John T R Isaac

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
  2. pmc Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity
    Andreas Lüthi
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, BS8 1TD, UK
    BMC Neurosci 5:44. 2004
  3. ncbi request reprint Kainate receptor trafficking: physiological roles and molecular mechanisms
    John T R Isaac
    National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 3701, USA
    Pharmacol Ther 104:163-72. 2004
  4. ncbi request reprint The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity
    John T R Isaac
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
    Neuron 54:859-71. 2007
  5. pmc Casein kinase 2 regulates the NR2 subunit composition of synaptic NMDA receptors
    Antonio Sanz-Clemente
    Receptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 67:984-96. 2010
  6. pmc mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch
    JOSE A MATTA
    Developmental Synaptic Plasticity Section, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 70:339-51. 2011
  7. pmc Maturation of a recurrent excitatory neocortical circuit by experience-dependent unsilencing of newly formed dendritic spines
    Michael C Ashby
    Developmental Synaptic Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 70:510-21. 2011
  8. pmc A neuronal role for SNAP-23 in postsynaptic glutamate receptor trafficking
    Young Ho Suh
    Receptor Biology Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    Nat Neurosci 13:338-43. 2010
  9. pmc Differential regulation of kainate receptor trafficking by phosphorylation of distinct sites on GluR6
    Yukiko Nasu-Nishimura
    NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:2847-56. 2010
  10. pmc Emergence of cortical inhibition by coordinated sensory-driven plasticity at distinct synaptic loci
    Ramesh Chittajallu
    Developmental Synaptic Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Nat Neurosci 13:1240-8. 2010

Collaborators

Detail Information

Publications41

  1. pmc Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
    ..The second international meeting on Neurons and Brain Disease will be held in Toronto (August 29-31, 2007)...
  2. pmc Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity
    Andreas Lüthi
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, BS8 1TD, UK
    BMC Neurosci 5:44. 2004
    ..In the present study we have used whole-cell dendritic recording, failures analysis and non-stationary fluctuation analysis to investigate the mechanism of depotentiation of LTP...
  3. ncbi request reprint Kainate receptor trafficking: physiological roles and molecular mechanisms
    John T R Isaac
    National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 3701, USA
    Pharmacol Ther 104:163-72. 2004
    ..This review summarizes the current state of knowledge on this topic, focusing on the molecular mechanisms of kainate receptor trafficking and the potential for these mechanisms to regulate neuronal kainate receptor function...
  4. ncbi request reprint The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity
    John T R Isaac
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
    Neuron 54:859-71. 2007
    ..Here, we bring together recent data highlighting the novel and important roles of GluR2 in synaptic function and plasticity...
  5. pmc Casein kinase 2 regulates the NR2 subunit composition of synaptic NMDA receptors
    Antonio Sanz-Clemente
    Receptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 67:984-96. 2010
    ..Thus, CK2 plays a central role in determining the NR2 subunit content of synaptic NMDARs...
  6. pmc mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch
    JOSE A MATTA
    Developmental Synaptic Plasticity Section, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 70:339-51. 2011
    ..Thus, we establish that mGluR5 and NMDARs are required for the activity-dependent NR2B-NR2A switch and play a critical role in experience-dependent regulation of NMDAR subunit composition in vivo...
  7. pmc Maturation of a recurrent excitatory neocortical circuit by experience-dependent unsilencing of newly formed dendritic spines
    Michael C Ashby
    Developmental Synaptic Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 70:510-21. 2011
    ..Thus we describe a approach for quantitative circuit mapping and show that sensory experience sculpts an intrinsically developing template network, which is based on NMDAR-only synapses, by driving AMPARs into newly formed silent spines...
  8. pmc A neuronal role for SNAP-23 in postsynaptic glutamate receptor trafficking
    Young Ho Suh
    Receptor Biology Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    Nat Neurosci 13:338-43. 2010
    ..SNAP-23 is therefore important for the functional regulation of postsynaptic glutamate receptors...
  9. pmc Differential regulation of kainate receptor trafficking by phosphorylation of distinct sites on GluR6
    Yukiko Nasu-Nishimura
    NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:2847-56. 2010
    ....
  10. pmc Emergence of cortical inhibition by coordinated sensory-driven plasticity at distinct synaptic loci
    Ramesh Chittajallu
    Developmental Synaptic Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Nat Neurosci 13:1240-8. 2010
    ....
  11. doi request reprint Thalamocortical inputs show post-critical-period plasticity
    Xin Yu
    Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 74:731-42. 2012
    ..Thus, TC inputs may represent a major site for adult plasticity in contrast to the consensus that adult plasticity mainly occurs at cortico-cortical connections...
  12. pmc An essential role for PICK1 in NMDA receptor-dependent bidirectional synaptic plasticity
    Akira Terashima
    Developmental Synaptic Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
    Neuron 57:872-82. 2008
    ..In addition, deletion of PICK1 or blockade of PICK1 PDZ binding prevented NMDAR-dependent LTD. Thus, PICK1 plays a critical role in bidirectional NMDAR-dependent long-term synaptic plasticity in the hippocampus...
  13. doi request reprint Mechanisms of bi-directional modulation of thalamocortical transmission in barrel cortex by presynaptic kainate receptors
    Jean Sébastien Jouhanneau
    Developmental Synaptic Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892 3701, USA
    Neuropharmacology 60:832-41. 2011
    ..Such presynaptic regulation provides a potentially powerful mechanism to influence sensory processing during development of barrel cortex...
  14. pmc Developmental synaptic plasticity at the thalamocortical input to barrel cortex: mechanisms and roles
    Michael I Daw
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Mol Cell Neurosci 34:493-502. 2007
    ..The expression mechanisms of some of the forms of neonatal synaptic plasticity are novel and, in combination with other mechanisms, produce a layer IV circuit that exhibits functional properties necessary for mature sensory processing...
  15. ncbi request reprint Identification of an endoplasmic reticulum-retention motif in an intracellular loop of the kainate receptor subunit KA2
    Yukiko Nasu-Nishimura
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 26:7014-21. 2006
    ..The combination of these mechanisms likely prevents surface expression of nonfunctional KA2 homomers and ensures a high level of GluR6/KA2 heteromeric kainate receptors...
  16. pmc Incorporation of inwardly rectifying AMPA receptors at silent synapses during hippocampal long-term potentiation
    Daiju Morita
    Developmental Synaptic Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
    Philos Trans R Soc Lond B Biol Sci 369:20130156. 2014
    ....
  17. ncbi request reprint Synaptic strength at the thalamocortical input to layer IV neonatal barrel cortex is regulated by protein kinase C
    Helen L Scott
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Neuropharmacology 52:185-92. 2007
    ..Therefore, the requirement for PKC in LTP suggests an important role for this kinase in the development of the barrel cortex sensory map...
  18. doi request reprint Two differential frequency-dependent mechanisms regulating tonic firing of thalamic reticular neurons
    Rajen B Mistry
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Eur J Neurosci 27:2643-56. 2008
    ..Thus, our data indicate that two intrinsic mechanisms play a role in controlling the tonic spike output of TRN neurons and these mechanisms are differentially related to two physiologically meaningful stimulus frequency ranges...
  19. ncbi request reprint Developmental and activity dependent regulation of ionotropic glutamate receptors at synapses
    Elek Molnar
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    ScientificWorldJournal 2:27-47. 2002
    ..Here we discuss the evidence that these basic mechanisms are used during developmental synaptic plasticity...
  20. ncbi request reprint Functional maturation of CA1 synapses involves activity-dependent loss of tonic kainate receptor-mediated inhibition of glutamate release
    Sari E Lauri
    Neuroscience Center and Department of Bio and Environmental Sciences, P O Box 65 Viikinkaari 1, 00014 University of Helsinki, Finland
    Neuron 50:415-29. 2006
    ..Early development of the glutamatergic connectivity thus involves an activity-dependent loss of presynaptic KAR function producing maturation in the mode of excitatory transmission from CA3 to CA1...
  21. ncbi request reprint Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation
    Karen Plant
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, UK
    Nat Neurosci 9:602-4. 2006
    ..Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation...
  22. ncbi request reprint A presynaptic kainate receptor is involved in regulating the dynamic properties of thalamocortical synapses during development
    Fleur L Kidd
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, BS8 1TD, United Kingdom
    Neuron 34:635-46. 2002
    ..This receptor may, therefore, limit the transfer of high-frequency activity to the developing cortex, the loss of which mechanism may be important for the maturation of sensory processing...
  23. ncbi request reprint Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression
    Michael I Daw
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Nat Neurosci 5:835-6. 2002
    ..These findings suggest that the synapse specificity of hippocampal LTD may not be an intrinsic property of this form of homosynaptic plasticity, but rather that it can be regulated by PI3 kinase...
  24. pmc Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP
    Hélène Hirbec
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom
    Neuron 37:625-38. 2003
    ....
  25. ncbi request reprint A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus
    Sari E Lauri
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    Neuron 39:327-41. 2003
    ..These findings suggest that presynaptic kainate receptors at mossy fiber synapses can initiate a cascade involving Ca2+ release from intracellular stores that is important in both short-term and long-term plasticity...
  26. ncbi request reprint Functional roles of protein interactions with AMPA and kainate receptors
    Graham L Collingridge
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Neurosci Res 47:3-15. 2003
    ..In this article we reflect upon this work, which has led to some new ideas about how AMPA and kainate receptors are regulated at synapses...
  27. ncbi request reprint Multiple, developmentally regulated expression mechanisms of long-term potentiation at CA1 synapses
    Mary J Palmer
    The Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, BS8 1TD, United Kingdom
    J Neurosci 24:4903-11. 2004
    ..These findings suggest that a single class of synapse uses a number of different molecular mechanisms to produce long-term changes in synaptic strength...
  28. pmc Regulation of synaptic strength and AMPA receptor subunit composition by PICK1
    Akira Terashima
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 24:5381-90. 2004
    ..These findings suggest that PICK1 acts to downregulate the GluR2 content of AMPARs at hippocampal CA1 synapses, thereby increasing synaptic strength at resting membrane potentials...
  29. ncbi request reprint ATP hydrolysis is required for the rapid regulation of AMPA receptors during basal synaptic transmission and long-term synaptic plasticity
    Wonil Lim
    Department of Anatomy, MRC Centre for Synaptic Plasticity, University of Bristol, Bristol BS8 1TD, UK
    Neuropharmacology 48:949-55. 2005
    ..Our data are consistent with the idea that such a mechanism that can acutely bi-directionally regulate AMPAR function at synapses and requires ATP hydrolysis is necessary for rapid activity-dependent changes in synaptic strength...
  30. pmc Profound regulation of neonatal CA1 rat hippocampal GABAergic transmission by functionally distinct kainate receptor populations
    Francois Maingret
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 567:131-42. 2005
    ..Thus kainate receptors are strategically located to play a critical role in shaping early hippocampal network activity and by virtue of this have a key role in hippocampal development...
  31. ncbi request reprint Long-term depression of kainate receptor-mediated synaptic transmission
    Yunkyung Park
    Biomedical Science, School of Medicine and Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Neuron 49:95-106. 2006
    ..Thus, we describe the induction and expression mechanism of a form of synaptic plasticity, EPSC(KA) LTD...
  32. ncbi request reprint Developmental changes in AMPA and kainate receptor-mediated quantal transmission at thalamocortical synapses in the barrel cortex
    Neil J Bannister
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 25:5259-71. 2005
    ..Thus, the developmental switch in transmission will dramatically alter information transfer at thalamocortical inputs to layer IV...
  33. pmc Hippocalcin functions as a calcium sensor in hippocampal LTD
    Claire L Palmer
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, United Kingdom
    Neuron 47:487-94. 2005
    ..These data indicate that the AP2-hippocalcin complex acts as a Ca(2+) sensor that couples NMDAR-dependent activation to regulated endocytosis of AMPARs during LTD...
  34. ncbi request reprint New intrathalamic pathways allowing modality-related and cross-modality switching in the dorsal thalamus
    John W Crabtree
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 22:8754-61. 2002
    ..Moreover, TRN-mediated switching between dorsal thalamic nuclei could provide a mechanism for the selection of competing transmissions of sensory and/or motor information through the dorsal thalamus...
  35. pmc Kainate receptors and the induction of mossy fibre long-term potentiation
    Zuner A Bortolotto
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Philos Trans R Soc Lond B Biol Sci 358:657-66. 2003
    ..We conclude that activation of presynaptic GLU(K5)-containing kainate receptors is an important trigger for the induction of mossy fibre LTP in the hippocampus...
  36. ncbi request reprint Coordinated developmental recruitment of latent fast spiking interneurons in layer IV barrel cortex
    Michael I Daw
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK
    Nat Neurosci 10:453-61. 2007
    ....
  37. ncbi request reprint Postsynaptic silent synapses: evidence and mechanisms
    John T R Isaac
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK
    Neuropharmacology 45:450-60. 2003
    ..This review is not intended to provide a full discussion of possible presynaptic mechanisms for silent synapses; these are covered in the accompanying recent article [Voronin and Cherubini (this issue)]...
  38. ncbi request reprint Endogenous activation of kainate receptors regulates glutamate release and network activity in the developing hippocampus
    Sari E Lauri
    Neuroscience Center and Department of Biological and Environmental Sciences, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 25:4473-84. 2005
    ..By virtue of this, KARs are likely to play a central role in the development of hippocampal synaptic circuits...
  39. ncbi request reprint LTP inhibits LTD in the hippocampus via regulation of GSK3beta
    Stephane Peineau
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol, BS8 1TD, United Kingdom
    Neuron 53:703-17. 2007
    ..We conclude that the regulation of GSK3beta activity provides a powerful mechanism to preserve information encoded during LTP from erasure by subsequent LTD, perhaps thereby permitting the initial consolidation of learnt information...
  40. ncbi request reprint Receptor trafficking and synaptic plasticity
    Graham L Collingridge
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Nat Rev Neurosci 5:952-62. 2004
    ..Recent insights into how these receptors are rapidly moved into and out of synaptic membranes has profound implications for our understanding of the mechanisms of long-term potentiation and long-term depression...
  41. ncbi request reprint Rapid, activity-dependent plasticity in timing precision in neonatal barrel cortex
    Michael I Daw
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 26:4178-87. 2006
    ..Therefore, neonatal thalamocortical LTP may be a critical prerequisite for the maturation of information processing in the barrel cortex...