Hyunbum Jang

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Multiple pathways in conformational transitions of the alanine dipeptide: an application of dynamic importance sampling
    Hyunbum Jang
    Department of Physiology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Comput Chem 27:1136-41. 2006
  2. pmc Models of toxic beta-sheet channels of protegrin-1 suggest a common subunit organization motif shared with toxic alzheimer beta-amyloid ion channels
    Hyunbum Jang
    Center for Cancer Research Nanobiology Program, NCI Frederick, SAIC Frederick, Frederick, Maryland, USA
    Biophys J 95:4631-42. 2008
  3. pmc Conformational study of the protegrin-1 (PG-1) dimer interaction with lipid bilayers and its effect
    Hyunbum Jang
    Center for Cancer Research Nanobiology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
    BMC Struct Biol 7:21. 2007
  4. pmc Antimicrobial protegrin-1 forms amyloid-like fibrils with rapid kinetics suggesting a functional link
    Hyunbum Jang
    Center for Cancer Research Nanobiology Program, National Cancer Institute Frederick, SAIC Frederick, Frederick, Maryland, USA
    Biophys J 100:1775-83. 2011
  5. pmc Structural convergence among diverse, toxic beta-sheet ion channels
    Hyunbum Jang
    Center for Cancer Research Nanobiology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
    J Phys Chem B 114:9445-51. 2010
  6. pmc Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome
    Hyunbum Jang
    Center for Cancer Research Nanobiology Program, SAIC Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 107:6538-43. 2010
  7. pmc Modeling the Alzheimer Abeta17-42 fibril architecture: tight intermolecular sheet-sheet association and intramolecular hydrated cavities
    Jie Zheng
    Basic Research Program, SAIC Frederick Center for Cancer Research, Nanobiology Program, NCI Frederick, Frederick, Maryland 21702, USA
    Biophys J 93:3046-57. 2007
  8. doi request reprint β-Barrel topology of Alzheimer's β-amyloid ion channels
    Hyunbum Jang
    Center for Cancer Research Nanobiology Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Mol Biol 404:917-34. 2010
  9. pmc Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels
    Hyunbum Jang
    Center for Cancer Research Nanobiology Program, NCI Frederick, SAIC Frederick, Frederick, Maryland, USA
    Biophys J 97:3029-37. 2009
  10. pmc Interaction of protegrin-1 with lipid bilayers: membrane thinning effect
    Hyunbum Jang
    Center for Cancer Research Nanobiology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
    Biophys J 91:2848-59. 2006

Detail Information

Publications23

  1. ncbi request reprint Multiple pathways in conformational transitions of the alanine dipeptide: an application of dynamic importance sampling
    Hyunbum Jang
    Department of Physiology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Comput Chem 27:1136-41. 2006
    ..The DIMS method represents an important step towards finding multiple transition pathways within complex biomolecular systems...
  2. pmc Models of toxic beta-sheet channels of protegrin-1 suggest a common subunit organization motif shared with toxic alzheimer beta-amyloid ion channels
    Hyunbum Jang
    Center for Cancer Research Nanobiology Program, NCI Frederick, SAIC Frederick, Frederick, Maryland, USA
    Biophys J 95:4631-42. 2008
    ..Consistent with the toxic beta-amyloid channels that are ion-conducting, the PG-1 channels permeate anions...
  3. pmc Conformational study of the protegrin-1 (PG-1) dimer interaction with lipid bilayers and its effect
    Hyunbum Jang
    Center for Cancer Research Nanobiology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
    BMC Struct Biol 7:21. 2007
    ..The experimental structure of the PG-1 dimer is currently unavailable...
  4. pmc Antimicrobial protegrin-1 forms amyloid-like fibrils with rapid kinetics suggesting a functional link
    Hyunbum Jang
    Center for Cancer Research Nanobiology Program, National Cancer Institute Frederick, SAIC Frederick, Frederick, Maryland, USA
    Biophys J 100:1775-83. 2011
    ..These combined properties support a functional relationship between amyloidogenic peptides and β-sheet-rich cytolytic AMPs, suggesting that amyloids channels may have an antimicrobial function...
  5. pmc Structural convergence among diverse, toxic beta-sheet ion channels
    Hyunbum Jang
    Center for Cancer Research Nanobiology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
    J Phys Chem B 114:9445-51. 2010
    ....
  6. pmc Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome
    Hyunbum Jang
    Center for Cancer Research Nanobiology Program, SAIC Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 107:6538-43. 2010
    ..The toxicity of nonamyloidogenic peptides via an ion channel mechanism necessitates a reevaluation of the current therapeutic approaches targeting the nonamyloidogenic pathway as avenue for AD treatment...
  7. pmc Modeling the Alzheimer Abeta17-42 fibril architecture: tight intermolecular sheet-sheet association and intramolecular hydrated cavities
    Jie Zheng
    Basic Research Program, SAIC Frederick Center for Cancer Research, Nanobiology Program, NCI Frederick, Frederick, Maryland 21702, USA
    Biophys J 93:3046-57. 2007
    ..Thus, we propose that Abeta fiber architecture consists of alternating layers of tight packing and hydrated cavities running along the fibrillar axis, which might be possibly detected by high-resolution imaging...
  8. doi request reprint β-Barrel topology of Alzheimer's β-amyloid ion channels
    Hyunbum Jang
    Center for Cancer Research Nanobiology Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Mol Biol 404:917-34. 2010
    ..The subunits appear mobile, allowing unregulated, hence toxic, ion flux...
  9. pmc Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels
    Hyunbum Jang
    Center for Cancer Research Nanobiology Program, NCI Frederick, SAIC Frederick, Frederick, Maryland, USA
    Biophys J 97:3029-37. 2009
    ..Nature designs folded channels but not misfolded toxic channels...
  10. pmc Interaction of protegrin-1 with lipid bilayers: membrane thinning effect
    Hyunbum Jang
    Center for Cancer Research Nanobiology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
    Biophys J 91:2848-59. 2006
    ..The thinning effects in the bilayer should relate to pore/channel formation in the lipid bilayer and thus be responsible for further defects in the membrane caused by oligomer...
  11. doi request reprint How to lose a kink and gain a helix: pH independent conformational changes of the fusion domains from influenza hemagglutinin in heterogeneous lipid bilayers
    Hyunbum Jang
    Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Proteins 72:299-312. 2008
    ..This conformational change is pH-independent, and is closely related to the peptide insertion into the lipid bilayer...
  12. pmc Models of beta-amyloid ion channels in the membrane suggest that channel formation in the bilayer is a dynamic process
    Hyunbum Jang
    Center for Cancer Research Nanobiology Program, SAIC Frederick, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Biophys J 93:1938-49. 2007
    ..The observed loosely connected subunit organization suggests that amyloid channel formation in the bilayer is a dynamic, fluid process involving subunit association, dissociation, and channel rearrangements...
  13. doi request reprint New structures help the modeling of toxic amyloidbeta ion channels
    Hyunbum Jang
    Center for Cancer Research Nanobiology Program, SAIC Frederick Inc NCI Frederick, Frederick, MD 21702, USA
    Trends Biochem Sci 33:91-100. 2008
    ..Molecular dynamics modeling can provide blueprints of 3D structural conformations for many other amyloids whose membrane association is key to their toxicity...
  14. pmc Alzheimer's disease: which type of amyloid-preventing drug agents to employ?
    Hyunbum Jang
    Center for Cancer Research, Nanobiology Program, Basic Science Program, SAIC Frederick, Inc, National Cancer Institute, Frederick, Maryland 21702, USA
    Phys Chem Chem Phys 15:8868-77. 2013
    ..Here we provide an overview, point to the need to account for the lipid environment when aiming to prevent the formation of toxic channels, and propose a combination therapy to target the species spectrum...
  15. pmc How environment supports a state: molecular dynamics simulations of two states in bacteriorhodopsin suggest lipid and water compensation
    Hyunbum Jang
    Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biophys J 87:129-45. 2004
    ....
  16. pmc Material properties of matrix lipids determine the conformation and intermolecular reactivity of diacetylenic phosphatidylcholine in the lipid bilayer
    Anu Puri
    Membrane Structure and Function Section, SAIC Frederick, Inc, Nanobiology Program, Center for Cancer Research, Frederick, Maryland 21702, USA
    Langmuir 27:15120-8. 2011
    ..These results show that the DC(8,9)PC molecules cluster and assume the preferred conformation in the gel-phase matrix for the UV-triggered polymerization reaction...
  17. ncbi request reprint Tools for channels: moving towards molecular calculations of gating and permeation in ion channel biophysics
    Thomas B Woolf
    Department of Physiology, Johns Hopkins University, School of Medicine, Biophysics 206, 725 N Wolfe Street, Baltimore, MD 21205, USA
    J Mol Graph Model 22:359-68. 2004
    ....
  18. pmc Assembly and kinetic folding pathways of a tetrameric beta-sheet complex: molecular dynamics simulations on simplified off-lattice protein models
    Hyunbum Jang
    Department of Chemical Engineering, North Carolina State University, Raleigh, North Carolina 27695 7905, USA
    Biophys J 86:31-49. 2004
    ....
  19. pmc Protein folding pathways and kinetics: molecular dynamics simulations of beta-strand motifs
    Hyunbum Jang
    Department of Chemical Engineering, North Carolina State University, Raleigh, North Carolina 27695, USA
    Biophys J 83:819-35. 2002
    ..The kinetic folding behavior of the beta-strand proteins strongly depends on the native-state geometry of the model proteins and the size of the bias gap g, an artificial measure of a model protein's preference for its native state...
  20. pmc Thermodynamics and stability of a beta-sheet complex: molecular dynamics simulations on simplified off-lattice protein models
    Hyunbum Jang
    Department of Chemical Engineering, North Carolina State University, Raleigh, North Carolina 27695 7905, USA
    Protein Sci 13:40-53. 2004
    ..The highly ordered beta-sheet complex has fully-stiff beta-sheet strands, the same as the global energy minimum structure, and is observed for all eta at low temperatures...
  21. doi request reprint Beta2-microglobulin amyloid fragment organization and morphology and its comparison to Abeta suggests that amyloid aggregation pathways are sequence specific
    Jie Zheng
    Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, Ohio 44325, USA
    Biochemistry 47:2497-509. 2008
    ....
  22. pmc Annular structures as intermediates in fibril formation of Alzheimer Abeta17-42
    Jie Zheng
    Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, Ohio 44325, USA
    J Phys Chem B 112:6856-65. 2008
    ....
  23. pmc Folding thermodynamics of model four-strand antiparallel beta-sheet proteins
    Hyunbum Jang
    Department of Chemical Engineering, North Carolina State University, Raleigh, North Carolina 27695 7905, USA
    Biophys J 82:646-59. 2002
    ..However the low temperature transitions, i.e., the folding transition and the liquid-to-solid transition, strongly depend on the native-state geometry of the model proteins and the size of the bias gap...