Research Topics
| A Z KapikianSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
To serotype or not to serotype: that is still the questionAlbert Z Kapikian
J Infect Dis 195:611-4. 2007- A hexavalent human rotavirus-bovine rotavirus (UK) reassortant vaccine designed for use in developing countries and delivered in a schedule with the potential to eliminate the risk of intussusceptionAlbert Z Kapikian
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Infect Dis 192:S22-9. 2005..e., ages 3-4 months through age 9 months). In this way, there may be the potential to eliminate or at least significantly decrease the risk of intussusception associated with rotavirus vaccination... - The discovery of the 27-nm Norwalk virus: an historic perspectiveA Z Kapikian
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0720, USA
J Infect Dis 181:S295-302. 2000..The fastidious 27-nm Norwalk virus is now considered to be the prototype strain of a group of noncultivatable viruses that are important etiologic agents of epidemic gastroenteritis in adults and older children... 
Antigenic relationships among human rotaviruses as determined by outer capsid protein VP4M Gorziglia
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
Proc Natl Acad Sci U S A 87:7155-9. 1990..Finally, evidence was obtained that the serotype-specific domain is located on the VP8 subunit of VP4...- Infection immunity of piglets to either VP3 or VP7 outer capsid protein confers resistance to challenge with a virulent rotavirus bearing the corresponding antigenY Hoshino
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
J Virol 62:744-8. 1988..The relevance of these findings to the development of effective reassortant rotavirus vaccines is discussed... - A rotavirus vaccine for prevention of severe diarrhoea of infants and young children: development, utilization and withdrawalA Z Kapikian
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
Novartis Found Symp 238:153-71; discussion 171-9. 2001..The implications of these developments from a practical, epidemiological, analytical and ethical perspective are discussed... - Rotavirus serotypes: classification and importance in epidemiology, immunity, and vaccine developmentY Hoshino
Epidemiology Section, National Institutes of Health, Bethesda, MD 20892, USA
J Health Popul Nutr 18:5-14. 2000..Thus, the first licensed rotavirus vaccine (RRV-based quadrivalent vaccine) was designed to cover the epidemiologically important VP7 serotype 1, 2, 3, and 4... - Reactions to and antigenicity of two human-rhesus rotavirus reassortant vaccine candidates of serotypes 1 and 2 in Venezuelan infantsJ Flores
Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
J Clin Microbiol 27:512-8. 1989..Vaccine shedding was detected in 53 to 86% of the vaccinees. Analysis of neutralization antibody responses indicates that the VP4 protein represents an important component of the response induced by the vaccines... - More on RotaShield and intussusception: the role of age at the time of vaccinationL Simonsen
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Infect Dis 192:S36-43. 2005..We explore here the effect of age on the risk of intussusception... - Expression and self-assembly of recombinant capsid protein from the antigenically distinct Hawaii human calicivirusK Y Green
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Clin Microbiol 35:1909-14. 1997..The ready availability of Hawaii VLPs should enable larger-scale epidemiological studies to further elucidate the importance of this agent... - Evaluation of three panels of monoclonal antibodies for the identification of human rotavirus VP7 serotype by ELISAK Y Green
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, MD 20892
Bull World Health Organ 68:601-10. 1990..It appears that a battery of monoclonal antibodies for each serotype may be required to identify antigenic variants within a serotype. Additional studies are needed to assess the extent of antigenic variation in rotavirus field strains... - Species-specific but not genotype-specific primary and secondary isotype-specific NSP4 antibody responses in gnotobiotic calves and piglets infected with homologous host bovine (NSP4[A]) or porcine (NSP4[B]) rotavirusLijuan Yuan
Epidemiology Section, Laboratory of Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Virology 330:92-104. 2004..Thus, in an approach to immunization with a live oral rotavirus vaccine, the NSP4 protein does not appear to play an important role in protection against rotavirus disease and infection... - A porcine G9 rotavirus strain shares neutralization and VP7 phylogenetic sequence lineage 3 characteristics with contemporary human G9 rotavirus strainsYasutaka Hoshino
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6308, 50 South Drive MSC 8026, Bethesda, MD 20892 8026, USA
Virology 332:177-88. 2005..Furthermore, by sequence analysis, the A2 VP7 was shown to belong to lineage 3 G9. These findings raise intriguing questions regarding possible explanations for the emergence of variations among the G9 strains... - Porcine rotavirus strain Gottfried-based human rotavirus candidate vaccines: construction and characterizationYasutaka Hoshino
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8026, USA
Vaccine 23:3791-9. 2005.... - A rotavirus strain isolated from pig-tailed macaque (Macaca nemestrina) with diarrhea bears a P6[1]:G8 specificityYasutaka Hoshino
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8026, USA
Virology 345:1-12. 2006..Because of its unique simian serotype, this virus may prove to be valuable in challenge studies in a non-human primate model in studies of rotavirus immunity... - Neonatal administration of rhesus rotavirus tetravalent vaccineTimo Vesikari
University of Tampere Medical School, Biokatu 10, 33520 Tampere, Finland
Pediatr Infect Dis J 25:118-22. 2006..We hypothesized that giving the first dose of RRV-TV vaccine during the neonatal period might reduce the reactogenicity of RRV-TV vaccine without compromising the utilization of the vaccine... - Rotavirus vaccinesLone Simonsen
N Engl J Med 354:1747-51; author reply 1747-51. 2006 - Safety, efficacy, and immunogenicity of 2 doses of bovine-human (UK) and rhesus-rhesus-human rotavirus reassortant tetravalent vaccines in Finnish childrenTimo Vesikari
Vaccine Research Center, University of Tampere Medical School, Tampere, Finland
J Infect Dis 194:370-6. 2006..A corresponding tetravalent (types G1, G2, G3, and G4) reassortant vaccine based on bovine-human (UK) rotavirus reassortant tetravalent (BRV-TV) vaccine was developed concurrently... - Rotavirus serotype G9 strains belonging to VP7 gene phylogenetic sequence lineage 1 may be more suitable for serotype G9 vaccine candidates than those belonging to lineage 2 or 3Yasutaka Hoshino
Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8026, USA
J Virol 78:7795-802. 2004..These findings may have important implications for the development of G9 rotavirus vaccine candidates, as the strain with the broadest reactivity (i.e., a prime strain) would certainly be the ideal strain for inclusion in a vaccine... - Homotypic and heterotypic serum isotype-specific antibody responses to rotavirus nonstructural protein 4 and viral protein (VP) 4, VP6, and VP7 in infants who received selected live oral rotavirus vaccinesLijuan Yuan
Epidemiology Section, Laboratory of Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Infect Dis 189:1833-45. 2004..Antibody titers to homotypic and/or heterotypic NSP4s were positively correlated with those to VP6 before and after vaccination... - Clinical evaluation of a single oral dose of human-bovine (UK) reassortant rotavirus vaccines Wa x UK (P1A[8],G6) and Wa x (DS-1 x UK) (P1A[8],G2)Maryna C Eichelberger
Center for Immunization Research, Department of International Health, Johns Hopkins School of Public Health, Baltimore, Maryland, USA
J Med Virol 66:407-16. 2002..Each of these vaccines appeared to be well-tolerated and immunogenic in infants less than 6 months of age following a single oral dose, and therefore should be evaluated further as vaccine candidates... - A predominant role for Norwalk-like viruses as agents of epidemic gastroenteritis in Maryland nursing homes for the elderlyKim Y Green
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Infect Dis 185:133-46. 2002..Taken together with a retrospective analysis of bacterial gastroenteritis in this same setting, these data support a major role for NLVs as etiologic agents of gastroenteritis in elderly persons... - Characterization of neutralization specificities of outer capsid spike protein VP4 of selected murine, lapine, and human rotavirus strainsYasutaka Hoshino
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8026, USA
Virology 299:64-71. 2002..P serotype 13[20] was assigned to murine rotavirus EHP strain VP4, which was shown to be distinct from all the P serotypes/genotypes examined in the present study... - Generation and characterization of six single VP4 gene substitution reassortant rotavirus vaccine candidates: each bears a single human rotavirus VP4 gene encoding P serotype 1A[8] or 1B[4] and the remaining 10 genes of rhesus monkey rotavirus MMU18006 orYasutaka Hoshino
Epidemiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6308, 50 South Drive MSC 8026, Bethesda, MD 20892 8026, USA
Vaccine 20:3576-84. 2002..Similarly, three single VP4 gene (P1A[8] or P1B[4]) substitution reassortants have also been generated in a background of 10 bovine (UK) rotavirus genes for addition to a second generation UK-based quadrivalent vaccine... - Horizontal transmission of rhesus monkey rotavirus-based quadrivalent vaccine during a phase 3 clinical trial in Caracas, VenezuelaYasutaka Hoshino
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 50, Rm 6308, 50 South Drive, Bethesda, MD 20892 8026, USA
J Infect Dis 187:791-800. 2003..5 mL of a 10% stool suspension. Reassortants of vaccine virus and wild-type human rotavirus were not detected... - Reappraisal of the association of intussusception with the licensed live rotavirus vaccine challenges initial conclusionsBrian R Murphy
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Infect Dis 187:1301-8. 2003 - Construction and characterization of rhesus monkey rotavirus (MMU18006)- or bovine rotavirus (UK)-based serotype G5, G8, G9 or G10 single VP7 gene substitution reassortant candidate vaccinesYasutaka Hoshino
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6308, 50 South Drive, MSC 8026, Bethesda, MD 20892 8026, USA
Vaccine 21:3003-10. 2003..These candidate vaccines could be evaluated singly in special populations or in combination with a RRV- or an UK-based quadrivalent vaccine to broaden its G serotype specificity... - Human rotavirus strains bearing VP4 gene P[6] allele recovered from asymptomatic or symptomatic infections share similar, if not identical, VP4 neutralization specificitiesYasutaka Hoshino
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8026, USA
Virology 316:1-8. 2003..In addition, a close VP4 serotypic relationship between human P[6] rotavirus strains and the porcine P[6] rotavirus Gottfried strain was confirmed... - Ecological studies, rotavirus vaccination, and intussusceptionAlbert Z Kapikian
Lancet 359:1065-6; author reply 1066. 2002