Research Topics
| Wendy JeffersonSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Adult ovarian function can be affected by high levels of soyWendy N Jefferson
Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
J Nutr 140:2322S-2325S. 2010..This paper summarizes the literature on adult soy consumption and its effect on ovarian function...
Disruption of the female reproductive system by the phytoestrogen genisteinWendy N Jefferson
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, PO Box 12233, Research Triangle Park, NC 27709, United States
Reprod Toxicol 23:308-16. 2007..Thus, neonatal treatment with genistein at environmentally relevant doses caused adverse consequences on reproduction in adulthood...- Neonatal genistein treatment alters ovarian differentiation in the mouse: inhibition of oocyte nest breakdown and increased oocyte survivalWendy Jefferson
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH DHHS, Research Triangle Park, NC 27709, USA
Biol Reprod 74:161-8. 2006..These data taken together suggest that genistein exposure during development alters ovarian differentiation by inhibiting oocyte nest breakdown and attenuating oocyte cell death... - Adverse effects on female development and reproduction in CD-1 mice following neonatal exposure to the phytoestrogen genistein at environmentally relevant dosesWendy N Jefferson
Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Biol Reprod 73:798-806. 2005..In summary, neonatal treatment with Gen caused abnormal estrous cycles, altered ovarian function, early reproductive senescence, and subfertility/infertility at environmentally relevant doses... - Disruption of the developing female reproductive system by phytoestrogens: genistein as an exampleWendy N Jefferson
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA
Mol Nutr Food Res 51:832-44. 2007.... - Oral exposure to genistin, the glycosylated form of genistein, during neonatal life adversely affects the female reproductive systemWendy N Jefferson
Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 117:1883-9. 2009..S. infants are fed soy formula. High circulating levels of GEN have been measured in the serum of these infants, indicating that GIN is readily absorbed, hydrolyzed, and circulated... - Circulating levels of genistein in the neonate, apart from dose and route, predict future adverse female reproductive outcomesWendy N Jefferson
Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States
Reprod Toxicol 31:272-9. 2011..Additional studies of reproductive function in human populations exposed to high levels of phytoestrogens during development are warranted... - Studies of the effects of neonatal exposure to genistein on the developing female reproductive systemWendy N Jefferson
National Institute of Environmental Health Sciences, NIH, DHHS, Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, Research Triangle Park, NC 27709, USA
J AOAC Int 89:1189-96. 2006..Thus, neonatal treatment with genistein at environmentally relevant doses caused adverse consequences on ovarian development and reproductive function... - Neonatal exposure to genistein disrupts ability of female mouse reproductive tract to support preimplantation embryo development and implantationWendy N Jefferson
Reproductive Medicine Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Biol Reprod 80:425-31. 2009.... - Developmental exposure to diethylstilbestrol alters uterine gene expression that may be associated with uterine neoplasia later in lifeRetha R Newbold
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, North Carolina 27709, USA
Mol Carcinog 46:783-96. 2007..These data suggested altered gene expression profiles observed 2 wk after treatment ceased, were established at the time of developmental exposure and maybe related to the initiation events resulting in carcinogenesis... - Neonatal exposure to genistein induces estrogen receptor (ER)alpha expression and multioocyte follicles in the maturing mouse ovary: evidence for ERbeta-mediated and nonestrogenic actionsWendy N Jefferson
Developmental Endocrinology Section, Laboratory of Molecular Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Biol Reprod 67:1285-96. 2002..Given that human infants are exposed to high levels of genistein in soy-based foods, this study indicates that the effects of such exposure on the developing reproductive tract warrant further investigation... - Neonatal exposure to the phytoestrogen genistein alters mammary gland growth and developmental programming of hormone receptor levelsElizabeth Padilla-Banks
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Endocrinology 147:4871-82. 2006..In summary, neonatal Gen exposure altered mammary gland growth and development as well as hormone receptor levels at all doses examined; higher doses of Gen led to permanent long-lasting morphological changes... - Assessing estrogenic activity of phytochemicals using transcriptional activation and immature mouse uterotrophic responsesWendy N Jefferson
Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
J Chromatogr B Analyt Technol Biomed Life Sci 777:179-89. 2002..Furthermore, having an estrogenic "fingerprint" for each phytochemical is an essential first step in determining potential adverse effects of exposure to phytoestrogens... - Prenatal exposure to bisphenol a at environmentally relevant doses adversely affects the murine female reproductive tract later in lifeRetha R Newbold
Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 117:879-85. 2009..Bisphenol A (BPA), an environmental estrogen used in the synthesis of plastics, is of concern because its chemical structure resembles that of DES, and it is a "high-volume production" chemical with widespread human exposure... 
Effects of endocrine disruptors on obesityRetha R Newbold
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Int J Androl 31:201-8. 2008..The emerging idea of an association of EDCs and obesity expands the focus on obesity from intervention and treatment to include prevention and avoidance of these chemical modifiers...- Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tractRetha R Newbold
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA
Reprod Toxicol 24:253-8. 2007..These data suggest that BPA causes long-term adverse effects if exposure occurs during critical periods of differentiation... - Perinatal exposure to environmental estrogens and the development of obesityRetha R Newbold
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA
Mol Nutr Food Res 51:912-7. 2007.... - Developmental exposure to diethylstilbestrol (DES) alters uterine response to estrogens in prepubescent mice: low versus high dose effectsRetha R Newbold
Developmental Endocrinology Section, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Reprod Toxicol 18:399-406. 2004.... - Developmental exposure to estrogenic compounds and obesityRetha R Newbold
Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Birth Defects Res A Clin Mol Teratol 73:478-80. 2005 - Developmental exposure to endocrine disruptors and the obesity epidemicRetha R Newbold
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, Mail Drop E4 02, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States
Reprod Toxicol 23:290-6. 2007..This experimental animal model provides an example of the growing scientific field termed "the developmental origins of adult disease" and suggests new targets of abnormal programming by endocrine disrupting chemicals... - Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generationsRetha R Newbold
Developmental Endocrinology and Endocrine Disruptor Section, Mail Drop E4 02, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Endocrinology 147:S11-7. 2006.... - Environmental estrogens and obesityRetha R Newbold
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States
Mol Cell Endocrinol 304:84-9. 2009.... - Intersection of nuclear receptors and the proteasome on the epigenetic landscapeH Karimi Kinyamu
Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Environ Mol Mutagen 49:83-95. 2008..In this review, we will explore molecular mechanisms by which NR-mediated gene expression, under the control of the proteasome, can result in altered epigenetic landscapes... - A natural antioxidant mixture from spinach does not have estrogenic or antiestrogenic activity in immature CD-1 miceLiat Lomnitski
Life Science Faculty, Bar-Ilan University, Ramat-Gan, Israel
J Nutr 133:3584-7. 2003..These data suggest that NAO does not have estrogenic or antiestrogenic activity. Thus, an antioxidant mixture has been identified that does not have potentially adverse estrogenic activity... - Estradiol, progesterone, and genistein inhibit oocyte nest breakdown and primordial follicle assembly in the neonatal mouse ovary in vitro and in vivoYing Chen
Department of Biology, Syracuse University, 130 College Place, Syracuse, New York 13244, USA
Endocrinology 148:3580-90. 2007..These findings also provide insight into the mechanism of multiple oocyte follicle formation... - Pharmacokinetic analysis in serum of genistein administered subcutaneously to neonatal miceDaniel R Doerge
Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
Cancer Lett 184:21-7. 2002..These results are consistent with a diminished capacity for enzymatic conjugation of genistein, based on the ontogeny, as an important determinant of estrogenicity in neonatal mice...