Ashish Jain

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations
    Jordan S Orange
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 109:1501-9. 2002
  2. pmc A novel mutation in NFKBIA/IKBA results in a degradation-resistant N-truncated protein and is associated with ectodermal dysplasia with immunodeficiency
    Eduardo Lopez-Granados
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Hum Mutat 29:861-8. 2008
  3. pmc The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor β (TGF-β) signaling and the development of regulatory T cells
    Yongge Zhao
    Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:40520-30. 2011
  4. pmc Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation
    Ashish Jain
    Laboratory of Host Defense, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 114:1593-602. 2004
  5. pmc Dendritic cells from humans with hypomorphic mutations in IKBKG/NEMO have impaired mitogen-activated protein kinase activity
    Chi A Ma
    Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland, USA
    Hum Mutat 32:318-24. 2011
  6. pmc Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice
    Jun Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 116:3042-9. 2006
  7. pmc Defective nuclear IKKα function in patients with ectodermal dysplasia with immune deficiency
    Stephane T Temmerman
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 122:315-26. 2012
  8. pmc Antibody deficiency associated with an inherited autosomal dominant mutation in TWEAK
    Hong Ying Wang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 110:5127-32. 2013
  9. pmc CD40 agonist antibody mediated improvement of chronic Cryptosporidium infection in patients with X-linked hyper IgM syndrome
    Xiying Fan
    Laboratory of Host Defenses, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    Clin Immunol 143:152-61. 2012
  10. pmc Impaired dendritic-cell function in ectodermal dysplasia with immune deficiency is linked to defective NEMO ubiquitination
    Stephane T Temmerman
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 108:2324-31. 2006

Collaborators

Detail Information

Publications19

  1. pmc Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations
    Jordan S Orange
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 109:1501-9. 2002
    ..These data suggest that NEMO participates in signaling pathways leading to NK cell cytotoxicity and that IL-2 can activate NF-kappaB and partially overcome the NK cell defect in patients with NEMO mutations...
  2. pmc A novel mutation in NFKBIA/IKBA results in a degradation-resistant N-truncated protein and is associated with ectodermal dysplasia with immunodeficiency
    Eduardo Lopez-Granados
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Hum Mutat 29:861-8. 2008
    ..These findings support the scanning model for translation initiation in eukaryotes and confirm the critical role of the NF-kappaB in the human immune response...
  3. pmc The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor β (TGF-β) signaling and the development of regulatory T cells
    Yongge Zhao
    Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:40520-30. 2011
    ..Together, our results show that CYLD regulates TGF-β signaling function in T cells and the development of Tregs through deubiquitination of Smad7...
  4. pmc Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation
    Ashish Jain
    Laboratory of Host Defense, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 114:1593-602. 2004
    ..Finally, using microarray analysis of patient B cells we identified downstream effects of impaired NF-kappaB activation and candidate factors that may be necessary for CSR and SHM in B cells...
  5. pmc Dendritic cells from humans with hypomorphic mutations in IKBKG/NEMO have impaired mitogen-activated protein kinase activity
    Chi A Ma
    Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland, USA
    Hum Mutat 32:318-24. 2011
    ....
  6. pmc Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice
    Jun Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 116:3042-9. 2006
    ..These results suggest that CYLD limits inflammation and tumorigenesis by regulating ubiquitination in vivo...
  7. pmc Defective nuclear IKKα function in patients with ectodermal dysplasia with immune deficiency
    Stephane T Temmerman
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 122:315-26. 2012
    ..Our findings suggest that NEMO regulates the nuclear function of IKKα and offer new insights into the mechanisms underlying diminished NF-κB signaling in patients with EDI...
  8. pmc Antibody deficiency associated with an inherited autosomal dominant mutation in TWEAK
    Hong Ying Wang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 110:5127-32. 2013
    ..As BAFF mediates T-cell-independent isotype switching and B-cell survival, our data implicate TWEAK as a disease-susceptibility gene for a humoral immunodeficiency...
  9. pmc CD40 agonist antibody mediated improvement of chronic Cryptosporidium infection in patients with X-linked hyper IgM syndrome
    Xiying Fan
    Laboratory of Host Defenses, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    Clin Immunol 143:152-61. 2012
    ..This study demonstrates that CP-870,893 suppressed oocysts shedding in XHM patients with biliary cryptosporidiosis. The continued study of CD40 agonists in XHM is warranted...
  10. pmc Impaired dendritic-cell function in ectodermal dysplasia with immune deficiency is linked to defective NEMO ubiquitination
    Stephane T Temmerman
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 108:2324-31. 2006
    ..These findings show for the first time how mutations in the zinc finger domain of NEMO can lead to pathway specific defects in NEMO ubiquitination and thus immune deficiency...
  11. pmc Partial immune reconstitution of X-linked hyper IgM syndrome with recombinant CD40 ligand
    Ashish Jain
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
    Blood 118:3811-7. 2011
    ..This clinical study showed that rCD40L is capable of improving T cell-immune function in patients with XHM...
  12. pmc Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression
    Liming Wu
    Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:2236-44. 2011
    ..Taken together, these results provide novel insight into NIR-mediated p53 suppression and also suggest an additional way for p53 regulation...
  13. pmc Novel sequencing-based strategies for high-throughput discovery of genetic mutations underlying inherited antibody deficiency disorders
    Hong Ying Wang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, CRC, 5W 3840, 10 Center Drive, Bethesda, MD 20892, USA
    Curr Allergy Asthma Rep 11:352-60. 2011
    ..The Hyper-IgM/CVID chip is one example of a resequencing platform that may be used to identify known or novel mutations in patents with various types of inherited antibody deficiency...
  14. pmc Osteopenia in X-linked hyper-IgM syndrome reveals a regulatory role for CD40 ligand in osteoclastogenesis
    Eduardo Lopez-Granados
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:5056-61. 2007
    ..These results show that CD40L can influence RANKL signaling through T cell priming, and thus they demonstrate a regulatory role for CD40L in bone mineralization that is absent in patients with X-linked hyper-IgM syndrome...
  15. pmc CD40 ligand deficiency: neurologic sequelae with radiographic correlation
    Shrinivas Bishu
    Section on Neuroadaptation and Protein Metabolism, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 2D54, Bethesda, MD 20892 1298, USA
    Pediatr Neurol 41:419-27. 2009
    ..Prospective neurocognitive and evaluation of patients with CD40 ligand deficiency may identify affected patients before overt clinical signs appear...
  16. pmc A custom 148 gene-based resequencing chip and the SNP explorer software: new tools to study antibody deficiency
    Hong Ying Wang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Hum Mutat 31:1080-8. 2010
    ....
  17. ncbi request reprint Disseminated vascular papules in an immunodeficient patient being treated with granulocyte colony-stimulating factor
    Joi M Lenczowski
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 1908, USA
    J Am Acad Dermatol 49:105-8. 2003
  18. pmc IKBKG (nuclear factor-kappa B essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function
    Bryn H Salt
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 121:976-82. 2008
    ..Patients with hypomorphic nuclear factor-kappaB essential modulator (NEMO) mutations have extensive phenotypic variability that can include atypical infectious susceptibility...
  19. ncbi request reprint The presentation and natural history of immunodeficiency caused by nuclear factor kappaB essential modulator mutation
    Jordan S Orange
    Department of Immunology, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    J Allergy Clin Immunol 113:725-33. 2004
    ..Hypomorphic mutations in the NFkappaB essential modulator (NEMO) impair NFkappaB function and are linked to both immunodeficiency and ectodermal dysplasia (ED), as well as susceptibility to atypical mycobacterial infections...