Research Topics
| A V KajavaSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
The net charge of the first 18 residues of the mature sequence affects protein translocation across the cytoplasmic membrane of gram-negative bacteriaA V Kajava
Center for Molecular Modeling, CIT, National Institutes of Health, Bethesda, Maryland 20892, USA
J Bacteriol 182:2163-9. 2000..These data provide new insight into the mechanism of protein export in gram-negative bacteria and lead to practical recommendations for successful secretion of hybrid proteins...- Assessment of the ability to model proteins with leucine-rich repeats in light of the latest structural informationAndrey V Kajava
Center for Molecular Modeling, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA
Protein Sci 11:1082-90. 2002..The reliability of the LRR protein modeling suggests that it would be informative to apply similar modeling approaches to other classes of solenoid proteins... 
Dimorphism of polyglycine I: structural models for crystal modificationsA V Kajava
Swiss Institute for Experimental Cancer Research, CH 1066 Epalinges s Lausanne, Switzerland
Acta Crystallogr D Biol Crystallogr 55:436-42. 1999..New insight into the structure of the polyglycine associates opens up the possibility of designing improved silk-like and nylon materials...- alpha-Helical solenoid model for the human involucrinA V Kajava
Center for Molecular Modeling, CIT, National Institutes of Health, Bldg 12A, Bethesda, MD, USA
FEBS Lett 473:127-31. 2000..It is ideally suited to serve as a scaffold for cell envelope assembly and proposes a possible mode of the intermolecular interactions of involucrin during cell cornification... - Beta-helix model for the filamentous haemagglutinin adhesin of Bordetella pertussis and related bacterial secretory proteinsA V Kajava
Center for Molecular Modeling, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bldg 6, Room B2 34, MSC 2717, Bethesda, MD 20892 2717, USA
Mol Microbiol 42:279-92. 2001..Finally, we applied the same profile search method to the sequence database and found several other proteins--all large secreted proteins of bacterial provenance--that have similar repeats and probably also similar structures... - Structural diversity of leucine-rich repeat proteinsA V Kajava
Swiss Institute for Experimental Cancer Research, Ch des Boveresses 155, s Lausanne, Epalinges, CH 1066, Switzerland
J Mol Biol 277:519-27. 1998..The approach used for the prediction of the leucine-rich repeat protein structures can be applied to other proteins containing internal repeats of about 20 to 30 residue in length... - Review: proteins with repeated sequence--structural prediction and modelingA V Kajava
Center for Molecular Modeling, Bethesda, Maryland 20892-5626, USA
J Struct Biol 134:132-44. 2001..The models of leucine-rich repeat proteins and bacterial proteins with pentapeptide repeats are examined in light of the recently solved structures of the related molecules... - A model of Cdc25 phosphatase catalytic domain and Cdk-interaction surface based on the presence of a rhodanese homology domainK Hofmann
Bioinformatics Group, Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, Epalinges, CH 1066, Switzerland
J Mol Biol 282:195-208. 1998.... - NMR solution structure of Mob1, a mitotic exit network protein and its interaction with an NDR kinase peptideLuc Ponchon
Centre de Biochimie Structurale INSERM U554 CNRS UMR5048 UM1, 29 rue de Navacelles, 34090 Montpellier, France
J Mol Biol 337:167-82. 2004..Our data suggest that the NDR kinase is a functional Dbf2 homologue in animal cells and contributes to the understanding of the molecular function of Mob1 proteins... - Processing of Escherichia coli alkaline phosphatase. Sequence requirements and possible conformations of the -6 to -4 region of the signal peptideAndrey V Kajava
Center for Molecular Modeling, CIT, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:50396-402. 2002..These results permit us to specify sequence requirements at -6, -5, and -4 positions for efficient processing and to improve the prediction of yet unknown cleavage sites... - The parallel superpleated beta-structure as a model for amyloid fibrils of human amylinAndrey V Kajava
Centre de Recherches de Biochimie Macromoleculaire, CNRS FRE 2593, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
J Mol Biol 348:247-52. 2005..The model is consistent with current biophysical, biochemical and genetic data and, in particular, affords a plausible explanation for why rodent amylin does not form fibrils... - Tubulin polyglutamylase enzymes are members of the TTL domain protein familyCarsten Janke
Centre de Recherches de Biochimie Macromoleculaire, CNRS, 34293 Montpellier, France
Science 308:1758-62. 2005..In the model protist Tetrahymena thermophila, two conserved types of polyglutamylases were characterized that differ in substrate preference and subcellular localization... - Standard conformations of beta-arches in beta-solenoid proteinsJérôme Hennetin
Centre de Recherches de Biochimie Macromoleculaire, CNRS FRE 2593, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
J Mol Biol 358:1094-105. 2006.... - Structure, function, and amyloidogenesis of fungal prions: filament polymorphism and prion variantsUlrich Baxa
Laboratory of Structural Biology, National Institute of Arthritis, Musculoskeletal, and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Adv Protein Chem 73:125-80. 2006..We discuss a possible structural basis for this phenomenon... - Functional architecture of the retromer cargo-recognition complexAitor Hierro
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA
Nature 449:1063-7. 2007..This extended structure presents multiple binding sites for the SNX complex and receptor cargo, and appears capable of flexing to conform to curved vesicular membranes... - Protein structure based strategies for antigen discovery and vaccine development against malaria and other pathogensGiampietro Corradin
Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
Endocr Metab Immune Disord Drug Targets 7:259-65. 2007.... - The axial channel of the 20S proteasome opens upon binding of the PA200 activatorJoaquin Ortega
Laboratory of Structural Biology, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bldg 50, Room 1517, 50 South Drive MSC 8025, Bethesda, MD 20892-8025, USA
J Mol Biol 346:1221-7. 2005..Thus, the activation mechanism of PA200 is expressed via its allosteric effects on the 20 S core particle, perhaps facilitating release of digestion products or the entrance of substrates... - A model for Ure2p prion filaments and other amyloids: the parallel superpleated beta-structureAndrey V Kajava
, Centre National de la Recherche Scientifique FRE-2593, 1919 Route de Mende, 34293 Montpellier 5, France
Proc Natl Acad Sci U S A 101:7885-90. 2004..47 nm) and is readily adaptable to other amyloids, for instance the core of Sup35p filaments and glutamine expansions in huntingtin... - New HEAT-like repeat motifs in proteins regulating proteasome structure and functionAndrey V Kajava
Centre de Recherches de Biochimie Macromoleculaire, CNRS FRE 2593, 1919 Route de Mende, 34293 Montpellier, Cedex 5, France
J Struct Biol 146:425-30. 2004..Both PA200 and Ecm29 are composed almost entirely of such repeats, and therefore are likely to have alpha-helical solenoid structures. These observations lead us to speculate on how PA200 and Ecm29 may associate with proteasomes... - The carboxy terminus of Prospero regulates its subcellular localizationXiaolin Bi
Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Cell Biol 23:1014-24. 2003..Multiple processes direct Prospero regulation of cell fate in embryonic nervous system development... - A novel potential surface protein in Trichomonas vaginalis contains a leucine-rich repeat shared by micro-organisms from all three domains of lifeRobert P Hirt
Department of Zoology, The Natural History Museum, Cromwell Road, London SW7 5BD, UK
Mol Biochem Parasitol 125:195-9. 2002 - Redesign of a four-helix bundle protein by phage display coupled with proteolysis and structural characterization by NMR and X-ray crystallographyRuiai Chu
Laboratory of Biochemistry, Building 37, Room 6114E, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
J Mol Biol 323:253-62. 2002..These results suggest that the hydrophobic interactions in the core are not sufficient to dictate the selection and that the location of the cutting site of the protease also influences the selection of structures... - What curves alpha-solenoids? Evidence for an alpha-helical toroid structure of Rpn1 and Rpn2 proteins of the 26 S proteasomeAndrey V Kajava
Center for Molecular Modeling, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892 5626, USA
J Biol Chem 277:49791-8. 2002..An evolutionary link between the PC repeat-containing proteins and tetratricopeptide repeat proteins is proposed... - Epithelial barrier function: assembly and structural features of the cornified cell envelopeAndrey E Kalinin
Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Bioessays 24:789-800. 2002..Here we describe our current understanding of CE structure, a possible mechanism of its assembly, and various disorders that cause a defective barrier... - Analysis of DsRed Mutants. Space around the fluorophore accelerates fluorescence developmentAlexey V Terskikh
Stanford University, School of Medicine, Beckman Center, Stanford, California 94305, USA
J Biol Chem 277:7633-6. 2002..Comparative analysis of the mutants in the context of the crystal structure of DsRed suggests that mutants with free space around the fluorophore mature faster and more completely... - Origin and evolution of GALA-LRR, a new member of the CC-LRR subfamily: from plants to bacteria?Andrey V Kajava
Centre de Recherches de Biochimie Macromoleculaire, CNRS, University of Montpellier 1 and 2, Montpellier, France
PLoS ONE 3:e1694. 2008..This conclusion provides a strong background for further functional studies aimed at determining the role of these type III effectors in the virulence of R. solanacearum...