Laszlo Kari

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Generation of targeted Chlamydia trachomatis null mutants
    Laszlo Kari
    Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 108:7189-93. 2011
  2. pmc Chlamydia trachomatis plasmid-encoded Pgp4 is a transcriptional regulator of virulence-associated genes
    Lihua Song
    Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    Infect Immun 81:636-44. 2013
  3. pmc A live-attenuated chlamydial vaccine protects against trachoma in nonhuman primates
    Laszlo Kari
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Exp Med 208:2217-23. 2011
  4. pmc Antibody signature of spontaneous clearance of Chlamydia trachomatis ocular infection and partial resistance against re-challenge in a nonhuman primate trachoma model
    Laszlo Kari
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    PLoS Negl Trop Dis 7:e2248. 2013
  5. pmc Chlamydia trachomatis native major outer membrane protein induces partial protection in nonhuman primates: implication for a trachoma transmission-blocking vaccine
    Laszlo Kari
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Immunol 182:8063-70. 2009
  6. pmc Frameshift mutations in a single novel virulence factor alter the in vivo pathogenicity of Chlamydia trachomatis for the female murine genital tract
    Gail L Sturdevant
    Laboratory of Intracellular Parasites, Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Infect Immun 78:3660-8. 2010
  7. pmc CD8+ T cells define an unexpected role in live-attenuated vaccine protective immunity against Chlamydia trachomatis infection in macaques
    Norma Olivares-Zavaleta
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840
    J Immunol 192:4648-54. 2014
  8. doi request reprint Pathogenic diversity among Chlamydia trachomatis ocular strains in nonhuman primates is affected by subtle genomic variations
    Laszlo Kari
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Infect Dis 197:449-56. 2008
  9. pmc The Chlamydia trachomatis plasmid is a transcriptional regulator of chromosomal genes and a virulence factor
    John H Carlson
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Infect Immun 76:2273-83. 2008
  10. pmc Chlamydial IFN-gamma immune evasion is linked to host infection tropism
    David E Nelson
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 102:10658-63. 2005

Collaborators

Detail Information

Publications10

  1. pmc Generation of targeted Chlamydia trachomatis null mutants
    Laszlo Kari
    Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 108:7189-93. 2011
    ..Additionally, this strategy could be applied to other medically important bacterial pathogens with no or difficult genetic systems...
  2. pmc Chlamydia trachomatis plasmid-encoded Pgp4 is a transcriptional regulator of virulence-associated genes
    Lihua Song
    Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    Infect Immun 81:636-44. 2013
    ..Our findings have major implications for understanding the plasmid's role in chlamydial pathogenesis at the molecular level...
  3. pmc A live-attenuated chlamydial vaccine protects against trachoma in nonhuman primates
    Laszlo Kari
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Exp Med 208:2217-23. 2011
    ..Epidemiological models of trachoma control indicate that a vaccine with this degree of efficacy would significantly reduce the prevalence of infection and rates of reinfection, known risk factors which drive blinding disease...
  4. pmc Antibody signature of spontaneous clearance of Chlamydia trachomatis ocular infection and partial resistance against re-challenge in a nonhuman primate trachoma model
    Laszlo Kari
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    PLoS Negl Trop Dis 7:e2248. 2013
    ....
  5. pmc Chlamydia trachomatis native major outer membrane protein induces partial protection in nonhuman primates: implication for a trachoma transmission-blocking vaccine
    Laszlo Kari
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Immunol 182:8063-70. 2009
    ..This would have a beneficial effect on the transmission between children and sensitized adults which drives blinding inflammatory disease...
  6. pmc Frameshift mutations in a single novel virulence factor alter the in vivo pathogenicity of Chlamydia trachomatis for the female murine genital tract
    Gail L Sturdevant
    Laboratory of Intracellular Parasites, Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Infect Immun 78:3660-8. 2010
    ..Our findings provide new information about the pathogenomics of chlamydial infection and insights for improving murine models of infection using human strains...
  7. pmc CD8+ T cells define an unexpected role in live-attenuated vaccine protective immunity against Chlamydia trachomatis infection in macaques
    Norma Olivares-Zavaleta
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840
    J Immunol 192:4648-54. 2014
    ..Collectively, our findings support the conclusion that CD8(+) T cells play an important but unexpected role in live-attenuated trachoma vaccine-mediated protective immunity. ..
  8. doi request reprint Pathogenic diversity among Chlamydia trachomatis ocular strains in nonhuman primates is affected by subtle genomic variations
    Laszlo Kari
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Infect Dis 197:449-56. 2008
    ..Our findings are the first to identify genes that correlate with differences in pathogenicity among trachoma strains...
  9. pmc The Chlamydia trachomatis plasmid is a transcriptional regulator of chromosomal genes and a virulence factor
    John H Carlson
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Infect Immun 76:2273-83. 2008
    ..Our findings have important implications in understanding a role for the plasmid in the pathogenesis of human infection and disease...
  10. pmc Chlamydial IFN-gamma immune evasion is linked to host infection tropism
    David E Nelson
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 102:10658-63. 2005
    ..Collectively, our findings show chlamydial host infection tropism is determined by IFN-gamma-mediated immunity...