Lubin Jiang

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Epigenetic control of the variable expression of a Plasmodium falciparum receptor protein for erythrocyte invasion
    Lubin Jiang
    Laboratory of Malaria Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 107:2224-9. 2010
  2. ncbi Evidence for erythrocyte-binding antigen 175 as a component of a ligand-blocking blood-stage malaria vaccine
    Lubin Jiang
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 108:7553-8. 2011
  3. ncbi Molecular basis of binding of the Plasmodium falciparum receptor BAEBL to erythrocyte receptor glycophorin C
    Lubin Jiang
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Bethesda, MD 20892 8132, USA
    Mol Biochem Parasitol 168:49-54. 2009
  4. ncbi Recombinant Plasmodium falciparum reticulocyte homology protein 4 binds to erythrocytes and blocks invasion
    Deepak Gaur
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook III, 12735 Twinbrook Parkway, Bethesda, MD 20892 8132, USA
    Proc Natl Acad Sci U S A 104:17789-94. 2007
  5. ncbi Erythrocyte binding protein PfRH5 polymorphisms determine species-specific pathways of Plasmodium falciparum invasion
    Karen Hayton
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 8132, USA
    Cell Host Microbe 4:40-51. 2008
  6. ncbi The glycophorin C N-linked glycan is a critical component of the ligand for the Plasmodium falciparum erythrocyte receptor BAEBL
    D C Ghislaine Mayer
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 103:2358-62. 2006
  7. ncbi Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malaria
    Ivo M B Francischetti
    Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Arterioscler Thromb Vasc Biol 32:786-98. 2012

Collaborators

Detail Information

Publications7

  1. ncbi Epigenetic control of the variable expression of a Plasmodium falciparum receptor protein for erythrocyte invasion
    Lubin Jiang
    Laboratory of Malaria Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 107:2224-9. 2010
    ..Our data indicate that the failure of Dd2 to express the sialic acid-independent invasion receptor gene RH4 is associated with the epigenetic silencing mark H3K9 trimethylation present throughout the cycle...
  2. ncbi Evidence for erythrocyte-binding antigen 175 as a component of a ligand-blocking blood-stage malaria vaccine
    Lubin Jiang
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 108:7553-8. 2011
    ..Our findings suggest that antibodies to region II of EBA-175, as one component of a ligand-blocking malaria vaccine, are largely unaffected by polymorphism in EBA-175...
  3. ncbi Molecular basis of binding of the Plasmodium falciparum receptor BAEBL to erythrocyte receptor glycophorin C
    Lubin Jiang
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Bethesda, MD 20892 8132, USA
    Mol Biochem Parasitol 168:49-54. 2009
    ..These findings suggest that the two arginine residues surrounding T121 are critical for the binding specificity of BAEBL (VSTK) to sialic acid and suggest a role for arginine in sialic acid binding independent of its negative charge...
  4. ncbi Recombinant Plasmodium falciparum reticulocyte homology protein 4 binds to erythrocytes and blocks invasion
    Deepak Gaur
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook III, 12735 Twinbrook Parkway, Bethesda, MD 20892 8132, USA
    Proc Natl Acad Sci U S A 104:17789-94. 2007
    ..These findings suggest that, although PfRH4 is required for invasion of neuraminidase-treated erythrocytes by Dd2/NM, it is inaccessible for antibody-mediated inhibition of the invasion process...
  5. ncbi Erythrocyte binding protein PfRH5 polymorphisms determine species-specific pathways of Plasmodium falciparum invasion
    Karen Hayton
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 8132, USA
    Cell Host Microbe 4:40-51. 2008
    ..nancymaae erythrocytes. Our results also suggest that PfRH5 is a parasite ligand for human infection, and that amino acid substitutions can cause its binding domain to recognize different human erythrocyte surface receptors...
  6. ncbi The glycophorin C N-linked glycan is a critical component of the ligand for the Plasmodium falciparum erythrocyte receptor BAEBL
    D C Ghislaine Mayer
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 103:2358-62. 2006
    ..falciparum to recognize oligosaccharides on different erythrocyte surface glycoproteins or glycolipids, greatly increasing its invasion range...
  7. ncbi Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malaria
    Ivo M B Francischetti
    Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Arterioscler Thromb Vasc Biol 32:786-98. 2012
    ..DF was investigated here as a drug to treat cerebral malaria...