Tian Jin

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Locally controlled inhibitory mechanisms are involved in eukaryotic GPCR-mediated chemosensing
    Xuehua Xu
    Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Cell Biol 178:141-53. 2007
  2. doi request reprint GPCR-controlled chemotaxis in Dictyostelium discoideum
    Tian Jin
    Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Twinbrook Facility, Rockville, MD, USA
    Wiley Interdiscip Rev Syst Biol Med 3:717-27. 2011
  3. pmc A vesicle surface tyrosine kinase regulates phagosome maturation
    Jun Fang
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Rockville, MD 20852, USA
    J Cell Biol 178:411-23. 2007
  4. pmc Genistein interferes with SDF-1- and HIV-mediated actin dynamics and inhibits HIV infection of resting CD4 T cells
    Jia Guo
    National Center for Biodefense and Infectious Diseases, Department of Molecular and Microbiology, George Mason University, Manassas VA 20110, USA
    Retrovirology 10:62. 2013
  5. doi request reprint Gradient sensing during chemotaxis
    Tian Jin
    Chemotaxis Signal Section, Laboratory of Immunogenetics, NIAID, NIH, Twinbrook II Facility, 12441 Parklawn Drive, Rockville, MD 20852, United States
    Curr Opin Cell Biol 25:532-7. 2013
  6. pmc Chemotaxis, chemokine receptors and human disease
    Tian Jin
    Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Twinbrook II Facility, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Cytokine 44:1-8. 2008
  7. doi request reprint How human leukocytes track down and destroy pathogens: lessons learned from the model organism Dictyostelium discoideum
    Tian Jin
    Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Twinbrook II Facility, 12331 Parklawn Drive, Rockville, MD 20852, USA
    Immunol Res 43:118-27. 2009
  8. ncbi request reprint Moving toward understanding eukaryotic chemotaxis
    Tian Jin
    Chemotaxis Signal Section, Laboratories of Immunogenetics, NIAID, NIH, Rockville, MD 20852, USA
    Eur J Cell Biol 85:905-13. 2006
  9. pmc Fluorescence resonance energy transfer imaging reveals that chemokine-binding modulates heterodimers of CXCR4 and CCR5 receptors
    Nilgun Isik
    Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Twinbrook II Facility, Rockville, MD, USA
    PLoS ONE 3:e3424. 2008
  10. pmc Quantitative imaging of single live cells reveals spatiotemporal dynamics of multistep signaling events of chemoattractant gradient sensing in Dictyostelium
    Xuehua Xu
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Mol Biol Cell 16:676-88. 2005

Collaborators

Detail Information

Publications29

  1. pmc Locally controlled inhibitory mechanisms are involved in eukaryotic GPCR-mediated chemosensing
    Xuehua Xu
    Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Cell Biol 178:141-53. 2007
    ..Our study demonstrates a novel spatiotemporal feature of currently unknown inhibitory mechanisms acting locally on the PI3K activation pathway...
  2. doi request reprint GPCR-controlled chemotaxis in Dictyostelium discoideum
    Tian Jin
    Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Twinbrook Facility, Rockville, MD, USA
    Wiley Interdiscip Rev Syst Biol Med 3:717-27. 2011
    ..We believe that such an approach will lead to a much better understanding of GPCR-controlled chemotaxis of all eukaryotic cells...
  3. pmc A vesicle surface tyrosine kinase regulates phagosome maturation
    Jun Fang
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Rockville, MD 20852, USA
    J Cell Biol 178:411-23. 2007
    ..Our findings suggest that localized tyrosine kinase signaling on the surface of endosome/lysosomes represents a control mechanism for phagosome maturation...
  4. pmc Genistein interferes with SDF-1- and HIV-mediated actin dynamics and inhibits HIV infection of resting CD4 T cells
    Jia Guo
    National Center for Biodefense and Infectious Diseases, Department of Molecular and Microbiology, George Mason University, Manassas VA 20110, USA
    Retrovirology 10:62. 2013
    ..To determine whether inhibiting SDF-1-mediated chemotactic activity can also inhibit HIV infection, we screened several inhibitors known to reduce SDF-1-mediated chemotaxis of T cells...
  5. doi request reprint Gradient sensing during chemotaxis
    Tian Jin
    Chemotaxis Signal Section, Laboratory of Immunogenetics, NIAID, NIH, Twinbrook II Facility, 12441 Parklawn Drive, Rockville, MD 20852, United States
    Curr Opin Cell Biol 25:532-7. 2013
    ..Here, I review our current understanding of the formation of chemoattractant gradients in vivo, the GPCR-mediated gradient sensing, and the sophisticated signaling network that guides the function of the actin cytoskeleton. ..
  6. pmc Chemotaxis, chemokine receptors and human disease
    Tian Jin
    Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Twinbrook II Facility, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Cytokine 44:1-8. 2008
    ..In this review, we wish to mention landmark discoveries in the chemotaxis research field that shaped our current understanding of this fundamental cell behavior and lay out key questions that remain to be addressed in the future...
  7. doi request reprint How human leukocytes track down and destroy pathogens: lessons learned from the model organism Dictyostelium discoideum
    Tian Jin
    Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Twinbrook II Facility, 12331 Parklawn Drive, Rockville, MD 20852, USA
    Immunol Res 43:118-27. 2009
    ..Here, we review recent research in these areas that have been conducted in the Chemotaxis Signal Section of NIAID's Laboratory of Immunogenetics...
  8. ncbi request reprint Moving toward understanding eukaryotic chemotaxis
    Tian Jin
    Chemotaxis Signal Section, Laboratories of Immunogenetics, NIAID, NIH, Rockville, MD 20852, USA
    Eur J Cell Biol 85:905-13. 2006
    ..In this review, we wish to look back at the journey that has led to our current understanding of chemotaxis of eukaryotic cells...
  9. pmc Fluorescence resonance energy transfer imaging reveals that chemokine-binding modulates heterodimers of CXCR4 and CCR5 receptors
    Nilgun Isik
    Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Twinbrook II Facility, Rockville, MD, USA
    PLoS ONE 3:e3424. 2008
    ..Both receptors are recruited to the immunological synapse during T-cell activation. However, it is not clear whether they form heterodimers and whether ligand binding modulates the dimer formation...
  10. pmc Quantitative imaging of single live cells reveals spatiotemporal dynamics of multistep signaling events of chemoattractant gradient sensing in Dictyostelium
    Xuehua Xu
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Mol Biol Cell 16:676-88. 2005
    ..We propose a revised model of gradient sensing, suggesting an important role for locally controlled components that inhibit PI3Kinase activity...
  11. ncbi request reprint A Gβγ effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis
    Jianshe Yan
    Chemotaxis Signal Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Dev Cell 22:92-103. 2012
    ..The pathway, consisting of GPCR, Gβγ, Elmo/Dock, Rac, and Arp2/3, spatially guides the growth of dendritic actin networks in pseudopods of eukaryotic cells during chemotaxis...
  12. doi request reprint Coupling mechanism of a GPCR and a heterotrimeric G protein during chemoattractant gradient sensing in Dictyostelium
    Xuehua Xu
    Chemotaxis Signal Section, National Institutes of Health, Rockville, MD 20852, USA
    Sci Signal 3:ra71. 2010
    ..We suggest that chemoattractant receptors use a ligand-induced coupling rather than a precoupled mechanism to control the activation of G proteins during chemotaxis...
  13. pmc Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method
    Martin Meier-Schellersheim
    Lymphocyte Biology Section and Program in Systems Immunology and Infectious Disease Modeling, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Comput Biol 2:e82. 2006
    ..These features of Simmune were critical to the model development and analysis presented here and are likely to be useful in the computational investigation of many aspects of cell biology...
  14. ncbi request reprint Using quantitative fluorescence microscopy and FRET imaging to measure spatiotemporal signaling events in single living cells
    Xuehua Xu
    Chemotaxis Signal Section, National Institutes of Health, NIAID LIG CSS, Rockville, MD, USA
    Methods Mol Biol 346:281-96. 2006
    ..Finally, we describe a fluorescence resonance energy transfer (FRET) method to determine the extent of heterotrimeric G protein activation in single living cells in response to various chemoattractant fields...
  15. pmc Ligand-induced partitioning of human CXCR1 chemokine receptors with lipid raft microenvironments facilitates G-protein-dependent signaling
    Xuanmao Jiao
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, 12441 Parklawn Drive, Twinbrook II, Rockville, Maryland 20852, USA
    Mol Cell Biol 25:5752-62. 2005
    ..Our results suggest a novel mechanism by which ligand binding to CXCR1 promotes lipid raft partitioning of receptors and facilitates activation of heterotrimeric G-proteins...
  16. doi request reprint An Elmo-like protein associated with myosin II restricts spurious F-actin events to coordinate phagocytosis and chemotaxis
    Nilgun Isik
    Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Twinbrook II Facility, 12331 Parklawn Drive, Rockville, MD 20852, USA
    Dev Cell 15:590-602. 2008
    ..Taken together, our data suggest that ElmoA modulates actin/myosin II at the cortex to prevent excessive F-actin polymerization around the cell periphery, thereby maintaining proper cell shape during phagocytosis and chemotaxis...
  17. ncbi request reprint HIV gp120-induced interaction between CD4 and CCR5 requires cholesterol-rich microenvironments revealed by live cell fluorescence resonance energy transfer imaging
    Ling Yi
    Laboratory of Immunogenetics, Twinbrook II Facility, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 281:35446-53. 2006
    ..Our studies suggest that, during the first step of the HIV entry process, gp120 binding alters the microenvironments of unbound CD4 and CCR5, with plasma membrane cholesterol required for the formation of the HIV entry complex...
  18. pmc Fluorescence resonance energy transfer in living cells reveals dynamic membrane changes in the initiation of B cell signaling
    Hae Won Sohn
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 103:8143-8. 2006
    ..Thus, FRET measurements in living B cells revealed highly dynamic and regulated antigen-induced changes in the plasma membrane, allowing association of the BCR with the earliest components of its signaling cascade...
  19. pmc A shortcut from GPCR signaling to Rac-mediated actin cytoskeleton through an ELMO/DOCK complex
    Xuehua Xu
    Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA
    Small Gtpases 3:183-5. 2012
    ..Recently, we discovered a novel function of an ELMO protein in Dictyostelium discoideum linking GPCR signaling from Gβ to actin dynamics through regulating Rac activation during chemotaxis...
  20. pmc Imaging protein-protein interactions by Förster resonance energy transfer (FRET) microscopy in live cells
    Joseph A Brzostowski
    NIH NIAID LIG Imaging Facility, Rockville, Maryland, USA
    Curr Protoc Protein Sci . 2009
    ..References that discuss the vagaries of acquiring and analyzing FRET between individually tagged molecules are provided...
  21. pmc Association between Gαi2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis
    Hongyan Li
    Tianjin Medical University Cancer Institute and Hospital and Research Center of Basic Medical Sciences, He Xi District, Tianjin 300060, China
    Nat Commun 4:1706. 2013
    ..Our findings indicate that a chemokine-controlled pathway, consisting of Gαi2, ELMO1/Dock180, Rac1 and Rac2, regulates the actin cytoskeleton during breast cancer metastasis...
  22. doi request reprint Slamming the DOR on chemokine receptor signaling: heterodimerization silences ligand-occupied CXCR4 and delta-opioid receptors
    Dale Hereld
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA
    Eur J Immunol 38:334-7. 2008
    ....
  23. pmc Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death
    Han Ming Shen
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 24:5914-22. 2004
    ..Therefore, our study uncovers a novel signaling pathway regulating oxidative stress-induced cell death...
  24. ncbi request reprint Spontaneous clustering and tyrosine phosphorylation of NK cell inhibitory receptor induced by ligand binding
    Mathias Faure
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    J Immunol 170:6107-14. 2003
    ..The unique property of KIR to become phosphorylated in the absence of adhesion and of actin cytoskeleton rearrangement explains how KIR can efficiently block early activation signals during NK-target cell contacts...
  25. pmc Attenuation of phospholipid signaling provides a novel mechanism for the action of valproic acid
    Xuehua Xu
    School of Biological Sciences, Royal Holloway University of London, Egham, United Kingdom
    Eukaryot Cell 6:899-906. 2007
    ....
  26. ncbi request reprint The neuroprotective agent, valproic acid, regulates the mitogen-activated protein kinase pathway through modulation of protein kinase A signalling in Dictyostelium discoideum
    Katrina Boeckeler
    Department of Biology and the Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK
    Eur J Cell Biol 85:1047-57. 2006
    ..This work therefore suggests a conserved pathway in eukaryotes that is targeted by neuroprotective and bipolar disorder drugs and allows us to propose a model for this neuroprotective effect...
  27. doi request reprint Endothelin signaling axis activates osteopontin expression through PI3 kinase pathway in A375 melanoma cells
    Huang Chang-zheng
    J Dermatol Sci 52:130-2. 2008
  28. pmc Cutting edge: identification of a pre-ligand assembly domain (PLAD) and ligand binding site in the IL-17 receptor
    Jill M Kramer
    Department of Oral Biology, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
    J Immunol 179:6379-83. 2007
    ..However, the FN1 domain is also required for high affinity interactions with IL-17. Therefore, although the PLAD is located entirely within FN2, effective ligand binding also involves contributions from the linker and FN1...
  29. pmc Genetic analysis of the role of G protein-coupled receptor signaling in electrotaxis
    Min Zhao
    Department of Biomedical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    J Cell Biol 157:921-7. 2002
    ....