Research Topics
Species | Elaine S JaffeSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphomaChung Che Chang
Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston TX, USA
J Hematol Oncol 2:47. 2009..The goal of the current study was to evaluate the genetic similarities and differences among PL, DLBCL (AIDS-related and non AIDS-related) and PCM using array-based comparative genomic hybridization...
Lymphoid lesions of the head and neck: a model of lymphocyte homing and lymphomagenesisElaine S Jaffe
Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA
Mod Pathol 15:255-63. 2002..Lymphomatoid granulomatosis is common in the lung but is rarely seen in the midline facial structures...- Highly effective treatment of acquired immunodeficiency syndrome-related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biologyRichard F Little
Center for Cancer Research (CCR, National Cancer Institute (NCI, National Institutes of Health, Bethesda, MD 20892, USA
Blood 101:4653-9. 2003..These results suggest that tumor pathogenesis is responsible for the improved outcome of ARLs in the era of HAART... - Dose-adjusted EPOCH chemotherapy for untreated large B-cell lymphomas: a pharmacodynamic approach with high efficacyWyndham H Wilson
Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Blood 99:2685-93. 2002..Dose-adjusted EPOCH may produce more cell kill than CHOP-based regimens. Dynamic dose adjustment may overcome inadequate drug concentrations, particularly in younger patients, and compensate for increased drug clearance over time... - The role of tumor histogenesis, FDG-PET, and short-course EPOCH with dose-dense rituximab (SC-EPOCH-RR) in HIV-associated diffuse large B-cell lymphomaKieron Dunleavy
Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Blood 115:3017-24. 2010..However, new therapeutic advances are needed for non-GCB DLBCL, which remains the important cause of lymphoma-specific death. This trial was registered at www.clinicaltrials.gov as NCT000019253... - Similarities of prosurvival signals in Bcl-2-positive and Bcl-2-negative follicular lymphomas identified by reverse phase protein microarrayHongbin Zha
Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Lab Invest 84:235-44. 2004..The activation of the Akt/Bad pathway provides further evidence of prosurvival signals in FL, independent of Bcl-2 alone. These data suggest that nodal FL represents a single disease with a final common biochemical pathway... - The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphomaAndreas Rosenwald
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
N Engl J Med 346:1937-47. 2002..CONCLUSIONS: DNA microarrays can be used to formulate a molecular predictor of survival after chemotherapy for diffuse large-B-cell lymphoma... - T-cell/histiocyte-rich large B-cell lymphoma: a heterogeneous entity with derivation from germinal center B cellsMegan S Lim
Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Am J Surg Pathol 26:1458-66. 2002..A subset of THRLBCL may be related to nodular lymphocyte predominance Hodgkin's lymphoma. A small percentage show features closely resembling classic Hodgkin's lymphoma and could be considered a variant of grey zone lymphoma... 
Marginal zone lymphomas in children and the young adult population; characterization of genetic aberrations by FISH and RT-PCRKathryn A Rizzo
Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1500, USA
Mod Pathol 23:866-73. 2010..Overall the incidence of genetic aberrations in marginal zone lymphomas in the pediatric and young adult population is low, but the aberrations seen are similar to those seen in the adult population...- Molecular diagnosis of Burkitt's lymphomaSandeep S Dave
National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
N Engl J Med 354:2431-42. 2006..CONCLUSIONS: Gene-expression profiling is an accurate, quantitative method for distinguishing Burkitt's lymphoma from diffuse large-B-cell lymphoma... - Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphomaAndreas Rosenwald
Metabolism Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
J Exp Med 198:851-62. 2003..The molecular diagnosis of PMBL should significantly aid in the development of therapies tailored to this clinically and pathogenetically distinctive subgroup of DLBCL... - Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphomaKieron Dunleavy
Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Blood 113:6069-76. 2009..This trial is registered with http://www.ClinicalTrials.gov under identifier NCT00057902... - In situ localization of follicular lymphoma: description and analysis by laser capture microdissectionPeijie Cong
Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
Blood 99:3376-82. 2002..These findings provide insight into the pathophysiology of early FL, and illustrate the utility of immunohistochemistry for early diagnosis... - Sequestration of p27Kip1 protein by cyclin D1 in typical and blastic variants of mantle cell lymphoma (MCL): implications for pathogenesisLeticia Quintanilla-Martinez
Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 101:3181-7. 2003.... - Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphomaFranziska C Eberle
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Haematologica 96:558-66. 2011..Epigenetic changes have been implicated in the loss of the B-cell program in classical Hodgkin's lymphoma, and might provide a basis for the immunophenotypic alterations seen in mediastinal gray zone lymphoma... - Hodgkin lymphoma: an update on its biology with new insights into classificationHaresh Mani
Laboratory of Pathology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
Clin Lymphoma Myeloma 9:206-16. 2009..Nodular sclerosis HL might also be related to primary mediastinal B-cell lymphoma and mediastinal gray-zone lymphomas. We present an update on the pathobiology of HL and discuss these biologic and clinical differences in this review... - Risk factors for lymphoproliferative disorders after allogeneic hematopoietic cell transplantationOla Landgren
Division of Cancer Epidemiology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Blood 113:4992-5001. 2009..Our findings identify subgroups of patients who underwent allogeneic HCT at elevated risk of PTLDs for whom prospective monitoring of Epstein-Barr virus activation and early treatment intervention may be particularly beneficial... - Lymphomatoid granulomatosis: abnormalities of the brain at MR imagingAthos D Patsalides
Department of Diagnostic Radiology, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bldg 10, Room 1C660, 9000 Rockville Pike, Bethesda, MD 20892 1182, USA
Radiology 237:265-73. 2005..To retrospectively evaluate the magnetic resonance (MR) imaging features of lymphomatoid granulomatosis in the brain... - Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphomaRichard L Piekarz
Departmentof Health and Human Services, Center for Cancer Researchand Cancer Therapy EvaluationProgram, National Cancer Institute, National Institutes of Health, Bethesda, USA
J Clin Oncol 27:5410-7. 2009..The median duration of response was 13.7 months. CONCLUSION The histone deacetylase inhibitor romidepsin has single-agent clinical activity with significant and durable responses in patients with CTCL... - Clonal relationship between precursor T-lymphoblastic leukaemia/lymphoma and Langerhans-cell histiocytosisAndrew L Feldman
Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
Lancet Oncol 6:435-7. 2005 - Large-scale profiling of archival lymph nodes reveals pervasive remodeling of the follicular lymphoma methylomeJ Keith Killian
Genetics Branch, Laboratory of Pathology, NIH National Cancer Institute, Bethesda, Maryland, USA
Cancer Res 69:758-64. 2009..Analysis of the DMT profile is consistent with a pervasive epigenomic remodeling process in FL that affects predominantly nonlymphoid genes... - Fluorodeoxyglucose positron emission tomography (FDG-PET) for monitoring lymphadenopathy in the autoimmune lymphoproliferative syndrome (ALPS)V Koneti Rao
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1888, USA
Am J Hematol 81:81-5. 2006.... - Classification of lymphoid neoplasms: the microscope as a tool for disease discoveryElaine S Jaffe
Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Blood 112:4384-99. 2008..In addition, accurate and precise classification of disease entities facilitates the discovery of the molecular basis of lymphoid neoplasms in the basic science laboratory... - Mycosis fungoides and Sézary syndromeSam T Hwang
Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, USA
Lancet 371:945-57. 2008.... - Phase II study of dose-adjusted EPOCH and rituximab in untreated diffuse large B-cell lymphoma with analysis of germinal center and post-germinal center biomarkersWyndham H Wilson
Metabolism Branch, National Cancer Institute, Building 10, 9000 Rockville Pike, Bethesda, MD 20892, USA
J Clin Oncol 26:2717-24. 2008.... - Expression of the interferon regulatory factor 8/ICSBP-1 in human reactive lymphoid tissues and B-cell lymphomas: a novel germinal center markerAntonio Martinez
Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
Am J Surg Pathol 32:1190-200. 2008..These results suggest an important role for IRF8 during germinal center B-cell development and in related lymphomas, and provide a new diagnostic marker helpful in distinguishing B-cell non-Hodgkin lymphoma subtypes... - Second cancer incidence and cause-specific mortality among 3104 patients with hairy cell leukemia: a population-based studyMichie Hisada
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 8008, Bethesda, MD 20892 7201, USA
J Natl Cancer Inst 99:215-22. 2007..The available evidence is conflicting, with most risk estimates based on sparse numbers. To our knowledge, no study has evaluated cause-specific mortality in patients with hairy cell leukemia... - IL-4 protein expression and basal activation of Erk in vivo in follicular lymphomaKatherine R Calvo
Hematopathology Section, Laboratory of Pathology LP, NIH Clinical Center, Department of Laboratory Medicine, 10 Center Drive, Bldg 10 2C306, Bethesda, MD 20892 1500, USA
Blood 112:3818-26. 2008..These findings suggest IL-4, Erk, and possibly Stat-6 may play a role in the biology of FL and may serve as targets for future therapies... - Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDSRobert J Biggar
Viral Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd, Rm EPS 7074, Bethesda, MD 20852, USA
Blood 108:3786-91. 2006..With more severe immunosuppression, nodular sclerosing HL becomes infrequent, explaining the higher proportion of mixed cellularity HL found in PWAs. Pathogenesis implications are discussed... - Proteomic analysis of apoptotic pathways reveals prognostic factors in follicular lymphomaChristian Gulmann
National Cancer Institute--Food and Drug Administration Clinical Proteomics Program, Laboratory of Pathology, Bethesda, MD 20892, USA
Clin Cancer Res 11:5847-55. 2005..Proteomic end points should be incorporated in larger, multicenter trials to validate the clinical utility of these protein microarray findings... - IgD positive L&H cells identify a unique subset of nodular lymphocyte predominant Hodgkin lymphomaSonam Prakash
Laboratory of Pathology, Hematopathology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Am J Surg Pathol 30:585-92. 2006..IgD positivity may represent an additional useful marker in the diagnosis of NLPHL... - Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathwaysGeorg Lenz
Metabolism Branch, Biometric Research Branch, Center for Information Technology, and Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 105:13520-5. 2008..Together, these data provide genetic evidence that the DLBCL subtypes are distinct diseases that use different oncogenic pathways... - Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma cloneAndrew L Feldman
Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892 1500, USA
Blood 111:5433-9. 2008..1 was seen in all cases tested. These results provide evidence for a common clonal origin of FL and H/DC neoplasms when occurring in the same patient, and suggest that lineage plasticity may occur in mature lymphoid neoplasms... - Bethesda proposals for classification of lymphoid neoplasms in miceHerbert C Morse
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0760, USA
Blood 100:246-58. 2002..The classification should facilitate communications about mouse models of human lymphoid diseases... - Peripheral T-cell lymphomas expressing CD30 and CD15Todd S Barry
Hematopathology Section, Laboratory of Pathology, National Cancer Intitute, National Institutes of Health, Bethesda, MD 20892, USA
Am J Surg Pathol 27:1513-22. 2003..In some PTCL cases, the overlap with classic HL can be striking, and combined immunophenotypic and molecular studies are often necessary to confirm the diagnosis... - Immunoblastic lymphoma in persons with AIDS-associated Kaposi's sarcoma: a role for Kaposi's sarcoma-associated herpesvirusEric A Engels
Viral Epidemiology Branch, Division of Cancer and Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
Mod Pathol 16:424-9. 2003..We conclude that Kaposi's sarcoma-associated herpesvirus is present in some immunoblastic lymphomas in persons with AIDS-associated Kaposi's sarcoma... - The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applicationsElias Campo
Hematopathology Section, Department of Anatomic Pathology, Hospital Clinic, Institute of Biomedical Research August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
Blood 117:5019-32. 2011..The issue of borderline categories having overlapping features with large B-cell lymphomas, as well as several provisional entities, is reviewed. These new observations chart a course for future research in the field... - Phase 2 trial of romidepsin in patients with peripheral T-cell lymphomaRichard L Piekarz
Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health DHHS, 6130 Executive Blvd, Rockville, MD 20852, USA
Blood 117:5827-34. 2011..The histone deacetylase inhibitor romidepsin has single agent clinical activity associated with durable responses in patients with relapsed PTCL... - Gamma-delta T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphomaJorge R Toro
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7231, USA
Blood 101:3407-12. 2003..067). No other prognostic factors were identified as having a notable association with outcome in this subgroup. TCR delta 1 expression in primary cutaneous lymphomas is an independent prognostic factor associated with decreased survival... - Why is it crucial to reintegrate pathology into cancer research?Jaime Rodriguez-Canales
Laser Capture Microdissection Core and Pathogenetics Unit, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Bioessays 33:490-8. 2011.... - Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United StatesJeffrey I Cohen
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA
Blood 117:5835-49. 2011..These studies are registered at http://www.clinicaltrials.gov as NCT00032513 for CAEBV, NCT00062868 and NCT00058812 for EBV-specific T-cell studies, and NCT00578539 for the hematopoietic stem cell transplantation protocol... - Anti-tumor activities of the angiogenesis inhibitors interferon-inducible protein-10 and the calreticulin fragment vasostatinLei Yao
Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 12N226 MSC 1907, 10 Center Drive, Bethesda, MD, USA
Cancer Immunol Immunother 51:358-66. 2002.... - Recommendations for the reporting of lymphoid neoplasms: a report from the Association of Directors of Anatomic and Surgical PathologyElaine S Jaffe
Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892 1500, USA
Mod Pathol 17:131-5. 2004..Ancillary studies are often required, and the Association recommends that immunophenotypic and genotypic information be integrated into the final report, to the extent possible... - Histiocytic sarcoma after acute lymphoblastic leukaemia: a common clonal originAndrew L Feldman
Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
Lancet Oncol 5:248-50. 2004 - Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cellsSandeep S Dave
National Cancer Institute, NIH, Bethesda, MD 20892, USA
N Engl J Med 351:2159-69. 2004..CONCLUSIONS: The length of survival among patients with follicular lymphoma correlates with the molecular features of nonmalignant immune cells present in the tumor at diagnosis... - Clonal T-cell populations and increased risk for cytotoxic T-cell lymphomas in B-CLL patients: clinicopathologic observations and molecular analysisAntonio Martinez
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Am J Surg Pathol 28:849-58. 2004..PTCL following CLL should be distinguished from typical Richter syndrome, which it can mimic clinically... - Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndromeKennichi C Dowdell
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1888, USA
Blood 115:5164-9. 2010..These findings also highlight the potential role for somatic mutations in the pathogenesis of nonmalignant and/or autoimmune hematologic conditions in adults and children... - Elevated serum-soluble interleukin-2 receptor levels in patients with anaplastic large cell lymphomaJohn E Janik
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Blood 104:3355-7. 2004..Serum sIL-2R levels were elevated in both patients with recurrent disease... - Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International WorkshopJoao B Oliveira
Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
Blood 116:e35-40. 2010..It is hoped that harmonizing the diagnosis and classification of ALPS will foster collaborative research and better understanding of the pathogenesis of autoimmune cytopenias and B-cell lymphomas... - Automatic classification of lymphoma images with transform-based global featuresNikita V Orlov
National Institute on Aging, NIH, Baltimore, MD 21224, USA
IEEE Trans Inf Technol Biomed 14:1003-13. 2010..The best signal (98%-99% on earlier unseen images) was found for the HE, H, and E channels of the H&E data set... - Development of disseminated histiocytic sarcoma in a patient with autoimmune lymphoproliferative syndrome and associated Rosai-Dorfman diseaseGirish Venkataraman
Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Am J Surg Pathol 34:589-94. 2010..Given the central role of defective Fas signaling in ALPS, histiocytes may be yet another lineage at risk for neoplastic transformation secondary to a block in apoptosis... - Gall bladder and extrahepatic bile duct lymphomas: clinicopathological observations and biological implicationsHaresh Mani
The Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Am J Surg Pathol 34:1277-86. 2010..31%). In conclusion, primary lymphomas of the gall bladder and extrahepatic bile ducts show a broad spectrum of disease types, but in many respects mirror the spectrum of primary lymphomas of the gastrointestinal tract... - Nodal and extranodal plasmacytomas expressing immunoglobulin a: an indolent lymphoproliferative disorder with a low risk of clinical progressionHaipeng Shao
Laboratory of Pathology and the Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Am J Surg Pathol 34:1425-35. 2010..Our results suggest that IgA plasmacytomas may represent a distinct form of extramedullary plasmacytoma characterized by younger age at presentation, frequent lymph node involvement, and low risk of progression to plasma cell myeloma... - The pathology of NK-cell lymphomas and leukemiasVictor E Nava
Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
Adv Anat Pathol 12:27-34. 2005..Benign proliferations of NK cells can be seen in association with viral infection. The disease formerly referred to as blastic NK-cell lymphoma is now considered to be a malignancy derived from a dendritic cell precursor... - Histologic features of sinus histiocytosis with massive lymphadenopathy in patients with autoimmune lymphoproliferative syndromeIrina Maric
Hematopathology Section, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
Am J Surg Pathol 29:903-11. 2005..It remains to be determined if some cases of apparently sporadic SHML may be associated with heritable defects in Fas-mediated apoptosis... - High incidence of occult leptomeningeal disease detected by flow cytometry in newly diagnosed aggressive B-cell lymphomas at risk for central nervous system involvement: the role of flow cytometry versus cytologyUpendra Hegde
Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda, MD 20892-1868, USA
Blood 105:496-502. 2005..Patients at risk for CNS spread should undergo staging CSF evaluation by flow cytometry... - Molecular profiling provides evidence of primary mediastinal large B-cell lymphoma as a distinct entity related to classic Hodgkin lymphoma: implications for mediastinal gray zone lymphomas as an intermediate form of B-cell lymphomaKatherine R Calvo
Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Adv Anat Pathol 11:227-38. 2004.... - Marginal zone B-cell lymphoma in children and young adultsLekidelu Taddesse-Heath
Hemopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute/NIH, 10 Center Drive, Bethesda, MD 20892, USA
Am J Surg Pathol 27:522-31. 2003..We conclude that EMZL in children and young adults are similar to EMZL of mucosa-associated lymphoma tissue occurring in older patients. However, pediatric NMZL appear to have distinctive clinical and histologic features... - CD5+ follicular lymphoma: a clinicopathologic study of three casesTodd S Barry
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Am J Clin Pathol 118:589-98. 2002..These cases highlight the difficulty classifying these lymphomas by flow cytometric studies alone and emphasize the importance of recognizing FL in the differential diagnosis of CD5+ B-cell lymphomas... - IG/MYC rearrangements are the main cytogenetic alteration in plasmablastic lymphomasAlexandra Valera
Hematopathology Section, Laboratory of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
Am J Surg Pathol 34:1686-94. 2010..The oncogenic activation of MYC in these lymphomas may be an important pathogenetic element associated with EBV infection... - Mature T-cell and NK-cell lymphomas in the pediatric age groupElaine S Jaffe
Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-1500, USA
Am J Clin Pathol 122:S110-21. 2004..This early component of the immune system might be targeted more often in pediatric hematologic malignant neoplasms, whereas tumors of the more mature adaptive immune system are more rare in children... - An immunohistochemical study of the bone marrow lesions of systemic mastocytosis: expression of stem cell factor by lesional mast cellsCem Akin
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1881, USA
Am J Clin Pathol 118:242-7. 2002.... - Histopathology of Hodgkin's lymphomaFranziska C Eberle
Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Cancer J 15:129-37. 2009..We present an update on the histopathological features of Hodgkin's lymphoma and the immunohistochemical tools available for diagnosis in the clinical setting... - Immunoguided laser assisted microdissection techniques for DNA methylation analysis of archival tissue specimensFranziska C Eberle
Hematopathology Section, National Cancer Institute, National Institutes of Health, 8717 Grovemont Circle, Bethesda, MD 20892, USA
J Mol Diagn 12:394-401. 2010..7%; P < 0.05). These results demonstrate the validity and utility of the herein described protocol, which allows the application of ILAM for large-scale genomic and epigenetic analyses of archival tissue specimens... - Diffuse large B-cell lymphomas with plasmablastic differentiation represent a heterogeneous group of disease entitiesLluis Colomo
Hematopathology Section, Laboratory of Pathology, and Department of Hematology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
Am J Surg Pathol 28:736-47. 2004..In conclusion, DLBCLs with plasmablastic differentiation are a heterogeneous group of neoplasms with different clinicopathological characteristics that may correspond to different entities... - The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphomaAndreas Rosenwald
The Lymphoma/Leukemia Molecular Profiling Project, National Cancer Institute/NIH, Bethesda, MD, USA
Cancer Cell 3:185-97. 2003..We propose a quantitative model of the aberrant cell cycle regulation in MCL that provides a rationale for the design of cell cycle inhibitor therapy in this malignancy... - Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphomaMartina Rudelius
Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Blood 108:1668-76. 2006..One possible mechanism of activation is loss of PTEN expression. These data suggest that PI3K/Akt inhibitors may be effective in the treatment of Akt-activated MCL... - Periodic fever with atypical dyshidrosis--quiz caseElektra J Papadopoulos
National Institutes of Health, Bethesda, MD, USA
Arch Dermatol 140:479-84. 2004 - BCL2 expression is a prognostic marker for the activated B-cell-like type of diffuse large B-cell lymphomaJaveed Iqbal
Leukemia/Lymphoma Molecular Profiling Project, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA
J Clin Oncol 24:961-8. 2006..Hence, the significance of BCL2 and other biomarkers should be assessed in the context of DLBCL subgroups in future studies... - Aggressive Epstein-Barr virus-associated, CD8+, CD30+, CD56+, surface CD3-, natural killer (NK)-like cytotoxic T-cell lymphomaJianguo Tao
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Am J Surg Pathol 26:111-8. 2002..1 cells normally present in hepatosplenic sinusoids. This tumor disseminated early and pursued a fulminant clinical course, thus emphasizing the importance of early recognition and diagnosis... - Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative studyKen H Young
Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, University of of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, USA
Blood 112:3088-98. 2008..This study shows the prognostic importance of mutations in the TP53 DNA-binding domains in patients with DLBCL... - ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma ProjectKerry J Savage
Department of Medical Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada
Blood 111:5496-504. 2008..Although the prognosis of ALK(-) ALCL appears to be better than that for PTCL-NOS, it is still unsatisfactory and better therapies are needed. Primary cutaneous ALCL is associated with an indolent course... - Identification of a proliferation signature related to survival in nodal peripheral T-cell lymphomasMarta Cuadros
Human Genetics Group and Genotyping Unit, Human Cancer Genetics Program, Spanish National Cancer Centre, Madrid, Spain
J Clin Oncol 25:3321-9. 2007..Initial expression profiling studies of T-cell lymphomas have been inconclusive in yielding clinically relevant insights. We applied DNA microarrays to gain insight into the molecular signatures associated with prognosis. Materials and.. - IgVH mutational status and clonality analysis of Richter's transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolutionZhengrong Mao
Institute of Pathology, University of Wurzburg, Germany
Am J Surg Pathol 31:1605-14. 2007..HRS or HRS-like cells in all 3 unrelated cases showed evidence of Epstein-Barr virus infection. Of interest, 5/6 cases of B-CLL with HL, and 5/6 cases of B-CLL with HRS cells showed mutated IgVH genes... - Unusual immunophenotype of CD8+ T cells in familial hemophagocytic lymphohistiocytosisNitin J Karandikar
Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 75390 9072, USA
Blood 104:2007-9. 2004..This case provides an instructive example of uncontrolled reactive proliferation of CD8+ T cells in FHL, resulting in atypical morphology and unusual immunophenotypic features that might suggest malignancy in other clinical settings... - The serine protease granzyme M is preferentially expressed in NK-cell, gamma delta T-cell, and intestinal T-cell lymphomas: evidence of origin from lymphocytes involved in innate immunityLaszlo Krenacs
Laboratory of Tumor Pathology and Molecular Diagnostics, Institute for Biotechnology, Bay Zoltan Foundation for Applied Research, Szeged, Hungary
Blood 101:3590-3. 2003..We conclude that GM expression is a distinctive feature of the nasal NK/T-cell, gamma delta T-cell, and intestinal T-cell lymphomas, and suggest that these tumors develop from lymphocytes involved in innate immunity... - BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphomaJaveed Iqbal
Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198-3135, USA
Am J Pathol 165:159-66. 2004..However, despite this higher proliferative activity, there was no significant difference in overall or failure-free survival between the t(14;18)-positive and -negative subsets within the GCB subgroup... - Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival predictionSilvia Bea
Department of Pathology and Hematology Hospital Clinic, University of Barcelona, Spain
Blood 106:3183-90. 2005..In addition, gains involving the chromosomal region 3p11-p12 provided prognostic information that was statistically independent of the previously defined gene-expression-based survival model, thereby improving its predictive power... - Flow cytometric immunophenotypic profiles of mature gamma delta T-cell malignancies involving peripheral blood and bone marrowEjaz Ahmad
Department of Pathology, Good Samaritan Hospital, Dayton, Ohio, USA
Cytometry B Clin Cytom 67:6-12. 2005..Because cutaneous gamma delta T-cell lymphoma can present with peripheral blood involvement, flow cytometric evaluation of peripheral blood is important in staging these patients... - Lymphomatoid granulomatosis with involvement of the hard palate: a case reportRabie M Shanti
Department of Oral and Maxillofacial Surgery, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
J Oral Maxillofac Surg 66:2161-3. 2008 - Molecular analysis of light-chain switch and acute lymphoblastic leukemia transformation in two follicular lymphomas: implications for lymphomagenesisCarol Kobrin
Intramural Research Support Program, SAIC-Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, USA
Leuk Lymphoma 47:1523-34. 2006..It is also possible that the outgrowth of these variants was a consequence of immunoselection... - What is anaplastic large cell lymphoma?Metin Ozdemirli
Am J Surg Pathol 28:1664-5; author reply 1665-7. 2004 - Aggressive natural killer cell leukemia/lymphoma: case report, use of telesynergy and review of the literatureJoanne Murdock
Haematology Department, Belfast City Hospital, Belfast, BT9 7AB, N. Ireland
Leuk Lymphoma 45:1269-73. 2004..We review the possible therapeutic options for this extremely aggressive malignancy and briefly discuss our center's experience of telemedicine technology... - Comprehensive analysis of GST-pi expression in B-cell lymphomas: Correlation with histological subtypes and survivalCatherine Thieblemont
Leuk Lymphoma 49:1403-6. 2008 - Enteropathy-type T-cell lymphoma after intestinal diffuse large B-cell lymphomaVictor E Nava
Department of Pathology, Lombardi Comprehensive Cancer Center, Georgetown University Hospital, Washington, DC 20007, USA
Am J Surg Pathol 31:476-80. 2007..To our best knowledge, this is the first reported case of metachronous ETL and DLBCL. Possible associations between the 2 types of lymphoma are discussed... - Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphomaTimothy C Greiner
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
Proc Natl Acad Sci U S A 103:2352-7. 2006..This information on molecular phenotypes may provide new areas of investigation for ATM function or may be exploited by designing specific therapies for MCL cases with p53 aberrations...