A Z Kapikian

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint To serotype or not to serotype: that is still the question
    Albert Z Kapikian
    J Infect Dis 195:611-4. 2007
  2. ncbi request reprint A hexavalent human rotavirus-bovine rotavirus (UK) reassortant vaccine designed for use in developing countries and delivered in a schedule with the potential to eliminate the risk of intussusception
    Albert Z Kapikian
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 192:S22-9. 2005
  3. ncbi request reprint The discovery of the 27-nm Norwalk virus: an historic perspective
    A Z Kapikian
    Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0720, USA
    J Infect Dis 181:S295-302. 2000
  4. pmc Antigenic relationships among human rotaviruses as determined by outer capsid protein VP4
    M Gorziglia
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 87:7155-9. 1990
  5. pmc Infection immunity of piglets to either VP3 or VP7 outer capsid protein confers resistance to challenge with a virulent rotavirus bearing the corresponding antigen
    Y Hoshino
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 62:744-8. 1988
  6. ncbi request reprint A rotavirus vaccine for prevention of severe diarrhoea of infants and young children: development, utilization and withdrawal
    A Z Kapikian
    Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    Novartis Found Symp 238:153-71; discussion 171-9. 2001
  7. ncbi request reprint Rotavirus serotypes: classification and importance in epidemiology, immunity, and vaccine development
    Y Hoshino
    Epidemiology Section, National Institutes of Health, Bethesda, MD 20892, USA
    J Health Popul Nutr 18:5-14. 2000
  8. pmc Reactions to and antigenicity of two human-rhesus rotavirus reassortant vaccine candidates of serotypes 1 and 2 in Venezuelan infants
    J Flores
    Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
    J Clin Microbiol 27:512-8. 1989
  9. ncbi request reprint More on RotaShield and intussusception: the role of age at the time of vaccination
    L Simonsen
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 192:S36-43. 2005
  10. pmc Expression and self-assembly of recombinant capsid protein from the antigenically distinct Hawaii human calicivirus
    K Y Green
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Microbiol 35:1909-14. 1997

Detail Information

Publications29

  1. ncbi request reprint To serotype or not to serotype: that is still the question
    Albert Z Kapikian
    J Infect Dis 195:611-4. 2007
  2. ncbi request reprint A hexavalent human rotavirus-bovine rotavirus (UK) reassortant vaccine designed for use in developing countries and delivered in a schedule with the potential to eliminate the risk of intussusception
    Albert Z Kapikian
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 192:S22-9. 2005
    ..e., ages 3-4 months through age 9 months). In this way, there may be the potential to eliminate or at least significantly decrease the risk of intussusception associated with rotavirus vaccination...
  3. ncbi request reprint The discovery of the 27-nm Norwalk virus: an historic perspective
    A Z Kapikian
    Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0720, USA
    J Infect Dis 181:S295-302. 2000
    ..The fastidious 27-nm Norwalk virus is now considered to be the prototype strain of a group of noncultivatable viruses that are important etiologic agents of epidemic gastroenteritis in adults and older children...
  4. pmc Antigenic relationships among human rotaviruses as determined by outer capsid protein VP4
    M Gorziglia
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 87:7155-9. 1990
    ..Finally, evidence was obtained that the serotype-specific domain is located on the VP8 subunit of VP4...
  5. pmc Infection immunity of piglets to either VP3 or VP7 outer capsid protein confers resistance to challenge with a virulent rotavirus bearing the corresponding antigen
    Y Hoshino
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 62:744-8. 1988
    ..The relevance of these findings to the development of effective reassortant rotavirus vaccines is discussed...
  6. ncbi request reprint A rotavirus vaccine for prevention of severe diarrhoea of infants and young children: development, utilization and withdrawal
    A Z Kapikian
    Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    Novartis Found Symp 238:153-71; discussion 171-9. 2001
    ..The implications of these developments from a practical, epidemiological, analytical and ethical perspective are discussed...
  7. ncbi request reprint Rotavirus serotypes: classification and importance in epidemiology, immunity, and vaccine development
    Y Hoshino
    Epidemiology Section, National Institutes of Health, Bethesda, MD 20892, USA
    J Health Popul Nutr 18:5-14. 2000
    ..Thus, the first licensed rotavirus vaccine (RRV-based quadrivalent vaccine) was designed to cover the epidemiologically important VP7 serotype 1, 2, 3, and 4...
  8. pmc Reactions to and antigenicity of two human-rhesus rotavirus reassortant vaccine candidates of serotypes 1 and 2 in Venezuelan infants
    J Flores
    Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
    J Clin Microbiol 27:512-8. 1989
    ..Vaccine shedding was detected in 53 to 86% of the vaccinees. Analysis of neutralization antibody responses indicates that the VP4 protein represents an important component of the response induced by the vaccines...
  9. ncbi request reprint More on RotaShield and intussusception: the role of age at the time of vaccination
    L Simonsen
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 192:S36-43. 2005
    ..We explore here the effect of age on the risk of intussusception...
  10. pmc Expression and self-assembly of recombinant capsid protein from the antigenically distinct Hawaii human calicivirus
    K Y Green
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Microbiol 35:1909-14. 1997
    ..The ready availability of Hawaii VLPs should enable larger-scale epidemiological studies to further elucidate the importance of this agent...
  11. pmc Evaluation of three panels of monoclonal antibodies for the identification of human rotavirus VP7 serotype by ELISA
    K Y Green
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, MD 20892
    Bull World Health Organ 68:601-10. 1990
    ..It appears that a battery of monoclonal antibodies for each serotype may be required to identify antigenic variants within a serotype. Additional studies are needed to assess the extent of antigenic variation in rotavirus field strains...
  12. ncbi request reprint Species-specific but not genotype-specific primary and secondary isotype-specific NSP4 antibody responses in gnotobiotic calves and piglets infected with homologous host bovine (NSP4[A]) or porcine (NSP4[B]) rotavirus
    Lijuan Yuan
    Epidemiology Section, Laboratory of Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Virology 330:92-104. 2004
    ..Thus, in an approach to immunization with a live oral rotavirus vaccine, the NSP4 protein does not appear to play an important role in protection against rotavirus disease and infection...
  13. ncbi request reprint A porcine G9 rotavirus strain shares neutralization and VP7 phylogenetic sequence lineage 3 characteristics with contemporary human G9 rotavirus strains
    Yasutaka Hoshino
    Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6308, 50 South Drive MSC 8026, Bethesda, MD 20892 8026, USA
    Virology 332:177-88. 2005
    ..Furthermore, by sequence analysis, the A2 VP7 was shown to belong to lineage 3 G9. These findings raise intriguing questions regarding possible explanations for the emergence of variations among the G9 strains...
  14. ncbi request reprint Porcine rotavirus strain Gottfried-based human rotavirus candidate vaccines: construction and characterization
    Yasutaka Hoshino
    Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8026, USA
    Vaccine 23:3791-9. 2005
    ....
  15. ncbi request reprint A rotavirus strain isolated from pig-tailed macaque (Macaca nemestrina) with diarrhea bears a P6[1]:G8 specificity
    Yasutaka Hoshino
    Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8026, USA
    Virology 345:1-12. 2006
    ..Because of its unique simian serotype, this virus may prove to be valuable in challenge studies in a non-human primate model in studies of rotavirus immunity...
  16. ncbi request reprint Neonatal administration of rhesus rotavirus tetravalent vaccine
    Timo Vesikari
    University of Tampere Medical School, Biokatu 10, 33520 Tampere, Finland
    Pediatr Infect Dis J 25:118-22. 2006
    ..We hypothesized that giving the first dose of RRV-TV vaccine during the neonatal period might reduce the reactogenicity of RRV-TV vaccine without compromising the utilization of the vaccine...
  17. ncbi request reprint Rotavirus vaccines
    Lone Simonsen
    N Engl J Med 354:1747-51; author reply 1747-51. 2006
  18. ncbi request reprint Safety, efficacy, and immunogenicity of 2 doses of bovine-human (UK) and rhesus-rhesus-human rotavirus reassortant tetravalent vaccines in Finnish children
    Timo Vesikari
    Vaccine Research Center, University of Tampere Medical School, Tampere, Finland
    J Infect Dis 194:370-6. 2006
    ..A corresponding tetravalent (types G1, G2, G3, and G4) reassortant vaccine based on bovine-human (UK) rotavirus reassortant tetravalent (BRV-TV) vaccine was developed concurrently...
  19. pmc Rotavirus serotype G9 strains belonging to VP7 gene phylogenetic sequence lineage 1 may be more suitable for serotype G9 vaccine candidates than those belonging to lineage 2 or 3
    Yasutaka Hoshino
    Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8026, USA
    J Virol 78:7795-802. 2004
    ..These findings may have important implications for the development of G9 rotavirus vaccine candidates, as the strain with the broadest reactivity (i.e., a prime strain) would certainly be the ideal strain for inclusion in a vaccine...
  20. ncbi request reprint Homotypic and heterotypic serum isotype-specific antibody responses to rotavirus nonstructural protein 4 and viral protein (VP) 4, VP6, and VP7 in infants who received selected live oral rotavirus vaccines
    Lijuan Yuan
    Epidemiology Section, Laboratory of Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 189:1833-45. 2004
    ..Antibody titers to homotypic and/or heterotypic NSP4s were positively correlated with those to VP6 before and after vaccination...
  21. ncbi request reprint Clinical evaluation of a single oral dose of human-bovine (UK) reassortant rotavirus vaccines Wa x UK (P1A[8],G6) and Wa x (DS-1 x UK) (P1A[8],G2)
    Maryna C Eichelberger
    Center for Immunization Research, Department of International Health, Johns Hopkins School of Public Health, Baltimore, Maryland, USA
    J Med Virol 66:407-16. 2002
    ..Each of these vaccines appeared to be well-tolerated and immunogenic in infants less than 6 months of age following a single oral dose, and therefore should be evaluated further as vaccine candidates...
  22. ncbi request reprint A predominant role for Norwalk-like viruses as agents of epidemic gastroenteritis in Maryland nursing homes for the elderly
    Kim Y Green
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 185:133-46. 2002
    ..Taken together with a retrospective analysis of bacterial gastroenteritis in this same setting, these data support a major role for NLVs as etiologic agents of gastroenteritis in elderly persons...
  23. ncbi request reprint Characterization of neutralization specificities of outer capsid spike protein VP4 of selected murine, lapine, and human rotavirus strains
    Yasutaka Hoshino
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8026, USA
    Virology 299:64-71. 2002
    ..P serotype 13[20] was assigned to murine rotavirus EHP strain VP4, which was shown to be distinct from all the P serotypes/genotypes examined in the present study...
  24. ncbi request reprint Generation and characterization of six single VP4 gene substitution reassortant rotavirus vaccine candidates: each bears a single human rotavirus VP4 gene encoding P serotype 1A[8] or 1B[4] and the remaining 10 genes of rhesus monkey rotavirus MMU18006 or
    Yasutaka Hoshino
    Epidemiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6308, 50 South Drive MSC 8026, Bethesda, MD 20892 8026, USA
    Vaccine 20:3576-84. 2002
    ..Similarly, three single VP4 gene (P1A[8] or P1B[4]) substitution reassortants have also been generated in a background of 10 bovine (UK) rotavirus genes for addition to a second generation UK-based quadrivalent vaccine...
  25. ncbi request reprint Horizontal transmission of rhesus monkey rotavirus-based quadrivalent vaccine during a phase 3 clinical trial in Caracas, Venezuela
    Yasutaka Hoshino
    Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 50, Rm 6308, 50 South Drive, Bethesda, MD 20892 8026, USA
    J Infect Dis 187:791-800. 2003
    ..5 mL of a 10% stool suspension. Reassortants of vaccine virus and wild-type human rotavirus were not detected...
  26. ncbi request reprint Reappraisal of the association of intussusception with the licensed live rotavirus vaccine challenges initial conclusions
    Brian R Murphy
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 187:1301-8. 2003
  27. ncbi request reprint Construction and characterization of rhesus monkey rotavirus (MMU18006)- or bovine rotavirus (UK)-based serotype G5, G8, G9 or G10 single VP7 gene substitution reassortant candidate vaccines
    Yasutaka Hoshino
    Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6308, 50 South Drive, MSC 8026, Bethesda, MD 20892 8026, USA
    Vaccine 21:3003-10. 2003
    ..These candidate vaccines could be evaluated singly in special populations or in combination with a RRV- or an UK-based quadrivalent vaccine to broaden its G serotype specificity...
  28. ncbi request reprint Human rotavirus strains bearing VP4 gene P[6] allele recovered from asymptomatic or symptomatic infections share similar, if not identical, VP4 neutralization specificities
    Yasutaka Hoshino
    Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8026, USA
    Virology 316:1-8. 2003
    ..In addition, a close VP4 serotypic relationship between human P[6] rotavirus strains and the porcine P[6] rotavirus Gottfried strain was confirmed...
  29. ncbi request reprint Ecological studies, rotavirus vaccination, and intussusception
    Albert Z Kapikian
    Lancet 359:1065-6; author reply 1066. 2002