Research Topics
| I M KapetanovicSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Overview of commonly used bioinformatics methods and their applicationsIzet M Kapetanovic
Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7322, USA
Ann N Y Acad Sci 1020:10-21. 2004..The goal of these efforts is to develop and identify bioinformatics methods with optimal sensitivity, specificity, and predictive capabilities...
Pharmacokinetics and tissue and tumor exposure of CP-31398, a p53-stabilizing agent, in ratsIzet M Kapetanovic
Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, Rm 2116, Bethesda, MD 20892, USA
Cancer Chemother Pharmacol 69:1301-6. 2012..The objective of the current study was to describe the pharmacokinetic profile and tissue distribution of this novel agent following intravenous or oral (gavage and dietary) administration...
Effects of bacterial and presystemic nitroreductase metabolism of 2-chloro-5-nitro-N-phenylbenzamide on its mutagenicity and bioavailabilityIzet M Kapetanovic
Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
Chem Biol Interact 197:16-22. 2012..However, the results shown here suggest that additional animal toxicological and bioavailability studies are required to establish a role of GW9662 as a chemopreventive agent...- Computer-aided drug discovery and development (CADDD): in silico-chemico-biological approachI M Kapetanovic
Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Building, Suite 2117, MSC 7322, Bethesda, MD 20892 7322, United States
Chem Biol Interact 171:165-76. 2008..It is expected that the power of CADDD will grow as the technology continues to evolve... - Effects of oral dosing paradigms (gavage versus diet) on pharmacokinetics and pharmacodynamicsI M Kapetanovic
Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892 7322, United States
Chem Biol Interact 164:68-75. 2006..This study illustrates potential pitfalls and limitations in trying to generalize based on data obtained with different oral dosing schemes and their extrapolation to potential efficacy and health risks in humans... - Exposure and toxicity of green tea polyphenols in fasted and non-fasted dogsI M Kapetanovic
Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
Toxicology 260:28-36. 2009.... - Pharmacokinetics and enhanced bioavailability of candidate cancer preventative agent, SR13668 in dogs and monkeysIzet M Kapetanovic
Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, Rm 2116, Bethesda, MD 20892, USA
Cancer Chemother Pharmacol 65:1109-16. 2010..However, it exhibited a very poor oral bioavailability (<1%) in both rats and dogs. Therefore, a study was initiated to develop and evaluate in dogs and non-human primates formulations with a more favorable oral bioavailability... - Proceedings: the Applications of Bioinformatics in Cancer Detection WorkshopIzet M Kapetanovic
Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7322, USA
Ann N Y Acad Sci 1020:1-9. 2004..This paper summarizes the proceedings of this conference and points out future directions for research... - Reactivity of atropaldehyde, a felbamate metabolite in human liver tissue in vitroIzet M Kapetanovic
Laboratory of Clinical Pharmacology, CDER, US FDA, MOD 1, Laurel, MD 20708, USA
Chem Biol Interact 142:119-34. 2002..Therefore, mechanisms of reactive aldehydes toxicity could include direct interaction with critical cellular macromolecules or indirect interference with cellular detoxification mechanisms... - Comparison of pharmacokinetic and pharmacodynamic profiles of aspirin following oral gavage and diet dosing in ratsIzet M Kapetanovic
Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd, Rm 2116, Bethesda, MD 20892, United States
Chem Biol Interact 179:233-9. 2009..Therefore, more easily accessible plasma salicylate and thromboxane B(2) concentrations were representative of the salicylate exposure and prostaglandin E(2) pharmacodynamic biomarker in the target colon, respectively... - The effects of D-23129, a new experimental anticonvulsant drug, on neurotransmitter amino acids in the rat hippocampus in vitroI M Kapetanovic
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Epilepsy Res 22:167-73. 1995..Therefore, D-23129 and D-20443 exhibited two different effects on de novo synthesis of neurotransmitter amino acids, both of which could potentially be anticonvulsant in nature... - Preventive effects of polyphenon E on urinary bladder and mammary cancers in rats and correlations with serum and urine levels of tea polyphenolsRonald A Lubet
National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA
Mol Cancer Ther 6:2022-8. 2007..The bioavailability of these tea polyphenols to different organ sites may contribute to the differing preventive efficacy of Polyphenon E against urinary bladder and mammary cancers... - Murine oncogenicity and pharmacokinetics studies of 9-cis-UAB30, an RXR agonist, for breast cancer chemopreventionIzet M Kapetanovic
National Cancer Institute, Bethesda, MD, USA
Int J Toxicol 29:157-64. 2010..These results suggest decreased absorption and/or possible induction of clearance mechanisms. Enzyme induction may underlie the hepatomegaly seen in mice treated with 9-cis-UAB30 for 6 months in the oncogenicity study... - Subchronic toxicity and toxicogenomic evaluation of tamoxifen citrate + bexarotene in female ratsThomas L Horn
Life Sciences Group, IIT Research Institute, Chicago, Illinois 60616, USA
Toxicol Sci 99:612-27. 2007..Differential expression of genes involved in drug and lipid metabolism may underlie the observed effects of BEX on cholesterol and triglyceride levels and its effects on liver histology... - Effect of resveratrol on 17beta-estradiol sulfation by human hepatic and jejunal S9 and recombinant sulfotransferase 1E1Anna M Furimsky
Toxicology and Metabolism, Biosciences Division, SRI International, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
Drug Metab Dispos 36:129-36. 2008..These findings also imply that resveratrol may inhibit the metabolism of other estrogen analogs or therapeutic agents such as ethinylestradiol or dietary components that are also substrates for SULT1E1... - Glucuronidation of trans-resveratrol by human liver and intestinal microsomes and UGT isoformsShirley S Brill
Toxicology and Metabolism, Biosciences Division, SRI International, Menlo Park, CA 94025, USA
J Pharm Pharmacol 58:469-79. 2006..2 +/- 2.1 microM) and 7-HFC (Ki = 0.6 +/- 0.2 microM). Hence, resveratrol has the potential to inhibit the glucuronidation of concomitantly administered therapeutic drugs or dietary components that are substrates of UGT1A1 and UGT1A9... - Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavoneRichard D Verschoyle
Department of Cancer Studies, LRI, RKCSB, University of Leicester, Leicester, LE2 7LX, UK
Cancer Chemother Pharmacol 57:1-6. 2006..Tricin lacked genotoxic properties in the systems studied here. CONCLUSION: The results tentatively suggest that tricin may be considered safe enough for clinical development as a cancer chemopreventive agent... - Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesolThomas L Horn
Life Sciences Group, IIT Research Institute, Chicago, IL 60616, USA
Chem Biol Interact 152:79-99. 2005..It is concluded that non-toxic or minimally toxic doses of farnesol could alter the metabolism, efficacy, and/or toxicity of drugs with which it is co-administered... - In vitro metabolic characterization, phenotyping, and kinetic studies of 9cUAB30, a retinoid X receptor-specific retinoidGregory S Gorman
Southern Research Institute, Birmingham, Alabama 35205, USA
Drug Metab Dispos 35:1157-64. 2007..Kinetic analysis of eight of the detected metabolites indicated that four seemed to follow classical hyperbolic kinetics, whereas the remaining four showed evidence of either autoactivation or substrate inhibition...