Teresa R Johnson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Respiratory syncytial virus and innate immunity: a complex interplay of exploitation and subversion
    Teresa R Johnson
    Vaccine Research Center, NIAID, NIH, Building 40 Room 2614, 40 Convent Drive MSC3017, Bethesda, MD 20892, USA
    Expert Rev Vaccines 5:371-80. 2006
  2. pmc Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein
    Teresa R Johnson
    Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892 3017, USA
    J Leukoc Biol 84:748-59. 2008
  3. pmc TLR9 agonist, but not TLR7/8, functions as an adjuvant to diminish FI-RSV vaccine-enhanced disease, while either agonist used as therapy during primary RSV infection increases disease severity
    Teresa R Johnson
    Vaccine Research Center, Viral Pathogenesis Laboratory, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892 3017, USA
    Vaccine 27:3045-52. 2009
  4. pmc Vbeta14(+) T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus (RSV) G glycoprotein but not with formalin-inactivated RSV
    Teresa R Johnson
    Vaccine Research Center, NIAID, NIH, Bldg 40, Room 2614, 40 Convent Dr, MSC 3017, Bethesda, MD 20892 3017, USA
    J Virol 78:8753-60. 2004
  5. pmc Respiratory syncytial virus (RSV) G glycoprotein is not necessary for vaccine-enhanced disease induced by immunization with formalin-inactivated RSV
    Teresa R Johnson
    VRC, NIAID, NIH, Bldg 40 Room 2614, 40 Convent Dr, MSC 3017, Bethesda, MD 20892 3017, USA
    J Virol 78:6024-32. 2004
  6. pmc Primary human mDC1, mDC2, and pDC dendritic cells are differentially infected and activated by respiratory syncytial virus
    Teresa R Johnson
    Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Bethesda, Maryland, United States of America
    PLoS ONE 6:e16458. 2011
  7. ncbi request reprint IL-13 is sufficient for respiratory syncytial virus G glycoprotein-induced eosinophilia after respiratory syncytial virus challenge
    Teresa R Johnson
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive MSC 3017, Building 40, Bethesda, MD 20892, USA
    J Immunol 170:2037-45. 2003
  8. pmc Characterization of respiratory syncytial virus M- and M2-specific CD4 T cells in a murine model
    Jie Liu
    Vaccine Research Center, NIAID, National Institutes of Health, 40 Convent Dr, Bethesda, MD 20892 3017, USA
    J Virol 83:4934-41. 2009
  9. pmc Epitope-specific regulatory CD4 T cells reduce virus-induced illness while preserving CD8 T-cell effector function at the site of infection
    Jie Liu
    Vaccine Research Center, NIAID, National Institutes of Health, 40 Convent Dr, Bethesda, MD 20892 3017, USA
    J Virol 84:10501-9. 2010
  10. ncbi request reprint Contribution of respiratory syncytial virus G antigenicity to vaccine-enhanced illness and the implications for severe disease during primary respiratory syncytial virus infection
    Teresa R Johnson
    Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA
    Pediatr Infect Dis J 23:S46-57. 2004

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Respiratory syncytial virus and innate immunity: a complex interplay of exploitation and subversion
    Teresa R Johnson
    Vaccine Research Center, NIAID, NIH, Building 40 Room 2614, 40 Convent Drive MSC3017, Bethesda, MD 20892, USA
    Expert Rev Vaccines 5:371-80. 2006
    ..This review will address the impact of these findings on respiratory syncytial virus research...
  2. pmc Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein
    Teresa R Johnson
    Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892 3017, USA
    J Leukoc Biol 84:748-59. 2008
    ..These findings have important implications for the evaluation of candidate RSV vaccines...
  3. pmc TLR9 agonist, but not TLR7/8, functions as an adjuvant to diminish FI-RSV vaccine-enhanced disease, while either agonist used as therapy during primary RSV infection increases disease severity
    Teresa R Johnson
    Vaccine Research Center, Viral Pathogenesis Laboratory, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892 3017, USA
    Vaccine 27:3045-52. 2009
    ..Furthermore, these data underscore that amplification of anti-viral immune responses may result in immunopathology rather than immune-mediated protection...
  4. pmc Vbeta14(+) T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus (RSV) G glycoprotein but not with formalin-inactivated RSV
    Teresa R Johnson
    Vaccine Research Center, NIAID, NIH, Bldg 40, Room 2614, 40 Convent Dr, MSC 3017, Bethesda, MD 20892 3017, USA
    J Virol 78:8753-60. 2004
    ....
  5. pmc Respiratory syncytial virus (RSV) G glycoprotein is not necessary for vaccine-enhanced disease induced by immunization with formalin-inactivated RSV
    Teresa R Johnson
    VRC, NIAID, NIH, Bldg 40 Room 2614, 40 Convent Dr, MSC 3017, Bethesda, MD 20892 3017, USA
    J Virol 78:6024-32. 2004
    ....
  6. pmc Primary human mDC1, mDC2, and pDC dendritic cells are differentially infected and activated by respiratory syncytial virus
    Teresa R Johnson
    Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Bethesda, Maryland, United States of America
    PLoS ONE 6:e16458. 2011
    ..Defining the influence of RSV on the function of selected DC subsets may improve the likelihood of achieving protective vaccine-induced immunity...
  7. ncbi request reprint IL-13 is sufficient for respiratory syncytial virus G glycoprotein-induced eosinophilia after respiratory syncytial virus challenge
    Teresa R Johnson
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive MSC 3017, Building 40, Bethesda, MD 20892, USA
    J Immunol 170:2037-45. 2003
    ....
  8. pmc Characterization of respiratory syncytial virus M- and M2-specific CD4 T cells in a murine model
    Jie Liu
    Vaccine Research Center, NIAID, National Institutes of Health, 40 Convent Dr, Bethesda, MD 20892 3017, USA
    J Virol 83:4934-41. 2009
    ..Characterization of epitope-specific CD4 T cells by novel fluorochrome-conjugated peptide-I-A(b) tetramers allows detailed analysis of their roles in RSV pathogenesis and immunity...
  9. pmc Epitope-specific regulatory CD4 T cells reduce virus-induced illness while preserving CD8 T-cell effector function at the site of infection
    Jie Liu
    Vaccine Research Center, NIAID, National Institutes of Health, 40 Convent Dr, Bethesda, MD 20892 3017, USA
    J Virol 84:10501-9. 2010
    ..Achieving the optimal balance of regulatory and effector T-cell function is an important consideration for designing future vaccines...
  10. ncbi request reprint Contribution of respiratory syncytial virus G antigenicity to vaccine-enhanced illness and the implications for severe disease during primary respiratory syncytial virus infection
    Teresa R Johnson
    Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA
    Pediatr Infect Dis J 23:S46-57. 2004
    ....
  11. pmc Modified vaccinia virus Ankara immunization protects against lethal challenge with recombinant vaccinia virus expressing murine interleukin-4
    Lewis H McCurdy
    Vaccine Research Center NIAID NIH, 40 Convent Drive, MSC 3017, Building 40, Room 2502, Bethesda, MD 20892 3017, USA
    J Virol 78:12471-9. 2004
    ..These data support the continued development of MVA as an alternative candidate vaccine for smallpox...
  12. pmc Treatment with anti-LFA-1 delays the CD8+ cytotoxic-T-lymphocyte response and viral clearance in mice with primary respiratory syncytial virus infection
    John A Rutigliano
    Vaccine Research Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 78:3014-23. 2004
    ..These results may prove useful in the development of new therapies to combat RSV infection or other inflammatory diseases...
  13. ncbi request reprint Respiratory syncytial virus immunobiology and pathogenesis
    Barney S Graham
    Viral Pathogenesis Laboratory, National Institutes of Health, Bethesda, Maryland 20892 3017, USA
    Virology 297:1-7. 2002
  14. pmc RhoA signaling is required for respiratory syncytial virus-induced syncytium formation and filamentous virion morphology
    Tara L Gower
    Vaccine Research Center, Building 40, Room 2502, NIAID, NIH, 40 Convent Dr, MSC 3017, Bethesda, MD 20892 3017, USA
    J Virol 79:5326-36. 2005
    ..These data suggest that viral filamentous protuberances characteristic of RSV infection are associated with RhoA signaling, are important for filamentous virion morphology, and may play a role in initiating cell-to-cell fusion...
  15. doi request reprint Coadministration of polyinosinic:polycytidylic acid and immunostimulatory complexes modifies antigen processing in dendritic cell subsets and enhances HIV gag-specific T cell immunity
    Kylie M Quinn
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 191:5085-96. 2013
    ..These data illustrate how combining adjuvants, such as poly I:C and ISCOMs, that modulate Ag processing and have potent innate activity, can enhance the magnitude, quality, and phenotype of T cell immunity. ..
  16. pmc Respiratory syncytial virus glycoprotein G interacts with DC-SIGN and L-SIGN to activate ERK1 and ERK2
    Teresa R Johnson
    Viral Pathogenesis Laboratorya and Structural Biology Section, b Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:1339-47. 2012
    ....
  17. doi request reprint Subtypes of type I IFN differentially enhance cytokine expression by suboptimally stimulated CD4(+) T cells
    Philippa Hillyer
    Laboratory of Immunobiochemistry, Division of Bacterial, Parasitic and Allergenic Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD, USA
    Eur J Immunol 43:3197-208. 2013
    ..While type I IFNs may beneficially enhance CD4(+) T-cell memory responses to vaccines or viral pathogens, they may also enhance the function of resident Th2 cells and exacerbate allergic inflammation. ..
  18. doi request reprint Genetic vaccine for respiratory syncytial virus provides protection without disease potentiation
    Teresa R Johnson
    GenVec, Inc, Gaithersburg, Maryland, USA
    Mol Ther 22:196-205. 2014
    ..Overall, this genetic vaccine is highly effective without potentiating immunopathology, and the results support development of the vaccine candidate for human testing. ..
  19. ncbi request reprint Role for innate IFNs in determining respiratory syncytial virus immunopathology
    Teresa R Johnson
    Columbus Children s Research Institute and Department of Pediatrics, Ohio State University College of Medicine and Public Health, Columbus, 43205, USA
    J Immunol 174:7234-41. 2005
    ....
  20. pmc NK T cells contribute to expansion of CD8(+) T cells and amplification of antiviral immune responses to respiratory syncytial virus
    Teresa R Johnson
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Virol 76:4294-303. 2002
    ..These findings indicate that CD1d-dependent NK T cells play a role in expansion of CD8(+) T cells and amplification of antiviral responses to RSV...
  21. ncbi request reprint The role of IFN in respiratory syncytial virus pathogenesis
    Joan E Durbin
    Children s Research Institute, Children s Hospital, Columbus, OH 43205, USA
    J Immunol 168:2944-52. 2002
    ..These findings suggest that STAT1 activation by both type I (alphabeta) and type II (gamma) IFNs plays an important role in establishing a protective, Th1 Ag-specific immune response to RSV infection...
  22. ncbi request reprint Respiratory syncytial virus and other pneumoviruses: a review of the international symposium--RSV 2003
    Alexander C Schmidt
    Department of Pediatric Pulmonology and Immunology, Charite University Hospital, Berlin, Germany
    Virus Res 106:1-13. 2004
    ..Chanock Award for lifetime achievement in RSV research, an award named in honor of the person who started the field of RSV research by recovering the first human RS virus from infants with severe bronchiolitis in 1956...
  23. ncbi request reprint Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Biol Chem 277:35466-74. 2002
    ..These responses are mediated by multiple mechanisms with mucus metaplasia being dependent on and the inflammation and fibrosis being independent of an IL-13/IL-4R(alpha)/STAT-6 activation pathway...