I M Kapetanovic

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Overview of commonly used bioinformatics methods and their applications
    Izet M Kapetanovic
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7322, USA
    Ann N Y Acad Sci 1020:10-21. 2004
  2. doi request reprint Pharmacokinetics and tissue and tumor exposure of CP-31398, a p53-stabilizing agent, in rats
    Izet M Kapetanovic
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, Rm 2116, Bethesda, MD 20892, USA
    Cancer Chemother Pharmacol 69:1301-6. 2012
  3. pmc Effects of bacterial and presystemic nitroreductase metabolism of 2-chloro-5-nitro-N-phenylbenzamide on its mutagenicity and bioavailability
    Izet M Kapetanovic
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
    Chem Biol Interact 197:16-22. 2012
  4. pmc Computer-aided drug discovery and development (CADDD): in silico-chemico-biological approach
    I M Kapetanovic
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Building, Suite 2117, MSC 7322, Bethesda, MD 20892 7322, United States
    Chem Biol Interact 171:165-76. 2008
  5. ncbi request reprint Effects of oral dosing paradigms (gavage versus diet) on pharmacokinetics and pharmacodynamics
    I M Kapetanovic
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892 7322, United States
    Chem Biol Interact 164:68-75. 2006
  6. pmc Exposure and toxicity of green tea polyphenols in fasted and non-fasted dogs
    I M Kapetanovic
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
    Toxicology 260:28-36. 2009
  7. doi request reprint Pharmacokinetics and enhanced bioavailability of candidate cancer preventative agent, SR13668 in dogs and monkeys
    Izet M Kapetanovic
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, Rm 2116, Bethesda, MD 20892, USA
    Cancer Chemother Pharmacol 65:1109-16. 2010
  8. ncbi request reprint Proceedings: the Applications of Bioinformatics in Cancer Detection Workshop
    Izet M Kapetanovic
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7322, USA
    Ann N Y Acad Sci 1020:1-9. 2004
  9. ncbi request reprint Reactivity of atropaldehyde, a felbamate metabolite in human liver tissue in vitro
    Izet M Kapetanovic
    Laboratory of Clinical Pharmacology, CDER, US FDA, MOD 1, Laurel, MD 20708, USA
    Chem Biol Interact 142:119-34. 2002
  10. doi request reprint Comparison of pharmacokinetic and pharmacodynamic profiles of aspirin following oral gavage and diet dosing in rats
    Izet M Kapetanovic
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, Rm 2116, Bethesda, MD 20892, United States
    Chem Biol Interact 179:233-9. 2009

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Overview of commonly used bioinformatics methods and their applications
    Izet M Kapetanovic
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7322, USA
    Ann N Y Acad Sci 1020:10-21. 2004
    ..The goal of these efforts is to develop and identify bioinformatics methods with optimal sensitivity, specificity, and predictive capabilities...
  2. doi request reprint Pharmacokinetics and tissue and tumor exposure of CP-31398, a p53-stabilizing agent, in rats
    Izet M Kapetanovic
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, Rm 2116, Bethesda, MD 20892, USA
    Cancer Chemother Pharmacol 69:1301-6. 2012
    ..The objective of the current study was to describe the pharmacokinetic profile and tissue distribution of this novel agent following intravenous or oral (gavage and dietary) administration...
  3. pmc Effects of bacterial and presystemic nitroreductase metabolism of 2-chloro-5-nitro-N-phenylbenzamide on its mutagenicity and bioavailability
    Izet M Kapetanovic
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
    Chem Biol Interact 197:16-22. 2012
    ..However, the results shown here suggest that additional animal toxicological and bioavailability studies are required to establish a role of GW9662 as a chemopreventive agent...
  4. pmc Computer-aided drug discovery and development (CADDD): in silico-chemico-biological approach
    I M Kapetanovic
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Building, Suite 2117, MSC 7322, Bethesda, MD 20892 7322, United States
    Chem Biol Interact 171:165-76. 2008
    ..It is expected that the power of CADDD will grow as the technology continues to evolve...
  5. ncbi request reprint Effects of oral dosing paradigms (gavage versus diet) on pharmacokinetics and pharmacodynamics
    I M Kapetanovic
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892 7322, United States
    Chem Biol Interact 164:68-75. 2006
    ..This study illustrates potential pitfalls and limitations in trying to generalize based on data obtained with different oral dosing schemes and their extrapolation to potential efficacy and health risks in humans...
  6. pmc Exposure and toxicity of green tea polyphenols in fasted and non-fasted dogs
    I M Kapetanovic
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
    Toxicology 260:28-36. 2009
    ....
  7. doi request reprint Pharmacokinetics and enhanced bioavailability of candidate cancer preventative agent, SR13668 in dogs and monkeys
    Izet M Kapetanovic
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, Rm 2116, Bethesda, MD 20892, USA
    Cancer Chemother Pharmacol 65:1109-16. 2010
    ..However, it exhibited a very poor oral bioavailability (<1%) in both rats and dogs. Therefore, a study was initiated to develop and evaluate in dogs and non-human primates formulations with a more favorable oral bioavailability...
  8. ncbi request reprint Proceedings: the Applications of Bioinformatics in Cancer Detection Workshop
    Izet M Kapetanovic
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7322, USA
    Ann N Y Acad Sci 1020:1-9. 2004
    ..This paper summarizes the proceedings of this conference and points out future directions for research...
  9. ncbi request reprint Reactivity of atropaldehyde, a felbamate metabolite in human liver tissue in vitro
    Izet M Kapetanovic
    Laboratory of Clinical Pharmacology, CDER, US FDA, MOD 1, Laurel, MD 20708, USA
    Chem Biol Interact 142:119-34. 2002
    ..Therefore, mechanisms of reactive aldehydes toxicity could include direct interaction with critical cellular macromolecules or indirect interference with cellular detoxification mechanisms...
  10. doi request reprint Comparison of pharmacokinetic and pharmacodynamic profiles of aspirin following oral gavage and diet dosing in rats
    Izet M Kapetanovic
    Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, Rm 2116, Bethesda, MD 20892, United States
    Chem Biol Interact 179:233-9. 2009
    ..Therefore, more easily accessible plasma salicylate and thromboxane B(2) concentrations were representative of the salicylate exposure and prostaglandin E(2) pharmacodynamic biomarker in the target colon, respectively...
  11. ncbi request reprint The effects of D-23129, a new experimental anticonvulsant drug, on neurotransmitter amino acids in the rat hippocampus in vitro
    I M Kapetanovic
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Epilepsy Res 22:167-73. 1995
    ..Therefore, D-23129 and D-20443 exhibited two different effects on de novo synthesis of neurotransmitter amino acids, both of which could potentially be anticonvulsant in nature...
  12. ncbi request reprint Preventive effects of polyphenon E on urinary bladder and mammary cancers in rats and correlations with serum and urine levels of tea polyphenols
    Ronald A Lubet
    National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
    Mol Cancer Ther 6:2022-8. 2007
    ..The bioavailability of these tea polyphenols to different organ sites may contribute to the differing preventive efficacy of Polyphenon E against urinary bladder and mammary cancers...
  13. doi request reprint Murine oncogenicity and pharmacokinetics studies of 9-cis-UAB30, an RXR agonist, for breast cancer chemoprevention
    Izet M Kapetanovic
    National Cancer Institute, Bethesda, MD, USA
    Int J Toxicol 29:157-64. 2010
    ..These results suggest decreased absorption and/or possible induction of clearance mechanisms. Enzyme induction may underlie the hepatomegaly seen in mice treated with 9-cis-UAB30 for 6 months in the oncogenicity study...
  14. ncbi request reprint Subchronic toxicity and toxicogenomic evaluation of tamoxifen citrate + bexarotene in female rats
    Thomas L Horn
    Life Sciences Group, IIT Research Institute, Chicago, Illinois 60616, USA
    Toxicol Sci 99:612-27. 2007
    ..Differential expression of genes involved in drug and lipid metabolism may underlie the observed effects of BEX on cholesterol and triglyceride levels and its effects on liver histology...
  15. ncbi request reprint Effect of resveratrol on 17beta-estradiol sulfation by human hepatic and jejunal S9 and recombinant sulfotransferase 1E1
    Anna M Furimsky
    Toxicology and Metabolism, Biosciences Division, SRI International, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Drug Metab Dispos 36:129-36. 2008
    ..These findings also imply that resveratrol may inhibit the metabolism of other estrogen analogs or therapeutic agents such as ethinylestradiol or dietary components that are also substrates for SULT1E1...
  16. ncbi request reprint Glucuronidation of trans-resveratrol by human liver and intestinal microsomes and UGT isoforms
    Shirley S Brill
    Toxicology and Metabolism, Biosciences Division, SRI International, Menlo Park, CA 94025, USA
    J Pharm Pharmacol 58:469-79. 2006
    ..2 +/- 2.1 microM) and 7-HFC (Ki = 0.6 +/- 0.2 microM). Hence, resveratrol has the potential to inhibit the glucuronidation of concomitantly administered therapeutic drugs or dietary components that are substrates of UGT1A1 and UGT1A9...
  17. ncbi request reprint Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone
    Richard D Verschoyle
    Department of Cancer Studies, LRI, RKCSB, University of Leicester, Leicester, LE2 7LX, UK
    Cancer Chemother Pharmacol 57:1-6. 2006
    ..Here, we explored safety aspects of the novel flavone tricin, a constituent of rice bran and other grass species, which has recently been found to interfere with murine gastrointestinal carcinogenesis...
  18. ncbi request reprint Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesol
    Thomas L Horn
    Life Sciences Group, IIT Research Institute, Chicago, IL 60616, USA
    Chem Biol Interact 152:79-99. 2005
    ..It is concluded that non-toxic or minimally toxic doses of farnesol could alter the metabolism, efficacy, and/or toxicity of drugs with which it is co-administered...
  19. ncbi request reprint In vitro metabolic characterization, phenotyping, and kinetic studies of 9cUAB30, a retinoid X receptor-specific retinoid
    Gregory S Gorman
    Southern Research Institute, Birmingham, Alabama 35205, USA
    Drug Metab Dispos 35:1157-64. 2007
    ..Kinetic analysis of eight of the detected metabolites indicated that four seemed to follow classical hyperbolic kinetics, whereas the remaining four showed evidence of either autoactivation or substrate inhibition...