Caroline H Johnson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Xenobiotic metabolomics: major impact on the metabolome
    Caroline H Johnson
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Pharmacol Toxicol 52:37-56. 2012
  2. pmc Cytochrome P450 regulation by α-tocopherol in Pxr-null and PXR-humanized mice
    Caroline H Johnson
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Drug Metab Dispos 41:406-13. 2013
  3. pmc Radiation metabolomics. 5. Identification of urinary biomarkers of ionizing radiation exposure in nonhuman primates by mass spectrometry-based metabolomics
    Caroline H Johnson
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Radiat Res 178:328-40. 2012
  4. pmc Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry-based metabolomics
    Caroline H Johnson
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD
    Am J Clin Nutr 96:818-30. 2012
  5. pmc Implication of intestinal VDR deficiency in inflammatory bowel disease
    Jung Hwan Kim
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Biochim Biophys Acta 1830:2118-28. 2013
  6. pmc Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity
    Huichang Bi
    School of Pharmaceutical Sciences, Sun Yat Sen University, 132 Waihuandong Road, University City, Guangzhou 510006, China Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Evid Based Complement Alternat Med 2013:985257. 2013
  7. doi request reprint Challenges and opportunities of metabolomics
    Caroline H Johnson
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Physiol 227:2975-81. 2012
  8. pmc Radiation metabolomics. 4. UPLC-ESI-QTOFMS-Based metabolomics for urinary biomarker discovery in gamma-irradiated rats
    Caroline H Johnson
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Radiat Res 175:473-84. 2011

Collaborators

Detail Information

Publications8

  1. doi request reprint Xenobiotic metabolomics: major impact on the metabolome
    Caroline H Johnson
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Pharmacol Toxicol 52:37-56. 2012
    ..This review discusses the impact that genetic, environmental, and gut microflora variation has on the metabolome, and how these variables may interact, positively and negatively, with xenobiotic metabolism...
  2. pmc Cytochrome P450 regulation by α-tocopherol in Pxr-null and PXR-humanized mice
    Caroline H Johnson
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Drug Metab Dispos 41:406-13. 2013
    ..This study revealed that α-tocopherol is a partial agonist of PXR and that PXR is necessary for Cyp3a induction by α-tocopherol. The implications of a novel role for α-tocopherol in Cyp2c gene regulation are also discussed...
  3. pmc Radiation metabolomics. 5. Identification of urinary biomarkers of ionizing radiation exposure in nonhuman primates by mass spectrometry-based metabolomics
    Caroline H Johnson
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Radiat Res 178:328-40. 2012
    ....
  4. pmc Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry-based metabolomics
    Caroline H Johnson
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD
    Am J Clin Nutr 96:818-30. 2012
    ..Cometabolism of vitamin E with other pharmaceutical products could affect the bioavailability of the drug. Thus, it is necessary to understand fully the metabolic routes and biological endpoints of vitamin E...
  5. pmc Implication of intestinal VDR deficiency in inflammatory bowel disease
    Jung Hwan Kim
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Biochim Biophys Acta 1830:2118-28. 2013
    ..To investigate the function of the intestinal Vdr gene in inflammatory bowel disease (IBD), in conjunction with the discovery of possible metabolic markers for IBD using intestine-specific Vdr knockout mice...
  6. pmc Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity
    Huichang Bi
    School of Pharmaceutical Sciences, Sun Yat Sen University, 132 Waihuandong Road, University City, Guangzhou 510006, China Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Evid Based Complement Alternat Med 2013:985257. 2013
    ..Taken together, the current study provides new insights into understanding the hepatoprotective effect of WZ against APAP-induced liver toxicity...
  7. doi request reprint Challenges and opportunities of metabolomics
    Caroline H Johnson
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Physiol 227:2975-81. 2012
    ..During drug treatment, the metabolic status of an individual could be monitored and used to indicate possible toxic effects. Metabolomics therefore has great potential for improving diagnosis, treatment and aftercare of disease...
  8. pmc Radiation metabolomics. 4. UPLC-ESI-QTOFMS-Based metabolomics for urinary biomarker discovery in gamma-irradiated rats
    Caroline H Johnson
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Radiat Res 175:473-84. 2011
    ..Downregulated biomarkers were shown to be related to food deprivation and starvation mechanisms. The UPLC-ESI-QTOFMS approach has aided in the advance for finding common biomarkers of ionizing radiation exposure...