A M Jetten

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint High incidence of T-cell lymphomas in mice deficient in the retinoid-related orphan receptor RORgamma
    Eiichiro Ueda
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences NIH, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Cancer Res 62:901-9. 2002
  2. ncbi request reprint Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma
    Shogo Kurebayashi
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Biochem Biophys Res Commun 315:919-27. 2004
  3. ncbi request reprint Recent advances in the mechanisms of action and physiological functions of the retinoid-related orphan receptors (RORs)
    Anton M Jetten
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Curr Drug Targets Inflamm Allergy 3:395-412. 2004
  4. ncbi request reprint Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism
    Hong Soon Kang
    Cell Biology Section, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Physiol Genomics 31:281-94. 2007
  5. pmc Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism
    Anton M Jetten
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Nucl Recept Signal 7:e003. 2009
  6. pmc Nuclear orphan receptor TAK1/TR4-deficient mice are protected against obesity-linked inflammation, hepatic steatosis, and insulin resistance
    Hong Soon Kang
    Cell Biology Section, Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Diabetes 60:177-88. 2011
  7. pmc Functional analysis of the zinc finger and activation domains of Glis3 and mutant Glis3(NDH1)
    Ju Youn Beak
    Cell Biology Section, LRB, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 36:1690-702. 2008
  8. pmc Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor alpha
    Jun Yan
    Cell Biology Section, Division of Intramural Research, National Institute of Enironmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 35:1673-86. 2007
  9. pmc Krüppel-like zinc finger protein Gli-similar 2 (Glis2) represses transcription through interaction with C-terminal binding protein 1 (CtBP1)
    Seong Chul Kim
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 33:6805-15. 2005
  10. pmc RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo
    Yukimasa Takeda
    Cell Biology Section, Systems Biology Group, Biostatistics Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 40:8519-35. 2012

Collaborators

Detail Information

Publications71

  1. ncbi request reprint High incidence of T-cell lymphomas in mice deficient in the retinoid-related orphan receptor RORgamma
    Eiichiro Ueda
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences NIH, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Cancer Res 62:901-9. 2002
    ....
  2. ncbi request reprint Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma
    Shogo Kurebayashi
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Biochem Biophys Res Commun 315:919-27. 2004
    ..These peptide antagonists provide a useful tool to analyze the conformation changes in the RORgamma(LBD) and to study RORgamma receptor signaling...
  3. ncbi request reprint Recent advances in the mechanisms of action and physiological functions of the retinoid-related orphan receptors (RORs)
    Anton M Jetten
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Curr Drug Targets Inflamm Allergy 3:395-412. 2004
    ..Therefore, the discovery of new (ant)agonists may lead to the development of novel therapeutic strategies for human disease in which RORs have been implicated...
  4. ncbi request reprint Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism
    Hong Soon Kang
    Cell Biology Section, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Physiol Genomics 31:281-94. 2007
    ....
  5. pmc Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism
    Anton M Jetten
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Nucl Recept Signal 7:e003. 2009
    ..This prospect was strengthened by recent evidence showing that RORs can function as ligand-dependent transcription factors...
  6. pmc Nuclear orphan receptor TAK1/TR4-deficient mice are protected against obesity-linked inflammation, hepatic steatosis, and insulin resistance
    Hong Soon Kang
    Cell Biology Section, Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Diabetes 60:177-88. 2011
    ..In this study, we investigate whether TAK1 functions as a regulator of lipid and energy homeostasis and has a role in metabolic syndrome...
  7. pmc Functional analysis of the zinc finger and activation domains of Glis3 and mutant Glis3(NDH1)
    Ju Youn Beak
    Cell Biology Section, LRB, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 36:1690-702. 2008
    ..We demonstrate that this truncation does not effect the nuclear localization but results in the loss of Glis3 transactivating activity. The loss in Glis3 transactivating function may be responsible for the abnormalities observed in NDH1...
  8. pmc Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor alpha
    Jun Yan
    Cell Biology Section, Division of Intramural Research, National Institute of Enironmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 35:1673-86. 2007
    ..These data indicate that the UIMs in RAP80 are critical for the function of RAP80. Our study identifies ERalpha as a new RAP80-interacting protein and suggests that RAP80 may be an important modulator of ERalpha activity...
  9. pmc Krüppel-like zinc finger protein Gli-similar 2 (Glis2) represses transcription through interaction with C-terminal binding protein 1 (CtBP1)
    Seong Chul Kim
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 33:6805-15. 2005
    ..Our observations suggest that the co-repressor CtBP1 and HDAC3 are part of transcription silencing complex that mediates the transcriptional repression by Glis2...
  10. pmc RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo
    Yukimasa Takeda
    Cell Biology Section, Systems Biology Group, Biostatistics Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 40:8519-35. 2012
    ....
  11. pmc Retinoic acid-related orphan receptors α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity
    Anton M Jetten
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park, NC, USA
    Front Endocrinol (Lausanne) 4:1. 2013
    ....
  12. pmc CD44 plays a critical role in regulating diet-induced adipose inflammation, hepatic steatosis, and insulin resistance
    Hong Soon Kang
    Cell Biology Section, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 8:e58417. 2013
    ..Our study indicates that CD44 plays a critical role in regulating several aspects of metabolic syndrome and may provide a new therapeutic target in the management of insulin resistance...
  13. pmc Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors α- and γ-mediated transactivation
    Yukimasa Takeda
    Division of Intramural Research, Cell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 41:6992-7008. 2013
    ..Our data suggest that Prox1 is part of a feedback loop that negatively regulates the transcriptional control of clock and metabolic networks by RORs. ..
  14. pmc Retinoic acid-related orphan receptor γ directly regulates neuronal PAS domain protein 2 transcription in vivo
    Yukimasa Takeda
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 39:4769-82. 2011
    ..Our results indicate that RORγ and Rev-Erbα are part of a feed-back loop that regulates the circadian expression of Npas2 suggesting a regulatory role for these receptors in Npas2-dependent physiological processes...
  15. pmc The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription
    Gary T Zeruth
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
    Mol Endocrinol 27:1692-705. 2013
    ..Taken together, these results indicate that Glis3 plays a pivotal role in the transcriptional regulation of insulin and may serve as an important therapeutic target for the treatment of diabetes. ..
  16. ncbi request reprint The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes
    A M Jetten
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA
    Prog Nucleic Acid Res Mol Biol 69:205-47. 2001
    ....
  17. ncbi request reprint Regulation of cornifin alpha expression in the vaginal and uterine epithelium by estrogen and retinoic acid
    A M Jetten
    Laboratory of Pulmonary Pathobiology, NIEHS, NIH, Research Triangle Park, NC 27709, USA
    Mol Cell Endocrinol 123:7-15. 1996
    ..Our results demonstrate that estrogen and retinoids play key roles in the regulation of differentiation and cornifin alpha expression in the uterine and vaginal epithelium...
  18. ncbi request reprint Cloning and regulation of cornifin beta, a new member of the cornifin/spr family. Suppression by retinoic acid receptor-selective retinoids
    S J Austin
    Cell Biology Section, Laboratory of Pulmonary Pathobiology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 271:3737-42. 1996
    ..Cornifin beta can function through some of its Gln residues as an amine acceptor in transglutaminase-catalyzed cross-linking reactions. These results indicate that cornifin beta functions as a cross-linked envelope precursor...
  19. ncbi request reprint cDNA cloning, genomic structure, and chromosome mapping of the human epithelial membrane protein CL-20 gene (EMP1), a member of the PMP22 family
    Y Chen
    Cell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Genomics 41:40-8. 1997
    ..The hCL-20 gene contains five exons about 0.2, 0.12, 0.1, 0.14, and 2.2 kb and four introns about 15, 1.9, 0.1, and 0.7 kb. We have mapped the hCL-20 gene to chromosome 12p12 by fluorescence in situ hybridization...
  20. ncbi request reprint Induction of the nuclear orphan receptor RORgamma during adipocyte differentiation of D1 and 3T3-L1 cells
    S Austin
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Cell Growth Differ 9:267-76. 1998
    ....
  21. pmc Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis
    S Kurebayashi
    Cell Biology Section, Laboratory of Pulmonary Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 97:10132-7. 2000
    ..Our observations indicate that RORgamma is essential for lymphoid organogenesis and plays an important regulatory role in thymopoiesis. Our findings support a model in which RORgamma negatively controls apoptosis in thymocytes...
  22. ncbi request reprint Characterization of the repressor function of the nuclear orphan receptor retinoid receptor-related testis-associated receptor/germ cell nuclear factor
    Z Yan
    Cell Biology Section, Laboratory of Pulmonary Pathobiology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 275:35077-85. 2000
    ..These repressor activities may provide important mechanisms by which RTR regulates gene expression during development and gametogenesis...
  23. ncbi request reprint Regulation of transglutaminase type I expression in squamous differentiating rabbit tracheal epithelial cells and human epidermal keratinocytes: effects of retinoic acid and phorbol esters
    N A Saunders
    Cell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park, North Carolina 27709
    Mol Endocrinol 7:387-98. 1993
    ..TPA-induced luciferase activity was inhibited by both bryostatin 1 and RA. No known RA response elements were identified in the promoter.(ABSTRACT TRUNCATED AT 250 WORDS)..
  24. ncbi request reprint TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily
    T Hirose
    Cell Biology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Mol Endocrinol 8:1667-80. 1994
    ..In the testis, TAK1 appears to control gene expression during spermatogenesis, particularly during the meiotic phase...
  25. ncbi request reprint Genomic structure and chromosomal mapping of the nuclear orphan receptor ROR gamma (RORC) gene
    A Medvedev
    Cell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Genomics 46:93-102. 1997
    ..1-2.2. The human ROR gamma was mapped to chromosome region 1q21. The results demonstrate that the ROR gamma genes are located in chromosomal regions that are syntenic between mouse and human...
  26. ncbi request reprint Cloning of a cDNA encoding the murine orphan receptor RZR/ROR gamma and characterization of its response element
    A Medvedev
    Cell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Gene 181:199-206. 1996
    ..ROR alpha 1 and ROR gamma inhibit the transactivation induced by GAL4(DBD)-ROR gamma in fibroblast D1 cells suggesting that these receptors compete for binding to the same coactivators...
  27. ncbi request reprint Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4
    Z H Yan
    Cell Biology Section, Laboratory of Pulmonary Pathobiology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 273:10948-57. 1998
    ..RXR for binding to PPREs as well as to common co-activators, such as RIP-140. Our results suggest an important role for TAK1 in modulating PPARalpha-controlled gene expression in hepatocytes...
  28. ncbi request reprint Genomic structure of the gene encoding the human GLI-related, Krüppel-like zinc finger protein GLIS2
    F Zhang
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health Research, Triangle Park, NC 27709, USA
    Gene 280:49-57. 2001
    ..3, a locus implicated in several human kidney diseases. The sequence and structure of human GLIS2 will be useful tools to study the regulation of GLIS2 and its potential role in human disease...
  29. ncbi request reprint ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle
    T Hirose
    Cell Biology Section, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
    Biochem Biophys Res Commun 205:1976-83. 1994
    ..ROR gamma was localized on human chromosome 1. Northern blot analysis using RNA from multiple tissues indicated that ROR gamma is expressed in several tissues but is most highly expressed in skeletal muscle...
  30. ncbi request reprint Induction of Egr-1 expression by the retinoid AHPN in human lung carcinoma cells is dependent on activated ERK1/2
    M Sakaue
    Cell Biology Section, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, NC 27709, USA
    Cell Death Differ 8:411-24. 2001
    ..Egr-1, in cooperation with several other growth-suppressor proteins, is likely involved in AHPN-induced inhibition of cell growth and cell death...
  31. ncbi request reprint Identification and characterization of a novel squamous cell-associated gene related to PMP22
    K W Marvin
    Cell Biology Section, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 270:28910-6. 1995
    ..The retinoic acid receptor-selective retinoid SRI-6751-84 is the most effective in suppressing CL-20, suggesting that the activation of the retinoic acid receptor signaling pathway is important in this suppression...
  32. ncbi request reprint Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation during embryonal carcinoma cell differentiation
    W Lei
    Cell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Mol Endocrinol 18:167-76. 1997
    ..Our observations suggest that GCNF/RTR plays a role in the control of gene expression in early embryogenesis and during spermatogenesis...
  33. pmc Cornifin, a cross-linked envelope precursor in keratinocytes that is down-regulated by retinoids
    K W Marvin
    Cell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709
    Proc Natl Acad Sci U S A 89:11026-30. 1992
    ..This cross-linking reaction appears to be mediated by transglutaminase type I. Our observations suggest that the protein encoded by SQ37 participates in the assembly of the cross-linked envelope...
  34. ncbi request reprint The peripheral myelin protein 22 and epithelial membrane protein family
    A M Jetten
    Cell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Prog Nucleic Acid Res Mol Biol 64:97-129. 2000
    ....
  35. ncbi request reprint Characterization of the expression of the retinoid-related, testis-associated receptor (RTR) in trophoblasts
    D V Mehta
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Placenta 23:281-7. 2002
    ..These results suggest the possibility of cross-talk between RTR and ERR alpha receptor signalling pathways in trophoblasts...
  36. ncbi request reprint Post-transcriptional regulation of MyD118 and GADD45 in human lung carcinoma cells during 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2- naphthalene carboxylic acid-induced apoptosis
    M Sakaue
    Cell Biology Section, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Pharmacol 55:668-76. 1999
    ..Our results support a role for MyD118 and GADD45 in the negative growth control by AHPN...
  37. ncbi request reprint Regulation of proliferation-specific and differentiation-specific genes during senescence of human epidermal keratinocyte and mammary epithelial cells
    N A Saunders
    Cell Biology Section, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709
    Biochem Biophys Res Commun 197:46-54. 1993
    ..E2F-1, cdc2 and cornifin were similarly altered in senescing human mammary epithelial cells. Our data suggest that events regulating senescence may also be linked to squamous differentiation...
  38. pmc Regulation of type I (epidermal) transglutaminase mRNA levels during squamous differentiation: down regulation by retinoids
    E E Floyd
    Cell Biology Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27713
    Mol Cell Biol 9:4846-51. 1989
    ..These data indicate that pTG-7 encodes the mRNA for transglutaminase type I and that expression of this mRNA is negatively regulated by retinoic acid...
  39. ncbi request reprint Cloning of the gene encoding the murine orphan receptor TAK1 and cell-type-specific expression in testis
    T Hirose
    Cell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Gene 163:239-42. 1995
    ..Southern analysis using genomic DNA prepared from a panel of hamster/human and mouse/human hybrid cell lines indicated that the TAK1 gene is located on human chromosome 3...
  40. ncbi request reprint RTR: a new member of the nuclear receptor superfamily that is highly expressed in murine testis
    T Hirose
    Cell Biology Section, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709
    Gene 152:247-51. 1995
    ..Our observations suggest that this putative transcription factor plays a role in the regulation of gene expression particularly during the post-meiotic phase of spermatogenesis...
  41. ncbi request reprint Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation
    T M Vollberg
    Cell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
    Mol Endocrinol 6:667-76. 1992
    ..These results demonstrate that the control of NHEK differentiation by RA is consistent with the interaction of the retinoid with RAR and the regulation of transcription by that ligand-receptor complex...
  42. ncbi request reprint The orphan receptor TAK1 acts as a repressor of RAR-, RXR- and T3R-mediated signaling pathways
    T Hirose
    Cell Biology Section, National Institute of Environmental Health and Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Biochem Biophys Res Commun 211:83-91. 1995
    ..Our results suggest that the orphan receptor TAK1 can be a negative modulator of the regulation of gene expression mediated by retinoid and thyroid hormone signaling pathways...
  43. ncbi request reprint Expression of a preprorelaxin-like gene during squamous differentiation of rabbit tracheobronchial epithelial cells and its suppression by retinoic acid
    A M Jetten
    Cell Biology Section, Nationai Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709
    Cell Growth Differ 3:549-56. 1992
    ..The concentration at which retinoic acid caused a 50% inhibition of SQ10 mRNA levels was approximately 5 nM.(ABSTRACT TRUNCATED AT 250 WORDS)..
  44. pmc Identification of human CYP2C8 as a retinoid-related orphan nuclear receptor target gene
    Yuping Chen
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 329:192-201. 2009
    ....
  45. ncbi request reprint Dual activation of PPARalpha and PPARgamma by mono-(2-ethylhexyl) phthalate in rat ovarian granulosa cells
    Tara Lovekamp-Swan
    Laboratory of Women s Health, National Institute of Environmental Health Sciences, P O Box 12233, MD A2 01, Research Triangle Park, NC 27709, USA
    Mol Cell Endocrinol 201:133-41. 2003
    ..These data support a model in which MEHP activates both PPARalpha and PPARgamma to suppress aromatase and alter other genes related to metabolism and differentiation in the granulosa cell...
  46. pmc Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis
    Martin Angers
    Cell Biology Section, LRB, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Biochem J 416:347-55. 2008
    ..The observed induction of Mfsd2a expression in cultured BAT cells by dibutyryl-cAMP is in agreement with this conclusion. The present study suggests that Mfsd2a plays a role in adaptive thermogenesis...
  47. pmc NABP1, a novel RORgamma-regulated gene encoding a single-stranded nucleic-acid-binding protein
    Hong Soon Kang
    Cell Biology Section, Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Biochem J 397:89-99. 2006
    ..Our results demonstrate that NABP1 binds single-stranded nucleic acids, but not double-stranded DNA, suggesting that it functions as a single-stranded nucleic acid binding protein...
  48. pmc Modulatory role for retinoid-related orphan receptor alpha in allergen-induced lung inflammation
    Maisa Jaradat
    Cell Biology Section, Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27599 7219, USA
    Am J Respir Crit Care Med 174:1299-309. 2006
    ..Nuclear receptors play a critical role in the regulation of inflammation, thus representing attractive targets for the treatment of asthma...
  49. ncbi request reprint Enhanced susceptibility of staggerer (RORalphasg/sg) mice to lipopolysaccharide-induced lung inflammation
    Cliona M Stapleton
    Division of Intramural Research, Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Am J Physiol Lung Cell Mol Physiol 289:L144-52. 2005
    ..Our observations indicate that RORalpha(sg/sg) mice are more susceptible to LPS-induced airway inflammation and are in agreement with the hypothesis that RORalpha functions as a negative regulator of LPS-induced inflammatory responses...
  50. pmc Regulatory role for Krüppel-like zinc-finger protein Gli-similar 1 (Glis1) in PMA-treated and psoriatic epidermis
    Gen Nakanishi
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    J Invest Dermatol 126:49-60. 2006
    ..This, in association with its induction in psoriasis, suggests that transcriptional factor Glis1 is involved in the regulation of aberrant differentiation observed in psoriatic epidermis...
  51. pmc Molecular mechanisms involved in farnesol-induced apoptosis
    Joung Hyuck Joo
    Cell Biology Section, LRB, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, United States
    Cancer Lett 287:123-35. 2010
    ..This review provides an overview of the biochemical and cellular processes regulated by farnesol in relationship to its growth-inhibitory, apoptosis-promoting, and anti-tumor effects...
  52. pmc GLIS3, a novel member of the GLIS subfamily of Krüppel-like zinc finger proteins with repressor and activation functions
    Yong Sik Kim
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 31:5513-25. 2003
    ..Both the repressor and activation functions of GLIS3 may be involved in this control...
  53. ncbi request reprint Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium
    Yaron Daniely
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, Triangle Park, NC 27709, USA
    Am J Physiol Cell Physiol 287:C171-81. 2004
    ....
  54. ncbi request reprint Krüppel-like zinc finger protein Glis3 promotes osteoblast differentiation by regulating FGF18 expression
    Ju Youn Beak
    Cell Biology Section, LRB, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health Research, Triangle Park, North Carolina, USA
    J Bone Miner Res 22:1234-44. 2007
    ..This induction of osteoblast differentiation is at least in part caused by the induction of FGF18 expression. This study supports a regulatory role for Glis3 in osteoblast differentiation...
  55. ncbi request reprint RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor
    Zhijiang Yan
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 277:32379-88. 2002
    ..RAP80 is able to inhibit the interaction of RTR with the co-repressor N-CoR likely by competing with N-CoR for RTR binding. Our results suggest that RAP80 may be functioning as a modulator of RTR signaling...
  56. ncbi request reprint Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions
    Yong Sik Kim
    Cell Biology Section, Division of Intramural Research, NIEHS National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Biol Chem 277:30901-13. 2002
    ..Our results suggest that Glis1 may play a critical role in the control of gene expression during specific stages of embryonic development...
  57. pmc Kruppel-like zinc finger protein Glis2 is essential for the maintenance of normal renal functions
    Yong Sik Kim
    Division of Intramural Research, Cell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 28:2358-67. 2008
    ..Our study indicates that Glis2 plays a critical role in the maintenance of normal kidney architecture and functions...
  58. ncbi request reprint Differential regulation of nonsteroidal anti-inflammatory drug-activated gene in normal human tracheobronchial epithelial and lung carcinoma cells by retinoids
    Donna Newman
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Mol Pharmacol 63:557-64. 2003
    ..The linkage between AHPN treatment and NAG-1 expression revealed in this study provides a new mechanism for the antitumorigenic activity of AHPN...
  59. ncbi request reprint Tsp57: a novel gene induced during a specific stage of spermatogenesis
    Yong Sik Kim
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 70:106-13. 2004
    ..The localization suggests a nuclear function for Tsp57. Pull-down analysis demonstrated that Tsp57 and RAP80 form a complex in intact cells...
  60. pmc TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4
    Takeshi Nakajima
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 32:4194-204. 2004
    ..This repression does not involve the inhibition of TAK1 homodimerization or DR1 binding but may be due to an effect on co-activator recruitment by TAK1. Our results indicate that TIP27 functions as a TAK1-selective repressor...
  61. pmc Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression
    Hong Soon Kang
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 29:6366-79. 2009
    ..In addition, we provide evidence that Glis3 regulates insulin gene expression through two Glis-binding sites in its proximal promoter, indicating that Glis3 also regulates beta-cell function...
  62. pmc Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease
    Hong Soon Kang
    LRB, Cell Biology Section, Division of Intramural Research, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 29:2556-69. 2009
    ..We propose that localization to the primary cilium and interaction with Wwtr1 are key elements of the Glis3 signaling pathway...
  63. ncbi request reprint Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    Roza Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nature 448:480-3. 2007
    ..IL-21 is therefore an autocrine cytokine that is sufficient and necessary for T(H)17 differentiation, and serves as a target for treating inflammatory diseases...
  64. pmc T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 28:29-39. 2008
    ..Therefore, Th17 differentiation is directed by two lineage-specific nuclear receptors, ROR alpha and ROR gamma...
  65. ncbi request reprint Analysis of germ cell nuclear factor transcripts and protein expression during spermatogenesis
    Genyan Yang
    The Laboratories for Reproductive Biology, University of North Carolina School of Medicine, Chapel Hill 27599, USA
    Biol Reprod 68:1620-30. 2003
    ..This expression profile suggests that GCNF plays a role in transcriptional regulation during meiosis and the early haploid phase of spermatogenesis...
  66. ncbi request reprint Overexpression of mucin genes induced by interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor alpha antagonist
    Ja Seok Koo
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Exp Lung Res 28:315-32. 2002
    ..Further investigation showed that the RARalpha antagonist also inhibited the stimulation of MUC2 and MUC5AC mRNA expression by tumor necrosis factor-alpha, LPS, and NE...
  67. ncbi request reprint Retinoid-related orphan receptor gamma controls immunoglobulin production and Th1/Th2 cytokine balance in the adaptive immune response to allergen
    Stephen L Tilley
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 178:3208-18. 2007
    ..These data reveal a critical role for RORgamma in the regulation of Ig production and Th1/Th2 balance in adaptive immunity...
  68. pmc Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, TX 77030, USA
    Immunity 29:138-49. 2008
    ..This study thus demonstrates that Tfh is a distinct Th cell lineage...
  69. pmc Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 29:44-56. 2008
    ..STAT3 regulated Foxp3 downregulation, whereas STAT3, RORgamma, and ROR* were required for IL-17 expression in Treg cells. Our data demonstrate molecular antagonism and plasticity of Treg and Th17 cell programs...
  70. pmc The emerging role of nuclear receptor RORalpha and its crosstalk with LXR in xeno- and endobiotic gene regulation
    Taira Wada
    Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Exp Biol Med (Maywood) 233:1191-201. 2008
    ..We conclude that RORs participate in the xeno- and endobiotic regulatory network by regulating gene expression directly or through crosstalk with LXR, which may have broad implications in metabolic homeostasis...
  71. ncbi request reprint Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)
    Taira Wada
    Center for Pharmacogenetics, 633 Salk Hall, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Pharmacol 73:891-9. 2008
    ..Our results have revealed a novel role for RORalpha and a functional interplay between RORalpha and LXR in regulating endo- and xenobiotic genes, which may have broad implications in metabolic homeostasis...