Research Topics
Genomes and Genes | Maria B KadiiskaSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Lipid-derived free radical production in superantigen-induced interstitial pneumoniaHisako Miyakawa
Free Radical Metabolite Section, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 47:241-9. 2009....
Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?M B Kadiiska
Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MD F0 02, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 38:698-710. 2005..All other products were not changed by CCl4 or showed fewer significant effects...- In vivo copper-mediated free radical production: an ESR spin-trapping studyMaria B Kadiiska
National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 2233, USA
Spectrochim Acta A Mol Biomol Spectrosc 58:1227-39. 2002..If these precautions were not taken, radical adducts generated ex vivo could be mistaken for radical adducts produced in vivo and excreted into the bile... - ESR investigation of the oxidative damage in lungs caused by asbestos and air pollution particlesM B Kadiiska
National Institutes of Environmental Health Sciences, National Institutes of Health, MD F0 02, P O Box 12233, Research Triangle Park, NC 27709, USA
Spectrochim Acta A Mol Biomol Spectrosc 60:1371-7. 2004..Furthermore, it is concluded that without the presence of a spin-trapping agent, no free radical metabolites could be detected directly by ESR in either exposure... - Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoningM B Kadiiska
National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 38:711-8. 2005.... - Ethylene glycol generates free radical metabolites in rats: an ESR in vivo spin trapping investigationM B Kadiiska
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Chem Res Toxicol 13:1187-91. 2000..This report is the first evidence of ethylene glycol free radical metabolism in rats with acute ethylene glycol intoxication... - Reduction of 1,3-diphenyl-1-triazene by rat hepatic microsomes, by cecal microflora, and in rats generates the phenyl radical metabolite: nn ESR spin-trapping investigationM B Kadiiska
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Chem Res Toxicol 13:1082-6. 2000..The results show for the first time that the phenyl radical is formed by the reduction of DPT and may indicate a toxic potential for this chemical... - Acute methanol intoxication generates free radicals in rats: an ESR spin trapping investigationM B Kadiiska
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 28:1106-14. 2000..This is the first ESR evidence of methanol-derived free radical generation in an animal model of acute methanol intoxication... - Biomarkers of oxidative stress study: are plasma antioxidants markers of CCl(4) poisoning?M B Kadiiska
National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 28:838-45. 2000.... - Biomarkers of Oxidative Stress Study IV: ozone exposure of rats and its effect on antioxidants in plasma and bronchoalveolar lavage fluidMaria B Kadiiska
Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 51:1636-42. 2011..We conclude that measurements of antioxidants in plasma are not sensitive biomarkers for oxidative damage induced by ozone and are not a useful choice for the assessment of oxidative damage by ozone in vivo... - Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic miceSaurabh Chatterjee
Free Radical Metabolites Group, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Free Radic Biol Med 46:454-61. 2009..This suggests the presence of a possible mechanism for CPB1 activity loss with compensatory protein production... - Cadmium generates reactive oxygen- and carbon-centered radical species in rats: insights from in vivo spin-trapping studiesJie Liu
Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 45:475-81. 2008..This is the first study to show Cd generation of reactive oxygen- and carbon-centered radical species by involvement of both iron mediation through iron-catalyzed reactions and activation of Kupffer cells, the resident liver macrophages... - Synergistic production of lung free radicals by diesel exhaust particles and endotoxinToyoko Arimoto
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Am J Respir Crit Care Med 171:379-87. 2005..This is the first demonstration that DEP and LPS work synergistically to enhance free radical generation in lungs, mediated by the activation of local XO... - Protein Radical Formation Resulting from Eosinophil Peroxidase-catalyzed Oxidation of SulfiteKalina Ranguelova
Laboratory of Pharmacology, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA
J Biol Chem 285:24195-205. 2010..These studies suggest that EPO-dependent oxidative damage may play a role in tissue injury in bisulfite-exacerbated eosinophilic inflammatory disorders... - Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosisKrisztian Stadler
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Am J Physiol Endocrinol Metab 295:E456-62. 2008..Taken together, our data demonstrate that acetone administration, a model of ketosis, can lead to protein oxidation and lipid peroxidation through a free radical-dependent mechanism driven mainly by iNOS overexpression... - A novel protocol to identify and quantify all spin trapped free radicals from in vitro/in vivo interaction of HO(.-) and DMSO: LC/ESR, LC/MS, and dual spin trapping combinationsSteven Yue Qian
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 38:125-35. 2005..This novel protocol provides a comprehensive way to characterize and quantify in vitro and in vivo free radical formation and will have many applications in biological research... - In vivo lipid-derived free radical formation by NADPH oxidase in acute lung injury induced by lipopolysaccharide: a model for ARDSKeizo Sato
Free Radical Metabolite Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
FASEB J 16:1713-20. 2002..Rats treated intratracheally with LPS generate lipid-derived free radicals via activation of NADPH oxidase... - Cadmium-induced toxicity in rat primary mid-brain neuroglia cultures: role of oxidative stress from microgliaZhengqin Yang
Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 98:488-94. 2007..In conclusion, Cd is toxic to neuron-glia cultures, and the oxidative stress from microglia may play important roles in Cd-induced damage to dopaminergic neurons... - Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetesKrisztian Stadler
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233 MD F0 02, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 45:866-74. 2008..Taken together, our studies support inducible nitric oxide synthase as a significant source of EPR-detectable reactive intermediates, which leads to lipid peroxidation and may contribute to disease progression as well... - Free radical production requires both inducible nitric oxide synthase and xanthine oxidase in LPS-treated skinKozo Nakai
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MD F0 01, Research Triangle Park, NC 27709, USA
Proc Natl Acad Sci U S A 103:4616-21. 2006..Our results imply that both iNOS and XO, but neither NADPH oxidase nor ferric iron, work synergistically to form lipid radical and nitrotyrosine early in the skin inflammation caused by LPS... - P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese miceSaurabh Chatterjee
Free Radical Metabolism Group, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 52:1666-79. 2012..We conclude that the P2X7 receptor is a primary mediator of oxidative stress-induced exacerbation of inflammatory liver injury in obese mice via NADPH oxidase-dependent mechanisms... - Thiazolidinedione treatment decreases oxidative stress in spontaneously hypertensive heart failure rats through attenuation of inducible nitric oxide synthase-mediated lipid radical formationMaria B Kadiiska
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
Diabetes 61:586-96. 2012..Our results suggest that hepatic iNOS expression may underlie the accumulation of lipid end products and that reducing the accumulation of toxic lipid metabolites contributes to a better redox status in insulin-sensitive tissues... 
Role of oxidative stress in cadmium toxicity and carcinogenesisJie Liu
Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 238:209-14. 2009..Adaptation to chronic Cd exposure reduces ROS production, but acquired Cd tolerance with aberrant gene expression plays important roles in chronic Cd toxicity and carcinogenesis...- An in vivo ESR spin-trapping study: free radical generation in rats from formate intoxication--role of the Fenton reactionA E Dikalova
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Proc Natl Acad Sci U S A 98:13549-53. 2001..The detection of formate free radical metabolites generated in vivo and the key role of the Fenton reaction in this process may be important for understanding the pathogenesis of both formate and methanol intoxication... - Characterization of the initial carbon-centered pentadienyl radical and subsequent radicals in lipid peroxidation: identification via on-line high performance liquid chromatography/electron spin resonance and mass spectrometrySteven Yue Qian
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 33:998-1009. 2002..were detected and identified. The optimization of chromatography in the LC/ESR and MS combination provided a reliable and sensitive way for the detection and identification of expected radical adducts in vitro and in vivo... - EPR studies of in vivo radical production by 3,3',5,5'-tetrabromobisphenol A (TBBPA) in the Sprague-Dawley ratC F Chignell
Laboratory of Pharmacology and Chemistry, NIEHS NIH, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 230:17-22. 2008.... - Stress-related gene expression in mice treated with inorganic arsenicalsJ Liu
Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute for Environmental Health Sciences, Mail Drop F0 09, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 61:314-20. 2001..In summary, this study profiled the gene expression pattern in mice treated with inorganic arsenicals, which adds to our understanding of acute arsenic poisoning and toxicity... - Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I/II-null miceJie Liu
Laboratory of Comparative Carcinogenesis, Mail Drop F0 09, NCI at NIEHS, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 32:525-35. 2002..Thus, the mechanism of acute cadmium toxicity involves multiple facets including oxidative damage and aberrant gene expression, and absence of MT exacerbates Cd-induced aberrant gene expression... - Enzymatic and nonenzymatic production of free radicals from the carcinogens 4-nitroquinoline N-oxide and 4-hydroxylaminoquinoline N-oxideY C Fann
Free Radical Metabolite Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA fann niehs nih gov
Chem Res Toxicol 12:450-8. 1999..The above is consistent with a one-electron reduction in the metabolism of these nitro compounds to anion free radicals by various flavoenzyme reductases... - An improved GC/MS-based procedure for the quantitation of the isoprostane 15-F2t-IsoP in rat plasmaC E Parker
Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Mol Biotechnol 18:105-18. 2001.... - Subacute oral and dermal toxicity of tert-butyl hydroperoxide in Fischer F344/N rats and B6C3F1 miceMamta Behl
Division of the National Toxicology Program, Research Triangle Park, NC 27709, USA
Cutan Ocul Toxicol 31:204-13. 2012..There was no evidence of systemic absorption by the dermal route of exposure based on lack of pathological findings (Supported by National Institute of Environmental Health Sciences Contract No. N01-ES-65406)... - Ceruloplasmin (ferroxidase) oxidizes hydroxylamine probes: deceptive implications for free radical detectionDouglas Ganini
Free Radical Metabolism Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 53:1514-21. 2012..In conclusion, we show that the ferroxidase activity of ceruloplasmin is a possible biological source of artifacts in the cyclic hydroxylamine-oxidation assay used for reactive oxygen species detection and quantification... - Sustained formation of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-alpha, but not NADPH oxidaseCourtney G Woods
Department of Environmental Sciences and Engineering, University of North Carolina, 0031 Michael Hooker Research Center, Chapel Hill, NC 27599 7431, USA
Free Radic Biol Med 42:335-42. 2007..Therefore, peroxisome proliferator-induced POBN radical production in Kupffer cells may be limited to an acute response to these compounds in mouse liver... - The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and miceFuyumi Isayama
Laboratory of Hepatobiology and Toxicology, Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Free Radic Biol Med 35:1568-81. 2003..These data support the hypothesis that oxidative stress and liver damage can occur independently of CYP activities in both rats and mice during early alcohol-induced liver injury... - In vivo identification of aflatoxin-induced free radicals in rat bileRheal A Towner
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
Free Radic Biol Med 35:1330-40. 2003..Trapped 4-POBN radical adducts were also detected in rat bile following the in vivo metabolism of aflatoxin-M1, one of the hydroxylated metabolites of AFB1... - EPR studies of in vivo radical production by lipopolysaccharide: potential role of iron mobilized from iron-nitrosyl complexesEdlaine Linares
, , , , Brazil
Free Radic Biol Med 34:766-73. 2003..Its formation is proposed to occur because of the mobilization of redox-active iron required to repair the nitrosyl complexes produced by LPS. The results suggest that iron chelation may be a useful adjuvant therapy for treating sepsis...