D Jankovic

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 164:3047-55. 2000
  2. pmc The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)
    Svenja Steinfelder
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 206:1681-90. 2009
  3. pmc CD4+ T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection
    David G Kugler
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases 2 Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute and 3 The Johns Hopkins University National Institutes of Health Graduate Partnership Program National Institutes of Health, Bethesda, MD 20892
    J Exp Med 210:1919-27. 2013
  4. pmc Age-related accumulation of T cells with markers of relatively stronger autoreactivity leads to functional erosion of T cells
    Zohreh Tatari-Calderone
    Center for Cancer and Immunology Research, Children s Research Institute, Washington, DC, USA
    BMC Immunol 13:8. 2012
  5. doi request reprint IL-10 production by CD4+ effector T cells: a mechanism for self-regulation
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Mucosal Immunol 3:239-46. 2010
  6. ncbi request reprint In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting
    Dragana Jankovic
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 16:429-39. 2002
  7. ncbi request reprint Parasite-induced Th2 polarization is associated with down-regulated dendritic cell responsiveness to Th1 stimuli and a transient delay in T lymphocyte cycling
    Dragana Jankovic
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 173:2419-27. 2004
  8. ncbi request reprint Th1/Th2 effector choice in parasitic infection: decision making by committee
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    Curr Opin Immunol 13:403-9. 2001
  9. pmc Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection
    Dragana Jankovic
    Immunobiology Section and 2Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:273-83. 2007
  10. ncbi request reprint Mechanisms underlying helminth- induced Th2 polarization: default, negative or positive pathways?
    Dragana Jankovic
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8003, USA
    Chem Immunol Allergy 90:65-81. 2006

Detail Information

Publications46

  1. ncbi request reprint Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 164:3047-55. 2000
    ....
  2. pmc The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)
    Svenja Steinfelder
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 206:1681-90. 2009
    ..Based on this evidence, we hypothesize that S. mansoni omega-1 acts by limiting the interaction of DCs with CD4(+) T lymphocytes, thereby lowering the strength of the activation signal delivered...
  3. pmc CD4+ T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection
    David G Kugler
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases 2 Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute and 3 The Johns Hopkins University National Institutes of Health Graduate Partnership Program National Institutes of Health, Bethesda, MD 20892
    J Exp Med 210:1919-27. 2013
    ..In the case of T. gondii infection, this self-regulatory pathway is critical for preventing collateral tissue damage and promoting host survival. ..
  4. pmc Age-related accumulation of T cells with markers of relatively stronger autoreactivity leads to functional erosion of T cells
    Zohreh Tatari-Calderone
    Center for Cancer and Immunology Research, Children s Research Institute, Washington, DC, USA
    BMC Immunol 13:8. 2012
    ....
  5. doi request reprint IL-10 production by CD4+ effector T cells: a mechanism for self-regulation
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Mucosal Immunol 3:239-46. 2010
    ..In the following review, we will discuss these findings that support the general concept that production of IL-10 is an important self-regulatory function of CD4(+) T lymphocytes...
  6. ncbi request reprint In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting
    Dragana Jankovic
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 16:429-39. 2002
    ....
  7. ncbi request reprint Parasite-induced Th2 polarization is associated with down-regulated dendritic cell responsiveness to Th1 stimuli and a transient delay in T lymphocyte cycling
    Dragana Jankovic
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 173:2419-27. 2004
    ..Together, these findings suggest that the emergence of IL-4-producing CD4(+) lymphocytes results from a suppression in DC function leading to a temporary delay in initial T cell cycling...
  8. ncbi request reprint Th1/Th2 effector choice in parasitic infection: decision making by committee
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    Curr Opin Immunol 13:403-9. 2001
    ....
  9. pmc Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection
    Dragana Jankovic
    Immunobiology Section and 2Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:273-83. 2007
    ..These findings indicate that IL-10 production by CD4(+) T lymphocytes need not involve a distinct regulatory Th cell subset but can be generated in Th1 cells as part of the effector response to intracellular pathogens...
  10. ncbi request reprint Mechanisms underlying helminth- induced Th2 polarization: default, negative or positive pathways?
    Dragana Jankovic
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8003, USA
    Chem Immunol Allergy 90:65-81. 2006
    ..negative vs. the absence of signals from antigen-presenting cells. In addition, we will discuss the similarities between the pathways involved in parasite- and allergen-induced Th2 differentiation...
  11. pmc Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism
    M C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
    Infect Immun 66:5157-66. 1998
    ....
  12. ncbi request reprint IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite
    T A Wynn
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 157:4068-78. 1996
    ..Together, these data demonstrate that IL-12, initially described as an adjuvant for cell-mediated immunity, may be used to simultaneously to promote both humoral and cell-mediated protective responses against infection...
  13. ncbi request reprint Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 163:337-42. 1999
    ..Taken together, these findings argue that tissue pathology in schistosomiasis requires, in addition to egg-specific CD4+ lymphocytes, a previously unrecognized IL-4Ralpha+ non-T cell effector population...
  14. ncbi request reprint Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-gamma-dependent effector mechanisms
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0425, USA
    J Immunol 162:345-51. 1999
    ....
  15. pmc Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice: cytokine requirements for the induction and maintenance of intestinal inflammation
    M C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0425, USA
    Infect Immun 69:4232-41. 2001
    ..Taken together, our results demonstrate a crucial role for IL-12 in both inducing and sustaining intestinal inflammation through recruitment and maintenance of a pool of pathogenic Th1 cells...
  16. pmc CD4+ T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signaling
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 187:619-29. 1998
    ..Together, the data demonstrate that humoral immune response/FcR interactions can play a major role in negatively controlling inflammatory disease induced by CD4+ T cells...
  17. pmc In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas
    C Reis e Sousa
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1892, USA
    J Exp Med 186:1819-29. 1997
    ..This model avoids the need to invoke a three-cell interaction for Th1 differentiation and points to the DC as both a sentinel for innate recognition and the dictator of class selection in the subsequent adaptive response...
  18. ncbi request reprint Role of cytokines in the formation and downregulation of hepatic circumoval granulomas and hepatic fibrosis in Schistosoma mansoni-infected mice
    A W Cheever
    Immunobiology Section, NIAID, NIH, Bethesda, MD 20892 0425, USA
    Mem Inst Oswaldo Cruz 93:25-32. 1998
    ..It is evident that the participation of cytokines in granuloma formation and regulation is complicated and that the mechanisms controlling both these phenomena are likely to involve both T cells and antibody/FcR interactions...
  19. pmc NOS-2 mediates the protective anti-inflammatory and antifibrotic effects of the Th1-inducing adjuvant, IL-12, in a Th2 model of granulomatous disease
    M Hesse
    Schistosomiasis Immunology and Pathology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Pathol 157:945-55. 2000
    ....
  20. ncbi request reprint Mice infected with Schistosoma mansoni develop a novel non-T-lymphocyte suppressor population which inhibits virus-specific CTL induction via a soluble factor
    M A Marshall
    Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, Building 10, Room 6B-12, NIH, Bethesda, MD 20892, USA
    Microbes Infect 3:1051-61. 2001
    ..mansoni-infected mice that provide a major source of IL-4 in these animals. Similar cells in schistosome-infected humans could affect susceptibility to other infections or responsiveness to vaccines...
  21. pmc T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells
    A A Lighvani
    Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:15137-42. 2001
    ..These findings substantially alter the current view of T-bet in IFN-gamma regulation and promotion of cell-mediated immune responses...
  22. pmc Unimpaired down-modulation of the hepatic granulomatous response in CD8 T-cell- and gamma interferon-deficient mice chronically infected with Schistosoma mansoni
    G Yap
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20982, USA
    Infect Immun 65:2583-6. 1997
    ..Thus, other mechanisms may be more important in the regulation of immunopathology in schistosomiasis...
  23. ncbi request reprint Th1- and Th2-cell commitment during infectious disease: asymmetry in divergent pathways
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Rm 126, 4 Center Drive MSC 0425, Bethesda, MD 20892, USA
    Trends Immunol 22:450-7. 2001
    ..A model is proposed that links together the pathogen, the innate response and Th-cell polarization...
  24. ncbi request reprint Differential roles for IL-12 in the maintenance of immune responses in infectious versus autoimmune disease
    R A Seder
    Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 157:2745-8. 1996
    ..Herein, we discuss the idea that memory responses for certain infections may be IL-12 independent, whereas memory responses for specific autoimmune diseases still require IL-12 to maintain a pathogenic response...
  25. ncbi request reprint Gadd45alpha regulates p38-dependent dendritic cell cytokine production and Th1 differentiation
    Ludmila Jirmanova
    Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 178:4153-8. 2007
    ..Therefore, Gadd45alpha has tissue-specific and opposing functions on p38 activity, and Gadd45alpha-regulated p38 activation in DCs is a critical event in Th1 polarization in vivo...
  26. pmc Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch
    Derk Amsen
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 27:89-99. 2007
    ..Moreover, absence of GATA-3 turned Notch from a Th2 inducer into a powerful inducer of Th1 differentiation. Therefore, Gata3 is a critical element determining inductive Th2 differentiation and limiting Th1 differentiation by Notch...
  27. pmc TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma production
    Romina S Goldszmid
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 204:2591-602. 2007
    ....
  28. ncbi request reprint IL-10 or not IL-10: that is the question
    Dragana Jankovic
    Nat Immunol 8:1281-3. 2007
  29. pmc The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases
    Francoise Meylan
    Immunoregulation Unit, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892
    Immunity 29:79-89. 2008
    ..DR3 could be an attractive therapeutic target for T cell-mediated autoimmune and allergic diseases...
  30. pmc The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death
    Carl G Feng
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:1279-87. 2008
    ..Our studies identify a feedback mechanism in the T helper type 1 response that limits the detrimental effects of IFN-gamma on effector T lymphocyte survival while promoting the antimicrobial functions of IFN-gamma...
  31. pmc Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:18214-9. 2006
    ..Reduced Th2 cell expansion in the absence of Gfi-1 was confirmed by the diminished frequency of IL-4-producing cells when these mice were infected with Schistosoma mansoni...
  32. pmc IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
    Marika C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:2485-94. 2006
    ....
  33. pmc SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:1551-65. 2006
    ..Thus, SAP affects expression of key molecules required for T-B cell collaboration by mechanisms that are distinct from its role in cytokine regulation...
  34. ncbi request reprint Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells
    Charles A Scanga
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:5997-6001. 2002
    ..Taken together, these data suggest that the induction of IL-12 by T. gondii depends on a unique mechanism involving both MyD88 and G protein-coupled signaling pathways...
  35. pmc Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis
    Marika C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIH, Building 50, Room 6146, 50 South Drive, Bethesda, MD 20892, USA
    J Exp Med 196:505-15. 2002
    ..The induction of such cells in response to gut flora may be a mechanism protecting normal individuals against inflammatory bowel disease...
  36. pmc Transgenic mice expressing human interleukin-10 in the antigen-presenting cell compartment show increased susceptibility to infection with Mycobacterium avium associated with decreased macrophage effector function and apoptosis
    Carl G Feng
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Infect Immun 70:6672-9. 2002
    ..Together, these data indicate that APC-derived IL-10 can exert a major inhibitory effect on control of mycobacterial infection by a mechanism involving the suppression of macrophage effector function and apoptosis...
  37. ncbi request reprint Induction and regulation of IL-12-dependent host resistance to Toxoplasma gondii
    Alan Sher
    National Institutes of Health, Bethesda, MD 20892 8003, USA
    Immunol Res 27:521-8. 2003
    ..In addition, we present an overview of our studies investigating the mechanisms by which the IFN-gamma produced as a consequence of IL-12 stimulation controls intracellular replication of the parasite in host cells...
  38. pmc Vaccination with novel immunostimulatory adjuvants against blood-stage malaria in mice
    Zhong Su
    Centre for the Study of Host Resistance, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada
    Infect Immun 71:5178-87. 2003
    ..chabaudi AS. These results illustrate that it is possible to enhance the potency of a crude malaria antigen preparation delivered in alum by inclusion of immunostimulatory molecules, such as IL-12 or CpG-ODN...
  39. pmc Improved immunogenicity and efficacy of the recombinant 19-kilodalton merozoite surface protein 1 by the addition of oligodeoxynucleotide and aluminum hydroxide gel in a murine malaria vaccine model
    Karen A Near
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
    Infect Immun 70:692-701. 2002
    ..Interleukin-10 (IL-10) levels were also elevated; however, no IL-5 was detected. The cytokine profile, as well as the predominant IgG1 antibody isotype, suggests the protective immune response was a mixed Th1/Th2 response...
  40. pmc Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope
    Marika C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:15830-5. 2003
    ....
  41. ncbi request reprint Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia
    Carl G Feng
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 6148, Building 50, 50 South Drive, Bethesda, MD 20892, USA
    J Immunol 172:1163-8. 2004
    ..These findings establish a role for LRG-47 in host control of mycobacteria and demonstrate that in the context of the IFN-gamma response to persistent infection, LRG-47 can have downstream regulatory effects on lymphocyte survival...
  42. pmc Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite
    Booki Min
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr, Bldg 10, Bethesda, MD 20892, USA
    J Exp Med 200:507-17. 2004
    ..Thus, infection with a parasite that induces a "Th2-type response" resulted in accumulation of tissue basophils, and these cells, stimulated by a non-FcR cross-linking mechanism, are a principal source of in vivo IL-4 production...
  43. ncbi request reprint Turning it on and off: regulation of dendritic cell function in Toxoplasma gondii infection
    Julio Aliberti
    Department of Immunology, Duke University School of Medicine, Durham, NC, USA
    Immunol Rev 201:26-34. 2004
    ..In addition, we discuss recent findings concerning the pathways responsible for endogenous regulation of DC IL-12 production during T. gondii infection...
  44. ncbi request reprint Maintenance of pulmonary Th1 effector function in chronic tuberculosis requires persistent IL-12 production
    Carl G Feng
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8003, USA
    J Immunol 174:4185-92. 2005
    ..tuberculosis infection and suggest that breakdown of this mechanism could be a contributing factor in reactivated disease...
  45. pmc Direct selection and phage display of a Gram-positive secretome
    Dragana Jankovic
    Institute of Molecular Biosciences, Massey University, Palmerston North, New Zealand
    Genome Biol 8:R266. 2007
    ..We have now developed and applied a phage display system for direct selection, identification, expression and purification of bacterial secretome proteins...
  46. ncbi request reprint Leukemogenic mechanisms and targets of a NUP98/HHEX fusion in acute myeloid leukemia
    Dragana Jankovic
    Department of Research, University Hospital Basel, Basel, Switzerland
    Blood 111:5672-82. 2008
    ..Some of these genes (Hoxa5, Hoxa9, Flt3) are deregulated in NUP98/HHEX-induced murine leukemia as well as in human blasts carrying this fusion and might represent bona fide therapeutic targets...