Wendy Jefferson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Disruption of the female reproductive system by the phytoestrogen genistein
    Wendy N Jefferson
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, PO Box 12233, Research Triangle Park, NC 27709, United States
    Reprod Toxicol 23:308-16. 2007
  2. ncbi request reprint Neonatal genistein treatment alters ovarian differentiation in the mouse: inhibition of oocyte nest breakdown and increased oocyte survival
    Wendy Jefferson
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH DHHS, Research Triangle Park, NC 27709, USA
    Biol Reprod 74:161-8. 2006
  3. pmc Circulating levels of genistein in the neonate, apart from dose and route, predict future adverse female reproductive outcomes
    Wendy N Jefferson
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States
    Reprod Toxicol 31:272-9. 2011
  4. ncbi request reprint Adverse effects on female development and reproduction in CD-1 mice following neonatal exposure to the phytoestrogen genistein at environmentally relevant doses
    Wendy N Jefferson
    Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Biol Reprod 73:798-806. 2005
  5. pmc Oral exposure to genistin, the glycosylated form of genistein, during neonatal life adversely affects the female reproductive system
    Wendy N Jefferson
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 117:1883-9. 2009
  6. pmc Adult ovarian function can be affected by high levels of soy
    Wendy N Jefferson
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Nutr 140:2322S-2325S. 2010
  7. ncbi request reprint Disruption of the developing female reproductive system by phytoestrogens: genistein as an example
    Wendy N Jefferson
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA
    Mol Nutr Food Res 51:832-44. 2007
  8. ncbi request reprint Studies of the effects of neonatal exposure to genistein on the developing female reproductive system
    Wendy N Jefferson
    National Institute of Environmental Health Sciences, NIH, DHHS, Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, Research Triangle Park, NC 27709, USA
    J AOAC Int 89:1189-96. 2006
  9. pmc Neonatal exposure to genistein disrupts ability of female mouse reproductive tract to support preimplantation embryo development and implantation
    Wendy N Jefferson
    Reproductive Medicine Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 80:425-31. 2009
  10. pmc Developmental exposure to diethylstilbestrol alters uterine gene expression that may be associated with uterine neoplasia later in life
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, North Carolina 27709, USA
    Mol Carcinog 46:783-96. 2007

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Disruption of the female reproductive system by the phytoestrogen genistein
    Wendy N Jefferson
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, PO Box 12233, Research Triangle Park, NC 27709, United States
    Reprod Toxicol 23:308-16. 2007
    ..Thus, neonatal treatment with genistein at environmentally relevant doses caused adverse consequences on reproduction in adulthood...
  2. ncbi request reprint Neonatal genistein treatment alters ovarian differentiation in the mouse: inhibition of oocyte nest breakdown and increased oocyte survival
    Wendy Jefferson
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH DHHS, Research Triangle Park, NC 27709, USA
    Biol Reprod 74:161-8. 2006
    ..These data taken together suggest that genistein exposure during development alters ovarian differentiation by inhibiting oocyte nest breakdown and attenuating oocyte cell death...
  3. pmc Circulating levels of genistein in the neonate, apart from dose and route, predict future adverse female reproductive outcomes
    Wendy N Jefferson
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States
    Reprod Toxicol 31:272-9. 2011
    ..Additional studies of reproductive function in human populations exposed to high levels of phytoestrogens during development are warranted...
  4. ncbi request reprint Adverse effects on female development and reproduction in CD-1 mice following neonatal exposure to the phytoestrogen genistein at environmentally relevant doses
    Wendy N Jefferson
    Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Biol Reprod 73:798-806. 2005
    ..In summary, neonatal treatment with Gen caused abnormal estrous cycles, altered ovarian function, early reproductive senescence, and subfertility/infertility at environmentally relevant doses...
  5. pmc Oral exposure to genistin, the glycosylated form of genistein, during neonatal life adversely affects the female reproductive system
    Wendy N Jefferson
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 117:1883-9. 2009
    ..S. infants are fed soy formula. High circulating levels of GEN have been measured in the serum of these infants, indicating that GIN is readily absorbed, hydrolyzed, and circulated...
  6. pmc Adult ovarian function can be affected by high levels of soy
    Wendy N Jefferson
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Nutr 140:2322S-2325S. 2010
    ..This paper summarizes the literature on adult soy consumption and its effect on ovarian function...
  7. ncbi request reprint Disruption of the developing female reproductive system by phytoestrogens: genistein as an example
    Wendy N Jefferson
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA
    Mol Nutr Food Res 51:832-44. 2007
    ....
  8. ncbi request reprint Studies of the effects of neonatal exposure to genistein on the developing female reproductive system
    Wendy N Jefferson
    National Institute of Environmental Health Sciences, NIH, DHHS, Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, Research Triangle Park, NC 27709, USA
    J AOAC Int 89:1189-96. 2006
    ..Thus, neonatal treatment with genistein at environmentally relevant doses caused adverse consequences on ovarian development and reproductive function...
  9. pmc Neonatal exposure to genistein disrupts ability of female mouse reproductive tract to support preimplantation embryo development and implantation
    Wendy N Jefferson
    Reproductive Medicine Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 80:425-31. 2009
    ....
  10. pmc Developmental exposure to diethylstilbestrol alters uterine gene expression that may be associated with uterine neoplasia later in life
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, North Carolina 27709, USA
    Mol Carcinog 46:783-96. 2007
    ..These data suggested altered gene expression profiles observed 2 wk after treatment ceased, were established at the time of developmental exposure and maybe related to the initiation events resulting in carcinogenesis...
  11. ncbi request reprint Neonatal exposure to genistein induces estrogen receptor (ER)alpha expression and multioocyte follicles in the maturing mouse ovary: evidence for ERbeta-mediated and nonestrogenic actions
    Wendy N Jefferson
    Developmental Endocrinology Section, Laboratory of Molecular Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 67:1285-96. 2002
    ..Given that human infants are exposed to high levels of genistein in soy-based foods, this study indicates that the effects of such exposure on the developing reproductive tract warrant further investigation...
  12. ncbi request reprint Neonatal exposure to the phytoestrogen genistein alters mammary gland growth and developmental programming of hormone receptor levels
    Elizabeth Padilla-Banks
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 147:4871-82. 2006
    ..In summary, neonatal Gen exposure altered mammary gland growth and development as well as hormone receptor levels at all doses examined; higher doses of Gen led to permanent long-lasting morphological changes...
  13. ncbi request reprint Assessing estrogenic activity of phytochemicals using transcriptional activation and immature mouse uterotrophic responses
    Wendy N Jefferson
    Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 777:179-89. 2002
    ..Furthermore, having an estrogenic "fingerprint" for each phytochemical is an essential first step in determining potential adverse effects of exposure to phytoestrogens...
  14. doi request reprint Effects of endocrine disruptors on obesity
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Androl 31:201-8. 2008
    ..The emerging idea of an association of EDCs and obesity expands the focus on obesity from intervention and treatment to include prevention and avoidance of these chemical modifiers...
  15. pmc Prenatal exposure to bisphenol a at environmentally relevant doses adversely affects the murine female reproductive tract later in life
    Retha R Newbold
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 117:879-85. 2009
    ..Bisphenol A (BPA), an environmental estrogen used in the synthesis of plastics, is of concern because its chemical structure resembles that of DES, and it is a "high-volume production" chemical with widespread human exposure...
  16. pmc Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA
    Reprod Toxicol 24:253-8. 2007
    ..These data suggest that BPA causes long-term adverse effects if exposure occurs during critical periods of differentiation...
  17. ncbi request reprint Perinatal exposure to environmental estrogens and the development of obesity
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA
    Mol Nutr Food Res 51:912-7. 2007
    ....
  18. ncbi request reprint Developmental exposure to diethylstilbestrol (DES) alters uterine response to estrogens in prepubescent mice: low versus high dose effects
    Retha R Newbold
    Developmental Endocrinology Section, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Reprod Toxicol 18:399-406. 2004
    ....
  19. ncbi request reprint Developmental exposure to estrogenic compounds and obesity
    Retha R Newbold
    Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Birth Defects Res A Clin Mol Teratol 73:478-80. 2005
  20. pmc Developmental exposure to endocrine disruptors and the obesity epidemic
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, Mail Drop E4 02, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States
    Reprod Toxicol 23:290-6. 2007
    ..This experimental animal model provides an example of the growing scientific field termed "the developmental origins of adult disease" and suggests new targets of abnormal programming by endocrine disrupting chemicals...
  21. ncbi request reprint Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Mail Drop E4 02, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 147:S11-7. 2006
    ....
  22. pmc Environmental estrogens and obesity
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States
    Mol Cell Endocrinol 304:84-9. 2009
    ....
  23. doi request reprint Expression of a dominant negative estrogen receptor alpha variant in transgenic mice accelerates uterine cancer induced by the potent estrogen diethylstilbestrol
    Vicki L Davis
    Receptor Biology Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States
    Reprod Toxicol 34:512-21. 2012
    ..These findings indicate that expression of this ERĪ± variant can influence determining events in uterine cancer development and its natural occurrence in the human uterus would unlikely be protective...
  24. pmc Intersection of nuclear receptors and the proteasome on the epigenetic landscape
    H Karimi Kinyamu
    Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 49:83-95. 2008
    ..In this review, we will explore molecular mechanisms by which NR-mediated gene expression, under the control of the proteasome, can result in altered epigenetic landscapes...
  25. ncbi request reprint Estradiol, progesterone, and genistein inhibit oocyte nest breakdown and primordial follicle assembly in the neonatal mouse ovary in vitro and in vivo
    Ying Chen
    Department of Biology, Syracuse University, 130 College Place, Syracuse, New York 13244, USA
    Endocrinology 148:3580-90. 2007
    ..These findings also provide insight into the mechanism of multiple oocyte follicle formation...
  26. ncbi request reprint A natural antioxidant mixture from spinach does not have estrogenic or antiestrogenic activity in immature CD-1 mice
    Liat Lomnitski
    Life Science Faculty, Bar Ilan University, Ramat Gan, Israel
    J Nutr 133:3584-7. 2003
    ..These data suggest that NAO does not have estrogenic or antiestrogenic activity. Thus, an antioxidant mixture has been identified that does not have potentially adverse estrogenic activity...
  27. ncbi request reprint Pharmacokinetic analysis in serum of genistein administered subcutaneously to neonatal mice
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Cancer Lett 184:21-7. 2002
    ..These results are consistent with a diminished capacity for enzymatic conjugation of genistein, based on the ontogeny, as an important determinant of estrogenicity in neonatal mice...