
    ..Collectively, our findings show chlamydial host infection tropism is determined by IFN-gamma-mediated immunity...