Andrew D Johnson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Incorporating biological knowledge in the search for gene x gene interaction in genome-wide association studies
    Alisa K Manning
    School of Public Health, Boston University, 715 Albany Street, Boston, Massachusetts 02118, USA
    BMC Proc 3:S81. 2009
  2. ncbi The genetics of common variation affecting platelet development, function and pharmaceutical targeting
    A D Johnson
    National Heart, Lung and Blood Institute s The Framingham Heart Study, Framingham, MA 01702, USA
    J Thromb Haemost 9:246-57. 2011
  3. ncbi An open access database of genome-wide association results
    Andrew D Johnson
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 10:6. 2009
  4. ncbi Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues
    Andrew D Johnson
    Department of Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Pharmacogenet Genomics 18:781-91. 2008
  5. ncbi Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists
    Andrew D Johnson
    National Heart, Lung, and Blood Institute s The Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 42:608-13. 2010
  6. ncbi Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
  7. ncbi Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals
    Andrew D Johnson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA
    Hypertension 57:903-10. 2011
  8. ncbi Genome-wide association of pericardial fat identifies a unique locus for ectopic fat
    Caroline S Fox
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America
    PLoS Genet 8:e1002705. 2012
  9. ncbi Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability
    Danxin Wang
    Department of Pharmacology, Program in Pharmacogenomics, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Pharmacogenet Genomics 15:693-704. 2005
  10. ncbi Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G
    Ying Zhang
    Program in Pharmacogenomics, Department of Pharmacology, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 280:32618-24. 2005

Detail Information

Publications31

  1. ncbi Incorporating biological knowledge in the search for gene x gene interaction in genome-wide association studies
    Alisa K Manning
    School of Public Health, Boston University, 715 Albany Street, Boston, Massachusetts 02118, USA
    BMC Proc 3:S81. 2009
    ..012)...
  2. ncbi The genetics of common variation affecting platelet development, function and pharmaceutical targeting
    A D Johnson
    National Heart, Lung and Blood Institute s The Framingham Heart Study, Framingham, MA 01702, USA
    J Thromb Haemost 9:246-57. 2011
    ..Further work is necessary to discover and characterise loci for platelet function, and to assess whether these loci contribute to disease aetiologies or response to therapeutics...
  3. ncbi An open access database of genome-wide association results
    Andrew D Johnson
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 10:6. 2009
    ..However, no database or centralized resource currently exists that contains anywhere near the full scope of GWAS results...
  4. ncbi Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues
    Andrew D Johnson
    Department of Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Pharmacogenet Genomics 18:781-91. 2008
    ..We have used AEI to discover and characterize regulatory polymorphisms in OPRM1, TPH2, MDR1, DRD2, and VKORC1. The objective of this study was to use AEI to determine the extent of cis-regulatory factors in pharmacogenetic genes...
  5. ncbi Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists
    Andrew D Johnson
    National Heart, Lung, and Blood Institute s The Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 42:608-13. 2010
    ..05 in an additional African-American cohort (N<or=840 in the Genetic Study of Atherosclerosis Risk). These results provide insights into platelet aggregation pathways and may suggest new antiplatelet therapeutic targets...
  6. ncbi Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
    ..Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension...
  7. ncbi Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals
    Andrew D Johnson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA
    Hypertension 57:903-10. 2011
    ..Our findings suggest that these genes warrant further studies of their genetic effects on blood pressure, including pharmacogenetic interactions...
  8. ncbi Genome-wide association of pericardial fat identifies a unique locus for ectopic fat
    Caroline S Fox
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America
    PLoS Genet 8:e1002705. 2012
    ..rs10198628 near TRIB2 is associated with pericardial fat but not measures of generalized or visceral adiposity, reinforcing the concept that there are unique genetic underpinnings to ectopic fat distribution...
  9. ncbi Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability
    Danxin Wang
    Department of Pharmacology, Program in Pharmacogenomics, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Pharmacogenet Genomics 15:693-704. 2005
    ..CONCLUSIONS: the abundant 3435C > T SNP appears to be a main factor in allelic variation of ABCB1 mRNA expression in the liver, by changing mRNA stability...
  10. ncbi Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G
    Ying Zhang
    Program in Pharmacogenomics, Department of Pharmacology, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 280:32618-24. 2005
    ..Clarifying the functional relevance of polymorphisms associated with susceptibility to a complex disorder such as drug addiction provides a foundation for clinical association studies...
  11. ncbi Association of genetic variation in the mitochondrial genome with blood pressure and metabolic traits
    Chunyu Liu
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Hypertension 60:949-56. 2012
    ..Replication in independent samples, however, is needed to confirm these putative associations...
  12. ncbi Clinical and genetic correlates of growth differentiation factor 15 in the community
    Jennifer E Ho
    Framingham Heart Study, Framingham, MA
    Clin Chem 58:1582-91. 2012
    ..We therefore examined the clinical and genetic correlates of circulating GDF15 concentrations, which have not been investigated collectively...
  13. ncbi CLIA-tested genetic variants on commercial SNP arrays: potential for incidental findings in genome-wide association studies
    Andrew D Johnson
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702, USA
    Genet Med 12:355-63. 2010
    ..We set out to survey potential notifiable variants on arrays used in genome-wide association studies and in direct-to-consumer genetic services...
  14. ncbi Resequencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the framingham heart study
    Andrew D Johnson
    National Institutes of Health National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Circulation 127:799-810. 2013
    ..3 region followed by a comprehensive study of genetic associations with clinical and subclinical cardiovascular disease and its risk factors, as well as with copy number variation and gene expression, in the Framingham Heart Study (FHS)...
  15. ncbi Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation
    Jie Huang
    National Heart, Lung, and Blood Institute NHBLI Framingham Heart Study, Framingham, MA 01702, USA
    Blood 120:4873-81. 2012
    ..1. In summary, SNPs in SERPINE1 and ARNTL and an SNP associated with the expression of MUC3 were robustly associated with circulating levels of PAI-1...
  16. ncbi Gene expression analysis of whole blood, peripheral blood mononuclear cells, and lymphoblastoid cell lines from the Framingham Heart Study
    Roby Joehanes
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Physiol Genomics 44:59-75. 2012
    ..LCL, however, was able to detect two genes related to smoking status. PAX and PBMC identified Y-chromosome probe sets similarly and slightly better than LCL...
  17. ncbi Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction
    Christopher J O'Donnell
    MPH, NHLBI s Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Circulation 124:2855-64. 2011
    ..We sought to identify common genetic variants associated with CAC and further investigate their associations with MI...
  18. ncbi Large scale genotype-phenotype correlation analysis based on phylogenetic trees
    Farhat Habib
    Department of Physics, The Ohio State University, Columbus, OH 43210, USA
    Bioinformatics 23:785-8. 2007
    ..We use these methods to find SNPs correlated with resistance to Bacillus anthracis in inbred mouse strains. Our findings are consistent with the current biological literature, and also suggest potential novel candidate genes...
  19. ncbi Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women
    Caroline S Fox
    Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, Massachusetts, United States of America
    PLoS Genet 8:e1002695. 2012
    ..More refined phenotypes for body composition and fat distribution can detect new loci not previously uncovered in large-scale GWAS of anthropometric traits...
  20. ncbi SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap
    Andrew D Johnson
    The Framingham Heart Study of the National Heart, Lung, and Blood Institute of the National Institutes of Health, USA
    Bioinformatics 24:2938-9. 2008
    ..AVAILABILITY: SNAP server is available at http://www.broad.mit.edu/mpg/snap/...
  21. ncbi Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins
    Jacqueline S Domire
    Department of Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Cell Mol Life Sci 68:2951-60. 2011
    ..Notably, the translocation of D1 from cilia requires proteins mutated in the ciliopathy Bardet-Biedl syndrome (BBS), and we find that one of the BBS proteins, Bbs5, specifically interacts with D1...
  22. ncbi An XML-based system for synthesis of data from disparate databases
    Tahsin Kurc
    Biomedical Informatics Department, Ohio State University, 3184 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA
    J Am Med Inform Assoc 13:289-301. 2006
    ..The data management system also allows collaborators to share data in a uniform way and supports complex queries that target data sets...
  23. ncbi Polymorphisms affecting gene regulation and mRNA processing: broad implications for pharmacogenetics
    Andrew D Johnson
    Integrated Biomedical Sciences Graduate Program, Department of Pharmacology, College of Medicine and Public Health, The Ohio State University, 5072 Graves Hall, 333 W 10th Avenue, Columbus, OH 43210 1239, USA
    Pharmacol Ther 106:19-38. 2005
    ..Current methods and challenges associated with the identification and characterization of functional polymorphisms are also discussed...
  24. ncbi PRIMe: a method for characterization and evaluation of pleiotropic regions from multiple genome-wide association studies
    Jie Huang
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Bioinformatics 27:1201-6. 2011
    ..The Pleiotropic Region Identification Method (PRIMe) was developed to evaluate potentially pleiotropic loci based upon data from multiple genome-wide association studies (GWAS)...
  25. ncbi Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Proc Natl Acad Sci U S A 107:9293-8. 2010
    ....
  26. ncbi Genome-wide association meta-analysis for total serum bilirubin levels
    Andrew D Johnson
    National Heart Lung and Blood Institute s The Framingham Heart Study, 73 Mt Wayte Avenue, Suite 2, Framingham, MA 01702, USA
    Hum Mol Genet 18:2700-10. 2009
    ..In analyses for association with gallbladder disease or gallstones, top bilirubin SNPs in UGT1A1 and SLCO1B1 were not associated...
  27. ncbi Identification of ciliary localization sequences within the third intracellular loop of G protein-coupled receptors
    Nicolas F Berbari
    Department of Pharmacology, Division of Human Genetics, and College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 19:1540-7. 2008
    ..As Mchr1 mediates feeding behavior and metabolism, our results implicate ciliary signaling in the regulation of body weight...
  28. ncbi Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study
    Jennifer E Ho
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    J Hypertens 29:62-9. 2011
    ....
  29. ncbi Reprogramming somatic cells into stem cells
    Ramiro Alberio
    School of Biosciences University of Nottingham, Loughborough, NG2 5RD, UK
    Reproduction 132:709-20. 2006
    ..We also overview reprogramming events after somatic cell nuclear transfer (SCNT), as they may further instruct ex ovo strategies for cellular manipulation...
  30. ncbi Differential nuclear remodeling of mammalian somatic cells by Xenopus laevis oocyte and egg cytoplasm
    Ramiro Alberio
    Animal Development and Biotechnology Group, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leics, LE12 5RD, UK
    Exp Cell Res 307:131-41. 2005
    ....
  31. ncbi Read-through histone transcripts containing 3' adenylate tails are zygotically expressed in Xenopus embryos and undergo processing to mature transcripts when introduced into oocyte nuclei
    Thomas Masi
    Department of Pathology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996-4500, USA
    Biochem Biophys Res Commun 304:612-8. 2003
    ..Also, these results shed light on the enigma of the developmental regulation of adenylated histone transcripts in Xenopus oocytes...