Maria B Kadiiska

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Lipid-derived free radical production in superantigen-induced interstitial pneumonia
    Hisako Miyakawa
    Free Radical Metabolite Section, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 47:241-9. 2009
  2. ncbi request reprint Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning
    M B Kadiiska
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 38:711-8. 2005
  3. ncbi request reprint Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?
    M B Kadiiska
    Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MD F0 02, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 38:698-710. 2005
  4. ncbi request reprint ESR investigation of the oxidative damage in lungs caused by asbestos and air pollution particles
    M B Kadiiska
    National Institutes of Environmental Health Sciences, National Institutes of Health, MD F0 02, P O Box 12233, Research Triangle Park, NC 27709, USA
    Spectrochim Acta A Mol Biomol Spectrosc 60:1371-7. 2004
  5. pmc Biomarkers of Oxidative Stress Study IV: ozone exposure of rats and its effect on antioxidants in plasma and bronchoalveolar lavage fluid
    Maria B Kadiiska
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 51:1636-42. 2011
  6. ncbi request reprint In vivo copper-mediated free radical production: an ESR spin-trapping study
    Maria B Kadiiska
    National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 2233, USA
    Spectrochim Acta A Mol Biomol Spectrosc 58:1227-39. 2002
  7. ncbi request reprint Biomarkers of oxidative stress study: are plasma antioxidants markers of CCl(4) poisoning?
    M B Kadiiska
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 28:838-45. 2000
  8. ncbi request reprint Acute methanol intoxication generates free radicals in rats: an ESR spin trapping investigation
    M B Kadiiska
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 28:1106-14. 2000
  9. ncbi request reprint Ethylene glycol generates free radical metabolites in rats: an ESR in vivo spin trapping investigation
    M B Kadiiska
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 13:1187-91. 2000
  10. ncbi request reprint Reduction of 1,3-diphenyl-1-triazene by rat hepatic microsomes, by cecal microflora, and in rats generates the phenyl radical metabolite: nn ESR spin-trapping investigation
    M B Kadiiska
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 13:1082-6. 2000

Collaborators

Detail Information

Publications38

  1. pmc Lipid-derived free radical production in superantigen-induced interstitial pneumonia
    Hisako Miyakawa
    Free Radical Metabolite Section, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 47:241-9. 2009
    ....
  2. ncbi request reprint Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning
    M B Kadiiska
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 38:711-8. 2005
    ....
  3. ncbi request reprint Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?
    M B Kadiiska
    Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MD F0 02, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 38:698-710. 2005
    ..All other products were not changed by CCl4 or showed fewer significant effects...
  4. ncbi request reprint ESR investigation of the oxidative damage in lungs caused by asbestos and air pollution particles
    M B Kadiiska
    National Institutes of Environmental Health Sciences, National Institutes of Health, MD F0 02, P O Box 12233, Research Triangle Park, NC 27709, USA
    Spectrochim Acta A Mol Biomol Spectrosc 60:1371-7. 2004
    ..Furthermore, it is concluded that without the presence of a spin-trapping agent, no free radical metabolites could be detected directly by ESR in either exposure...
  5. pmc Biomarkers of Oxidative Stress Study IV: ozone exposure of rats and its effect on antioxidants in plasma and bronchoalveolar lavage fluid
    Maria B Kadiiska
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 51:1636-42. 2011
    ..We conclude that measurements of antioxidants in plasma are not sensitive biomarkers for oxidative damage induced by ozone and are not a useful choice for the assessment of oxidative damage by ozone in vivo...
  6. ncbi request reprint In vivo copper-mediated free radical production: an ESR spin-trapping study
    Maria B Kadiiska
    National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 2233, USA
    Spectrochim Acta A Mol Biomol Spectrosc 58:1227-39. 2002
    ..If these precautions were not taken, radical adducts generated ex vivo could be mistaken for radical adducts produced in vivo and excreted into the bile...
  7. ncbi request reprint Biomarkers of oxidative stress study: are plasma antioxidants markers of CCl(4) poisoning?
    M B Kadiiska
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 28:838-45. 2000
    ....
  8. ncbi request reprint Acute methanol intoxication generates free radicals in rats: an ESR spin trapping investigation
    M B Kadiiska
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 28:1106-14. 2000
    ..This is the first ESR evidence of methanol-derived free radical generation in an animal model of acute methanol intoxication...
  9. ncbi request reprint Ethylene glycol generates free radical metabolites in rats: an ESR in vivo spin trapping investigation
    M B Kadiiska
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 13:1187-91. 2000
    ..This report is the first evidence of ethylene glycol free radical metabolism in rats with acute ethylene glycol intoxication...
  10. ncbi request reprint Reduction of 1,3-diphenyl-1-triazene by rat hepatic microsomes, by cecal microflora, and in rats generates the phenyl radical metabolite: nn ESR spin-trapping investigation
    M B Kadiiska
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 13:1082-6. 2000
    ..The results show for the first time that the phenyl radical is formed by the reduction of DPT and may indicate a toxic potential for this chemical...
  11. pmc Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice
    Saurabh Chatterjee
    Free Radical Metabolites Group, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Free Radic Biol Med 46:454-61. 2009
    ..This suggests the presence of a possible mechanism for CPB1 activity loss with compensatory protein production...
  12. ncbi request reprint Synergistic production of lung free radicals by diesel exhaust particles and endotoxin
    Toyoko Arimoto
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 171:379-87. 2005
    ..This is the first demonstration that DEP and LPS work synergistically to enhance free radical generation in lungs, mediated by the activation of local XO...
  13. pmc Cadmium generates reactive oxygen- and carbon-centered radical species in rats: insights from in vivo spin-trapping studies
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 45:475-81. 2008
    ..This is the first study to show Cd generation of reactive oxygen- and carbon-centered radical species by involvement of both iron mediation through iron-catalyzed reactions and activation of Kupffer cells, the resident liver macrophages...
  14. pmc Protein Radical Formation Resulting from Eosinophil Peroxidase-catalyzed Oxidation of Sulfite
    Kalina Ranguelova
    Laboratory of Pharmacology, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Biol Chem 285:24195-205. 2010
    ..These studies suggest that EPO-dependent oxidative damage may play a role in tissue injury in bisulfite-exacerbated eosinophilic inflammatory disorders...
  15. pmc Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis
    Krisztian Stadler
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Am J Physiol Endocrinol Metab 295:E456-62. 2008
    ..Taken together, our data demonstrate that acetone administration, a model of ketosis, can lead to protein oxidation and lipid peroxidation through a free radical-dependent mechanism driven mainly by iNOS overexpression...
  16. ncbi request reprint A novel protocol to identify and quantify all spin trapped free radicals from in vitro/in vivo interaction of HO(.-) and DMSO: LC/ESR, LC/MS, and dual spin trapping combinations
    Steven Yue Qian
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 38:125-35. 2005
    ..This novel protocol provides a comprehensive way to characterize and quantify in vitro and in vivo free radical formation and will have many applications in biological research...
  17. ncbi request reprint In vivo lipid-derived free radical formation by NADPH oxidase in acute lung injury induced by lipopolysaccharide: a model for ARDS
    Keizo Sato
    Free Radical Metabolite Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    FASEB J 16:1713-20. 2002
    ..Rats treated intratracheally with LPS generate lipid-derived free radicals via activation of NADPH oxidase...
  18. pmc Cadmium-induced toxicity in rat primary mid-brain neuroglia cultures: role of oxidative stress from microglia
    Zhengqin Yang
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 98:488-94. 2007
    ..In conclusion, Cd is toxic to neuron-glia cultures, and the oxidative stress from microglia may play important roles in Cd-induced damage to dopaminergic neurons...
  19. pmc Free radical production requires both inducible nitric oxide synthase and xanthine oxidase in LPS-treated skin
    Kozo Nakai
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MD F0 01, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 103:4616-21. 2006
    ..Our results imply that both iNOS and XO, but neither NADPH oxidase nor ferric iron, work synergistically to form lipid radical and nitrotyrosine early in the skin inflammation caused by LPS...
  20. pmc Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes
    Krisztian Stadler
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233 MD F0 02, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 45:866-74. 2008
    ..Taken together, our studies support inducible nitric oxide synthase as a significant source of EPR-detectable reactive intermediates, which leads to lipid peroxidation and may contribute to disease progression as well...
  21. pmc P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice
    Saurabh Chatterjee
    Free Radical Metabolism Group, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 52:1666-79. 2012
    ..We conclude that the P2X7 receptor is a primary mediator of oxidative stress-induced exacerbation of inflammatory liver injury in obese mice via NADPH oxidase-dependent mechanisms...
  22. pmc Thiazolidinedione treatment decreases oxidative stress in spontaneously hypertensive heart failure rats through attenuation of inducible nitric oxide synthase-mediated lipid radical formation
    Maria B Kadiiska
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Diabetes 61:586-96. 2012
    ..Our results suggest that hepatic iNOS expression may underlie the accumulation of lipid end products and that reducing the accumulation of toxic lipid metabolites contributes to a better redox status in insulin-sensitive tissues...
  23. doi request reprint Role of oxidative stress in cadmium toxicity and carcinogenesis
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 238:209-14. 2009
    ..Adaptation to chronic Cd exposure reduces ROS production, but acquired Cd tolerance with aberrant gene expression plays important roles in chronic Cd toxicity and carcinogenesis...
  24. pmc An in vivo ESR spin-trapping study: free radical generation in rats from formate intoxication--role of the Fenton reaction
    A E Dikalova
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 98:13549-53. 2001
    ..The detection of formate free radical metabolites generated in vivo and the key role of the Fenton reaction in this process may be important for understanding the pathogenesis of both formate and methanol intoxication...
  25. pmc Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis
    Saurabh Chatterjee
    Environmental Health and Disease Laboratory, Department of Environmental Health Sciences, University of South Carolina, Columbia, SC 29208, USA Free Radical Metabolism Group, Laboratories of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA Electronic address
    J Hepatol 58:778-84. 2013
    ..Here we have examined the role of leptin in inducing oxidative stress and Kupffer cell activation in CCl4-mediated steatohepatitic lesions of obese mice...
  26. pmc Ceruloplasmin (ferroxidase) oxidizes hydroxylamine probes: deceptive implications for free radical detection
    Douglas Ganini
    Free Radical Metabolism Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 53:1514-21. 2012
    ..In conclusion, we show that the ferroxidase activity of ceruloplasmin is a possible biological source of artifacts in the cyclic hydroxylamine-oxidation assay used for reactive oxygen species detection and quantification...
  27. ncbi request reprint Characterization of the initial carbon-centered pentadienyl radical and subsequent radicals in lipid peroxidation: identification via on-line high performance liquid chromatography/electron spin resonance and mass spectrometry
    Steven Yue Qian
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 33:998-1009. 2002
    ..were detected and identified. The optimization of chromatography in the LC/ESR and MS combination provided a reliable and sensitive way for the detection and identification of expected radical adducts in vitro and in vivo...
  28. doi request reprint Catalase has a key role in protecting cells from the genotoxic effects of monomethylarsonous acid: a highly active metabolite of arsenic
    Jorge G Muñiz Ortiz
    Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Mol Mutagen 54:317-26. 2013
    ..These experiments suggest that CAT is involved in protecting cells against the genotoxic effects of the ·OH generated by MMA(III) ...
  29. doi request reprint EPR studies of in vivo radical production by 3,3',5,5'-tetrabromobisphenol A (TBBPA) in the Sprague-Dawley rat
    C F Chignell
    Laboratory of Pharmacology and Chemistry, NIEHS NIH, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 230:17-22. 2008
    ....
  30. ncbi request reprint Stress-related gene expression in mice treated with inorganic arsenicals
    J Liu
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute for Environmental Health Sciences, Mail Drop F0 09, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 61:314-20. 2001
    ..In summary, this study profiled the gene expression pattern in mice treated with inorganic arsenicals, which adds to our understanding of acute arsenic poisoning and toxicity...
  31. ncbi request reprint Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I/II-null mice
    Jie Liu
    Laboratory of Comparative Carcinogenesis, Mail Drop F0 09, NCI at NIEHS, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 32:525-35. 2002
    ..Thus, the mechanism of acute cadmium toxicity involves multiple facets including oxidative damage and aberrant gene expression, and absence of MT exacerbates Cd-induced aberrant gene expression...
  32. ncbi request reprint An improved GC/MS-based procedure for the quantitation of the isoprostane 15-F2t-IsoP in rat plasma
    C E Parker
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Biotechnol 18:105-18. 2001
    ....
  33. ncbi request reprint Enzymatic and nonenzymatic production of free radicals from the carcinogens 4-nitroquinoline N-oxide and 4-hydroxylaminoquinoline N-oxide
    Y C Fann
    Free Radical Metabolite Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA fann niehs nih gov
    Chem Res Toxicol 12:450-8. 1999
    ..The above is consistent with a one-electron reduction in the metabolism of these nitro compounds to anion free radicals by various flavoenzyme reductases...
  34. doi request reprint Subacute oral and dermal toxicity of tert-butyl hydroperoxide in Fischer F344/N rats and B6C3F1 mice
    Mamta Behl
    Division of the National Toxicology Program, Research Triangle Park, NC 27709, USA
    Cutan Ocul Toxicol 31:204-13. 2012
    ..There was no evidence of systemic absorption by the dermal route of exposure based on lack of pathological findings (Supported by National Institute of Environmental Health Sciences Contract No. N01-ES-65406)...
  35. ncbi request reprint In vivo identification of aflatoxin-induced free radicals in rat bile
    Rheal A Towner
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Free Radic Biol Med 35:1330-40. 2003
    ..Trapped 4-POBN radical adducts were also detected in rat bile following the in vivo metabolism of aflatoxin-M1, one of the hydroxylated metabolites of AFB1...
  36. ncbi request reprint The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and mice
    Fuyumi Isayama
    Laboratory of Hepatobiology and Toxicology, Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Free Radic Biol Med 35:1568-81. 2003
    ..These data support the hypothesis that oxidative stress and liver damage can occur independently of CYP activities in both rats and mice during early alcohol-induced liver injury...
  37. pmc Sustained formation of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-alpha, but not NADPH oxidase
    Courtney G Woods
    Department of Environmental Sciences and Engineering, University of North Carolina, 0031 Michael Hooker Research Center, Chapel Hill, NC 27599 7431, USA
    Free Radic Biol Med 42:335-42. 2007
    ..Therefore, peroxisome proliferator-induced POBN radical production in Kupffer cells may be limited to an acute response to these compounds in mouse liver...
  38. ncbi request reprint EPR studies of in vivo radical production by lipopolysaccharide: potential role of iron mobilized from iron-nitrosyl complexes
    Edlaine Linares
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Free Radic Biol Med 34:766-73. 2003
    ..Its formation is proposed to occur because of the mobilization of redox-active iron required to repair the nitrosyl complexes produced by LPS. The results suggest that iron chelation may be a useful adjuvant therapy for treating sepsis...