Andrew D Johnson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Synthesis of 53 tissue and cell line expression QTL datasets reveals master eQTLs
    Xiaoling Zhang
    Division of Intramural Research, National Heart, Lung and Blood Institute, Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, 73 Mt, Wayte Ave, Suite 2, Framingham, MA, USA
    BMC Genomics 15:532. 2014
  2. pmc Incorporating biological knowledge in the search for gene x gene interaction in genome-wide association studies
    Alisa K Manning
    School of Public Health, Boston University, 715 Albany Street, Boston, Massachusetts 02118, USA
    BMC Proc 3:S81. 2009
  3. pmc The genetics of common variation affecting platelet development, function and pharmaceutical targeting
    A D Johnson
    National Heart, Lung and Blood Institute s The Framingham Heart Study, Framingham, MA 01702, USA
    J Thromb Haemost 9:246-57. 2011
  4. pmc Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists
    Andrew D Johnson
    National Heart, Lung, and Blood Institute s The Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 42:608-13. 2010
  5. pmc An open access database of genome-wide association results
    Andrew D Johnson
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 10:6. 2009
  6. pmc Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues
    Andrew D Johnson
    Department of Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Pharmacogenet Genomics 18:781-91. 2008
  7. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
  8. pmc Gene expression signatures of coronary heart disease
    Roby Joehanes
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 33:1418-26. 2013
  9. pmc Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals
    Andrew D Johnson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA
    Hypertension 57:903-10. 2011
  10. ncbi request reprint Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability
    Danxin Wang
    Department of Pharmacology, Program in Pharmacogenomics, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Pharmacogenet Genomics 15:693-704. 2005

Detail Information

Publications39

  1. pmc Synthesis of 53 tissue and cell line expression QTL datasets reveals master eQTLs
    Xiaoling Zhang
    Division of Intramural Research, National Heart, Lung and Blood Institute, Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, 73 Mt, Wayte Ave, Suite 2, Framingham, MA, USA
    BMC Genomics 15:532. 2014
    ..We synthesized eQTL results from >50 datasets, including new primary data from human brain, peripheral plaque and kidney samples, in order to discover features of human eQTLs...
  2. pmc Incorporating biological knowledge in the search for gene x gene interaction in genome-wide association studies
    Alisa K Manning
    School of Public Health, Boston University, 715 Albany Street, Boston, Massachusetts 02118, USA
    BMC Proc 3:S81. 2009
    ..012)...
  3. pmc The genetics of common variation affecting platelet development, function and pharmaceutical targeting
    A D Johnson
    National Heart, Lung and Blood Institute s The Framingham Heart Study, Framingham, MA 01702, USA
    J Thromb Haemost 9:246-57. 2011
    ..Further work is necessary to discover and characterise loci for platelet function, and to assess whether these loci contribute to disease aetiologies or response to therapeutics...
  4. pmc Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists
    Andrew D Johnson
    National Heart, Lung, and Blood Institute s The Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 42:608-13. 2010
    ..05 in an additional African-American cohort (N<or=840 in the Genetic Study of Atherosclerosis Risk). These results provide insights into platelet aggregation pathways and may suggest new antiplatelet therapeutic targets...
  5. pmc An open access database of genome-wide association results
    Andrew D Johnson
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 10:6. 2009
    ..However, no database or centralized resource currently exists that contains anywhere near the full scope of GWAS results...
  6. pmc Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues
    Andrew D Johnson
    Department of Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Pharmacogenet Genomics 18:781-91. 2008
    ..We have used AEI to discover and characterize regulatory polymorphisms in OPRM1, TPH2, MDR1, DRD2, and VKORC1. The objective of this study was to use AEI to determine the extent of cis-regulatory factors in pharmacogenetic genes...
  7. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
    ..Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension...
  8. pmc Gene expression signatures of coronary heart disease
    Roby Joehanes
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 33:1418-26. 2013
    ..To identify transcriptomic biomarkers of coronary heart disease (CHD) in 188 cases with CHD and 188 age- and sex-matched controls who were participants in the Framingham Heart Study...
  9. pmc Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals
    Andrew D Johnson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA
    Hypertension 57:903-10. 2011
    ..Our findings suggest that these genes warrant further studies of their genetic effects on blood pressure, including pharmacogenetic interactions...
  10. ncbi request reprint Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability
    Danxin Wang
    Department of Pharmacology, Program in Pharmacogenomics, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Pharmacogenet Genomics 15:693-704. 2005
    ..Among numerous polymorphisms in human ABCB1, the synonymous SNP 3435C > T has been associated with decreased mRNA and protein levels, via unknown mechanisms...
  11. pmc Genome-wide association of pericardial fat identifies a unique locus for ectopic fat
    Caroline S Fox
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, United States of America
    PLoS Genet 8:e1002705. 2012
    ..rs10198628 near TRIB2 is associated with pericardial fat but not measures of generalized or visceral adiposity, reinforcing the concept that there are unique genetic underpinnings to ectopic fat distribution...
  12. ncbi request reprint Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G
    Ying Zhang
    Program in Pharmacogenomics, Department of Pharmacology, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 280:32618-24. 2005
    ..Clarifying the functional relevance of polymorphisms associated with susceptibility to a complex disorder such as drug addiction provides a foundation for clinical association studies...
  13. pmc Resequencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the Framingham heart study
    Andrew D Johnson
    National Institutes of Health National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Circulation 127:799-810. 2013
    ..3 region followed by a comprehensive study of genetic associations with clinical and subclinical cardiovascular disease and its risk factors, as well as with copy number variation and gene expression, in the Framingham Heart Study (FHS)...
  14. pmc Association of genetic variation in the mitochondrial genome with blood pressure and metabolic traits
    Chunyu Liu
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Hypertension 60:949-56. 2012
    ..Replication in independent samples, however, is needed to confirm these putative associations...
  15. pmc Clinical and genetic correlates of growth differentiation factor 15 in the community
    Jennifer E Ho
    Framingham Heart Study, Framingham, MA, USA
    Clin Chem 58:1582-91. 2012
    ..We therefore examined the clinical and genetic correlates of circulating GDF15 concentrations, which have not been investigated collectively...
  16. pmc CLIA-tested genetic variants on commercial SNP arrays: potential for incidental findings in genome-wide association studies
    Andrew D Johnson
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702, USA
    Genet Med 12:355-63. 2010
    ..We set out to survey potential notifiable variants on arrays used in genome-wide association studies and in direct-to-consumer genetic services...
  17. pmc Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2
    Jie Huang
    From National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA J H, A D J, C J O Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD J H, A D J, C J O MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom J E H, V V, A F W, C H The Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY M Y, C J L Departments of Cardiology S T, J W J, Gerontology and Geriatrics S T, A J M d C, R G J W, and Molecular Epidemiology P E S, Leiden University Medical Center, The Netherlands Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands F W A Durrer Center for Cardiogenetic Research, P.O. Box 1365-91775
    Arterioscler Thromb Vasc Biol 34:1093-101. 2014
    ..We conducted a meta-analysis of genome-wide association studies to identify novel correlates of circulating levels of tPA...
  18. pmc A systems biology framework identifies molecular underpinnings of coronary heart disease
    Tianxiao Huan
    From the National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 33:1427-34. 2013
    ..The molecular mechanisms underlying CHD gene-disease associations, however, remain unclear. We hypothesized that genetic variants with both strong and subtle effects drive gene subnetworks that in turn affect CHD...
  19. pmc Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation
    Jie Huang
    National Heart, Lung, and Blood Institute NHBLI Framingham Heart Study, Framingham, MA 01702, USA
    Blood 120:4873-81. 2012
    ..1. In summary, SNPs in SERPINE1 and ARNTL and an SNP associated with the expression of MUC3 were robustly associated with circulating levels of PAI-1...
  20. pmc Gene expression analysis of whole blood, peripheral blood mononuclear cells, and lymphoblastoid cell lines from the Framingham Heart Study
    Roby Joehanes
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Physiol Genomics 44:59-75. 2012
    ..LCL, however, was able to detect two genes related to smoking status. PAX and PBMC identified Y-chromosome probe sets similarly and slightly better than LCL...
  21. pmc Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction
    Christopher J O'Donnell
    MPH, NHLBI s Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Circulation 124:2855-64. 2011
    ..We sought to identify common genetic variants associated with CAC and further investigate their associations with MI...
  22. ncbi request reprint Large scale genotype-phenotype correlation analysis based on phylogenetic trees
    Farhat Habib
    Department of Physics, The Ohio State University, Columbus, OH 43210, USA
    Bioinformatics 23:785-8. 2007
    ..We use these methods to find SNPs correlated with resistance to Bacillus anthracis in inbred mouse strains. Our findings are consistent with the current biological literature, and also suggest potential novel candidate genes...
  23. pmc Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Proc Natl Acad Sci U S A 107:9293-8. 2010
    ....
  24. pmc Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes
    Xiaoling Zhang
    Division of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, MD, USA
    Hum Mol Genet 23:782-95. 2014
    ..In conclusion, strong cis-acting variants are localized within nearly half of the GWAS loci studied, with particularly strong evidence for a regulatory role of the top GWAS SNP for expression of LPL, FADS2 and C6orf184...
  25. pmc Sex- and age-interacting eQTLs in human complex diseases
    Chen Yao
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Hum Mol Genet 23:1947-56. 2014
    ..We show that these eQTLs are also associated with many sex- or age-associated traits. These findings provide important context regarding the regulation of phenotypes by genotype-environment interaction...
  26. pmc Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women
    Caroline S Fox
    Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, Massachusetts, United States of America
    PLoS Genet 8:e1002695. 2012
    ..More refined phenotypes for body composition and fat distribution can detect new loci not previously uncovered in large-scale GWAS of anthropometric traits...
  27. pmc Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins
    Jacqueline S Domire
    Department of Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Cell Mol Life Sci 68:2951-60. 2011
    ..Notably, the translocation of D1 from cilia requires proteins mutated in the ciliopathy Bardet-Biedl syndrome (BBS), and we find that one of the BBS proteins, Bbs5, specifically interacts with D1...
  28. pmc SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap
    Andrew D Johnson
    The Framingham Heart Study of the National Heart, Lung, and Blood Institute of the National Institutes of Health, USA
    Bioinformatics 24:2938-9. 2008
    ....
  29. pmc An XML-based system for synthesis of data from disparate databases
    Tahsin Kurc
    Biomedical Informatics Department, Ohio State University, 3184 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA
    J Am Med Inform Assoc 13:289-301. 2006
    ..The data management system also allows collaborators to share data in a uniform way and supports complex queries that target data sets...
  30. ncbi request reprint Polymorphisms affecting gene regulation and mRNA processing: broad implications for pharmacogenetics
    Andrew D Johnson
    Integrated Biomedical Sciences Graduate Program, Department of Pharmacology, College of Medicine and Public Health, The Ohio State University, 5072 Graves Hall, 333 W 10th Avenue, Columbus, OH 43210 1239, USA
    Pharmacol Ther 106:19-38. 2005
    ..Current methods and challenges associated with the identification and characterization of functional polymorphisms are also discussed...
  31. pmc PRIMe: a method for characterization and evaluation of pleiotropic regions from multiple genome-wide association studies
    Jie Huang
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Bioinformatics 27:1201-6. 2011
    ..The Pleiotropic Region Identification Method (PRIMe) was developed to evaluate potentially pleiotropic loci based upon data from multiple genome-wide association studies (GWAS)...
  32. pmc Genome-wide association meta-analysis for total serum bilirubin levels
    Andrew D Johnson
    National Heart Lung and Blood Institute s The Framingham Heart Study, 73 Mt Wayte Avenue, Suite 2, Framingham, MA 01702, USA
    Hum Mol Genet 18:2700-10. 2009
    ..In analyses for association with gallbladder disease or gallstones, top bilirubin SNPs in UGT1A1 and SLCO1B1 were not associated...
  33. pmc Identification of ciliary localization sequences within the third intracellular loop of G protein-coupled receptors
    Nicolas F Berbari
    Department of Pharmacology, Division of Human Genetics, and College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 19:1540-7. 2008
    ..As Mchr1 mediates feeding behavior and metabolism, our results implicate ciliary signaling in the regulation of body weight...
  34. pmc GRASP: analysis of genotype-phenotype results from 1390 genome-wide association studies and corresponding open access database
    Richard Leslie
    Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung and Blood Institute, The Framingham Heart Study, Framingham, MA 01702, University of Massachusetts Medical School, Worcester, MA 01655 and Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USACardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung and Blood Institute, The Framingham Heart Study, Framingham, MA 01702, University of Massachusetts Medical School, Worcester, MA 01655 and Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Bioinformatics 30:i185-94. 2014
    ..GRASP v1.0 contains >6.2 million SNP-phenotype association from among 1390 GWAS studies. We re-annotated GWAS results with 16 annotation sources including some rarely compared to GWAS results (e.g. RNAediting sites, lincRNAs, PTMs)...
  35. pmc Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study
    Jennifer E Ho
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    J Hypertens 29:62-9. 2011
    ....
  36. ncbi request reprint Differential nuclear remodeling of mammalian somatic cells by Xenopus laevis oocyte and egg cytoplasm
    Ramiro Alberio
    Animal Development and Biotechnology Group, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leics, LE12 5RD, UK
    Exp Cell Res 307:131-41. 2005
    ....
  37. ncbi request reprint Reprogramming somatic cells into stem cells
    Ramiro Alberio
    School of Biosciences University of Nottingham, Loughborough, NG2 5RD, UK
    Reproduction 132:709-20. 2006
    ..We also overview reprogramming events after somatic cell nuclear transfer (SCNT), as they may further instruct ex ovo strategies for cellular manipulation...
  38. ncbi request reprint Read-through histone transcripts containing 3' adenylate tails are zygotically expressed in Xenopus embryos and undergo processing to mature transcripts when introduced into oocyte nuclei
    Thomas Masi
    Department of Pathology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996 4500, USA
    Biochem Biophys Res Commun 304:612-8. 2003
    ..Also, these results shed light on the enigma of the developmental regulation of adenylated histone transcripts in Xenopus oocytes...