Samithamby Jeyaseelan

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. ncbi request reprint Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli
    Samithamby Jeyaseelan
    Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 175:7484-95. 2005
  2. pmc Transcriptional profiling of lipopolysaccharide-induced acute lung injury
    Samithamby Jeyaseelan
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson St, Neustadt D 403, Denver, CO 80206, USA
    Infect Immun 72:7247-56. 2004
  3. pmc Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury
    Samithamby Jeyaseelan
    Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson St, Neustadt D 403, Denver, CO 80206, USA
    Infect Immun 73:1754-63. 2005
  4. pmc Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium
    Samithamby Jeyaseelan
    Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street Neustadt D 403, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 32:531-9. 2005
  5. ncbi request reprint Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia
    Samithamby Jeyaseelan
    Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street Neustadt D 403, Denver, CO 80206, USA
    J Immunol 178:3153-60. 2007
  6. ncbi request reprint Toll/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosa
    Samithamby Jeyaseelan
    Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Immunol 177:538-47. 2006
  7. ncbi request reprint A role for hydroxy-methylglutaryl coenzyme a reductase in pulmonary inflammation and host defense
    Michael B Fessler
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, D403 Neustadt, Denver, CO 80206, USA
    Am J Respir Crit Care Med 171:606-15. 2005
  8. ncbi request reprint A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice
    Qun Wu
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1064-72. 2007
  9. ncbi request reprint TLR2 signaling is critical for Mycoplasma pneumoniae-induced airway mucin expression
    Hong Wei Chu
    Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Immunol 174:5713-9. 2005
  10. pmc Ethanol exposure impairs LPS-induced pulmonary LIX expression: alveolar epithelial cell dysfunction as a consequence of acute intoxication
    James E Walker
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
    Alcohol Clin Exp Res 33:357-65. 2009

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli
    Samithamby Jeyaseelan
    Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 175:7484-95. 2005
    ..Taken together, this is the first study illustrating the crucial role of TIRAP in the generation of an effective early immune response against E. coli LPS and viable E. coli, and in lung defense against a bacterial pathogen...
  2. pmc Transcriptional profiling of lipopolysaccharide-induced acute lung injury
    Samithamby Jeyaseelan
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson St, Neustadt D 403, Denver, CO 80206, USA
    Infect Immun 72:7247-56. 2004
    ..Moreover, we identified a role for LIX in the induction of ALI, and therefore LIX may serve as a novel therapeutic target for the minimization of ALI...
  3. pmc Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury
    Samithamby Jeyaseelan
    Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson St, Neustadt D 403, Denver, CO 80206, USA
    Infect Immun 73:1754-63. 2005
    ....
  4. pmc Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium
    Samithamby Jeyaseelan
    Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street Neustadt D 403, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 32:531-9. 2005
    ..These novel observations demonstrate that activation of AEII cells via TLR4-dependent signaling is important for the production of CXCL5 in the lung exposed to LPS...
  5. ncbi request reprint Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia
    Samithamby Jeyaseelan
    Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street Neustadt D 403, Denver, CO 80206, USA
    J Immunol 178:3153-60. 2007
    ..coli burden in the lungs and E. coli dissemination. Thus, rapid activation of TRIF-dependent TLR4-mediated signaling cascade serves to augment pulmonary host defense against a Gram-negative pathogen...
  6. ncbi request reprint Toll/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosa
    Samithamby Jeyaseelan
    Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Immunol 177:538-47. 2006
    ..These novel findings illustrate a pathogen-specific role for TIRAP in pulmonary defense and suggest that TLR5 plays an essential role for Pa-induced neutrophil influx via LIX production...
  7. ncbi request reprint A role for hydroxy-methylglutaryl coenzyme a reductase in pulmonary inflammation and host defense
    Michael B Fessler
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, D403 Neustadt, Denver, CO 80206, USA
    Am J Respir Crit Care Med 171:606-15. 2005
    ..No studies to date, however, have addressed whether statins modulate pulmonary inflammation triggered by aerogenic stimuli or whether they affect host defense...
  8. ncbi request reprint A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice
    Qun Wu
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1064-72. 2007
    ..A bacterial infection in asthmatic subjects with weakened TLR2-IFN-gamma signaling may result in an exaggerated airway mucin production...
  9. ncbi request reprint TLR2 signaling is critical for Mycoplasma pneumoniae-induced airway mucin expression
    Hong Wei Chu
    Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Immunol 174:5713-9. 2005
    ..These results clearly demonstrate that respiratory Mp infection increases airway mucin expression, which is dependent on the activation of TLR2 signaling...
  10. pmc Ethanol exposure impairs LPS-induced pulmonary LIX expression: alveolar epithelial cell dysfunction as a consequence of acute intoxication
    James E Walker
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
    Alcohol Clin Exp Res 33:357-65. 2009
    ..The effect of acute alcohol intoxication on AE2 cell expression of LIX is unknown...
  11. pmc Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense
    Kathleen Smoak
    Laboratory of Respiratory Biology, Department of Health and Human Services, Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Immunol 180:3305-12. 2008
    ..Taken together, these data define a novel role for LXR in lung pathophysiology and neutrophil biology and identify pharmacologic activation of LXR as a potential tool for modulation of innate immunity in the lung...
  12. ncbi request reprint Unraveling the host immune response to vacuolar pathogens
    Samithamby Jeyaseelan
    Trends Microbiol 10:117. 2002