Research Topics
| G D JahnkeSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators |
Detail Information
Publications
Thyroid toxicants: assessing reproductive health effectsGloria D Jahnke
Sciences International Inc, Research Triangle Park, NC 27709, USA
Environ Health Perspect 112:363-8. 2004..Potential screening methods to assess toxicant-induced thyroid dysfunction were outlined, and postnatal bioassays of thyroid-related effects were discussed...- Developmental toxicity evaluation of emodin in rats and miceGloria D Jahnke
Sciences International Inc, Alexandria, Virginia, USA
Birth Defects Res B Dev Reprod Toxicol 71:89-101. 2004..Emodin, a widely available herbal remedy, was evaluated for potential effects on pregnancy outcome... - Center for the evaluation of risks to human reproduction--the first five yearsGloria D Jahnke
Sciences International, Inc, Research Triangle Park, North Carolina 27709, USA
Birth Defects Res B Dev Reprod Toxicol 74:1-8. 2005..At this time, 13 panel reports have been published and 12 NTP-CERHR monographs have been issued. Additionally, CERHR conducted a 2-day workshop on the role of thyroid hormones in reproductive and developmental health... - Neurotoxicant-induced elevation of adrenomedullin expression in hippocampus and glia culturesG D Jahnke
Laboratory of Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
J Neurosci Res 66:464-74. 2001..These data suggest an interaction between the proinflammatory cytokines and glia response in the regulation of AM in response to injury... - Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley ratsG Jahnke
Reproductive Toxicology Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 50:271-9. 1999..Thus, in the definitive study, the maternal toxicity NOAEL and LOAEL were 100 and 200 mg/kg/day, respectively, and the developmental toxicity NOAEL was > or =200 mg/kg/day... - Evaluation of the developmental toxicity of isoeugenol in Sprague-Dawley (CD) ratsJ D George
Chemistry and Life Sciences, Research Triangle Institute, P O Box 12194, Research Triangle Park, North Carolina 27709 2194, USA
Toxicol Sci 60:112-20. 2001..The developmental toxicity LOAEL was 1000 mg/kg/day based on intrauterine growth retardation and mildly delayed skeletal ossification. The developmental toxicity NOAEL was 500 mg/kg/day... - Evaluation of the developmental toxicity of formamide in Sprague-Dawley (CD) ratsJ D George
Chemistry and Life Sciences, Research Triangle Institute, Post Office Box 12194, Research Triangle Park, North Carolina 27709 2194, USA
Toxicol Sci 57:284-91. 2000..Similarly, the developmental toxicity NOAEL was 50 mg/kg/day and the LOAEL was 100 mg/kg/day... - Developmental toxicity evaluation of 1,2,3,4-butanetetracarboxylic acid in Sprague Dawley (CD) ratsJ D George
Center for Life Sciences and Toxicology, Chemistry and Life Sciences, Research Triangle Institute, Research Triangle Park, NC 27709 2194, USA
Reprod Toxicol 15:413-20. 2001..The maternal toxicity NOAEL and LOAEL are 500 and 1000 mg/kg/day, respectively. The developmental toxicity NOAEL is > or = 1000 mg/kg/day, and the LOAEL was not established in this study... - Developmental toxicity evaluation of berberine in rats and miceGloria D Jahnke
Sciences International Inc, Research Triangle Park, North Carolina 27709, USA
Birth Defects Res B Dev Reprod Toxicol 77:195-206. 2006..Berberine, a plant alkaloid, is found in some herbal teas and health-related products. It is a component of goldenseal, an herbal supplement. Berberine chloride dihydrate (BCD) was evaluated for developmental toxicity in rats and mice... - Prenatal developmental toxicity evaluation of 2',3'-dideoxyinosine (ddI) and 2',3'-didehydro-3'-deoxythymidine (d4T) co-administered to Swiss Albino (CD-1) miceCatherine J Price
Life Sciences and Toxicology, RTI International, Research Triangle Park, North Carolina 27709 2194, USA
Birth Defects Res B Dev Reprod Toxicol 77:207-15. 2006..In pregnant women, antiretroviral drugs improve maternal health and reduce vertical transmission of human immunodeficiency virus to the infant. However, few nonclinical studies have examined the potential for adverse drug interactions... - Developmental toxicity evaluation of sodium thioglycolate administered topically to Sprague-Dawley (CD) rats and New Zealand White rabbitsR W Tyl
RTI International, Center for Life Sciences and Toxicology, Research Triangle Park, North Carolina 27709 2194, USA
Birth Defects Res B Dev Reprod Toxicol 68:144-61. 2003..Sodium thioglycolate, which has widespread occupational and consumer exposure to women from cosmetics and hair-care products, was evaluated for developmental toxicity by topical exposure during the embryonic and fetal periods of pregnancy.. - Evaluation of the developmental toxicity of formamide in New Zealand white rabbitsJulia D George
Chemistry and Life Sciences, Center for Life Sciences and Toxicology, Herman Laboratory Building, Research Triangle Institute, P O Box 12194, Research Triangle Park, North Carolina 27709 2194, USA
Toxicol Sci 69:165-74. 2002..Similarly, the NOAEL for developmental toxicity was 70 mg/kg/day and the LOAEL was 140 mg/kg/day... - Postnatal development of rat pups after maternal exposure to diethanolamineCatherine J Price
Life Sciences and Toxicology, RTI International, Research Triangle Park, North Carolina 27709 2194, USA
Birth Defects Res B Dev Reprod Toxicol 74:243-54. 2005..Teratology 37:503-504, 1988]. The toxicity profile for DEA differs among rodent species. This study investigated DEA-induced postnatal toxicity in a second species... - Adrenomedullin expression in the mouse mammary gland: evidence for the mature form in milkG D Jahnke
Laboratory of Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
J Mol Endocrinol 19:279-89. 1997..These data suggest a potential role for AM and its receptor in the maintenance of mammary gland homeostasis and suggests a potential role for AM in development of the newborn... - Role of thyroid hormones in human and laboratory animal reproductive healthNeepa Y Choksi
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Birth Defects Res B Dev Reprod Toxicol 68:479-91. 2003..Consideration of such information is important in designing, conducting, and interpreting studies to assess the potential effects of thyroid toxicants on reproduction and development...