Elaine S Jaffe

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma
    Chung Che Chang
    Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston TX, USA
    J Hematol Oncol 2:47. 2009
  2. ncbi request reprint Lymphoid lesions of the head and neck: a model of lymphocyte homing and lymphomagenesis
    Elaine S Jaffe
    Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA
    Mod Pathol 15:255-63. 2002
  3. ncbi request reprint Highly effective treatment of acquired immunodeficiency syndrome-related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biology
    Richard F Little
    Center for Cancer Research CCR, National Cancer Institute NCI, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:4653-9. 2003
  4. ncbi request reprint Dose-adjusted EPOCH chemotherapy for untreated large B-cell lymphomas: a pharmacodynamic approach with high efficacy
    Wyndham H Wilson
    Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 99:2685-93. 2002
  5. pmc The role of tumor histogenesis, FDG-PET, and short-course EPOCH with dose-dense rituximab (SC-EPOCH-RR) in HIV-associated diffuse large B-cell lymphoma
    Kieron Dunleavy
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 115:3017-24. 2010
  6. ncbi request reprint Similarities of prosurvival signals in Bcl-2-positive and Bcl-2-negative follicular lymphomas identified by reverse phase protein microarray
    Hongbin Zha
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Lab Invest 84:235-44. 2004
  7. ncbi request reprint The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
    Andreas Rosenwald
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 346:1937-47. 2002
  8. ncbi request reprint T-cell/histiocyte-rich large B-cell lymphoma: a heterogeneous entity with derivation from germinal center B cells
    Megan S Lim
    Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Surg Pathol 26:1458-66. 2002
  9. doi request reprint Marginal zone lymphomas in children and the young adult population; characterization of genetic aberrations by FISH and RT-PCR
    Kathryn A Rizzo
    Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1500, USA
    Mod Pathol 23:866-73. 2010
  10. ncbi request reprint Molecular diagnosis of Burkitt's lymphoma
    Sandeep S Dave
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 354:2431-42. 2006

Detail Information

Publications86

  1. pmc Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma
    Chung Che Chang
    Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston TX, USA
    J Hematol Oncol 2:47. 2009
    ..The goal of the current study was to evaluate the genetic similarities and differences among PL, DLBCL (AIDS-related and non AIDS-related) and PCM using array-based comparative genomic hybridization...
  2. ncbi request reprint Lymphoid lesions of the head and neck: a model of lymphocyte homing and lymphomagenesis
    Elaine S Jaffe
    Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA
    Mod Pathol 15:255-63. 2002
    ..Lymphomatoid granulomatosis is common in the lung but is rarely seen in the midline facial structures...
  3. ncbi request reprint Highly effective treatment of acquired immunodeficiency syndrome-related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biology
    Richard F Little
    Center for Cancer Research CCR, National Cancer Institute NCI, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:4653-9. 2003
    ..These results suggest that tumor pathogenesis is responsible for the improved outcome of ARLs in the era of HAART...
  4. ncbi request reprint Dose-adjusted EPOCH chemotherapy for untreated large B-cell lymphomas: a pharmacodynamic approach with high efficacy
    Wyndham H Wilson
    Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 99:2685-93. 2002
    ..Dose-adjusted EPOCH may produce more cell kill than CHOP-based regimens. Dynamic dose adjustment may overcome inadequate drug concentrations, particularly in younger patients, and compensate for increased drug clearance over time...
  5. pmc The role of tumor histogenesis, FDG-PET, and short-course EPOCH with dose-dense rituximab (SC-EPOCH-RR) in HIV-associated diffuse large B-cell lymphoma
    Kieron Dunleavy
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 115:3017-24. 2010
    ..However, new therapeutic advances are needed for non-GCB DLBCL, which remains the important cause of lymphoma-specific death. This trial was registered at www.clinicaltrials.gov as NCT000019253...
  6. ncbi request reprint Similarities of prosurvival signals in Bcl-2-positive and Bcl-2-negative follicular lymphomas identified by reverse phase protein microarray
    Hongbin Zha
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Lab Invest 84:235-44. 2004
    ..The activation of the Akt/Bad pathway provides further evidence of prosurvival signals in FL, independent of Bcl-2 alone. These data suggest that nodal FL represents a single disease with a final common biochemical pathway...
  7. ncbi request reprint The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
    Andreas Rosenwald
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 346:1937-47. 2002
    ..The survival of patients with diffuse large-B-cell lymphoma after chemotherapy is influenced by molecular features of the tumors. We used the gene-expression profiles of these lymphomas to develop a molecular predictor of survival...
  8. ncbi request reprint T-cell/histiocyte-rich large B-cell lymphoma: a heterogeneous entity with derivation from germinal center B cells
    Megan S Lim
    Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Surg Pathol 26:1458-66. 2002
    ..A subset of THRLBCL may be related to nodular lymphocyte predominance Hodgkin's lymphoma. A small percentage show features closely resembling classic Hodgkin's lymphoma and could be considered a variant of grey zone lymphoma...
  9. doi request reprint Marginal zone lymphomas in children and the young adult population; characterization of genetic aberrations by FISH and RT-PCR
    Kathryn A Rizzo
    Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1500, USA
    Mod Pathol 23:866-73. 2010
    ..Overall the incidence of genetic aberrations in marginal zone lymphomas in the pediatric and young adult population is low, but the aberrations seen are similar to those seen in the adult population...
  10. ncbi request reprint Molecular diagnosis of Burkitt's lymphoma
    Sandeep S Dave
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 354:2431-42. 2006
    ..We examined whether gene-expression profiling could reliably distinguish Burkitt's lymphoma from diffuse large-B-cell lymphoma...
  11. pmc Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma
    Andreas Rosenwald
    Metabolism Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
    J Exp Med 198:851-62. 2003
    ..The molecular diagnosis of PMBL should significantly aid in the development of therapies tailored to this clinically and pathogenetically distinctive subgroup of DLBCL...
  12. pmc Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma
    Kieron Dunleavy
    Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 113:6069-76. 2009
    ..This trial is registered with http://www.ClinicalTrials.gov under identifier NCT00057902...
  13. ncbi request reprint In situ localization of follicular lymphoma: description and analysis by laser capture microdissection
    Peijie Cong
    Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Blood 99:3376-82. 2002
    ..These findings provide insight into the pathophysiology of early FL, and illustrate the utility of immunohistochemistry for early diagnosis...
  14. ncbi request reprint Sequestration of p27Kip1 protein by cyclin D1 in typical and blastic variants of mantle cell lymphoma (MCL): implications for pathogenesis
    Leticia Quintanilla-Martinez
    Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:3181-7. 2003
    ....
  15. pmc Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma
    Franziska C Eberle
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Haematologica 96:558-66. 2011
    ..Epigenetic changes have been implicated in the loss of the B-cell program in classical Hodgkin's lymphoma, and might provide a basis for the immunophenotypic alterations seen in mediastinal gray zone lymphoma...
  16. pmc Hodgkin lymphoma: an update on its biology with new insights into classification
    Haresh Mani
    Laboratory of Pathology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Lymphoma Myeloma 9:206-16. 2009
    ..Nodular sclerosis HL might also be related to primary mediastinal B-cell lymphoma and mediastinal gray-zone lymphomas. We present an update on the pathobiology of HL and discuss these biologic and clinical differences in this review...
  17. pmc Risk factors for lymphoproliferative disorders after allogeneic hematopoietic cell transplantation
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Blood 113:4992-5001. 2009
    ..Our findings identify subgroups of patients who underwent allogeneic HCT at elevated risk of PTLDs for whom prospective monitoring of Epstein-Barr virus activation and early treatment intervention may be particularly beneficial...
  18. ncbi request reprint Lymphomatoid granulomatosis: abnormalities of the brain at MR imaging
    Athos D Patsalides
    Department of Diagnostic Radiology, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bldg 10, Room 1C660, 9000 Rockville Pike, Bethesda, MD 20892 1182, USA
    Radiology 237:265-73. 2005
    ..To retrospectively evaluate the magnetic resonance (MR) imaging features of lymphomatoid granulomatosis in the brain...
  19. pmc Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma
    Richard L Piekarz
    Departmentof Health and Human Services, Center for Cancer Researchand Cancer Therapy EvaluationProgram, National Cancer Institute, National Institutes of Health, Bethesda, USA
    J Clin Oncol 27:5410-7. 2009
    ..The median duration of response was 13.7 months. CONCLUSION The histone deacetylase inhibitor romidepsin has single-agent clinical activity with significant and durable responses in patients with CTCL...
  20. ncbi request reprint Clonal relationship between precursor T-lymphoblastic leukaemia/lymphoma and Langerhans-cell histiocytosis
    Andrew L Feldman
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Lancet Oncol 6:435-7. 2005
  21. doi request reprint Large-scale profiling of archival lymph nodes reveals pervasive remodeling of the follicular lymphoma methylome
    J Keith Killian
    Genetics Branch, Laboratory of Pathology, NIH National Cancer Institute, Bethesda, Maryland, USA
    Cancer Res 69:758-64. 2009
    ..Analysis of the DMT profile is consistent with a pervasive epigenomic remodeling process in FL that affects predominantly nonlymphoid genes...
  22. ncbi request reprint Fluorodeoxyglucose positron emission tomography (FDG-PET) for monitoring lymphadenopathy in the autoimmune lymphoproliferative syndrome (ALPS)
    V Koneti Rao
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1888, USA
    Am J Hematol 81:81-5. 2006
    ....
  23. pmc Classification of lymphoid neoplasms: the microscope as a tool for disease discovery
    Elaine S Jaffe
    Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 112:4384-99. 2008
    ..In addition, accurate and precise classification of disease entities facilitates the discovery of the molecular basis of lymphoid neoplasms in the basic science laboratory...
  24. doi request reprint Mycosis fungoides and S├ęzary syndrome
    Sam T Hwang
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, USA
    Lancet 371:945-57. 2008
    ....
  25. pmc Phase II study of dose-adjusted EPOCH and rituximab in untreated diffuse large B-cell lymphoma with analysis of germinal center and post-germinal center biomarkers
    Wyndham H Wilson
    Metabolism Branch, National Cancer Institute, Building 10, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Clin Oncol 26:2717-24. 2008
    ....
  26. doi request reprint Expression of the interferon regulatory factor 8/ICSBP-1 in human reactive lymphoid tissues and B-cell lymphomas: a novel germinal center marker
    Antonio Martinez
    Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Surg Pathol 32:1190-200. 2008
    ..These results suggest an important role for IRF8 during germinal center B-cell development and in related lymphomas, and provide a new diagnostic marker helpful in distinguishing B-cell non-Hodgkin lymphoma subtypes...
  27. ncbi request reprint Second cancer incidence and cause-specific mortality among 3104 patients with hairy cell leukemia: a population-based study
    Michie Hisada
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 8008, Bethesda, MD 20892 7201, USA
    J Natl Cancer Inst 99:215-22. 2007
    ..The available evidence is conflicting, with most risk estimates based on sparse numbers. To our knowledge, no study has evaluated cause-specific mortality in patients with hairy cell leukemia...
  28. pmc IL-4 protein expression and basal activation of Erk in vivo in follicular lymphoma
    Katherine R Calvo
    Hematopathology Section, Laboratory of Pathology LP, NIH Clinical Center, Department of Laboratory Medicine, 10 Center Drive, Bldg 10 2C306, Bethesda, MD 20892 1500, USA
    Blood 112:3818-26. 2008
    ..These findings suggest IL-4, Erk, and possibly Stat-6 may play a role in the biology of FL and may serve as targets for future therapies...
  29. pmc Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS
    Robert J Biggar
    Viral Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd, Rm EPS 7074, Bethesda, MD 20852, USA
    Blood 108:3786-91. 2006
    ..With more severe immunosuppression, nodular sclerosing HL becomes infrequent, explaining the higher proportion of mixed cellularity HL found in PWAs. Pathogenesis implications are discussed...
  30. ncbi request reprint Proteomic analysis of apoptotic pathways reveals prognostic factors in follicular lymphoma
    Christian Gulmann
    National Cancer Institute Food and Drug Administration Clinical Proteomics Program, Laboratory of Pathology, Bethesda, MD 20892, USA
    Clin Cancer Res 11:5847-55. 2005
    ..Proteomic end points should be incorporated in larger, multicenter trials to validate the clinical utility of these protein microarray findings...
  31. ncbi request reprint IgD positive L&H cells identify a unique subset of nodular lymphocyte predominant Hodgkin lymphoma
    Sonam Prakash
    Laboratory of Pathology, Hematopathology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Surg Pathol 30:585-92. 2006
    ..IgD positivity may represent an additional useful marker in the diagnosis of NLPHL...
  32. pmc Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways
    Georg Lenz
    Metabolism Branch, Biometric Research Branch, Center for Information Technology, and Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:13520-5. 2008
    ..Together, these data provide genetic evidence that the DLBCL subtypes are distinct diseases that use different oncogenic pathways...
  33. pmc Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone
    Andrew L Feldman
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892 1500, USA
    Blood 111:5433-9. 2008
    ..1 was seen in all cases tested. These results provide evidence for a common clonal origin of FL and H/DC neoplasms when occurring in the same patient, and suggest that lineage plasticity may occur in mature lymphoid neoplasms...
  34. ncbi request reprint Bethesda proposals for classification of lymphoid neoplasms in mice
    Herbert C Morse
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0760, USA
    Blood 100:246-58. 2002
    ..The classification should facilitate communications about mouse models of human lymphoid diseases...
  35. ncbi request reprint Peripheral T-cell lymphomas expressing CD30 and CD15
    Todd S Barry
    Hematopathology Section, Laboratory of Pathology, National Cancer Intitute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Surg Pathol 27:1513-22. 2003
    ..In some PTCL cases, the overlap with classic HL can be striking, and combined immunophenotypic and molecular studies are often necessary to confirm the diagnosis...
  36. ncbi request reprint Immunoblastic lymphoma in persons with AIDS-associated Kaposi's sarcoma: a role for Kaposi's sarcoma-associated herpesvirus
    Eric A Engels
    Viral Epidemiology Branch, Division of Cancer and Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
    Mod Pathol 16:424-9. 2003
    ..We conclude that Kaposi's sarcoma-associated herpesvirus is present in some immunoblastic lymphomas in persons with AIDS-associated Kaposi's sarcoma...
  37. pmc The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications
    Elias Campo
    Hematopathology Section, Department of Anatomic Pathology, Hospital Clinic, Institute of Biomedical Research August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Blood 117:5019-32. 2011
    ..The issue of borderline categories having overlapping features with large B-cell lymphomas, as well as several provisional entities, is reviewed. These new observations chart a course for future research in the field...
  38. pmc Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma
    Richard L Piekarz
    Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health DHHS, 6130 Executive Blvd, Rockville, MD 20852, USA
    Blood 117:5827-34. 2011
    ..The histone deacetylase inhibitor romidepsin has single agent clinical activity associated with durable responses in patients with relapsed PTCL...
  39. ncbi request reprint Gamma-delta T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma
    Jorge R Toro
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7231, USA
    Blood 101:3407-12. 2003
    ..067). No other prognostic factors were identified as having a notable association with outcome in this subgroup. TCR delta 1 expression in primary cutaneous lymphomas is an independent prognostic factor associated with decreased survival...
  40. doi request reprint Why is it crucial to reintegrate pathology into cancer research?
    Jaime Rodriguez-Canales
    Laser Capture Microdissection Core and Pathogenetics Unit, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Bioessays 33:490-8. 2011
    ....
  41. pmc Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States
    Jeffrey I Cohen
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    Blood 117:5835-49. 2011
    ..These studies are registered at http://www.clinicaltrials.gov as NCT00032513 for CAEBV, NCT00062868 and NCT00058812 for EBV-specific T-cell studies, and NCT00578539 for the hematopoietic stem cell transplantation protocol...
  42. ncbi request reprint Anti-tumor activities of the angiogenesis inhibitors interferon-inducible protein-10 and the calreticulin fragment vasostatin
    Lei Yao
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 12N226 MSC 1907, 10 Center Drive, Bethesda, MD, USA
    Cancer Immunol Immunother 51:358-66. 2002
    ....
  43. ncbi request reprint Recommendations for the reporting of lymphoid neoplasms: a report from the Association of Directors of Anatomic and Surgical Pathology
    Elaine S Jaffe
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892 1500, USA
    Mod Pathol 17:131-5. 2004
    ..Ancillary studies are often required, and the Association recommends that immunophenotypic and genotypic information be integrated into the final report, to the extent possible...
  44. ncbi request reprint Histiocytic sarcoma after acute lymphoblastic leukaemia: a common clonal origin
    Andrew L Feldman
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Lancet Oncol 5:248-50. 2004
  45. ncbi request reprint Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells
    Sandeep S Dave
    National Cancer Institute, NIH, Bethesda, MD 20892, USA
    N Engl J Med 351:2159-69. 2004
    ..We used gene-expression profiles of tumor-biopsy specimens obtained at diagnosis to develop a molecular predictor of the length of survival...
  46. ncbi request reprint Clonal T-cell populations and increased risk for cytotoxic T-cell lymphomas in B-CLL patients: clinicopathologic observations and molecular analysis
    Antonio Martinez
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Surg Pathol 28:849-58. 2004
    ..PTCL following CLL should be distinguished from typical Richter syndrome, which it can mimic clinically...
  47. pmc Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome
    Kennichi C Dowdell
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1888, USA
    Blood 115:5164-9. 2010
    ..These findings also highlight the potential role for somatic mutations in the pathogenesis of nonmalignant and/or autoimmune hematologic conditions in adults and children...
  48. ncbi request reprint Elevated serum-soluble interleukin-2 receptor levels in patients with anaplastic large cell lymphoma
    John E Janik
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 104:3355-7. 2004
    ..Serum sIL-2R levels were elevated in both patients with recurrent disease...
  49. pmc Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop
    Joao B Oliveira
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 116:e35-40. 2010
    ..It is hoped that harmonizing the diagnosis and classification of ALPS will foster collaborative research and better understanding of the pathogenesis of autoimmune cytopenias and B-cell lymphomas...
  50. pmc Automatic classification of lymphoma images with transform-based global features
    Nikita V Orlov
    National Institute on Aging, NIH, Baltimore, MD 21224, USA
    IEEE Trans Inf Technol Biomed 14:1003-13. 2010
    ..The best signal (98%-99% on earlier unseen images) was found for the HE, H, and E channels of the H&E data set...
  51. pmc Development of disseminated histiocytic sarcoma in a patient with autoimmune lymphoproliferative syndrome and associated Rosai-Dorfman disease
    Girish Venkataraman
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Surg Pathol 34:589-94. 2010
    ..Given the central role of defective Fas signaling in ALPS, histiocytes may be yet another lineage at risk for neoplastic transformation secondary to a block in apoptosis...
  52. pmc Gall bladder and extrahepatic bile duct lymphomas: clinicopathological observations and biological implications
    Haresh Mani
    The Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Surg Pathol 34:1277-86. 2010
    ..31%). In conclusion, primary lymphomas of the gall bladder and extrahepatic bile ducts show a broad spectrum of disease types, but in many respects mirror the spectrum of primary lymphomas of the gastrointestinal tract...
  53. pmc Nodal and extranodal plasmacytomas expressing immunoglobulin a: an indolent lymphoproliferative disorder with a low risk of clinical progression
    Haipeng Shao
    Laboratory of Pathology and the Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Surg Pathol 34:1425-35. 2010
    ..Our results suggest that IgA plasmacytomas may represent a distinct form of extramedullary plasmacytoma characterized by younger age at presentation, frequent lymph node involvement, and low risk of progression to plasma cell myeloma...
  54. ncbi request reprint The pathology of NK-cell lymphomas and leukemias
    Victor E Nava
    Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Adv Anat Pathol 12:27-34. 2005
    ..Benign proliferations of NK cells can be seen in association with viral infection. The disease formerly referred to as blastic NK-cell lymphoma is now considered to be a malignancy derived from a dendritic cell precursor...
  55. ncbi request reprint Histologic features of sinus histiocytosis with massive lymphadenopathy in patients with autoimmune lymphoproliferative syndrome
    Irina Maric
    Hematopathology Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Am J Surg Pathol 29:903-11. 2005
    ..It remains to be determined if some cases of apparently sporadic SHML may be associated with heritable defects in Fas-mediated apoptosis...
  56. ncbi request reprint High incidence of occult leptomeningeal disease detected by flow cytometry in newly diagnosed aggressive B-cell lymphomas at risk for central nervous system involvement: the role of flow cytometry versus cytology
    Upendra Hegde
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda, MD 20892 1868, USA
    Blood 105:496-502. 2005
    ..Patients at risk for CNS spread should undergo staging CSF evaluation by flow cytometry...
  57. ncbi request reprint Molecular profiling provides evidence of primary mediastinal large B-cell lymphoma as a distinct entity related to classic Hodgkin lymphoma: implications for mediastinal gray zone lymphomas as an intermediate form of B-cell lymphoma
    Katherine R Calvo
    Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Adv Anat Pathol 11:227-38. 2004
    ....
  58. ncbi request reprint Marginal zone B-cell lymphoma in children and young adults
    Lekidelu Taddesse-Heath
    Hemopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Am J Surg Pathol 27:522-31. 2003
    ..We conclude that EMZL in children and young adults are similar to EMZL of mucosa-associated lymphoma tissue occurring in older patients. However, pediatric NMZL appear to have distinctive clinical and histologic features...
  59. ncbi request reprint CD5+ follicular lymphoma: a clinicopathologic study of three cases
    Todd S Barry
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Clin Pathol 118:589-98. 2002
    ..These cases highlight the difficulty classifying these lymphomas by flow cytometric studies alone and emphasize the importance of recognizing FL in the differential diagnosis of CD5+ B-cell lymphomas...
  60. pmc IG/MYC rearrangements are the main cytogenetic alteration in plasmablastic lymphomas
    Alexandra Valera
    Hematopathology Section, Laboratory of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Am J Surg Pathol 34:1686-94. 2010
    ..The oncogenic activation of MYC in these lymphomas may be an important pathogenetic element associated with EBV infection...
  61. ncbi request reprint Mature T-cell and NK-cell lymphomas in the pediatric age group
    Elaine S Jaffe
    Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 1500, USA
    Am J Clin Pathol 122:S110-21. 2004
    ..This early component of the immune system might be targeted more often in pediatric hematologic malignant neoplasms, whereas tumors of the more mature adaptive immune system are more rare in children...
  62. ncbi request reprint An immunohistochemical study of the bone marrow lesions of systemic mastocytosis: expression of stem cell factor by lesional mast cells
    Cem Akin
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1881, USA
    Am J Clin Pathol 118:242-7. 2002
    ....
  63. doi request reprint Histopathology of Hodgkin's lymphoma
    Franziska C Eberle
    Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Cancer J 15:129-37. 2009
    ..We present an update on the histopathological features of Hodgkin's lymphoma and the immunohistochemical tools available for diagnosis in the clinical setting...
  64. pmc Immunoguided laser assisted microdissection techniques for DNA methylation analysis of archival tissue specimens
    Franziska C Eberle
    Hematopathology Section, National Cancer Institute, National Institutes of Health, 8717 Grovemont Circle, Bethesda, MD 20892, USA
    J Mol Diagn 12:394-401. 2010
    ..7%; P < 0.05). These results demonstrate the validity and utility of the herein described protocol, which allows the application of ILAM for large-scale genomic and epigenetic analyses of archival tissue specimens...
  65. ncbi request reprint Diffuse large B-cell lymphomas with plasmablastic differentiation represent a heterogeneous group of disease entities
    Lluis Colomo
    Hematopathology Section, Laboratory of Pathology, and Department of Hematology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Am J Surg Pathol 28:736-47. 2004
    ..In conclusion, DLBCLs with plasmablastic differentiation are a heterogeneous group of neoplasms with different clinicopathological characteristics that may correspond to different entities...
  66. ncbi request reprint The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma
    Andreas Rosenwald
    The Lymphoma Leukemia Molecular Profiling Project, National Cancer Institute NIH, Bethesda, MD, USA
    Cancer Cell 3:185-97. 2003
    ..We propose a quantitative model of the aberrant cell cycle regulation in MCL that provides a rationale for the design of cell cycle inhibitor therapy in this malignancy...
  67. pmc Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma
    Martina Rudelius
    Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Blood 108:1668-76. 2006
    ..One possible mechanism of activation is loss of PTEN expression. These data suggest that PI3K/Akt inhibitors may be effective in the treatment of Akt-activated MCL...
  68. ncbi request reprint Periodic fever with atypical dyshidrosis--quiz case
    Elektra J Papadopoulos
    National Institutes of Health, Bethesda, MD, USA
    Arch Dermatol 140:479-84. 2004
  69. ncbi request reprint BCL2 expression is a prognostic marker for the activated B-cell-like type of diffuse large B-cell lymphoma
    Javeed Iqbal
    Leukemia Lymphoma Molecular Profiling Project, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    J Clin Oncol 24:961-8. 2006
    ..DLBCL is heterogeneous, and the expression of BCL2 is variable within the two major subgroups of DLBCL, germinal center B-cell-like (GCB) and activated B-cell-like (ABC) DLBCL, as well as primary mediastinal DLBCL...
  70. ncbi request reprint Aggressive Epstein-Barr virus-associated, CD8+, CD30+, CD56+, surface CD3-, natural killer (NK)-like cytotoxic T-cell lymphoma
    Jianguo Tao
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Surg Pathol 26:111-8. 2002
    ..1 cells normally present in hepatosplenic sinusoids. This tumor disseminated early and pursued a fulminant clinical course, thus emphasizing the importance of early recognition and diagnosis...
  71. pmc Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study
    Ken H Young
    Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, University of of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, USA
    Blood 112:3088-98. 2008
    ..This study shows the prognostic importance of mutations in the TP53 DNA-binding domains in patients with DLBCL...
  72. doi request reprint ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project
    Kerry J Savage
    Department of Medical Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada
    Blood 111:5496-504. 2008
    ..Although the prognosis of ALK(-) ALCL appears to be better than that for PTCL-NOS, it is still unsatisfactory and better therapies are needed. Primary cutaneous ALCL is associated with an indolent course...
  73. ncbi request reprint Identification of a proliferation signature related to survival in nodal peripheral T-cell lymphomas
    Marta Cuadros
    Human Genetics Group and Genotyping Unit, Human Cancer Genetics Program, Spanish National Cancer Centre, Madrid, Spain
    J Clin Oncol 25:3321-9. 2007
    ..Initial expression profiling studies of T-cell lymphomas have been inconclusive in yielding clinically relevant insights. We applied DNA microarrays to gain insight into the molecular signatures associated with prognosis. Materials and..
  74. ncbi request reprint IgVH mutational status and clonality analysis of Richter's transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution
    Zhengrong Mao
    Institute of Pathology, University of Wurzburg, Germany
    Am J Surg Pathol 31:1605-14. 2007
    ..HRS or HRS-like cells in all 3 unrelated cases showed evidence of Epstein-Barr virus infection. Of interest, 5/6 cases of B-CLL with HL, and 5/6 cases of B-CLL with HRS cells showed mutated IgVH genes...
  75. ncbi request reprint Unusual immunophenotype of CD8+ T cells in familial hemophagocytic lymphohistiocytosis
    Nitin J Karandikar
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 75390 9072, USA
    Blood 104:2007-9. 2004
    ..This case provides an instructive example of uncontrolled reactive proliferation of CD8+ T cells in FHL, resulting in atypical morphology and unusual immunophenotypic features that might suggest malignancy in other clinical settings...
  76. ncbi request reprint The serine protease granzyme M is preferentially expressed in NK-cell, gamma delta T-cell, and intestinal T-cell lymphomas: evidence of origin from lymphocytes involved in innate immunity
    Laszlo Krenacs
    Laboratory of Tumor Pathology and Molecular Diagnostics, Institute for Biotechnology, Bay Zoltan Foundation for Applied Research, Szeged, Hungary
    Blood 101:3590-3. 2003
    ..We conclude that GM expression is a distinctive feature of the nasal NK/T-cell, gamma delta T-cell, and intestinal T-cell lymphomas, and suggest that these tumors develop from lymphocytes involved in innate immunity...
  77. pmc BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma
    Javeed Iqbal
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Am J Pathol 165:159-66. 2004
    ..However, despite this higher proliferative activity, there was no significant difference in overall or failure-free survival between the t(14;18)-positive and -negative subsets within the GCB subgroup...
  78. pmc Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction
    Silvia Bea
    Department of Pathology and Hematology Hospital Clinic, University of Barcelona, Spain
    Blood 106:3183-90. 2005
    ..In addition, gains involving the chromosomal region 3p11-p12 provided prognostic information that was statistically independent of the previously defined gene-expression-based survival model, thereby improving its predictive power...
  79. ncbi request reprint Flow cytometric immunophenotypic profiles of mature gamma delta T-cell malignancies involving peripheral blood and bone marrow
    Ejaz Ahmad
    Department of Pathology, Good Samaritan Hospital, Dayton, Ohio, USA
    Cytometry B Clin Cytom 67:6-12. 2005
    ..In this study we compared clinical findings with flow cytometric immunophenotypic results in a series of patients with aggressive and indolent gamma delta T-cell malignancies with peripheral blood and/or bone marrow involvement...
  80. pmc Lymphomatoid granulomatosis with involvement of the hard palate: a case report
    Rabie M Shanti
    Department of Oral and Maxillofacial Surgery, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
    J Oral Maxillofac Surg 66:2161-3. 2008
  81. ncbi request reprint Molecular analysis of light-chain switch and acute lymphoblastic leukemia transformation in two follicular lymphomas: implications for lymphomagenesis
    Carol Kobrin
    Intramural Research Support Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, USA
    Leuk Lymphoma 47:1523-34. 2006
    ..It is also possible that the outgrowth of these variants was a consequence of immunoselection...
  82. ncbi request reprint What is anaplastic large cell lymphoma?
    Metin Ozdemirli
    Am J Surg Pathol 28:1664-5; author reply 1665-7. 2004
  83. ncbi request reprint Aggressive natural killer cell leukemia/lymphoma: case report, use of telesynergy and review of the literature
    Joanne Murdock
    Haematology Department, Belfast City Hospital, Belfast, BT9 7AB, N Ireland
    Leuk Lymphoma 45:1269-73. 2004
    ..We review the possible therapeutic options for this extremely aggressive malignancy and briefly discuss our center's experience of telemedicine technology...
  84. pmc Comprehensive analysis of GST-pi expression in B-cell lymphomas: Correlation with histological subtypes and survival
    Catherine Thieblemont
    Leuk Lymphoma 49:1403-6. 2008
  85. ncbi request reprint Enteropathy-type T-cell lymphoma after intestinal diffuse large B-cell lymphoma
    Victor E Nava
    Department of Pathology, Lombardi Comprehensive Cancer Center, Georgetown University Hospital, Washington, DC 20007, USA
    Am J Surg Pathol 31:476-80. 2007
    ..To our best knowledge, this is the first reported case of metachronous ETL and DLBCL. Possible associations between the 2 types of lymphoma are discussed...
  86. pmc Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphoma
    Timothy C Greiner
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Proc Natl Acad Sci U S A 103:2352-7. 2006
    ..This information on molecular phenotypes may provide new areas of investigation for ATM function or may be exploited by designing specific therapies for MCL cases with p53 aberrations...