Genomes and Genes
Christina M Van Itallie
Affiliation: National Institutes of Health
- The N and C termini of ZO-1 are surrounded by distinct proteins and functional protein networksChristina M Van Itallie
Laboratory of Tight Junction Structure and Function, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA
J Biol Chem 288:13775-88. 2013..Biotin ligase tagging with ZO-1 was applied to identify a more complete tight junction proteome...
- Phosphorylation of claudin-2 on serine 208 promotes membrane retention and reduces trafficking to lysosomesChristina M Van Itallie
National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Sci 125:4902-12. 2012..Together these data are consistent with phosphorylation at S208 playing a major role in the retention of claudin-2 at the plasma membrane...
- SUMOylation of claudin-2Christina M Van Itallie
National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
Ann N Y Acad Sci 1258:60-4. 2012..We conclude that the cellular levels of claudin-2 may be modulated by SUMOylation, warranting further investigation of cellular pathways that regulate this modification in vivo...
- Claudin-2 forms homodimers and is a component of a high molecular weight protein complexChristina M Van Itallie
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 286:3442-50. 2011..Our results suggest that BN-PAGE may be a useful tool in understanding tight junction structure...
- Caveolin binds independently to claudin-2 and occludinChristina M Van Itallie
National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Ann N Y Acad Sci 1257:103-7. 2012..The finding that caveolin-1 interacts with claudin-2 and occludin, but not with claudin-4 or ZO-1, suggests a potential mechanism for selective retrieval of tight junction components...