Kathryn S Jones

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Pathways of cell-cell transmission of HTLV-1
    Claudine Pique
    CNRS UMR 8104, INSERM U567, Universite Paris Descartes, Institut Cochin Paris, France
    Front Microbiol 3:378. 2012
  2. pmc Current concepts regarding the HTLV-1 receptor complex
    David Ghez
    CNRS UMR8147, Universite Rene Descartes, Paris 5, 161 rue de Sevres, 75743 Paris Cedex 15, France
    Retrovirology 7:99. 2010
  3. doi Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4(+) T cells
    Kathryn S Jones
    Basic Research Program, Science Applications International Corporation Frederick, Frederick, Maryland 21702, USA
    Nat Med 14:429-36. 2008
  4. pmc Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors
    Kathryn S Jones
    Basic Science Program, SAIC Frederick, Inc, NCI Frederick, Maryland, MD 21702, USA
    Viruses 3:794-810. 2011
  5. pmc Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 use different receptor complexes to enter T cells
    Kathryn S Jones
    Basic Research Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Maryland 21702, USA
    J Virol 80:8291-302. 2006
  6. pmc The receptor complex associated with human T-cell lymphotropic virus type 3 (HTLV-3) Env-mediated binding and entry is distinct from, but overlaps with, the receptor complexes of HTLV-1 and HTLV-2
    Kathryn S Jones
    Basic Science Program, SAIC Frederick, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    J Virol 83:5244-55. 2009
  7. ncbi Induction of human T cell leukemia virus type I receptors on quiescent naive T lymphocytes by TGF-beta
    Kathryn S Jones
    Basic Research Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    J Immunol 174:4262-70. 2005
  8. ncbi Regulation of the cell-surface expression of an HTLV-I binding protein in human T cells during immune activation
    Manisha D Nath
    Basic Research Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, MD 21702, USA
    Blood 101:3085-92. 2003
  9. pmc HTLV-1 uses HSPG and neuropilin-1 for entry by molecular mimicry of VEGF165
    Sophie Lambert
    Centre National de la Recherche Scientifique Unite Mixte de Recherche, INSERM U, Universite Paris Descartes, Institut Cochin, France
    Blood 113:5176-85. 2009
  10. pmc Heparan sulfate proteoglycans mediate attachment and entry of human T-cell leukemia virus type 1 virions into CD4+ T cells
    Kathryn S Jones
    Basic Research Program, SAIC Frederick, National Cancer Institute Frederick, MD 21702 1201, USA
    J Virol 79:12692-702. 2005

Collaborators

Detail Information

Publications14

  1. pmc Pathways of cell-cell transmission of HTLV-1
    Claudine Pique
    CNRS UMR 8104, INSERM U567, Universite Paris Descartes, Institut Cochin Paris, France
    Front Microbiol 3:378. 2012
    ..We also review in vitro and in vivo studies of infection and discuss how these finding may relate to the spread of HTLV-1 between individuals...
  2. pmc Current concepts regarding the HTLV-1 receptor complex
    David Ghez
    CNRS UMR8147, Universite Rene Descartes, Paris 5, 161 rue de Sevres, 75743 Paris Cedex 15, France
    Retrovirology 7:99. 2010
    ..In light of the most recent data, we propose a model of the HTLV-1 receptor complex and discuss its potential impact on HTLV-1 infection...
  3. doi Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4(+) T cells
    Kathryn S Jones
    Basic Research Program, Science Applications International Corporation Frederick, Frederick, Maryland 21702, USA
    Nat Med 14:429-36. 2008
    ..In addition to altering the current paradigm concerning how HTLV-1 transmission occurs, these studies suggest that impairment of DC function after HTLV-1 infection plays a part in pathogenesis...
  4. pmc Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors
    Kathryn S Jones
    Basic Science Program, SAIC Frederick, Inc, NCI Frederick, Maryland, MD 21702, USA
    Viruses 3:794-810. 2011
    ..We also discuss the similarities and differences between HTLV-1 and other deltaretroviruses in regards to receptor usage...
  5. pmc Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 use different receptor complexes to enter T cells
    Kathryn S Jones
    Basic Research Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Maryland 21702, USA
    J Virol 80:8291-302. 2006
    ....
  6. pmc The receptor complex associated with human T-cell lymphotropic virus type 3 (HTLV-3) Env-mediated binding and entry is distinct from, but overlaps with, the receptor complexes of HTLV-1 and HTLV-2
    Kathryn S Jones
    Basic Science Program, SAIC Frederick, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    J Virol 83:5244-55. 2009
    ..These results indicate that the complex of receptor molecules used by HTLV-3 to bind to primary T lymphocytes differs from that of both HTLV-1 and HTLV-2...
  7. ncbi Induction of human T cell leukemia virus type I receptors on quiescent naive T lymphocytes by TGF-beta
    Kathryn S Jones
    Basic Research Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    J Immunol 174:4262-70. 2005
    ....
  8. ncbi Regulation of the cell-surface expression of an HTLV-I binding protein in human T cells during immune activation
    Manisha D Nath
    Basic Research Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, MD 21702, USA
    Blood 101:3085-92. 2003
    ..These results indicate that cell-surface expression of the HTLV SU binding protein is up-regulated during in vitro activation and suggest a role for the HTLV-I SU binding proteins in the immunobiology of CD4(+) T cells...
  9. pmc HTLV-1 uses HSPG and neuropilin-1 for entry by molecular mimicry of VEGF165
    Sophie Lambert
    Centre National de la Recherche Scientifique Unite Mixte de Recherche, INSERM U, Universite Paris Descartes, Institut Cochin, France
    Blood 113:5176-85. 2009
    ..These findings demonstrate that HSPGs and NRP-1 function as HTLV-1 receptors in a cooperative manner and reveal an unexpected mimicry mechanism that may have major implications in vivo...
  10. pmc Heparan sulfate proteoglycans mediate attachment and entry of human T-cell leukemia virus type 1 virions into CD4+ T cells
    Kathryn S Jones
    Basic Research Program, SAIC Frederick, National Cancer Institute Frederick, MD 21702 1201, USA
    J Virol 79:12692-702. 2005
    ..Thus, HSPGs play a critical role in the binding and entry of HTLV-1 into CD4(+) T cells...
  11. pmc Similar regulation of cell surface human T-cell leukemia virus type 1 (HTLV-1) surface binding proteins in cells highly and poorly transduced by HTLV-1-pseudotyped virions
    Kathryn S Jones
    Basic Research Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
    J Virol 76:12723-34. 2002
    ..These results suggest that factors other than the number of primary binding receptors are responsible for the differences in the titers of HTLV-1 pseudotypes between highly susceptible cells and poorly susceptible cells...
  12. pmc Differential inhibitory effects of cyanovirin-N, griffithsin, and scytovirin on entry mediated by envelopes of gammaretroviruses and deltaretroviruses
    Stig M R Jensen
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA
    J Virol 88:2327-32. 2014
    ..For gammaretroviruses, CV-N inhibited entry mediated by some but not all of the envelopes examined, whereas GRFT and SVN displayed only little or no effect. ..
  13. pmc GLUT1 is not the primary binding receptor but is associated with cell-to-cell transmission of human T-cell leukemia virus type 1
    Norihiro Takenouchi
    Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20982, USA
    J Virol 81:1506-10. 2007
    ....
  14. pmc Cholesterol dependence of HTLV-I infection
    Matthew M Wielgosz
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    AIDS Res Hum Retroviruses 21:43-50. 2005
    ..Depletion of cholesterol did not alter receptor binding activity, suggesting a requirement for cholesterol in a postbinding virus entry step...