Research Topics
Genomes and Genes | Samithamby JeyaseelanSummaryAffiliation: National Jewish Medical and Research Center Country: USA Publications
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Publications
Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coliSamithamby Jeyaseelan
Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 175:7484-95. 2005..Taken together, this is the first study illustrating the crucial role of TIRAP in the generation of an effective early immune response against E. coli LPS and viable E. coli, and in lung defense against a bacterial pathogen...- Transcriptional profiling of lipopolysaccharide-induced acute lung injurySamithamby Jeyaseelan
Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson St, Neustadt D 403, Denver, CO 80206, USA
Infect Immun 72:7247-56. 2004..Moreover, we identified a role for LIX in the induction of ALI, and therefore LIX may serve as a novel therapeutic target for the minimization of ALI... - Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injurySamithamby Jeyaseelan
Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson St, Neustadt D 403, Denver, CO 80206, USA
Infect Immun 73:1754-63. 2005.... - Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epitheliumSamithamby Jeyaseelan
Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street Neustadt D 403, Denver, CO 80206, USA
Am J Respir Cell Mol Biol 32:531-9. 2005..These novel observations demonstrate that activation of AEII cells via TLR4-dependent signaling is important for the production of CXCL5 in the lung exposed to LPS... - Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumoniaSamithamby Jeyaseelan
Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street Neustadt D 403, Denver, CO 80206, USA
J Immunol 178:3153-60. 2007..coli burden in the lungs and E. coli dissemination. Thus, rapid activation of TRIF-dependent TLR4-mediated signaling cascade serves to augment pulmonary host defense against a Gram-negative pathogen... - Toll/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosaSamithamby Jeyaseelan
Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
J Immunol 177:538-47. 2006..These novel findings illustrate a pathogen-specific role for TIRAP in pulmonary defense and suggest that TLR5 plays an essential role for Pa-induced neutrophil influx via LIX production... - A role for hydroxy-methylglutaryl coenzyme a reductase in pulmonary inflammation and host defenseMichael B Fessler
Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, D403 Neustadt, Denver, CO 80206, USA
Am J Respir Crit Care Med 171:606-15. 2005..No studies to date, however, have addressed whether statins modulate pulmonary inflammation triggered by aerogenic stimuli or whether they affect host defense... - A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic miceQun Wu
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Am J Physiol Lung Cell Mol Physiol 292:L1064-72. 2007..A bacterial infection in asthmatic subjects with weakened TLR2-IFN-gamma signaling may result in an exaggerated airway mucin production... - TLR2 signaling is critical for Mycoplasma pneumoniae-induced airway mucin expressionHong Wei Chu
Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
J Immunol 174:5713-9. 2005..These results clearly demonstrate that respiratory Mp infection increases airway mucin expression, which is dependent on the activation of TLR2 signaling... - Ethanol exposure impairs LPS-induced pulmonary LIX expression: alveolar epithelial cell dysfunction as a consequence of acute intoxicationJames E Walker
Section of Pulmonary and Critical Care Medicine, Department of Medicine, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
Alcohol Clin Exp Res 33:357-65. 2009..The effect of acute alcohol intoxication on AE2 cell expression of LIX is unknown... - Effects of liver X receptor agonist treatment on pulmonary inflammation and host defenseKathleen Smoak
Laboratory of Respiratory Biology, Department of Health and Human Services, Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
J Immunol 180:3305-12. 2008..Taken together, these data define a novel role for LXR in lung pathophysiology and neutrophil biology and identify pharmacologic activation of LXR as a potential tool for modulation of innate immunity in the lung... - Unraveling the host immune response to vacuolar pathogensSamithamby Jeyaseelan
Trends Microbiol 10:117. 2002