Kathryn S Jones
Affiliation: National Institutes of Health
- Conference highlights of the 16th International Conference on Human Retrovirology: HTLV and related retroviruses, 26-30 June 2013, Montreal, CanadaBenoit Barbeau
Département des Sciences Biologiques and BioMed Research Center, Universite du Quebec a Montreal, Room SB 3335, 2080 St Urbain, Montreal, Quebec, Canada
Retrovirology 11:19. 2014..In this review, highlights of the meeting are provided by different experts for each of these research areas. ..
- Pathways of cell-cell transmission of HTLV-1Claudine Pique
CNRS UMR 8104, INSERM U567, Universite Paris Descartes, Institut Cochin Paris, France
Front Microbiol 3:378. 2012..We also review in vitro and in vivo studies of infection and discuss how these finding may relate to the spread of HTLV-1 between individuals...
- Current concepts regarding the HTLV-1 receptor complexDavid Ghez
CNRS UMR8147, Universite Rene Descartes, Paris 5, 161 rue de Sevres, 75743 Paris Cedex 15, France
Retrovirology 7:99. 2010..In light of the most recent data, we propose a model of the HTLV-1 receptor complex and discuss its potential impact on HTLV-1 infection...
- Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptorsKathryn S Jones
Basic Science Program, SAIC Frederick, Inc, NCI Frederick, Maryland, MD 21702, USA
Viruses 3:794-810. 2011..We also discuss the similarities and differences between HTLV-1 and other deltaretroviruses in regards to receptor usage...
- The receptor complex associated with human T-cell lymphotropic virus type 3 (HTLV-3) Env-mediated binding and entry is distinct from, but overlaps with, the receptor complexes of HTLV-1 and HTLV-2Kathryn S Jones
Basic Science Program, SAIC Frederick, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
J Virol 83:5244-55. 2009..These results indicate that the complex of receptor molecules used by HTLV-3 to bind to primary T lymphocytes differs from that of both HTLV-1 and HTLV-2...
- Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4(+) T cellsKathryn S Jones
Basic Research Program, Science Applications International Corporation Frederick, Frederick, Maryland 21702, USA
Nat Med 14:429-36. 2008..In addition to altering the current paradigm concerning how HTLV-1 transmission occurs, these studies suggest that impairment of DC function after HTLV-1 infection plays a part in pathogenesis...
- Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 use different receptor complexes to enter T cellsKathryn S Jones
Basic Research Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Maryland 21702, USA
J Virol 80:8291-302. 2006....
- Induction of human T cell leukemia virus type I receptors on quiescent naive T lymphocytes by TGF-betaKathryn S Jones
Basic Research Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
J Immunol 174:4262-70. 2005....
- Regulation of the cell-surface expression of an HTLV-I binding protein in human T cells during immune activationManisha D Nath
Basic Research Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, MD 21702, USA
Blood 101:3085-92. 2003..These results indicate that cell-surface expression of the HTLV SU binding protein is up-regulated during in vitro activation and suggest a role for the HTLV-I SU binding proteins in the immunobiology of CD4(+) T cells...
- HTLV-1 uses HSPG and neuropilin-1 for entry by molecular mimicry of VEGF165Sophie Lambert
Centre National de la Recherche Scientifique Unite Mixte de Recherche, INSERM U, Universite Paris Descartes, Institut Cochin, France
Blood 113:5176-85. 2009..These findings demonstrate that HSPGs and NRP-1 function as HTLV-1 receptors in a cooperative manner and reveal an unexpected mimicry mechanism that may have major implications in vivo...
- Heparan sulfate proteoglycans mediate attachment and entry of human T-cell leukemia virus type 1 virions into CD4+ T cellsKathryn S Jones
Basic Research Program, SAIC Frederick, National Cancer Institute Frederick, MD 21702 1201, USA
J Virol 79:12692-702. 2005..Thus, HSPGs play a critical role in the binding and entry of HTLV-1 into CD4(+) T cells...
- Similar regulation of cell surface human T-cell leukemia virus type 1 (HTLV-1) surface binding proteins in cells highly and poorly transduced by HTLV-1-pseudotyped virionsKathryn S Jones
Basic Research Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
J Virol 76:12723-34. 2002..These results suggest that factors other than the number of primary binding receptors are responsible for the differences in the titers of HTLV-1 pseudotypes between highly susceptible cells and poorly susceptible cells...
- Differential inhibitory effects of cyanovirin-N, griffithsin, and scytovirin on entry mediated by envelopes of gammaretroviruses and deltaretrovirusesStig M R Jensen
Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA
J Virol 88:2327-32. 2014..For gammaretroviruses, CV-N inhibited entry mediated by some but not all of the envelopes examined, whereas GRFT and SVN displayed only little or no effect. ..
- GLUT1 is not the primary binding receptor but is associated with cell-to-cell transmission of human T-cell leukemia virus type 1Norihiro Takenouchi
Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20982, USA
J Virol 81:1506-10. 2007....
- Cholesterol dependence of HTLV-I infectionMatthew M Wielgosz
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
AIDS Res Hum Retroviruses 21:43-50. 2005..Depletion of cholesterol did not alter receptor binding activity, suggesting a requirement for cholesterol in a postbinding virus entry step...