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Genomes and Genes | D JankovicSummaryAffiliation: National Institutes of Health Country: USA Publications
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Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profileD Jankovic
Immunobiology Section, Laboratory of Parasitic Diseases, and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 164:3047-55. 2000....
Age-related accumulation of T cells with markers of relatively stronger autoreactivity leads to functional erosion of T cellsZohreh Tatari-Calderone
Center for Cancer and Immunology Research, Children s Research Institute, Washington, DC, USA
BMC Immunol 13:8. 2012....- In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) settingDragana Jankovic
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 16:429-39. 2002.... - Parasite-induced Th2 polarization is associated with down-regulated dendritic cell responsiveness to Th1 stimuli and a transient delay in T lymphocyte cyclingDragana Jankovic
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 173:2419-27. 2004..Together, these findings suggest that the emergence of IL-4-producing CD4(+) lymphocytes results from a suppression in DC function leading to a temporary delay in initial T cell cycling... 
IL-10 production by CD4+ effector T cells: a mechanism for self-regulationD Jankovic
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Mucosal Immunol 3:239-46. 2010..In the following review, we will discuss these findings that support the general concept that production of IL-10 is an important self-regulatory function of CD4(+) T lymphocytes...- Th1/Th2 effector choice in parasitic infection: decision making by committeeD Jankovic
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
Curr Opin Immunol 13:403-9. 2001.... - Mechanisms underlying helminth- induced Th2 polarization: default, negative or positive pathways?Dragana Jankovic
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8003, USA
Chem Immunol Allergy 90:65-81. 2006..negative vs. the absence of signals from antigen-presenting cells. In addition, we will discuss the similarities between the pathways involved in parasite- and allergen-induced Th2 differentiation... 
Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infectionDragana Jankovic
Immunobiology Section and 2Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 204:273-83. 2007..These findings indicate that IL-10 production by CD4(+) T lymphocytes need not involve a distinct regulatory Th cell subset but can be generated in Th1 cells as part of the effector response to intracellular pathogens...- Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanismM C Kullberg
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
Infect Immun 66:5157-66. 1998.... - IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasiteT A Wynn
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 157:4068-78. 1996..Together, these data demonstrate that IL-12, initially described as an adjuvant for cell-mediated immunity, may be used to simultaneously to promote both humoral and cell-mediated protective responses against infection... - Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-gamma-dependent effector mechanismsD Jankovic
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0425, USA
J Immunol 162:345-51. 1999.... - Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice: cytokine requirements for the induction and maintenance of intestinal inflammationM C Kullberg
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0425, USA
Infect Immun 69:4232-41. 2001..Taken together, our results demonstrate a crucial role for IL-12 in both inducing and sustaining intestinal inflammation through recruitment and maintenance of a pool of pathogenic Th1 cells... - Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profileD Jankovic
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
J Immunol 163:337-42. 1999..Taken together, these findings argue that tissue pathology in schistosomiasis requires, in addition to egg-specific CD4+ lymphocytes, a previously unrecognized IL-4Ralpha+ non-T cell effector population... - CD4+ T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signalingD Jankovic
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Exp Med 187:619-29. 1998..Together, the data demonstrate that humoral immune response/FcR interactions can play a major role in negatively controlling inflammatory disease induced by CD4+ T cells... - In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areasC Reis e Sousa
Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1892, USA
J Exp Med 186:1819-29. 1997..This model avoids the need to invoke a three-cell interaction for Th1 differentiation and points to the DC as both a sentinel for innate recognition and the dictator of class selection in the subsequent adaptive response... - Role of cytokines in the formation and downregulation of hepatic circumoval granulomas and hepatic fibrosis in Schistosoma mansoni-infected miceA W Cheever
Immunobiology Section, NIAID, NIH, Bethesda, MD 20892 0425, USA
Mem Inst Oswaldo Cruz 93:25-32. 1998..It is evident that the participation of cytokines in granuloma formation and regulation is complicated and that the mechanisms controlling both these phenomena are likely to involve both T cells and antibody/FcR interactions... - NOS-2 mediates the protective anti-inflammatory and antifibrotic effects of the Th1-inducing adjuvant, IL-12, in a Th2 model of granulomatous diseaseM Hesse
Schistosomiasis Immunology and Pathology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Am J Pathol 157:945-55. 2000.... - Mice infected with Schistosoma mansoni develop a novel non-T-lymphocyte suppressor population which inhibits virus-specific CTL induction via a soluble factorM A Marshall
Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, Building 10, Room 6B-12, NIH, Bethesda, MD 20892, USA
Microbes Infect 3:1051-61. 2001..mansoni-infected mice that provide a major source of IL-4 in these animals. Similar cells in schistosome-infected humans could affect susceptibility to other infections or responsiveness to vaccines... - Unimpaired down-modulation of the hepatic granulomatous response in CD8 T-cell- and gamma interferon-deficient mice chronically infected with Schistosoma mansoniG Yap
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20982, USA
Infect Immun 65:2583-6. 1997..Thus, other mechanisms may be more important in the regulation of immunopathology in schistosomiasis... - T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cellsA A Lighvani
Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 98:15137-42. 2001..These findings substantially alter the current view of T-bet in IFN-gamma regulation and promotion of cell-mediated immune responses... - Th1- and Th2-cell commitment during infectious disease: asymmetry in divergent pathwaysD Jankovic
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Rm 126, 4 Center Drive MSC 0425, Bethesda, MD 20892, USA
Trends Immunol 22:450-7. 2001..A model is proposed that links together the pathogen, the innate response and Th-cell polarization... - Differential roles for IL-12 in the maintenance of immune responses in infectious versus autoimmune diseaseR A Seder
Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 157:2745-8. 1996..Herein, we discuss the idea that memory responses for certain infections may be IL-12 independent, whereas memory responses for specific autoimmune diseases still require IL-12 to maintain a pathogenic response... - Improved immunogenicity and efficacy of the recombinant 19-kilodalton merozoite surface protein 1 by the addition of oligodeoxynucleotide and aluminum hydroxide gel in a murine malaria vaccine modelKaren A Near
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
Infect Immun 70:692-701. 2002..Interleukin-10 (IL-10) levels were also elevated; however, no IL-5 was detected. The cytokine profile, as well as the predominant IgG1 antibody isotype, suggests the protective immune response was a mixed Th1/Th2 response... - Gadd45alpha regulates p38-dependent dendritic cell cytokine production and Th1 differentiationLudmila Jirmanova
Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 178:4153-8. 2007..Therefore, Gadd45alpha has tissue-specific and opposing functions on p38 activity, and Gadd45alpha-regulated p38 activation in DCs is a critical event in Th1 polarization in vivo... - Direct regulation of Gata3 expression determines the T helper differentiation potential of NotchDerk Amsen
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
Immunity 27:89-99. 2007..Moreover, absence of GATA-3 turned Notch from a Th2 inducer into a powerful inducer of Th1 differentiation. Therefore, Gata3 is a critical element determining inductive Th2 differentiation and limiting Th1 differentiation by Notch... - TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma productionRomina S Goldszmid
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
J Exp Med 204:2591-602. 2007.... - IL-10 or not IL-10: that is the questionDragana Jankovic
Nat Immunol 8:1281-3. 2007 - Vaccination with novel immunostimulatory adjuvants against blood-stage malaria in miceZhong Su
Centre for the Study of Host Resistance, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada
Infect Immun 71:5178-87. 2003..chabaudi AS. These results illustrate that it is possible to enhance the potency of a crude malaria antigen preparation delivered in alum by inclusion of immunostimulatory molecules, such as IL-12 or CpG-ODN... - The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseasesFrancoise Meylan
Immunoregulation Unit, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892
Immunity 29:79-89. 2008..DR3 could be an attractive therapeutic target for T cell-mediated autoimmune and allergic diseases... - The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell deathCarl G Feng
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Immunol 9:1279-87. 2008..Our studies identify a feedback mechanism in the T helper type 1 response that limits the detrimental effects of IFN-gamma on effector T lymphocyte survival while promoting the antimicrobial functions of IFN-gamma... - Gfi-1 plays an important role in IL-2-mediated Th2 cell expansionJinfang Zhu
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 103:18214-9. 2006..Reduced Th2 cell expansion in the absence of Gfi-1 was confirmed by the diminished frequency of IL-4-producing cells when these mice were infected with Schistosoma mansoni... - IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitisMarika C Kullberg
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 203:2485-94. 2006.... - SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulationJennifer L Cannons
National Human Genome Research Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
J Exp Med 203:1551-65. 2006..Thus, SAP affects expression of key molecules required for T-B cell collaboration by mechanisms that are distinct from its role in cytokine regulation... - Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cellsCharles A Scanga
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 168:5997-6001. 2002..Taken together, these data suggest that the induction of IL-12 by T. gondii depends on a unique mechanism involving both MyD88 and G protein-coupled signaling pathways... - Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitisMarika C Kullberg
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIH, Building 50, Room 6146, 50 South Drive, Bethesda, MD 20892, USA
J Exp Med 196:505-15. 2002..The induction of such cells in response to gut flora may be a mechanism protecting normal individuals against inflammatory bowel disease... - Transgenic mice expressing human interleukin-10 in the antigen-presenting cell compartment show increased susceptibility to infection with Mycobacterium avium associated with decreased macrophage effector function and apoptosisCarl G Feng
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Infect Immun 70:6672-9. 2002..Together, these data indicate that APC-derived IL-10 can exert a major inhibitory effect on control of mycobacterial infection by a mechanism involving the suppression of macrophage effector function and apoptosis... - Induction and regulation of IL-12-dependent host resistance to Toxoplasma gondiiAlan Sher
National Institutes of Health, Bethesda, MD 20892 8003, USA
Immunol Res 27:521-8. 2003..In addition, we present an overview of our studies investigating the mechanisms by which the IFN-gamma produced as a consequence of IL-12 stimulation controls intracellular replication of the parasite in host cells... - Induction of colitis by a CD4+ T cell clone specific for a bacterial epitopeMarika C Kullberg
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 100:15830-5. 2003.... - Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopeniaCarl G Feng
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 6148, Building 50, 50 South Drive, Bethesda, MD 20892, USA
J Immunol 172:1163-8. 2004..These findings establish a role for LRG-47 in host control of mycobacteria and demonstrate that in the context of the IFN-gamma response to persistent infection, LRG-47 can have downstream regulatory effects on lymphocyte survival... - Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasiteBooki Min
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr, Bldg. 10, Bethesda, MD 20892, USA
J Exp Med 200:507-17. 2004.... - Turning it on and off: regulation of dendritic cell function in Toxoplasma gondii infectionJulio Aliberti
Department of Immunology, Duke University School of Medicine, Durham, NC, USA
Immunol Rev 201:26-34. 2004..In addition, we discuss recent findings concerning the pathways responsible for endogenous regulation of DC IL-12 production during T. gondii infection... - Maintenance of pulmonary Th1 effector function in chronic tuberculosis requires persistent IL-12 productionCarl G Feng
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8003, USA
J Immunol 174:4185-92. 2005..tuberculosis infection and suggest that breakdown of this mechanism could be a contributing factor in reactivated disease... - Leukemogenic mechanisms and targets of a NUP98/HHEX fusion in acute myeloid leukemiaDragana Jankovic
Department of Research, University Hospital Basel, Basel, Switzerland
Blood 111:5672-82. 2008..Some of these genes (Hoxa5, Hoxa9, Flt3) are deregulated in NUP98/HHEX-induced murine leukemia as well as in human blasts carrying this fusion and might represent bona fide therapeutic targets... - Direct selection and phage display of a Gram-positive secretomeDragana Jankovic
Institute of Molecular Biosciences, Massey University, Palmerston North, New Zealand
Genome Biol 8:R266. 2007..We have now developed and applied a phage display system for direct selection, identification, expression and purification of bacterial secretome proteins...