Elaine S Jaffe

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a study of seven cases
    Haipeng Shao
    Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mod Pathol 24:1421-32. 2011
  2. pmc Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma
    Chung Che Chang
    Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston TX, USA
    J Hematol Oncol 2:47. 2009
  3. ncbi request reprint Lymphoid lesions of the head and neck: a model of lymphocyte homing and lymphomagenesis
    Elaine S Jaffe
    Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA
    Mod Pathol 15:255-63. 2002
  4. pmc The role of tumor histogenesis, FDG-PET, and short-course EPOCH with dose-dense rituximab (SC-EPOCH-RR) in HIV-associated diffuse large B-cell lymphoma
    Kieron Dunleavy
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 115:3017-24. 2010
  5. pmc Phase II study of dose-adjusted EPOCH and rituximab in untreated diffuse large B-cell lymphoma with analysis of germinal center and post-germinal center biomarkers
    Wyndham H Wilson
    Metabolism Branch, National Cancer Institute, Building 10, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Clin Oncol 26:2717-24. 2008
  6. ncbi request reprint The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma
    Andreas Rosenwald
    The Lymphoma Leukemia Molecular Profiling Project, National Cancer Institute NIH, Bethesda, MD, USA
    Cancer Cell 3:185-97. 2003
  7. pmc Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma
    Kieron Dunleavy
    Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 113:6069-76. 2009
  8. doi request reprint Expression of the interferon regulatory factor 8/ICSBP-1 in human reactive lymphoid tissues and B-cell lymphomas: a novel germinal center marker
    Antonio Martinez
    Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Surg Pathol 32:1190-200. 2008
  9. ncbi request reprint Clonal T-cell populations and increased risk for cytotoxic T-cell lymphomas in B-CLL patients: clinicopathologic observations and molecular analysis
    Antonio Martinez
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Surg Pathol 28:849-58. 2004
  10. pmc Low-intensity therapy in adults with Burkitt's lymphoma
    Kieron Dunleavy
    From the Center for Cancer Research, National Cancer Institute, Bethesda, MD
    N Engl J Med 369:1915-25. 2013

Detail Information

Publications110 found, 100 shown here

  1. pmc Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a study of seven cases
    Haipeng Shao
    Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mod Pathol 24:1421-32. 2011
    ..Our study provides evidence for transdifferentiation of CLL/SLL B cells to tumors of dendritic and less often histiocytic lineage, and suggests that secondary genetic events may play a role in this phenomenon...
  2. pmc Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma
    Chung Che Chang
    Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston TX, USA
    J Hematol Oncol 2:47. 2009
    ..The goal of the current study was to evaluate the genetic similarities and differences among PL, DLBCL (AIDS-related and non AIDS-related) and PCM using array-based comparative genomic hybridization...
  3. ncbi request reprint Lymphoid lesions of the head and neck: a model of lymphocyte homing and lymphomagenesis
    Elaine S Jaffe
    Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA
    Mod Pathol 15:255-63. 2002
    ..Lymphomatoid granulomatosis is common in the lung but is rarely seen in the midline facial structures...
  4. pmc The role of tumor histogenesis, FDG-PET, and short-course EPOCH with dose-dense rituximab (SC-EPOCH-RR) in HIV-associated diffuse large B-cell lymphoma
    Kieron Dunleavy
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 115:3017-24. 2010
    ..However, new therapeutic advances are needed for non-GCB DLBCL, which remains the important cause of lymphoma-specific death. This trial was registered at www.clinicaltrials.gov as NCT000019253...
  5. pmc Phase II study of dose-adjusted EPOCH and rituximab in untreated diffuse large B-cell lymphoma with analysis of germinal center and post-germinal center biomarkers
    Wyndham H Wilson
    Metabolism Branch, National Cancer Institute, Building 10, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Clin Oncol 26:2717-24. 2008
    ....
  6. ncbi request reprint The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma
    Andreas Rosenwald
    The Lymphoma Leukemia Molecular Profiling Project, National Cancer Institute NIH, Bethesda, MD, USA
    Cancer Cell 3:185-97. 2003
    ..We propose a quantitative model of the aberrant cell cycle regulation in MCL that provides a rationale for the design of cell cycle inhibitor therapy in this malignancy...
  7. pmc Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma
    Kieron Dunleavy
    Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 113:6069-76. 2009
    ..This trial is registered with http://www.ClinicalTrials.gov under identifier NCT00057902...
  8. doi request reprint Expression of the interferon regulatory factor 8/ICSBP-1 in human reactive lymphoid tissues and B-cell lymphomas: a novel germinal center marker
    Antonio Martinez
    Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Surg Pathol 32:1190-200. 2008
    ..These results suggest an important role for IRF8 during germinal center B-cell development and in related lymphomas, and provide a new diagnostic marker helpful in distinguishing B-cell non-Hodgkin lymphoma subtypes...
  9. ncbi request reprint Clonal T-cell populations and increased risk for cytotoxic T-cell lymphomas in B-CLL patients: clinicopathologic observations and molecular analysis
    Antonio Martinez
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Surg Pathol 28:849-58. 2004
    ..PTCL following CLL should be distinguished from typical Richter syndrome, which it can mimic clinically...
  10. pmc Low-intensity therapy in adults with Burkitt's lymphoma
    Kieron Dunleavy
    From the Center for Cancer Research, National Cancer Institute, Bethesda, MD
    N Engl J Med 369:1915-25. 2013
    ..Current treatments are less effective and have more severe side effects in adults and patients with immunodeficiency than in children...
  11. ncbi request reprint Elevated serum-soluble interleukin-2 receptor levels in patients with anaplastic large cell lymphoma
    John E Janik
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 104:3355-7. 2004
    ..Serum sIL-2R levels were elevated in both patients with recurrent disease...
  12. ncbi request reprint Vaccine-induced tumor-specific immunity despite severe B-cell depletion in mantle cell lymphoma
    Sattva S Neelapu
    Experimental and Transplantation Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Med 11:986-91. 2005
    ..Based on these results, it is justifiable to administer vaccines in the setting of B-cell depletion; however, vaccine boosts after B-cell recovery may be necessary for optimal humoral responses...
  13. ncbi request reprint T-cell/histiocyte-rich large B-cell lymphoma: a heterogeneous entity with derivation from germinal center B cells
    Megan S Lim
    Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Surg Pathol 26:1458-66. 2002
    ..A subset of THRLBCL may be related to nodular lymphocyte predominance Hodgkin's lymphoma. A small percentage show features closely resembling classic Hodgkin's lymphoma and could be considered a variant of grey zone lymphoma...
  14. pmc Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone
    Andrew L Feldman
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892 1500, USA
    Blood 111:5433-9. 2008
    ..1 was seen in all cases tested. These results provide evidence for a common clonal origin of FL and H/DC neoplasms when occurring in the same patient, and suggest that lineage plasticity may occur in mature lymphoid neoplasms...
  15. ncbi request reprint Molecular diagnosis of Burkitt's lymphoma
    Sandeep S Dave
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 354:2431-42. 2006
    ..We examined whether gene-expression profiling could reliably distinguish Burkitt's lymphoma from diffuse large-B-cell lymphoma...
  16. ncbi request reprint Marginal zone lymphomas in children and the young adult population; characterization of genetic aberrations by FISH and RT-PCR
    Kathryn A Rizzo
    Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1500, USA
    Mod Pathol 23:866-73. 2010
    ..Overall the incidence of genetic aberrations in marginal zone lymphomas in the pediatric and young adult population is low, but the aberrations seen are similar to those seen in the adult population...
  17. pmc Nodal and extranodal plasmacytomas expressing immunoglobulin a: an indolent lymphoproliferative disorder with a low risk of clinical progression
    Haipeng Shao
    Laboratory of Pathology and the Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Surg Pathol 34:1425-35. 2010
    ..Our results suggest that IgA plasmacytomas may represent a distinct form of extramedullary plasmacytoma characterized by younger age at presentation, frequent lymph node involvement, and low risk of progression to plasma cell myeloma...
  18. doi request reprint Oncogenically active MYD88 mutations in human lymphoma
    Vu N Ngo
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Nature 470:115-9. 2011
    ....
  19. ncbi request reprint Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells
    Sandeep S Dave
    National Cancer Institute, NIH, Bethesda, MD 20892, USA
    N Engl J Med 351:2159-69. 2004
    ..We used gene-expression profiles of tumor-biopsy specimens obtained at diagnosis to develop a molecular predictor of the length of survival...
  20. pmc Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma
    Franziska C Eberle
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Haematologica 96:558-66. 2011
    ..Epigenetic changes have been implicated in the loss of the B-cell program in classical Hodgkin's lymphoma, and might provide a basis for the immunophenotypic alterations seen in mediastinal gray zone lymphoma...
  21. pmc Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma
    Richard L Piekarz
    Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health DHHS, 6130 Executive Blvd, Rockville, MD 20852, USA
    Blood 117:5827-34. 2011
    ..The histone deacetylase inhibitor romidepsin has single agent clinical activity associated with durable responses in patients with relapsed PTCL...
  22. doi request reprint Marginal zone lymphomas involving meningeal dura: possible link to IgG4-related diseases
    Girish Venkataraman
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mod Pathol 24:355-66. 2011
    ..Cytogenetic aberrations are present only in a minority of dural marginal zone lymphomas...
  23. doi request reprint Gray zone lymphoma: better treated like hodgkin lymphoma or mediastinal large B-cell lymphoma?
    Kieron Dunleavy
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, Rockville Pk, Bethesda, MD 20892, USA
    Curr Hematol Malig Rep 7:241-7. 2012
    ....
  24. pmc IG/MYC rearrangements are the main cytogenetic alteration in plasmablastic lymphomas
    Alexandra Valera
    Hematopathology Section, Laboratory of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Am J Surg Pathol 34:1686-94. 2010
    ..The oncogenic activation of MYC in these lymphomas may be an important pathogenetic element associated with EBV infection...
  25. pmc Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States
    Jeffrey I Cohen
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
    Blood 117:5835-49. 2011
    ..These studies are registered at http://www.clinicaltrials.gov as NCT00032513 for CAEBV, NCT00062868 and NCT00058812 for EBV-specific T-cell studies, and NCT00578539 for the hematopoietic stem cell transplantation protocol...
  26. ncbi request reprint Proteomic analysis of apoptotic pathways reveals prognostic factors in follicular lymphoma
    Christian Gulmann
    National Cancer Institute Food and Drug Administration Clinical Proteomics Program, Laboratory of Pathology, Bethesda, MD 20892, USA
    Clin Cancer Res 11:5847-55. 2005
    ..Proteomic end points should be incorporated in larger, multicenter trials to validate the clinical utility of these protein microarray findings...
  27. pmc Aberrant T-cell antigen expression in classical Hodgkin lymphoma is associated with decreased event-free survival and overall survival
    Girish Venkataraman
    Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 121:1795-804. 2013
    ..61, 6.84]; P = .001) and EFS (HRadj = 2.55 [95% CI: 1.45, 4.49]; P = .001). TCA-cHL often display NS histology, lack T-cell genotype, and are independently associated with significantly shorter OS and EFS compared with TCA-negative cHLs...
  28. pmc Follicular lymphomas in children and young adults: a comparison of the pediatric variant with usual follicular lymphoma
    Qingyan Liu
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Surg Pathol 37:333-43. 2013
    ..PFL associated with particular anatomic sites have distinctive features and should be evaluated separately in future clinical and biological studies...
  29. pmc Nodal involvement by cutaneous CD30-positive T-cell lymphoma mimicking classical Hodgkin lymphoma
    Franziska C Eberle
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Surg Pathol 36:716-25. 2012
    ..We show that cHL is less often associated with MF and primary cutaneous CD30-T-LPD than previously thought and that the coexpression of CD30 and CD15 in these TCLs may lead to a mistaken diagnosis of cHL...
  30. ncbi request reprint Similarities of prosurvival signals in Bcl-2-positive and Bcl-2-negative follicular lymphomas identified by reverse phase protein microarray
    Hongbin Zha
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Lab Invest 84:235-44. 2004
    ..The activation of the Akt/Bad pathway provides further evidence of prosurvival signals in FL, independent of Bcl-2 alone. These data suggest that nodal FL represents a single disease with a final common biochemical pathway...
  31. doi request reprint Gray zone lymphoma: chromosomal aberrations with immunophenotypic and clinical correlations
    Franziska C Eberle
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Mod Pathol 24:1586-97. 2011
    ....
  32. pmc Immunoguided laser assisted microdissection techniques for DNA methylation analysis of archival tissue specimens
    Franziska C Eberle
    Hematopathology Section, National Cancer Institute, National Institutes of Health, 8717 Grovemont Circle, Bethesda, MD 20892, USA
    J Mol Diagn 12:394-401. 2010
    ..7%; P < 0.05). These results demonstrate the validity and utility of the herein described protocol, which allows the application of ILAM for large-scale genomic and epigenetic analyses of archival tissue specimens...
  33. pmc Blastic plasmacytoid dendritic cell neoplasm in children: diagnostic features and clinical implications
    Armin G Jegalian
    Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Haematologica 95:1873-9. 2010
    ..Blastic plasmacytoid dendritic cell neoplasm is a rare malignancy that typically follows a highly aggressive clinical course in adults, whereas experience in children with this disease is very limited...
  34. doi request reprint Dose-adjusted EPOCH-rituximab therapy in primary mediastinal B-cell lymphoma
    Kieron Dunleavy
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 368:1408-16. 2013
    ..We aimed to develop a strategy that improves the rate of cure and obviates the need for radiotherapy...
  35. pmc Coexisting and clonally identical classic hodgkin lymphoma and nodular lymphocyte predominant hodgkin lymphoma
    Joo Y Song
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Am J Surg Pathol 35:767-72. 2011
    ..NLPHL and cHL are 2 distinct diseases and are almost never seen concurrently. We present a case in which polymerase chain reaction analysis indicated that the tumor cells of these 2 distinct entities were clonally identical...
  36. ncbi request reprint Peripheral T-cell lymphomas expressing CD30 and CD15
    Todd S Barry
    Hematopathology Section, Laboratory of Pathology, National Cancer Intitute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Surg Pathol 27:1513-22. 2003
    ..In some PTCL cases, the overlap with classic HL can be striking, and combined immunophenotypic and molecular studies are often necessary to confirm the diagnosis...
  37. pmc Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways
    Georg Lenz
    Metabolism Branch, Biometric Research Branch, Center for Information Technology, and Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:13520-5. 2008
    ..Together, these data provide genetic evidence that the DLBCL subtypes are distinct diseases that use different oncogenic pathways...
  38. pmc Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics
    Roland Schmitz
    Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Nature 490:116-20. 2012
    ..In 38% of sporadic BL cases, oncogenic CCND3 mutations produced highly stable cyclin D3 isoforms that drive cell cycle progression. These findings suggest opportunities to improve therapy for patients with BL...
  39. ncbi request reprint IgD positive L&H cells identify a unique subset of nodular lymphocyte predominant Hodgkin lymphoma
    Sonam Prakash
    Laboratory of Pathology, Hematopathology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Surg Pathol 30:585-92. 2006
    ..IgD positivity may represent an additional useful marker in the diagnosis of NLPHL...
  40. ncbi request reprint High incidence of occult leptomeningeal disease detected by flow cytometry in newly diagnosed aggressive B-cell lymphomas at risk for central nervous system involvement: the role of flow cytometry versus cytology
    Upendra Hegde
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda, MD 20892 1868, USA
    Blood 105:496-502. 2005
    ..Patients at risk for CNS spread should undergo staging CSF evaluation by flow cytometry...
  41. pmc EBV may be expressed in the LP cells of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) in both children and adults
    Alison R Huppmann
    National Cancer Institute, Bethesda, MD Massachusetts General Hospital, Boston, MA British Columbia Cancer Agency, Vancouver, BC, Canada
    Am J Surg Pathol 38:316-24. 2014
    ..However, the overall appearance and maintenance of B-cell phenotype, with strong and diffuse CD20 and OCT-2 expression, support the diagnosis of NLPHL in these cases...
  42. pmc Development of disseminated histiocytic sarcoma in a patient with autoimmune lymphoproliferative syndrome and associated Rosai-Dorfman disease
    Girish Venkataraman
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Surg Pathol 34:589-94. 2010
    ..Given the central role of defective Fas signaling in ALPS, histiocytes may be yet another lineage at risk for neoplastic transformation secondary to a block in apoptosis...
  43. ncbi request reprint Highly effective treatment of acquired immunodeficiency syndrome-related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biology
    Richard F Little
    Center for Cancer Research CCR, National Cancer Institute NCI, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:4653-9. 2003
    ..These results suggest that tumor pathogenesis is responsible for the improved outcome of ARLs in the era of HAART...
  44. ncbi request reprint Fluorodeoxyglucose positron emission tomography (FDG-PET) for monitoring lymphadenopathy in the autoimmune lymphoproliferative syndrome (ALPS)
    V Koneti Rao
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1888, USA
    Am J Hematol 81:81-5. 2006
    ....
  45. pmc Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma
    Andreas Rosenwald
    Metabolism Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
    J Exp Med 198:851-62. 2003
    ..The molecular diagnosis of PMBL should significantly aid in the development of therapies tailored to this clinically and pathogenetically distinctive subgroup of DLBCL...
  46. ncbi request reprint ALK-positive large B-cell lymphomas express a terminal B-cell differentiation program and activated STAT3 but lack MYC rearrangements
    Alexandra Valera
    Hematopathology Section, Laboratory of Pathology, Hospital Clinic de Barcelona, Insititut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Mod Pathol 26:1329-37. 2013
    ..The relevance of the ALK/STAT3 pathway in the pathogenesis of ALK-positive large B-cell lymphomas may offer an attractive target for new therapies. ..
  47. pmc Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival
    Adrian Wiestner
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Blood 109:4599-606. 2007
    ..We conclude that alterations of CCND1 3'UTR structure can significantly increase its oncogenic effect and worsen the clinical course of MCL patients...
  48. pmc Gall bladder and extrahepatic bile duct lymphomas: clinicopathological observations and biological implications
    Haresh Mani
    The Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Surg Pathol 34:1277-86. 2010
    ..31%). In conclusion, primary lymphomas of the gall bladder and extrahepatic bile ducts show a broad spectrum of disease types, but in many respects mirror the spectrum of primary lymphomas of the gastrointestinal tract...
  49. pmc Peripheral T-cell lymphomas of follicular T-helper cell derivation with Hodgkin/Reed-Sternberg cells of B-cell lineage: both EBV-positive and EBV-negative variants exist
    Alina Nicolae
    Hematopathology Section Molecular Diagnostics Unit, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Surg Pathol 37:816-26. 2013
    ....
  50. pmc Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
    R Eric Davis
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 463:88-92. 2010
    ..These findings establish chronic active BCR signalling as a new pathogenetic mechanism in ABC DLBCL, suggesting several therapeutic strategies...
  51. ncbi request reprint Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma
    Alexandra Traverse-Glehen
    Hematopathology Section, Laboratory of Pathology, National Institutes of Health, Bethesda, MD, USA
    Am J Surg Pathol 29:1411-21. 2005
    ..Further support for a relationship between MLBCL and cHL-NS is provided by composite and metachronous lymphomas in the same patient, as well as the existence of MGZL with transitional morphology and phenotype...
  52. pmc Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma
    Martina Rudelius
    Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Blood 108:1668-76. 2006
    ..One possible mechanism of activation is loss of PTEN expression. These data suggest that PI3K/Akt inhibitors may be effective in the treatment of Akt-activated MCL...
  53. ncbi request reprint Dose-adjusted EPOCH chemotherapy for untreated large B-cell lymphomas: a pharmacodynamic approach with high efficacy
    Wyndham H Wilson
    Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 99:2685-93. 2002
    ..Dose-adjusted EPOCH may produce more cell kill than CHOP-based regimens. Dynamic dose adjustment may overcome inadequate drug concentrations, particularly in younger patients, and compensate for increased drug clearance over time...
  54. ncbi request reprint The pathology of NK-cell lymphomas and leukemias
    Victor E Nava
    Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Adv Anat Pathol 12:27-34. 2005
    ..Benign proliferations of NK cells can be seen in association with viral infection. The disease formerly referred to as blastic NK-cell lymphoma is now considered to be a malignancy derived from a dendritic cell precursor...
  55. doi request reprint Primary mediastinal large B-cell lymphoma, classic Hodgkin lymphoma presenting in the mediastinum, and mediastinal gray zone lymphoma: what is the oncologist to do?
    Cliona Grant
    Metabolism Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Hematol Malig Rep 6:157-63. 2011
    ..Historical data indicate that they have done poorly with traditional approaches developed for the treatment of either CHL or diffuse large B-cell lymphoma...
  56. pmc Human herpesvirus-6-associated acute lymphadenitis in immunocompetent adults
    Irina Maric
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mod Pathol 17:1427-33. 2004
    ..This is the first report that documents distinctive histologic features of HHV-6 lymphadenitis and demonstrates that the cells harboring the virus in vivo are CD4-positive T lymphocytes...
  57. ncbi request reprint Recommendations for the reporting of lymphoid neoplasms: a report from the Association of Directors of Anatomic and Surgical Pathology
    Elaine S Jaffe
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892 1500, USA
    Mod Pathol 17:131-5. 2004
    ..Ancillary studies are often required, and the Association recommends that immunophenotypic and genotypic information be integrated into the final report, to the extent possible...
  58. pmc Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS
    Robert J Biggar
    Viral Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd, Rm EPS 7074, Bethesda, MD 20852, USA
    Blood 108:3786-91. 2006
    ..With more severe immunosuppression, nodular sclerosing HL becomes infrequent, explaining the higher proportion of mixed cellularity HL found in PWAs. Pathogenesis implications are discussed...
  59. pmc The histological and biological spectrum of diffuse large B-cell lymphoma in the World Health Organization classification
    Madhu P Menon
    Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer J 18:411-20. 2012
    ..Ongoing investigations at the genomic level, with both exome and whole-genome sequencing, are sure to reveal new pathways of transformation in the future...
  60. pmc Hodgkin lymphoma: an update on its biology with new insights into classification
    Haresh Mani
    Laboratory of Pathology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Lymphoma Myeloma 9:206-16. 2009
    ..Nodular sclerosis HL might also be related to primary mediastinal B-cell lymphoma and mediastinal gray-zone lymphomas. We present an update on the pathobiology of HL and discuss these biologic and clinical differences in this review...
  61. pmc Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome
    Kennichi C Dowdell
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1888, USA
    Blood 115:5164-9. 2010
    ..These findings also highlight the potential role for somatic mutations in the pathogenesis of nonmalignant and/or autoimmune hematologic conditions in adults and children...
  62. ncbi request reprint Marginal zone B-cell lymphoma in children and young adults
    Lekidelu Taddesse-Heath
    Hemopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Am J Surg Pathol 27:522-31. 2003
    ..We conclude that EMZL in children and young adults are similar to EMZL of mucosa-associated lymphoma tissue occurring in older patients. However, pediatric NMZL appear to have distinctive clinical and histologic features...
  63. ncbi request reprint Histologic features of sinus histiocytosis with massive lymphadenopathy in patients with autoimmune lymphoproliferative syndrome
    Irina Maric
    Hematopathology Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Am J Surg Pathol 29:903-11. 2005
    ..It remains to be determined if some cases of apparently sporadic SHML may be associated with heritable defects in Fas-mediated apoptosis...
  64. ncbi request reprint Gamma-delta T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma
    Jorge R Toro
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7231, USA
    Blood 101:3407-12. 2003
    ..067). No other prognostic factors were identified as having a notable association with outcome in this subgroup. TCR delta 1 expression in primary cutaneous lymphomas is an independent prognostic factor associated with decreased survival...
  65. pmc Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma
    Georg Lenz
    Metabolism Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 204:633-43. 2007
    ..Accordingly, aberrant switch recombination was responsible for translocations in ABC DLBCLs involving BCL6, MYC, and a novel translocation partner, SPIB...
  66. ncbi request reprint The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
    Andreas Rosenwald
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 346:1937-47. 2002
    ..The survival of patients with diffuse large-B-cell lymphoma after chemotherapy is influenced by molecular features of the tumors. We used the gene-expression profiles of these lymphomas to develop a molecular predictor of survival...
  67. ncbi request reprint Sequestration of p27Kip1 protein by cyclin D1 in typical and blastic variants of mantle cell lymphoma (MCL): implications for pathogenesis
    Leticia Quintanilla-Martinez
    Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:3181-7. 2003
    ....
  68. ncbi request reprint In situ localization of follicular lymphoma: description and analysis by laser capture microdissection
    Peijie Cong
    Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Blood 99:3376-82. 2002
    ..These findings provide insight into the pathophysiology of early FL, and illustrate the utility of immunohistochemistry for early diagnosis...
  69. pmc Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop
    Joao B Oliveira
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 116:e35-40. 2010
    ..It is hoped that harmonizing the diagnosis and classification of ALPS will foster collaborative research and better understanding of the pathogenesis of autoimmune cytopenias and B-cell lymphomas...
  70. pmc The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications
    Elias Campo
    Hematopathology Section, Department of Anatomic Pathology, Hospital Clinic, Institute of Biomedical Research August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Blood 117:5019-32. 2011
    ..The issue of borderline categories having overlapping features with large B-cell lymphomas, as well as several provisional entities, is reviewed. These new observations chart a course for future research in the field...
  71. pmc Automatic classification of lymphoma images with transform-based global features
    Nikita V Orlov
    National Institute on Aging, NIH, Baltimore, MD 21224, USA
    IEEE Trans Inf Technol Biomed 14:1003-13. 2010
    ..The best signal (98%-99% on earlier unseen images) was found for the HE, H, and E channels of the H&E data set...
  72. pmc Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma
    Richard L Piekarz
    Departmentof Health and Human Services, Center for Cancer Researchand Cancer Therapy EvaluationProgram, National Cancer Institute, National Institutes of Health, Bethesda, USA
    J Clin Oncol 27:5410-7. 2009
    ..The median duration of response was 13.7 months. CONCLUSION The histone deacetylase inhibitor romidepsin has single-agent clinical activity with significant and durable responses in patients with CTCL...
  73. ncbi request reprint Bethesda proposals for classification of lymphoid neoplasms in mice
    Herbert C Morse
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0760, USA
    Blood 100:246-58. 2002
    ..The classification should facilitate communications about mouse models of human lymphoid diseases...
  74. ncbi request reprint Clonal relationship between precursor T-lymphoblastic leukaemia/lymphoma and Langerhans-cell histiocytosis
    Andrew L Feldman
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Lancet Oncol 6:435-7. 2005
  75. ncbi request reprint Second cancer incidence and cause-specific mortality among 3104 patients with hairy cell leukemia: a population-based study
    Michie Hisada
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 8008, Bethesda, MD 20892 7201, USA
    J Natl Cancer Inst 99:215-22. 2007
    ..The available evidence is conflicting, with most risk estimates based on sparse numbers. To our knowledge, no study has evaluated cause-specific mortality in patients with hairy cell leukemia...
  76. doi request reprint Why is it crucial to reintegrate pathology into cancer research?
    Jaime Rodriguez-Canales
    Laser Capture Microdissection Core and Pathogenetics Unit, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Bioessays 33:490-8. 2011
    ....
  77. ncbi request reprint Histiocytic sarcoma after acute lymphoblastic leukaemia: a common clonal origin
    Andrew L Feldman
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Lancet Oncol 5:248-50. 2004
  78. doi request reprint Mycosis fungoides and Sézary syndrome
    Sam T Hwang
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, USA
    Lancet 371:945-57. 2008
    ....
  79. ncbi request reprint Immunoblastic lymphoma in persons with AIDS-associated Kaposi's sarcoma: a role for Kaposi's sarcoma-associated herpesvirus
    Eric A Engels
    Viral Epidemiology Branch, Division of Cancer and Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
    Mod Pathol 16:424-9. 2003
    ..We conclude that Kaposi's sarcoma-associated herpesvirus is present in some immunoblastic lymphomas in persons with AIDS-associated Kaposi's sarcoma...
  80. ncbi request reprint Lymphomatoid granulomatosis: abnormalities of the brain at MR imaging
    Athos D Patsalides
    Department of Diagnostic Radiology, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bldg 10, Room 1C660, 9000 Rockville Pike, Bethesda, MD 20892 1182, USA
    Radiology 237:265-73. 2005
    ..To retrospectively evaluate the magnetic resonance (MR) imaging features of lymphomatoid granulomatosis in the brain...
  81. pmc Risk factors for lymphoproliferative disorders after allogeneic hematopoietic cell transplantation
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Blood 113:4992-5001. 2009
    ..Our findings identify subgroups of patients who underwent allogeneic HCT at elevated risk of PTLDs for whom prospective monitoring of Epstein-Barr virus activation and early treatment intervention may be particularly beneficial...
  82. doi request reprint Large-scale profiling of archival lymph nodes reveals pervasive remodeling of the follicular lymphoma methylome
    J Keith Killian
    Genetics Branch, Laboratory of Pathology, NIH National Cancer Institute, Bethesda, Maryland, USA
    Cancer Res 69:758-64. 2009
    ..Analysis of the DMT profile is consistent with a pervasive epigenomic remodeling process in FL that affects predominantly nonlymphoid genes...
  83. pmc Classification of lymphoid neoplasms: the microscope as a tool for disease discovery
    Elaine S Jaffe
    Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 112:4384-99. 2008
    ..In addition, accurate and precise classification of disease entities facilitates the discovery of the molecular basis of lymphoid neoplasms in the basic science laboratory...
  84. pmc IL-4 protein expression and basal activation of Erk in vivo in follicular lymphoma
    Katherine R Calvo
    Hematopathology Section, Laboratory of Pathology LP, NIH Clinical Center, Department of Laboratory Medicine, 10 Center Drive, Bldg 10 2C306, Bethesda, MD 20892 1500, USA
    Blood 112:3818-26. 2008
    ..These findings suggest IL-4, Erk, and possibly Stat-6 may play a role in the biology of FL and may serve as targets for future therapies...
  85. ncbi request reprint Anti-tumor activities of the angiogenesis inhibitors interferon-inducible protein-10 and the calreticulin fragment vasostatin
    Lei Yao
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 12N226 MSC 1907, 10 Center Drive, Bethesda, MD, USA
    Cancer Immunol Immunother 51:358-66. 2002
    ....
  86. ncbi request reprint Molecular profiling provides evidence of primary mediastinal large B-cell lymphoma as a distinct entity related to classic Hodgkin lymphoma: implications for mediastinal gray zone lymphomas as an intermediate form of B-cell lymphoma
    Katherine R Calvo
    Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Adv Anat Pathol 11:227-38. 2004
    ....
  87. ncbi request reprint CD5+ follicular lymphoma: a clinicopathologic study of three cases
    Todd S Barry
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Clin Pathol 118:589-98. 2002
    ..These cases highlight the difficulty classifying these lymphomas by flow cytometric studies alone and emphasize the importance of recognizing FL in the differential diagnosis of CD5+ B-cell lymphomas...
  88. ncbi request reprint An immunohistochemical study of the bone marrow lesions of systemic mastocytosis: expression of stem cell factor by lesional mast cells
    Cem Akin
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1881, USA
    Am J Clin Pathol 118:242-7. 2002
    ....
  89. ncbi request reprint Mature T-cell and NK-cell lymphomas in the pediatric age group
    Elaine S Jaffe
    Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 1500, USA
    Am J Clin Pathol 122:S110-21. 2004
    ..This early component of the immune system might be targeted more often in pediatric hematologic malignant neoplasms, whereas tumors of the more mature adaptive immune system are more rare in children...
  90. doi request reprint Histopathology of Hodgkin's lymphoma
    Franziska C Eberle
    Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Cancer J 15:129-37. 2009
    ..We present an update on the histopathological features of Hodgkin's lymphoma and the immunohistochemical tools available for diagnosis in the clinical setting...
  91. ncbi request reprint Diffuse large B-cell lymphomas with plasmablastic differentiation represent a heterogeneous group of disease entities
    Lluis Colomo
    Hematopathology Section, Laboratory of Pathology, and Department of Hematology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Am J Surg Pathol 28:736-47. 2004
    ..In conclusion, DLBCLs with plasmablastic differentiation are a heterogeneous group of neoplasms with different clinicopathological characteristics that may correspond to different entities...
  92. ncbi request reprint Periodic fever with atypical dyshidrosis--quiz case
    Elektra J Papadopoulos
    National Institutes of Health, Bethesda, MD, USA
    Arch Dermatol 140:479-84. 2004
  93. ncbi request reprint BCL2 expression is a prognostic marker for the activated B-cell-like type of diffuse large B-cell lymphoma
    Javeed Iqbal
    Leukemia Lymphoma Molecular Profiling Project, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    J Clin Oncol 24:961-8. 2006
    ..DLBCL is heterogeneous, and the expression of BCL2 is variable within the two major subgroups of DLBCL, germinal center B-cell-like (GCB) and activated B-cell-like (ABC) DLBCL, as well as primary mediastinal DLBCL...
  94. ncbi request reprint IgVH mutational status and clonality analysis of Richter's transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution
    Zhengrong Mao
    Institute of Pathology, University of Wurzburg, Germany
    Am J Surg Pathol 31:1605-14. 2007
    ..HRS or HRS-like cells in all 3 unrelated cases showed evidence of Epstein-Barr virus infection. Of interest, 5/6 cases of B-CLL with HL, and 5/6 cases of B-CLL with HRS cells showed mutated IgVH genes...
  95. ncbi request reprint ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project
    Kerry J Savage
    Department of Medical Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada
    Blood 111:5496-504. 2008
    ..Although the prognosis of ALK(-) ALCL appears to be better than that for PTCL-NOS, it is still unsatisfactory and better therapies are needed. Primary cutaneous ALCL is associated with an indolent course...
  96. ncbi request reprint The serine protease granzyme M is preferentially expressed in NK-cell, gamma delta T-cell, and intestinal T-cell lymphomas: evidence of origin from lymphocytes involved in innate immunity
    Laszlo Krenacs
    Laboratory of Tumor Pathology and Molecular Diagnostics, Institute for Biotechnology, Bay Zoltan Foundation for Applied Research, Szeged, Hungary
    Blood 101:3590-3. 2003
    ..We conclude that GM expression is a distinctive feature of the nasal NK/T-cell, gamma delta T-cell, and intestinal T-cell lymphomas, and suggest that these tumors develop from lymphocytes involved in innate immunity...
  97. pmc Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study
    Ken H Young
    Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, University of of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, USA
    Blood 112:3088-98. 2008
    ..This study shows the prognostic importance of mutations in the TP53 DNA-binding domains in patients with DLBCL...
  98. pmc Comprehensive analysis of GST-pi expression in B-cell lymphomas: Correlation with histological subtypes and survival
    Catherine Thieblemont
    Leuk Lymphoma 49:1403-6. 2008
  99. pmc Lymphomatoid granulomatosis with involvement of the hard palate: a case report
    Rabie M Shanti
    Department of Oral and Maxillofacial Surgery, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
    J Oral Maxillofac Surg 66:2161-3. 2008
  100. ncbi request reprint Unusual immunophenotype of CD8+ T cells in familial hemophagocytic lymphohistiocytosis
    Nitin J Karandikar
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 75390 9072, USA
    Blood 104:2007-9. 2004
    ..This case provides an instructive example of uncontrolled reactive proliferation of CD8+ T cells in FHL, resulting in atypical morphology and unusual immunophenotypic features that might suggest malignancy in other clinical settings...
  101. pmc BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma
    Javeed Iqbal
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Am J Pathol 165:159-66. 2004
    ..However, despite this higher proliferative activity, there was no significant difference in overall or failure-free survival between the t(14;18)-positive and -negative subsets within the GCB subgroup...