Junfang Ji

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Development of a miR-26 companion diagnostic test for adjuvant interferon-alpha therapy in hepatocellular carcinoma
    Junfang Ji
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Int J Biol Sci 9:303-12. 2013
  2. pmc Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinoma
    Junfang Ji
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Centre for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    J Hepatol 52:690-7. 2010
  3. pmc Integrated metabolite and gene expression profiles identify lipid biomarkers associated with progression of hepatocellular carcinoma and patient outcomes
    Anuradha Budhu
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Gastroenterology 144:1066-1075.e1. 2013
  4. pmc Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma
    Naoki Oishi
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Hepatology 56:1792-803. 2012
  5. pmc Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival
    Stephanie Roessler
    Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Gastroenterology 142:957-966.e12. 2012
  6. pmc EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    Taro Yamashita
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Gastroenterology 136:1012-24. 2009
  7. pmc MicroRNA expression, survival, and response to interferon in liver cancer
    Junfang Ji
    Liver Carcinogenesis Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 361:1437-47. 2009
  8. doi request reprint Identification of cancer stem cell-related microRNAs in hepatocellular carcinoma
    Junfang Ji
    Laboratory of Human Carcinogenesis, Bethesda, MD, USA
    Methods Mol Biol 826:163-75. 2012
  9. ncbi request reprint New kids on the block: diagnostic and prognostic microRNAs in hepatocellular carcinoma
    Junfang Ji
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Biol Ther 8:1686-93. 2009
  10. pmc Clinical implications of cancer stem cell biology in hepatocellular carcinoma
    Junfang Ji
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Semin Oncol 39:461-72. 2012

Detail Information

Publications14

  1. pmc Development of a miR-26 companion diagnostic test for adjuvant interferon-alpha therapy in hepatocellular carcinoma
    Junfang Ji
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Int J Biol Sci 9:303-12. 2013
    ..The purpose of this study is to develop a standardized miR-26 diagnostic test (referred as MIR26-DX) to assist identification of candidate HCC patients for adjuvant interferon-alpha therapy...
  2. pmc Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinoma
    Junfang Ji
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Centre for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    J Hepatol 52:690-7. 2010
    ..Using microarray analysis, we recently identified 20 miRNAs associated with HCC metastasis. Here, we carried out further analyses on one of these microRNAs, let-7g, to determine whether it is functionally linked to HCC metastasis...
  3. pmc Integrated metabolite and gene expression profiles identify lipid biomarkers associated with progression of hepatocellular carcinoma and patient outcomes
    Anuradha Budhu
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Gastroenterology 144:1066-1075.e1. 2013
    ..We combined gene expression and metabolic profiling analyses to identify factors associated with outcomes of patients with hepatocellular carcinoma (HCC)...
  4. pmc Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma
    Naoki Oishi
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Hepatology 56:1792-803. 2012
    ..NCAM1, a known hepatic stem/progenitor cell marker, was experimentally demonstrated to be a direct target of miR-200c...
  5. pmc Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival
    Stephanie Roessler
    Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Gastroenterology 142:957-966.e12. 2012
    ..We used an integrative approach to identify HCC driver genes, defined as genes whose copy numbers associate with gene expression and cancer progression...
  6. pmc EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    Taro Yamashita
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Gastroenterology 136:1012-24. 2009
    ..We hypothesized that the heterogeneous nature of hepatocellular carcinoma (HCC), in part, may be owing to the presence of hepatic cancer cells with stem/progenitor features...
  7. pmc MicroRNA expression, survival, and response to interferon in liver cancer
    Junfang Ji
    Liver Carcinogenesis Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 361:1437-47. 2009
    ..Hepatocellular carcinoma is a common and aggressive cancer that occurs mainly in men. We examined microRNA expression patterns, survival, and response to interferon alfa in both men and women with the disease...
  8. doi request reprint Identification of cancer stem cell-related microRNAs in hepatocellular carcinoma
    Junfang Ji
    Laboratory of Human Carcinogenesis, Bethesda, MD, USA
    Methods Mol Biol 826:163-75. 2012
    ..Here, we described methods to screen hepatic CSC-related miRNAs, and to validate and examine their expressions and functions in vitro and in vivo, which contribute to the maintenance of stemness and differentiation of hepatic CSCs...
  9. ncbi request reprint New kids on the block: diagnostic and prognostic microRNAs in hepatocellular carcinoma
    Junfang Ji
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Biol Ther 8:1686-93. 2009
    ..Here, we mainly focus on the diagnostic and prognostic roles of miRNAs as a group of new biomarkers for HCC...
  10. pmc Clinical implications of cancer stem cell biology in hepatocellular carcinoma
    Junfang Ji
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Semin Oncol 39:461-72. 2012
    ..In this review, we summarize recent evidence including the identification of the hepatic CSC and its underlying biological mechanisms, and discuss the potential clinical implications in HCC...
  11. pmc Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma
    Junfang Ji
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Cell Biosci 1:4. 2011
    ..abstract:..
  12. pmc SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity
    Hyun Seok Kim
    Genetics of Development and Disease Branch, 10 9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Cell 20:487-99. 2011
    ..Human breast cancers and HCC samples exhibited reduced SIRT2 levels compared with normal tissues. These data demonstrate that SIRT2 is a tumor suppressor through its role in regulating mitosis and genome integrity...
  13. pmc Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells
    Junfang Ji
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Hepatology 50:472-80. 2009
    ..Taken together, our results define a novel regulatory link between miR-181s and human EpCAM(+) liver cancer stem/progenitor cells and imply that molecular targeting of miR-181 may eradicate HCC...
  14. pmc The clinical potential of microRNAs
    Anuradha Budhu
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    J Hematol Oncol 3:37. 2010
    ..Moreover, the potential application of microRNAs in clinical settings will also be highlighted. Finally, the challenges regarding the translation of research involving microRNAs to the clinical realm will be discussed...