Research Topics
Genomes and Genes
| Kuan Teh JeangSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Specific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complexYick Pang Ching
Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, China
Retrovirology 1:18. 2004..Human T-cell leukemia virus type I (HTLV-I) Tax protein is a transcriptional regulator of viral and cellular genes. In this study we have examined in detail the determinants for Tax-mediated transcriptional activation...- Jacov Tal (1940 - 2005): remembrances of a friendGabriel Kaufmann
Department of Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel
Retrovirology 2:12. 2005..An obituary commemorates the life and works of Jacov Tal... - Retrovirology and young TurksKuan-Teh Jeang
Retrovirology 1:1. 2004 - The young, not-so-young, and the 2007 Retrovirology Prize: call for nominationsKuan-Teh Jeang
Retrovirology 4:64. 2007..The Retrovirology Prize seeks to recognize and encourage the work of a mid-career retrovirologist between the ages of 45 and 60. The 2006 Retrovirology Prize was awarded to Dr. Joseph G. Sodroski... - Please comment, but with civilityKuan-Teh Jeang
Retrovirology 5:35. 2008..These comments are moderated by the journal editors and are often peer reviewed prior to posting. Retrovirology welcomes comments, but asks that they be written civilly... - Ku protein as a potential human T-cell leukemia virus type 1 (HTLV-1) Tax target in clastogenic chromosomal instability of mammalian cellsFranca Majone
Department of Biology, University of Padua, Padua, Italy
Retrovirology 2:45. 2005..Taken together, our findings suggest Ku80 as a cellular factor targeted by Tax in engendering clastogenic DNA damage... - Life after 45 and before 60: the Retrovirology PrizeKuan Teh Jeang
National Institutes of Health, Bethesda, MD, USA
Retrovirology 2:26. 2005..Retrovirology announces an annual prize to recognize one outstanding mid-career retrovirologist... - Mohmmar Qadaffi, open access, and retrovirologyKuan Teh Jeang
National Institutes of Health, Bethesda, MD, USA
Retrovirology 1:24. 2004..In this editorial, I review the reasons for and the advantages of Open Access publishing, update our progress to date, and summarize where we intend to go with this journal... - Retrovirology highlights a quarter century of HTLV-I researchKuan Teh Jeang
Laboratory of Molecular Microbiology, NIAID, NIH Bethesda, Maryland 20892, USA
Retrovirology 2:15. 2005..This month, Retrovirology commemorates these two land mark findings by publishing separate personal recollections by Takatsuki and Gallo respectively on the discovery of ATL and HTLV... - Small philanthropy and big science: the RETROVIROLOGY prize and Stephen P. GoffKuan Teh Jeang
The National Institutes of Health, Bethesda, MD, USA
Retrovirology 2:43. 2005..Stephen P. Goff wins the 2005 RETROVIROLOGY prize... 
Tat, Tat-associated kinase, and transcriptionK T Jeang
Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, MD 20892 0460, USA
J Biomed Sci 5:24-7. 1998..Here we review, in brief, the role of Tat-associated kinase in Tat-activated transcription. We discuss evidence that suggests involvement of TFIIH and/or P-TEFb...- Role of RNA helicases in HIV-1 replicationKuan Teh Jeang
Molecular Virology Section, Laboratory of Molecular Medicine, NIAID, NIH, Bethesda, MD 20892, USA
Nucleic Acids Res 34:4198-205. 2006..Here, we review in brief the notion that the human immunodeficiency virus (HIV-1) has adopted the ability to use one or more cellular RNA helicases for its replicative life cycle... - Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-kappa BK T Jeang
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 306, Building 4, 4 Center Drive, MSC 0460, Bethesda, MD 20892 0460, USA
Cytokine Growth Factor Rev 12:207-17. 2001..In this paper, we review aspects of Tax's transcriptional potential with particular focus on recent evidence linking Tax to IKK (I kappa B-kinase)-complex and MAP3Ks (mitogen-activated protein kinase kinase kinases)... - Progress, challenges, and responsibilities in retrovirologyKuan Teh Jeang
National Institutes of Health, Bethesda, MD, USA
Retrovirology 2:1. 2005..In this editorial, Retrovirology's choice for best basic science "retrovirus paper of the year" and a perspective on challenges and responsibilities facing HIV-1 and HTLV-I research are presented... - Life, death, and tax: role of HTLV-I oncoprotein in genetic instability and cellular transformationKuan-Teh Jeang
Laboratory of Molecular Microbiology, Nattional Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:31991-4. 2004 - Reflections on searching for a postdoctoral position: three points to ponderKuan Teh Jeang
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Yale J Biol Med 84:191-3. 2011.... - Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoproteinJean Marie Peloponese
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
Proc Natl Acad Sci U S A 102:18974-9. 2005..We report that Tax directly binds Ran and Ran-binding protein-1, locates to centrosomes/spindle poles, and causes supernumerary centrosomes... - Trimethylguanosine capping selectively promotes expression of Rev-dependent HIV-1 RNAsVenkat S R K Yedavalli
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
Proc Natl Acad Sci U S A 107:14787-92. 2010..TMG capping of unspliced/partially spliced HIV-1 RNAs represents a new regulatory mechanism for selective expression... - Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in miceYoichi Iwanaga
Molecular Virology Section, Laboratory of Molecular Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Cancer Res 67:160-6. 2007..Our results indicate an essential MAD1 function in mouse development and correlate Mad1 haploinsufficiency with increased constitutive tumors... - Evidence for cooperative transforming activity of the human pituitary tumor transforming gene and human T-cell leukemia virus type 1 TaxSergey V Sheleg
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Virol 81:7894-901. 2007..Cells that overexpressed both PTTG and Tax induced tumors more robustly in nude mice than cells that expressed either PTTG alone or Tax alone... - Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signalingHidekatsu Iha
Laboratory of Molecular Microbiology, Molecular Virology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
Oncogene 22:8912-23. 2003..We provide the first evidence that selective targeting of NEMO can abrogate oncogenic Tax signaling without affecting signals used for normal cellular metabolism... - Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathiesChia Yen Chen
National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, MD 20892, USA
Cell 149:565-77. 2012..Collectively, these findings implicate Sun1 protein accumulation as a common pathogenic event in Lmna(-/-), LmnaΔ9, and HGPS disorders... - Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomesYa Hui Chi
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
J Biol Chem 282:27447-58. 2007..We propose that nascently reforming nuclear envelope employs hsSUN1 and hALP to acetylate histones for de-compacting DNA at the end of mitosis... - Polyarginine inhibits gp160 processing by furin and suppresses productive human immunodeficiency virus type 1 infectionKaren V Kibler
Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
J Biol Chem 279:49055-63. 2004..Taken together, our data support that inhibitors of proteolytic processing of gp160 may be useful for combating human immunodeficiency virus-1 and that polyarginine represents a lead example of such inhibitors... - Pyrosequencing of small non-coding RNAs in HIV-1 infected cells: evidence for the processing of a viral-cellular double-stranded RNA hybridMan Lung Yeung
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
Nucleic Acids Res 37:6575-86. 2009..It was found to associate with the Ago2 protein, suggesting its possible function in the cellular RNAi machinery for targeting HIV-1... - Identification of small molecules that suppress microRNA function and reverse tumorigenesisKoichi Watashi
Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 285:24707-16. 2010..These findings indicate that miRNA pathway-suppressing small molecules could potentially reverse tumorigenesis... - Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export functionVenkat S R K Yedavalli
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
Cell 119:381-92. 2004..Plausibly, DDX3 is the human RNA helicase which functions in the CRM1 RNA export pathway analogously to the postulated role for Dbp5p in yeast mRNA export... - Changes in microRNA expression profiles in HIV-1-transfected human cellsMan Lung Yeung
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892 0460, USA
Retrovirology 2:81. 2005..We report distinct differences in miRNA profiles in mock-transfected HeLa cells versus HeLa cells transfected with an infectious HIV-1 molecular clone, pNL4-3... - Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1Venkat S R K Yedavalli
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
J Biol Chem 278:6404-10. 2003..Thus, like cellular promoters, HIV-1 LTR can use P-TEFb function without a Tat/TAR RNA complex. This activity could explain recent findings of robust HIV-1 replication in rat cells that cannot form a P-TEFb/Tat/TAR moiety... - Expression of mitotic spindle checkpoint protein hsMAD1 correlates with cellular proliferation and is activated by a gain-of-function p53 mutantYoichi Iwanaga
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 0460, USA
Cancer Res 62:2618-24. 2002.... - A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replicationMan Lung Yeung
Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
J Biol Chem 284:19463-73. 2009..We discuss the similarities and differences between our shRNA findings for HIV-1 using a spreading infection assay in human Jurkat T-cells and results from other investigators who used siRNA-based screenings in HeLa or 293T cells... - HIV-1 Tat interaction with Dicer: requirement for RNAYamina Bennasser
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
Retrovirology 3:95. 2006..Here, we have investigated the requirements for Tat interaction with Dicer. We report that Tat-Dicer interaction depends on RNA, requires the helicase domain of Dicer, and is independent of Tat's transactivation domain... - HTLV-1 Tax and adult T-cell leukemiaChou Zen Giam
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
Front Biosci 12:1496-507. 2007.... - Human T-cell leukemia virus type 1 Tax and cellular transformationJean Marie Peloponese
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
Int J Hematol 86:101-6. 2007..In this review, we summarize current thinking on how Tax may affect ATL leukemogenesis... - HIV-1 encoded candidate micro-RNAs and their cellular targetsYamina Bennasser
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
Retrovirology 1:43. 2004..We propose that HIV has evolved to use vmiRNAs as a means to regulate cellular milieu for its benefit... - MicroRNAs and HIV-1: complex interactionsZachary Klase
Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 287:40884-90. 2012..Lessons learned from and questions outstanding about the complex interactions between HIV-1 and cellular miRNAs are discussed... - The extent of sequence complementarity correlates with the potency of cellular miRNA-mediated restriction of HIV-1Laurent Houzet
Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
Nucleic Acids Res 40:11684-96. 2012..Antagomirs to miR-326 that knocked down this cell endogenous miRNA increased HIV-1 replication in cells, suggesting that miR-326 is physiologically functional in moderating HIV-1 replication in human cells... - Rev-ing up post-transcriptional HIV-1 RNA expressionVenkat S R K Yedavalli
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, MD, USA
RNA Biol 8:195-9. 2011..Here, the post-transcriptional activities of Rev are discussed in the context of a recent finding that an RNA cap methyltransferase contributes to the expression of unspliced / partially spliced HIV-1 transcripts... - Matrin 3 is a co-factor for HIV-1 Rev in regulating post-transcriptional viral gene expressionVenkat S R K Yedavalli
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland 20892 0460, USA
Retrovirology 8:61. 2011..This binding interaction stabilizes unspliced and partially spliced HIV-1 transcripts leading to increased cytoplasmic expression of these viral RNAs... - Human T-cell lymphotropic virus type 1 tax inhibits transforming growth factor-beta signaling by blocking the association of Smad proteins with Smad-binding elementDug Keun Lee
Laboratory of Cell Regulation and Carcinogenesis, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:33766-75. 2002..Furthermore, Tax inhibits Smad3.Smad4 complex formation and its DNA binding. These results suggest that suppression of Smad-mediated signaling by Tax may contribute to HTLV-1-associated leukemogenesis... - Induction of reactive oxygen species by human T-cell leukemia virus type 1 tax correlates with DNA damage and expression of cellular senescence markerTakao Kinjo
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Virol 84:5431-7. 2010..Our data suggest that ROS induction explains Tax-induced cellular DNA damage and cellular senescence... - MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individualsLaurent Houzet
Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
Retrovirology 5:118. 2008..The HIV-1-positive individuals were categorized operationally into four classes based on their CD4+ T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes... - The nuclear envelopathies and human diseasesYa Hui Chi
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Biomed Sci 16:96. 2009..Here, we review the functions of the nuclear envelope in chromosome organization, gene expression, DNA repair and cell cycle progression, and correlate deficiencies in envelope function with human pathologies... - Peptidylproline cis-trans-isomerase Pin1 interacts with human T-cell leukemia virus type 1 tax and modulates its activation of NF-kappaBJean Marie Peloponese
Molecular Virology Section, Laboratory of Molecular, Microbiology, The National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland 20892 0460, USA
J Virol 83:3238-48. 2009..We show here that prolyl isomerase Pin1 is over expressed in HTLV-1 cell lines; Pin1 binds Tax and regulates Tax-induced NF-kappaB activation... - The cellular autophagy pathway modulates human T-cell leukemia virus type 1 replicationSai Wen Tang
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Virol 87:1699-707. 2013..Our current findings indicate that by interrupting the cell's autophagic process, Tax exerts a positive feedback on its own stability... - Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesisLinda Zane
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
Retrovirology 9:114. 2012..All ATLL cases are believed to have reduced p53 activity although only a minority of ATLLs have genetic mutations in their p53 gene. It has been suggested that p53 function is inactivated by the Tax protein... - Two discrete events, human T-cell leukemia virus type I Tax oncoprotein expression and a separate stress stimulus, are required for induction of apoptosis in T-cellsTakefumi Kasai
Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
Retrovirology 1:7. 2004..At first glance, the ability to transform and the ability to engender apoptosis seem to be contradictory. Interestingly, both abilities have been widely reported in the literature for the HTLV-I Tax protein... - Methylation: a regulator of HIV-1 replication?Venkat R K Yedavalli
Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, The National Institutes of Health, Bethesda, Maryland 20892, USA
Retrovirology 4:9. 2007..Emerging evidence suggests that protein-methylation can positively and negatively regulate HIV-1 replication. How DNA- and RNA- methylation might impact HIV-1 is also discussed... - Aneuploidy and cancerYa Hui Chi
Molecular Virology Section, Laboratory of Molecular Microbiology, The National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
J Cell Biochem 102:531-8. 2007..Here, we review in brief some mechanisms which contribute to cellular aneuploidy and offer a perspective on the relationship between aneuploidy and human cancers... 
HTLV-1 and adult T-cell leukemia: insights into viral transformation of cells 30 years after virus discoveryKuan Teh Jeang
National Institutes of Health, Bethesda, Maryland 20892, USA
J Formos Med Assoc 109:688-93. 2010..This review discusses recent insights into the role of the HTLV-1 Tax oncoprotein in cellular proliferation and the abrogation of cellular checkpoints that lead to disease progression...- Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signalingJunichiro Yasunaga
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Virol 85:6212-9. 2011..Our results point to USP20 as a key negative regulator of Tax-induced NF-κB signaling... - miRNAs in the biology of cancers and viral infectionsMan Lung Yeung
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
Curr Med Chem 14:191-7. 2007..Here, we will discuss examples of roles served by cellular miRNAs and virus-encoded miRNAs in the development of cancers and viral diseases... - RNAi therapy for HIV infection: principles and practicalitiesYamina Bennasser
Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
BioDrugs 21:17-22. 2007.... - Requirement for Sun1 in the expression of meiotic reproductive genes and piRNAYa Hui Chi
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Development 136:965-73. 2009..These findings raise a heretofore unrecognized role of Sun1 in the selective gene expression of coding and non-coding RNAs needed for gametogenesis... - Roles for microRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1Man Lung Yeung
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
Cancer Res 68:8976-85. 2008..Collectively, the findings implicate a miR-93/miR-130b-TP53INP1 axis that affects the proliferation and survival of HTLV-1-infected/transformed cells... - Requirements for protein phosphorylation and the kinase activity of polo-like kinase 1 (Plk1) for the kinetochore function of mitotic arrest deficiency protein 1 (Mad1)Ya Hui Chi
Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 283:35834-44. 2008..Collectively, these findings indicate mechanistic roles contributed by protein phosphorylation and Plk1 to the SAC activity of Mad1... - Human cellular restriction factors that target HIV-1 replicationKlaus Strebel
Laboratory of Molecular Microbiology, NIAID, The National Institutes of Health, Bethesda, Maryland, USA
BMC Med 7:48. 2009..We point to countermeasures encoded by HIV-1 for moderating the potency of these cellular restriction functions... - MicroRNAs and human retrovirusesLaurent Houzet
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Biochim Biophys Acta 1809:686-93. 2011..This article is part of a Special Issue entitled: MicroRNAs in viral gene regulation... - Human immunodeficiency virus type 1 replication and regulation of APOBEC3G by peptidyl prolyl isomerase Pin1Koichi Watashi
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 82:9928-36. 2008..Intriguingly, HIV-1 infection modulates the phosphorylation state of Pin1, enhancing its ability to moderate A3G activity. These new findings suggest a potential Vif-independent way for HIV-1 to moderate the cellular action of A3G... - Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activationHidekatsu Iha
Laboratory of Molecular Microbiology, Molecular Virology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
EMBO J 27:629-41. 2008..TAX1BP1-/- cells are more highly activated for NF-kappaB than control cells when stimulated with TNF-alpha or IL-1beta. Mechanistically, TAX1BP1 acts in NF-kappaB signalling as an essential adaptor between A20 and its targets... - A method to study the role of DDX3 RNA helicase in HIV-1Chia Yen Chen
Molecular Virology Section, Laboratory of Molecular, Microbiology, the NIAID, NIH, Bethesda, MD, USA
Methods Mol Biol 587:281-9. 2010..In this chapter, we briefly summarize the approach for assaying the RNA unwinding activity of RNA helicases measuring the effect of helicase inhibitors on HIV-1 replication... - Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interactionLea Cunningham
Oncogenesis and Development Section, National Institute of Allergy and Infectious Diseases, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 109:14592-7. 2012..Our data thus confirmed that RUNX1-CBFβ interaction can be targeted for leukemia treatment and we have identified a promising lead compound for this purpose... - Genome-wide screening using RNA interference to study host factors in viral replication and pathogenesisLaurent Houzet
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
Exp Biol Med (Maywood) 236:962-7. 2011..In this brief review, we focus on recent studies performed using genome-wide RNAi-based screens in mammalian cells for the identification of essential host factors for viral infection and pathogenesis... - Small non-coding RNAs, mammalian cells, and viruses: regulatory interactions?Man Lung Yeung
Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892 0460, USA
Retrovirology 4:74. 2007..Here, we comment on several lines of evidence that support this concept. We discuss how viruses may in turn protect, suppress, evade, modulate, or adapt to the host cell's ncRNA regulatory schema... - Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-beta (PKG1beta)Jia Hai Lee
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
Retrovirology 4:91. 2007..These findings provide evidence that cGMP and PKG serve to regulate HIV-1 infection in human cells... - Viral transformation and aneuploidyJunichiro Yasunaga
Molecular Virology Section, Laboratory of Molecular Microbiology, The National Institute of Allergy and Infectious Diseases NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
Environ Mol Mutagen 50:733-40. 2009..Here, we review in brief some of the mechanisms used by viruses that can cause cellular aneuploidy... - Ring expanded nucleoside analogues inhibit RNA helicase and intracellular human immunodeficiency virus type 1 replicationVenkat S R K Yedavalli
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Med Chem 51:5043-51. 2008..Neither compound at therapeutic doses was significantly toxic in ex vivo cell culture or in vivo in mice. Our findings provide proof-of-concept that a cellular factor, an RNA helicase, could be targeted for inhibiting HIV-1 replication... - If you organize, they will joinKuan Teh Jeang
The National Institutes of Health, Bethesda, MD, USA
Cell Biosci 1:2. 2011..ABSTRACT: This Editorial briefly introduces the Society of Chinese Bioscientists in America (SCBA) to readers of Cell & Bioscience... - The rise of Bioscience in the EastKuan Teh Jeang
The National Institutes of Health, Bethesda, MD, USA
Retrovirology 7:106. 2010..ABSTRACT: The rapid growth of bioscience in China is considered... - RNAi in the regulation of mammalian viral infectionsKuan Teh Jeang
The National Institutes of Health, Bethesda, MD 20892 0460, USA
BMC Biol 10:58. 2012..Here, I discuss the reasons for the dispute, and review the evidence that RNAi is a part of the physiological defense of mammalian cells against viral infections... - Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replicationDeyun Wang
Laboratory of Bioorganic Chemistry, NIDDK, NIH, DHHS, Bethesda, MD 20892, USA
Bioorg Med Chem Lett 19:6893-7. 2009..Antiviral studies are also consistent with the in vitro and cell-based assays. MBOs provide a framework for the development of future RNA-targeting molecules... - Human T cell leukemia virus type 1 (HTLV-1) and oncogene or oncomiR addiction?Kuan Teh Jeang
Kuan Teh Jeang, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland 20892, USA
Oncotarget 1:453-6. 2010..Here we discuss the possibility that early ATL cells are Tax-oncogene-addicted while late ATL cells are oncogenic microRNA (oncomiR) - addicted. The potential utility of interrupting oncomiR addiction as a cancer treatment is broached... - Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in miceYa Hui Chi
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Int J Cancer 124:1483-9. 2009..The findings here provide evidence for a cooperative role of Mad1/Mad2 and p53 genes in preventing tumor development... - A proteomic study of TAR-RNA binding protein (TRBP)-associated factorsYa Hui Chi
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Cell Biosci 1:9. 2011..abstract:.. - Replication competent HIV-1 viruses that express intragenomic microRNA reveal discrete RNA-interference mechanisms that affect viral replicationZachary Klase
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda MD, 20892, USA
Cell Biosci 1:38. 2011..abstract:.. - siRNA, miRNA and HIV: promises and challengesMan Lung Yeung
National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892-0460, USA
Cell Res 15:935-46. 2005..In this review, we discuss stratagems used by various viruses to avoid the cells' antiviral si/mi-RNA defenses and notions of how viruses might control and regulate host cell genes by encoding viral miRNAs (vmiRNAs)... - The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplicationYick Pang Ching
Department of Biochemistry, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
Nat Cell Biol 8:717-24. 2006..Our findings suggest that the HTLV-I Tax oncoprotein targets TAX1BP2 causing genomic instability and aneuploidy... - Modulation of nuclear factor-kappaB by human T cell leukemia virus type 1 Tax protein: implications for oncogenesis and inflammationJean-Marie Peloponese
Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892-0460, USA
Immunol Res 34:1-12. 2006..Here, we review current thinking on how Tax may affect both diseases through activation of NF-kappaB signaling... - Insights into cellular microRNAs and human immunodeficiency virus type 1 (HIV-1)Ajit Kumar
Department of Biochemistry and Molecular Biology, George Washington University School of Medicine, Washington, District of Columbia, USA
J Cell Physiol 216:327-31. 2008..Several cellular miRNAs potentially act to restrict HIV-1 replication, and the virus has countermeasures to evade such restriction... - Role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoproteinJean-Marie Peloponese
Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892-0460, USA
J Biol Chem 281:8927-38. 2006..Tax is shown to activate activator protein-1 through the phosphatidylinositol 3-kinase/Akt pathway... - Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replicationSeongwoo Hwang
Chemical Biology Program, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605-2324, USA
J Biol Chem 278:39092-103. 2003..Our results also suggest a general strategy for discovering pharmacophores targeting RNA structures that are essential in progression of other infectious, inflammatory, and genetic diseases... - Human T-cell leukemia virus oncoprotein tax represses nuclear receptor-dependent transcription by targeting coactivator TAX1BP1King Tung Chin
Department of Biochemistry, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
Cancer Res 67:1072-81. 2007..We propose that Tax-TAX1BP1 interaction mechanistically explains the previously reported repression of nuclear receptor activity by Tax... - MicroRNAs in human immunodeficiency virus-1 infectionYamina Bennasser
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institue of Health, Bethesda, MD, USA
Methods Mol Biol 342:241-53. 2006..Finally, we use a scanning algorithm to search 3' untranslated regions (UTRs) of human messenger RNAs (mRNAs) in the attempt to predict potential sites targeted by HIV-1 miRNAs... - Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cellsMarianne Löhr
The Wolfson Institute for Biomedical Research, University College London, The Cruciform Building, Gower Street, London WC1E 6BT, UK
Biochem Biophys Res Commun 300:609-13. 2003..Here, we report a sequence-specific contribution of Tat residues 31-35 to anti-HIV-1 activity... - Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencingYamina Bennasser
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 22:607-19. 2005..Tat abrogates the cell's RNA-silencing defense by subverting the ability of Dicer to process precursor double-stranded RNAs into siRNAs... - Differential requirements for activation of integrated and transiently transfected human T-cell leukemia virus type 1 long terminal repeatMasahiko Okada
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892-0460, USA
J Virol 76:12564-73. 2002..Our findings point to additional complexities in the regulated expression of HTLV-1 proviruses compared with those hitherto revealed through transfection studies... - TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeatsYeung Tung Siu
Department of Biochemistry, The University of Hong Kong, 3 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong
J Virol 80:7052-9. 2006..In addition, coactivators in the p300 family are required for full activity of Tax independently of TORC1/2/3. Thus, both TORC and p300 families of coactivators are essential for optimal activation of HTLV-1 transcription by Tax... - HIV-1 TAR RNA subverts RNA interference in transfected cells through sequestration of TAR RNA-binding protein, TRBPYamina Bennasser
Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892-0460, USA
J Biol Chem 281:27674-8. 2006..Our data suggest that TAR RNA sequesters TRBP rendering it unavailable for downstream Dicer-RISC complexes. TAR-induced inhibition of Dicer-RISC activity in transfected cells was partially relieved by exogenous expression of TRBP... - A macrophage-tropic HIV-1 that expresses green fluorescent protein and infects alveolar and blood monocyte-derived macrophagesElizabeth A Rich
Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
J Biomed Sci 9:721-6. 2002..NLAD8-EGFP-infected macrophages can be easily and sensitively detected based on the visualization of intracellular green fluorescent protein... - Damaged DNA and miscounted chromosomes: human T cell leukemia virus type I tax oncoprotein and genetic lesions in transformed cellsSusan J Marriott
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
J Biomed Sci 9:292-8. 2002..The consequences of these effects as well as the evolutionary advantage this may provide to HTLV-I are discussed... - Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma proteinKerstin Haller
Institut fur Klinische und Molekulare Virologie, D 91054 Erlangen, Germany
Mol Cell Biol 22:3327-38. 2002..Thus, protein-protein contact between Tax and the components of the cyclin D/CDK complexes provides a further mechanistic explanation for the mitogenic and immortalizing effects of this HTLV-1 oncoprotein... - Suppression of microRNA-silencing pathway by HIV-1 during virus replicationRobinson Triboulet
Laboratoire de Virologie Moleculaire, Institut de Genetique Humaine, Montpellier, France
Science 315:1579-82. 2007..Our results highlight the involvement of the miRNA-silencing pathway in HIV-1 replication and latency... - Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformationMasao Matsuoka
Laboratory of Virus Immunology, Institute for Virus Research, Kyoto University, Japan
Nat Rev Cancer 7:270-80. 2007..We also explore the contribution of a newly discovered protein and RNA on the HTLV-1 minus strand, HTLV-1 basic leucine zipper factor (HBZ), to the maintenance of virus-induced leukaemia... - Remembering Ralph Grassmann (1957-2008)Klemens Pichler
Retrovirology 5:71. 2008 - An alternative splice product of IkappaB kinase (IKKgamma), IKKgamma-delta, differentially mediates cytokine and human T-cell leukemia virus type 1 tax-induced NF-kappaB activationTao Hai
Department of Internal Medicine, The University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555 1060, USA
J Virol 80:4227-41. 2006..Differing levels of IKKgamma-delta expression, therefore, may affect signal transduction cascades coupling to IKK... - Meeting report on the 13th International Conference on Human Retrovirology: human T-cell leukemia virus research 30 years after adult T-cell leukemiaMasao Matsuoka
Institute for Virus Research, Kyoto University, Kyoto, Japan
Cancer Res 67:10638-41. 2007 - Molecular mechanisms of cellular transformation by HTLV-1 TaxRalph Grassmann
Institut fur Klinische und Molekulare Virologie, Universitat Erlangen Nurnberg, Schlossgarten 4, Germany
Oncogene 24:5976-85. 2005..g. p53, DLG). Moreover, Tax silences cellular checkpoints, which guard against DNA structural damage and chromosomal missegregation, thereby favoring the manifestation of a mutator phenotype in cells... - Viral and cellular RNA helicases as antiviral targetsAnn D Kwong
Vertex Pharmaceuticals Inc, 130 Waverly Street, Cambridge, Massachusetts 02139, USA
Nat Rev Drug Discov 4:845-53. 2005.... - Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleusIzzet Enunlu
Institute of Biochemistry, Szeged, Hungary
Biochem Biophys Res Commun 309:44-51. 2003.... - Transcriptional and post-transcriptional regulation of HIV-1 gene expression: role of cellular factors for Tat and RevSergei Nekhai
Center for Sickle Cell Disease and Department of Biochemistry and Molecular Biolology, Howard University, NW Washington, DC 20059, USA
Future Microbiol 1:417-26. 2006..Rev primarily functions to export unspliced and partially spliced viral RNAs from the nucleus into the cytoplasm. For this activity, Rev cooperates with cellular transport protein CRM1 and RNA helicases DDX1 and DDX3, amongst others... - Replication of human immunodeficiency virus type 1 from entry to exitAndrew M L Lever
University of Cambridge Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
Int J Hematol 84:23-30. 2006..Here, we review in a nonexhaustive manner our current knowledge of the replication of HIV-1 inside human cells from entry to exit of the virus...