Kuan Teh Jeang

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Life, death, and tax: role of HTLV-I oncoprotein in genetic instability and cellular transformation
    Kuan Teh Jeang
    Laboratory of Molecular Microbiology, Nattional Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:31991-4. 2004
  2. pmc Specific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complex
    Yick Pang Ching
    Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, China
    Retrovirology 1:18. 2004
  3. pmc Jacov Tal (1940 - 2005): remembrances of a friend
    Gabriel Kaufmann
    Department of Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel
    Retrovirology 2:12. 2005
  4. pmc Retrovirology and young Turks
    Kuan Teh Jeang
    Retrovirology 1:1. 2004
  5. pmc The young, not-so-young, and the 2007 Retrovirology Prize: call for nominations
    Kuan Teh Jeang
    Retrovirology 4:64. 2007
  6. pmc Please comment, but with civility
    Kuan Teh Jeang
    Retrovirology 5:35. 2008
  7. pmc Ku protein as a potential human T-cell leukemia virus type 1 (HTLV-1) Tax target in clastogenic chromosomal instability of mammalian cells
    Franca Majone
    Department of Biology, University of Padua, Padua, Italy
    Retrovirology 2:45. 2005
  8. pmc Role of RNA helicases in HIV-1 replication
    Kuan Teh Jeang
    Molecular Virology Section, Laboratory of Molecular Medicine, NIAID, NIH, Bethesda, MD 20892, USA
    Nucleic Acids Res 34:4198-205. 2006
  9. pmc Progress, challenges, and responsibilities in retrovirology
    Kuan Teh Jeang
    National Institutes of Health, Bethesda, MD, USA
    Retrovirology 2:1. 2005
  10. pmc Retrovirology highlights a quarter century of HTLV-I research
    Kuan Teh Jeang
    Laboratory of Molecular Microbiology, NIAID, NIH Bethesda, Maryland 20892, USA
    Retrovirology 2:15. 2005

Collaborators

Detail Information

Publications115 found, 100 shown here

  1. ncbi request reprint Life, death, and tax: role of HTLV-I oncoprotein in genetic instability and cellular transformation
    Kuan Teh Jeang
    Laboratory of Molecular Microbiology, Nattional Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:31991-4. 2004
  2. pmc Specific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complex
    Yick Pang Ching
    Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, China
    Retrovirology 1:18. 2004
    ..Human T-cell leukemia virus type I (HTLV-I) Tax protein is a transcriptional regulator of viral and cellular genes. In this study we have examined in detail the determinants for Tax-mediated transcriptional activation...
  3. pmc Jacov Tal (1940 - 2005): remembrances of a friend
    Gabriel Kaufmann
    Department of Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel
    Retrovirology 2:12. 2005
    ..An obituary commemorates the life and works of Jacov Tal...
  4. pmc Retrovirology and young Turks
    Kuan Teh Jeang
    Retrovirology 1:1. 2004
  5. pmc The young, not-so-young, and the 2007 Retrovirology Prize: call for nominations
    Kuan Teh Jeang
    Retrovirology 4:64. 2007
    ..The Retrovirology Prize seeks to recognize and encourage the work of a mid-career retrovirologist between the ages of 45 and 60. The 2006 Retrovirology Prize was awarded to Dr. Joseph G. Sodroski...
  6. pmc Please comment, but with civility
    Kuan Teh Jeang
    Retrovirology 5:35. 2008
    ..These comments are moderated by the journal editors and are often peer reviewed prior to posting. Retrovirology welcomes comments, but asks that they be written civilly...
  7. pmc Ku protein as a potential human T-cell leukemia virus type 1 (HTLV-1) Tax target in clastogenic chromosomal instability of mammalian cells
    Franca Majone
    Department of Biology, University of Padua, Padua, Italy
    Retrovirology 2:45. 2005
    ..Taken together, our findings suggest Ku80 as a cellular factor targeted by Tax in engendering clastogenic DNA damage...
  8. pmc Role of RNA helicases in HIV-1 replication
    Kuan Teh Jeang
    Molecular Virology Section, Laboratory of Molecular Medicine, NIAID, NIH, Bethesda, MD 20892, USA
    Nucleic Acids Res 34:4198-205. 2006
    ..Here, we review in brief the notion that the human immunodeficiency virus (HIV-1) has adopted the ability to use one or more cellular RNA helicases for its replicative life cycle...
  9. pmc Progress, challenges, and responsibilities in retrovirology
    Kuan Teh Jeang
    National Institutes of Health, Bethesda, MD, USA
    Retrovirology 2:1. 2005
    ..In this editorial, Retrovirology's choice for best basic science "retrovirus paper of the year" and a perspective on challenges and responsibilities facing HIV-1 and HTLV-I research are presented...
  10. pmc Retrovirology highlights a quarter century of HTLV-I research
    Kuan Teh Jeang
    Laboratory of Molecular Microbiology, NIAID, NIH Bethesda, Maryland 20892, USA
    Retrovirology 2:15. 2005
    ..This month, Retrovirology commemorates these two land mark findings by publishing separate personal recollections by Takatsuki and Gallo respectively on the discovery of ATL and HTLV...
  11. pmc Mohmmar Qadaffi, open access, and retrovirology
    Kuan Teh Jeang
    National Institutes of Health, Bethesda, MD, USA
    Retrovirology 1:24. 2004
    ..In this editorial, I review the reasons for and the advantages of Open Access publishing, update our progress to date, and summarize where we intend to go with this journal...
  12. pmc Life after 45 and before 60: the Retrovirology Prize
    Kuan Teh Jeang
    National Institutes of Health, Bethesda, MD, USA
    Retrovirology 2:26. 2005
    ..Retrovirology announces an annual prize to recognize one outstanding mid-career retrovirologist...
  13. pmc Small philanthropy and big science: the RETROVIROLOGY prize and Stephen P. Goff
    Kuan Teh Jeang
    The National Institutes of Health, Bethesda, MD, USA
    Retrovirology 2:43. 2005
    ..Stephen P. Goff wins the 2005 RETROVIROLOGY prize...
  14. pmc Reflections on searching for a postdoctoral position: three points to ponder
    Kuan Teh Jeang
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Yale J Biol Med 84:191-3. 2011
    ....
  15. ncbi request reprint Tat, Tat-associated kinase, and transcription
    K T Jeang
    Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, MD 20892 0460, USA
    J Biomed Sci 5:24-7. 1998
    ..Here we review, in brief, the role of Tat-associated kinase in Tat-activated transcription. We discuss evidence that suggests involvement of TFIIH and/or P-TEFb...
  16. ncbi request reprint Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-kappa B
    K T Jeang
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 306, Building 4, 4 Center Drive, MSC 0460, Bethesda, MD 20892 0460, USA
    Cytokine Growth Factor Rev 12:207-17. 2001
    ..In this paper, we review aspects of Tax's transcriptional potential with particular focus on recent evidence linking Tax to IKK (I kappa B-kinase)-complex and MAP3Ks (mitogen-activated protein kinase kinase kinases)...
  17. ncbi request reprint Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors
    Takefumi Kasai
    Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Biol Chem 277:5187-93. 2002
    ..This altered localization of hsMAD1 and hsMAD2 correlated with loss of mitotic checkpoint function and chemoresistance to microtubule inhibitors...
  18. pmc Trimethylguanosine capping selectively promotes expression of Rev-dependent HIV-1 RNAs
    Venkat S R K Yedavalli
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
    Proc Natl Acad Sci U S A 107:14787-92. 2010
    ..TMG capping of unspliced/partially spliced HIV-1 RNAs represents a new regulatory mechanism for selective expression...
  19. pmc Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein
    Jean Marie Peloponese
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
    Proc Natl Acad Sci U S A 102:18974-9. 2005
    ..We report that Tax directly binds Ran and Ran-binding protein-1, locates to centrosomes/spindle poles, and causes supernumerary centrosomes...
  20. ncbi request reprint Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing
    Yamina Bennasser
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 22:607-19. 2005
    ..Tat abrogates the cell's RNA-silencing defense by subverting the ability of Dicer to process precursor double-stranded RNAs into siRNAs...
  21. pmc Ubiquitination of human T-cell leukemia virus type 1 tax modulates its activity
    Jean Marie Peloponese
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 78:11686-95. 2004
    ..We show that ubiquitination does not target Tax for degradation by the proteasome. Rather, ubiquitin addition modifies Tax in a proteasome-independent manner from an active to a less-active transcriptional form...
  22. ncbi request reprint Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice
    Yoichi Iwanaga
    Molecular Virology Section, Laboratory of Molecular Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Cancer Res 67:160-6. 2007
    ..Our results indicate an essential MAD1 function in mouse development and correlate Mad1 haploinsufficiency with increased constitutive tumors...
  23. pmc Evidence for NF-kappaB- and CBP-independent repression of p53's transcriptional activity by human T-cell leukemia virus type 1 Tax in mouse embryo and primary human fibroblasts
    Akiko Miyazato
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 79:9346-50. 2005
    ..Curiously, p53's activity in MEFs was also repressed by a p300/CBP-binding deficient Tax protein. Our results highlight the complex nature of Tax-mediated repression of p53- activity, which requires further investigation...
  24. ncbi request reprint Characterization of regions in hsMAD1 needed for binding hsMAD2. A polymorphic change in an hsMAD1 leucine zipper affects MAD1-MAD2 interaction and spindle checkpoint function
    Yoichi Iwanaga
    Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 0460, USA
    J Biol Chem 277:31005-13. 2002
    ..Based on our findings, it is possible that hsMAD1H558 could be an at-risk polymorphism that contributes to attenuated spindle checkpoint function in human cells...
  25. pmc Differential requirements for activation of integrated and transiently transfected human T-cell leukemia virus type 1 long terminal repeat
    Masahiko Okada
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 0460, USA
    J Virol 76:12564-73. 2002
    ..Our findings point to additional complexities in the regulated expression of HTLV-1 proviruses compared with those hitherto revealed through transfection studies...
  26. ncbi request reprint Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signaling
    Hidekatsu Iha
    Laboratory of Molecular Microbiology, Molecular Virology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
    Oncogene 22:8912-23. 2003
    ..We provide the first evidence that selective targeting of NEMO can abrogate oncogenic Tax signaling without affecting signals used for normal cellular metabolism...
  27. pmc Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies
    Chia Yen Chen
    National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, MD 20892, USA
    Cell 149:565-77. 2012
    ..Collectively, these findings implicate Sun1 protein accumulation as a common pathogenic event in Lmna(-/-), LmnaΔ9, and HGPS disorders...
  28. ncbi request reprint Role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoprotein
    Jean Marie Peloponese
    Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Biol Chem 281:8927-38. 2006
    ..Tax is shown to activate activator protein-1 through the phosphatidylinositol 3-kinase/Akt pathway...
  29. ncbi request reprint HIV-1 TAR RNA subverts RNA interference in transfected cells through sequestration of TAR RNA-binding protein, TRBP
    Yamina Bennasser
    Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Biol Chem 281:27674-8. 2006
    ..Our data suggest that TAR RNA sequesters TRBP rendering it unavailable for downstream Dicer-RISC complexes. TAR-induced inhibition of Dicer-RISC activity in transfected cells was partially relieved by exogenous expression of TRBP...
  30. ncbi request reprint Polyarginine inhibits gp160 processing by furin and suppresses productive human immunodeficiency virus type 1 infection
    Karen V Kibler
    Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Biol Chem 279:49055-63. 2004
    ..Taken together, our data support that inhibitors of proteolytic processing of gp160 may be useful for combating human immunodeficiency virus-1 and that polyarginine represents a lead example of such inhibitors...
  31. pmc Evidence for cooperative transforming activity of the human pituitary tumor transforming gene and human T-cell leukemia virus type 1 Tax
    Sergey V Sheleg
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 81:7894-901. 2007
    ..Cells that overexpressed both PTTG and Tax induced tumors more robustly in nude mice than cells that expressed either PTTG alone or Tax alone...
  32. pmc Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesis
    Linda Zane
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    Retrovirology 9:114. 2012
    ..All ATLL cases are believed to have reduced p53 activity although only a minority of ATLLs have genetic mutations in their p53 gene. It has been suggested that p53 function is inactivated by the Tax protein...
  33. pmc Identification of small molecules that suppress microRNA function and reverse tumorigenesis
    Koichi Watashi
    Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:24707-16. 2010
    ..These findings indicate that miRNA pathway-suppressing small molecules could potentially reverse tumorigenesis...
  34. pmc Pyrosequencing of small non-coding RNAs in HIV-1 infected cells: evidence for the processing of a viral-cellular double-stranded RNA hybrid
    Man Lung Yeung
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
    Nucleic Acids Res 37:6575-86. 2009
    ..It was found to associate with the Ago2 protein, suggesting its possible function in the cellular RNAi machinery for targeting HIV-1...
  35. ncbi request reprint RNA interference and HIV-1
    Man Lung Yeung
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Adv Pharmacol 55:427-38. 2007
  36. pmc Changes in microRNA expression profiles in HIV-1-transfected human cells
    Man Lung Yeung
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892 0460, USA
    Retrovirology 2:81. 2005
    ..We report distinct differences in miRNA profiles in mock-transfected HeLa cells versus HeLa cells transfected with an infectious HIV-1 molecular clone, pNL4-3...
  37. ncbi request reprint Modulation of nuclear factor-kappaB by human T cell leukemia virus type 1 Tax protein: implications for oncogenesis and inflammation
    Jean Marie Peloponese
    Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892 0460, USA
    Immunol Res 34:1-12. 2006
    ..Here, we review current thinking on how Tax may affect both diseases through activation of NF-kappaB signaling...
  38. ncbi request reprint Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1
    Venkat S R K Yedavalli
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Biol Chem 278:6404-10. 2003
    ..Thus, like cellular promoters, HIV-1 LTR can use P-TEFb function without a Tat/TAR RNA complex. This activity could explain recent findings of robust HIV-1 replication in rat cells that cannot form a P-TEFb/Tat/TAR moiety...
  39. ncbi request reprint Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes
    Ya Hui Chi
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Biol Chem 282:27447-58. 2007
    ..We propose that nascently reforming nuclear envelope employs hsSUN1 and hALP to acetylate histones for de-compacting DNA at the end of mitosis...
  40. ncbi request reprint Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function
    Venkat S R K Yedavalli
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Cell 119:381-92. 2004
    ..Plausibly, DDX3 is the human RNA helicase which functions in the CRM1 RNA export pathway analogously to the postulated role for Dbp5p in yeast mRNA export...
  41. ncbi request reprint Expression of mitotic spindle checkpoint protein hsMAD1 correlates with cellular proliferation and is activated by a gain-of-function p53 mutant
    Yoichi Iwanaga
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 0460, USA
    Cancer Res 62:2618-24. 2002
    ....
  42. ncbi request reprint Rhesus monkey simian immunodeficiency virus infection as a model for assessing the role of selenium in AIDS
    Xue Ming Xu
    Section on the Molecular Biology of Selenium, Basic Research Laboratory, National Cancer Institute NIH, Building 37, Room 2D09, Bethesda, MD 20892, USA
    J Acquir Immune Defic Syndr 31:453-63. 2002
    ....
  43. pmc A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication
    Man Lung Yeung
    Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Biol Chem 284:19463-73. 2009
    ..We discuss the similarities and differences between our shRNA findings for HIV-1 using a spreading infection assay in human Jurkat T-cells and results from other investigators who used siRNA-based screenings in HeLa or 293T cells...
  44. pmc HIV-1 Tat interaction with Dicer: requirement for RNA
    Yamina Bennasser
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    Retrovirology 3:95. 2006
    ..Here, we have investigated the requirements for Tat interaction with Dicer. We report that Tat-Dicer interaction depends on RNA, requires the helicase domain of Dicer, and is independent of Tat's transactivation domain...
  45. pmc HIV-1 encoded candidate micro-RNAs and their cellular targets
    Yamina Bennasser
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    Retrovirology 1:43. 2004
    ..We propose that HIV has evolved to use vmiRNAs as a means to regulate cellular milieu for its benefit...
  46. ncbi request reprint Requirement for the second coding exon of Tat in the optimal replication of macrophage-tropic HIV-1
    Christine Neuveut
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0460, USA
    J Biomed Sci 10:651-60. 2003
    ..Similarly, two-exon Tat expressing HIV-1 also replicates better than one-exon Tat expressing HIV-1 in two different models of human cells/tissue reconstituted SCID mice...
  47. ncbi request reprint HTLV-1 Tax and adult T-cell leukemia
    Chou Zen Giam
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Front Biosci 12:1496-507. 2007
    ....
  48. pmc Human immunodeficiency virus type 1 Vpr interacts with antiapoptotic mitochondrial protein HAX-1
    Venkat S R K Yedavalli
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, Maryland 20892 0460, USA
    J Virol 79:13735-46. 2005
    ..Overexpression of Vpr in cells dislocates HAX-1 from its normal residence in mitochondria and creates mitochondrion instability and cell death. Conversely, overexpression of HAX-1 suppressed the proapoptotic activity of Vpr...
  49. pmc The extent of sequence complementarity correlates with the potency of cellular miRNA-mediated restriction of HIV-1
    Laurent Houzet
    Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
    Nucleic Acids Res 40:11684-96. 2012
    ..Antagomirs to miR-326 that knocked down this cell endogenous miRNA increased HIV-1 replication in cells, suggesting that miR-326 is physiologically functional in moderating HIV-1 replication in human cells...
  50. pmc MicroRNAs and HIV-1: complex interactions
    Zachary Klase
    Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:40884-90. 2012
    ..Lessons learned from and questions outstanding about the complex interactions between HIV-1 and cellular miRNAs are discussed...
  51. pmc Rev-ing up post-transcriptional HIV-1 RNA expression
    Venkat S R K Yedavalli
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, MD, USA
    RNA Biol 8:195-9. 2011
    ..Here, the post-transcriptional activities of Rev are discussed in the context of a recent finding that an RNA cap methyltransferase contributes to the expression of unspliced / partially spliced HIV-1 transcripts...
  52. pmc Matrin 3 is a co-factor for HIV-1 Rev in regulating post-transcriptional viral gene expression
    Venkat S R K Yedavalli
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    Retrovirology 8:61. 2011
    ..This binding interaction stabilizes unspliced and partially spliced HIV-1 transcripts leading to increased cytoplasmic expression of these viral RNAs...
  53. pmc Peptidylproline cis-trans-isomerase Pin1 interacts with human T-cell leukemia virus type 1 tax and modulates its activation of NF-kappaB
    Jean Marie Peloponese
    Molecular Virology Section, Laboratory of Molecular, Microbiology, The National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Virol 83:3238-48. 2009
    ..We show here that prolyl isomerase Pin1 is over expressed in HTLV-1 cell lines; Pin1 binds Tax and regulates Tax-induced NF-kappaB activation...
  54. pmc Induction of reactive oxygen species by human T-cell leukemia virus type 1 tax correlates with DNA damage and expression of cellular senescence marker
    Takao Kinjo
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 84:5431-7. 2010
    ..Our data suggest that ROS induction explains Tax-induced cellular DNA damage and cellular senescence...
  55. pmc MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals
    Laurent Houzet
    Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    Retrovirology 5:118. 2008
    ..The HIV-1-positive individuals were categorized operationally into four classes based on their CD4+ T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes...
  56. pmc The nuclear envelopathies and human diseases
    Ya Hui Chi
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Biomed Sci 16:96. 2009
    ..Here, we review the functions of the nuclear envelope in chromosome organization, gene expression, DNA repair and cell cycle progression, and correlate deficiencies in envelope function with human pathologies...
  57. ncbi request reprint Human T-cell lymphotropic virus type 1 tax inhibits transforming growth factor-beta signaling by blocking the association of Smad proteins with Smad-binding element
    Dug Keun Lee
    Laboratory of Cell Regulation and Carcinogenesis, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:33766-75. 2002
    ..Furthermore, Tax inhibits Smad3.Smad4 complex formation and its DNA binding. These results suggest that suppression of Smad-mediated signaling by Tax may contribute to HTLV-1-associated leukemogenesis...
  58. ncbi request reprint MicroRNAs in human immunodeficiency virus-1 infection
    Yamina Bennasser
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institue of Health, Bethesda, MD, USA
    Methods Mol Biol 342:241-53. 2006
    ..Finally, we use a scanning algorithm to search 3' untranslated regions (UTRs) of human messenger RNAs (mRNAs) in the attempt to predict potential sites targeted by HIV-1 miRNAs...
  59. ncbi request reprint Human T-lymphotropic virus type I tax activates I-kappa B kinase by inhibiting I-kappa B kinase-associated serine/threonine protein phosphatase 2A
    De Xue Fu
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Biol Chem 278:1487-93. 2003
    ....
  60. ncbi request reprint Human T-cell leukemia virus type 1 Tax and cellular transformation
    Jean Marie Peloponese
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    Int J Hematol 86:101-6. 2007
    ..In this review, we summarize current thinking on how Tax may affect ATL leukemogenesis...
  61. pmc Cellular RNA helicases and HIV-1: insights from genome-wide, proteomic, and molecular studies
    Chia Yen Chen
    Molecular Virology Section 1, Laboratory of Molecular, Microbiology, The National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, MD 20892, USA
    Virus Res 171:357-65. 2013
    ..Some of these helicases augment virus propagation while others apparently participate in antiviral defenses against viral replication...
  62. pmc The cellular autophagy pathway modulates human T-cell leukemia virus type 1 replication
    Sai Wen Tang
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 87:1699-707. 2013
    ..Our current findings indicate that by interrupting the cell's autophagic process, Tax exerts a positive feedback on its own stability...
  63. pmc Methylation: a regulator of HIV-1 replication?
    Venkat R K Yedavalli
    Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, The National Institutes of Health, Bethesda, Maryland 20892, USA
    Retrovirology 4:9. 2007
    ..Emerging evidence suggests that protein-methylation can positively and negatively regulate HIV-1 replication. How DNA- and RNA- methylation might impact HIV-1 is also discussed...
  64. pmc Two discrete events, human T-cell leukemia virus type I Tax oncoprotein expression and a separate stress stimulus, are required for induction of apoptosis in T-cells
    Takefumi Kasai
    Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    Retrovirology 1:7. 2004
    ..At first glance, the ability to transform and the ability to engender apoptosis seem to be contradictory. Interestingly, both abilities have been widely reported in the literature for the HTLV-I Tax protein...
  65. pmc Human cellular restriction factors that target HIV-1 replication
    Klaus Strebel
    Laboratory of Molecular Microbiology, NIAID, The National Institutes of Health, Bethesda, Maryland, USA
    BMC Med 7:48. 2009
    ..We point to countermeasures encoded by HIV-1 for moderating the potency of these cellular restriction functions...
  66. pmc Roles for microRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1
    Man Lung Yeung
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
    Cancer Res 68:8976-85. 2008
    ..Collectively, the findings implicate a miR-93/miR-130b-TP53INP1 axis that affects the proliferation and survival of HTLV-1-infected/transformed cells...
  67. pmc Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA
    Ya Hui Chi
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Development 136:965-73. 2009
    ..These findings raise a heretofore unrecognized role of Sun1 in the selective gene expression of coding and non-coding RNAs needed for gametogenesis...
  68. ncbi request reprint Aneuploidy and cancer
    Ya Hui Chi
    Molecular Virology Section, Laboratory of Molecular Microbiology, The National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Cell Biochem 102:531-8. 2007
    ..Here, we review in brief some mechanisms which contribute to cellular aneuploidy and offer a perspective on the relationship between aneuploidy and human cancers...
  69. doi request reprint HTLV-1 and adult T-cell leukemia: insights into viral transformation of cells 30 years after virus discovery
    Kuan Teh Jeang
    National Institutes of Health, Bethesda, Maryland 20892, USA
    J Formos Med Assoc 109:688-93. 2010
    ..This review discusses recent insights into the role of the HTLV-1 Tax oncoprotein in cellular proliferation and the abrogation of cellular checkpoints that lead to disease progression...
  70. ncbi request reprint miRNAs in the biology of cancers and viral infections
    Man Lung Yeung
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    Curr Med Chem 14:191-7. 2007
    ..Here, we will discuss examples of roles served by cellular miRNAs and virus-encoded miRNAs in the development of cancers and viral diseases...
  71. pmc Requirements for protein phosphorylation and the kinase activity of polo-like kinase 1 (Plk1) for the kinetochore function of mitotic arrest deficiency protein 1 (Mad1)
    Ya Hui Chi
    Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 283:35834-44. 2008
    ..Collectively, these findings indicate mechanistic roles contributed by protein phosphorylation and Plk1 to the SAC activity of Mad1...
  72. pmc Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling
    Junichiro Yasunaga
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 85:6212-9. 2011
    ..Our results point to USP20 as a key negative regulator of Tax-induced NF-κB signaling...
  73. ncbi request reprint RNAi therapy for HIV infection: principles and practicalities
    Yamina Bennasser
    Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    BioDrugs 21:17-22. 2007
    ....
  74. pmc MicroRNAs and human retroviruses
    Laurent Houzet
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Biochim Biophys Acta 1809:686-93. 2011
    ..This article is part of a Special Issue entitled: MicroRNAs in viral gene regulation...
  75. pmc Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation
    Hidekatsu Iha
    Laboratory of Molecular Microbiology, Molecular Virology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
    EMBO J 27:629-41. 2008
    ..TAX1BP1-/- cells are more highly activated for NF-kappaB than control cells when stimulated with TNF-alpha or IL-1beta. Mechanistically, TAX1BP1 acts in NF-kappaB signalling as an essential adaptor between A20 and its targets...
  76. pmc A method to study the role of DDX3 RNA helicase in HIV-1
    Chia Yen Chen
    Molecular Virology Section, Laboratory of Molecular, Microbiology, the NIAID, NIH, Bethesda, MD, USA
    Methods Mol Biol 587:281-9. 2010
    ..In this chapter, we briefly summarize the approach for assaying the RNA unwinding activity of RNA helicases measuring the effect of helicase inhibitors on HIV-1 replication...
  77. pmc Human immunodeficiency virus type 1 replication and regulation of APOBEC3G by peptidyl prolyl isomerase Pin1
    Koichi Watashi
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 82:9928-36. 2008
    ..Intriguingly, HIV-1 infection modulates the phosphorylation state of Pin1, enhancing its ability to moderate A3G activity. These new findings suggest a potential Vif-independent way for HIV-1 to moderate the cellular action of A3G...
  78. pmc Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction
    Lea Cunningham
    Oncogenesis and Development Section, National Institute of Allergy and Infectious Diseases, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:14592-7. 2012
    ..Our data thus confirmed that RUNX1-CBFβ interaction can be targeted for leukemia treatment and we have identified a promising lead compound for this purpose...
  79. pmc Small non-coding RNAs, mammalian cells, and viruses: regulatory interactions?
    Man Lung Yeung
    Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892 0460, USA
    Retrovirology 4:74. 2007
    ..Here, we comment on several lines of evidence that support this concept. We discuss how viruses may in turn protect, suppress, evade, modulate, or adapt to the host cell's ncRNA regulatory schema...
  80. pmc Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-beta (PKG1beta)
    Jia Hai Lee
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    Retrovirology 4:91. 2007
    ..These findings provide evidence that cGMP and PKG serve to regulate HIV-1 infection in human cells...
  81. pmc Genome-wide screening using RNA interference to study host factors in viral replication and pathogenesis
    Laurent Houzet
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
    Exp Biol Med (Maywood) 236:962-7. 2011
    ..In this brief review, we focus on recent studies performed using genome-wide RNAi-based screens in mammalian cells for the identification of essential host factors for viral infection and pathogenesis...
  82. pmc Ring expanded nucleoside analogues inhibit RNA helicase and intracellular human immunodeficiency virus type 1 replication
    Venkat S R K Yedavalli
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Med Chem 51:5043-51. 2008
    ..Neither compound at therapeutic doses was significantly toxic in ex vivo cell culture or in vivo in mice. Our findings provide proof-of-concept that a cellular factor, an RNA helicase, could be targeted for inhibiting HIV-1 replication...
  83. pmc Viral transformation and aneuploidy
    Junichiro Yasunaga
    Molecular Virology Section, Laboratory of Molecular Microbiology, The National Institute of Allergy and Infectious Diseases NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Environ Mol Mutagen 50:733-40. 2009
    ..Here, we review in brief some of the mechanisms used by viruses that can cause cellular aneuploidy...
  84. pmc The rise of Bioscience in the East
    Kuan Teh Jeang
    The National Institutes of Health, Bethesda, MD, USA
    Retrovirology 7:106. 2010
    ..ABSTRACT: The rapid growth of bioscience in China is considered...
  85. pmc If you organize, they will join
    Kuan Teh Jeang
    The National Institutes of Health, Bethesda, MD, USA
    Cell Biosci 1:2. 2011
    ..ABSTRACT: This Editorial briefly introduces the Society of Chinese Bioscientists in America (SCBA) to readers of Cell & Bioscience...
  86. pmc RNAi in the regulation of mammalian viral infections
    Kuan Teh Jeang
    The National Institutes of Health, Bethesda, MD 20892 0460, USA
    BMC Biol 10:58. 2012
    ..Here, I discuss the reasons for the dispute, and review the evidence that RNAi is a part of the physiological defense of mammalian cells against viral infections...
  87. pmc Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication
    Deyun Wang
    Laboratory of Bioorganic Chemistry, NIDDK, NIH, DHHS, Bethesda, MD 20892, USA
    Bioorg Med Chem Lett 19:6893-7. 2009
    ..Antiviral studies are also consistent with the in vitro and cell-based assays. MBOs provide a framework for the development of future RNA-targeting molecules...
  88. pmc Human T cell leukemia virus type 1 (HTLV-1) and oncogene or oncomiR addiction?
    Kuan Teh Jeang
    Kuan Teh Jeang, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland 20892, USA
    Oncotarget 1:453-6. 2010
    ..Here we discuss the possibility that early ATL cells are Tax-oncogene-addicted while late ATL cells are oncogenic microRNA (oncomiR) - addicted. The potential utility of interrupting oncomiR addiction as a cancer treatment is broached...
  89. pmc Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice
    Ya Hui Chi
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Int J Cancer 124:1483-9. 2009
    ..The findings here provide evidence for a cooperative role of Mad1/Mad2 and p53 genes in preventing tumor development...
  90. pmc Replication competent HIV-1 viruses that express intragenomic microRNA reveal discrete RNA-interference mechanisms that affect viral replication
    Zachary Klase
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda MD, 20892, USA
    Cell Biosci 1:38. 2011
    ..abstract:..
  91. pmc A proteomic study of TAR-RNA binding protein (TRBP)-associated factors
    Ya Hui Chi
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Cell Biosci 1:9. 2011
    ..abstract:..
  92. ncbi request reprint siRNA, miRNA and HIV: promises and challenges
    Man Lung Yeung
    National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892 0460, USA
    Cell Res 15:935-46. 2005
    ..In this review, we discuss stratagems used by various viruses to avoid the cells' antiviral si/mi-RNA defenses and notions of how viruses might control and regulate host cell genes by encoding viral miRNAs (vmiRNAs)...
  93. ncbi request reprint The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication
    Yick Pang Ching
    Department of Biochemistry, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
    Nat Cell Biol 8:717-24. 2006
    ..Our findings suggest that the HTLV-I Tax oncoprotein targets TAX1BP2 causing genomic instability and aneuploidy...
  94. ncbi request reprint Viral and cellular RNA helicases as antiviral targets
    Ann D Kwong
    Vertex Pharmaceuticals Inc, 130 Waverly Street, Cambridge, Massachusetts 02139, USA
    Nat Rev Drug Discov 4:845-53. 2005
    ....
  95. ncbi request reprint Molecular mechanisms of cellular transformation by HTLV-1 Tax
    Ralph Grassmann
    Institut fur Klinische und Molekulare Virologie, Universitat Erlangen Nurnberg, Schlossgarten 4, Germany
    Oncogene 24:5976-85. 2005
    ..g. p53, DLG). Moreover, Tax silences cellular checkpoints, which guard against DNA structural damage and chromosomal missegregation, thereby favoring the manifestation of a mutator phenotype in cells...
  96. ncbi request reprint Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cells
    Marianne Löhr
    The Wolfson Institute for Biomedical Research, University College London, The Cruciform Building, Gower Street, London WC1E 6BT, UK
    Biochem Biophys Res Commun 300:609-13. 2003
    ..Here, we report a sequence-specific contribution of Tat residues 31-35 to anti-HIV-1 activity...
  97. pmc An alternative splice product of IkappaB kinase (IKKgamma), IKKgamma-delta, differentially mediates cytokine and human T-cell leukemia virus type 1 tax-induced NF-kappaB activation
    Tao Hai
    Department of Internal Medicine, The University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555 1060, USA
    J Virol 80:4227-41. 2006
    ..Differing levels of IKKgamma-delta expression, therefore, may affect signal transduction cascades coupling to IKK...
  98. pmc Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein
    Kerstin Haller
    Institut fur Klinische und Molekulare Virologie, D 91054 Erlangen, Germany
    Mol Cell Biol 22:3327-38. 2002
    ..Thus, protein-protein contact between Tax and the components of the cyclin D/CDK complexes provides a further mechanistic explanation for the mitogenic and immortalizing effects of this HTLV-1 oncoprotein...
  99. pmc TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats
    Yeung Tung Siu
    Department of Biochemistry, The University of Hong Kong, 3 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong
    J Virol 80:7052-9. 2006
    ..In addition, coactivators in the p300 family are required for full activity of Tax independently of TORC1/2/3. Thus, both TORC and p300 families of coactivators are essential for optimal activation of HTLV-1 transcription by Tax...
  100. ncbi request reprint Replication of human immunodeficiency virus type 1 from entry to exit
    Andrew M L Lever
    University of Cambridge Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    Int J Hematol 84:23-30. 2006
    ..Here, we review in a nonexhaustive manner our current knowledge of the replication of HIV-1 inside human cells from entry to exit of the virus...
  101. ncbi request reprint Binding of hybrid molecules containing pyrrolo [2,1-c][1,4]benzodiazepine (PBD) and oligopyrrole carriers to the human immunodeficiency type 1 virus TAR-RNA
    Carlo Mischiati
    Department of Biochemistry and Molecular Biology, University of Ferrara, Via Luigi Borsari 46, 44100 Ferrara, Italy
    Biochem Pharmacol 67:401-10. 2004
    ....