Research Topics
Genomes and Genes | John T R IsaacSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Recent advances in basic neurosciences and brain disease: from synapses to behaviorGuo Qiang Bi
Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
Mol Pain 2:38. 2006..The second international meeting on Neurons and Brain Disease will be held in Toronto (August 29-31, 2007)...- Bi-directional modulation of AMPA receptor unitary conductance by synaptic activityAndreas Lüthi
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, BS8 1TD, UK
BMC Neurosci 5:44. 2004..In the present study we have used whole-cell dendritic recording, failures analysis and non-stationary fluctuation analysis to investigate the mechanism of depotentiation of LTP... - The role of the GluR2 subunit in AMPA receptor function and synaptic plasticityJohn T R Isaac
National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
Neuron 54:859-71. 2007..Here, we bring together recent data highlighting the novel and important roles of GluR2 in synaptic function and plasticity... - Kainate receptor trafficking: physiological roles and molecular mechanismsJohn T R Isaac
National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 3701, USA
Pharmacol Ther 104:163-72. 2004..This review summarizes the current state of knowledge on this topic, focusing on the molecular mechanisms of kainate receptor trafficking and the potential for these mechanisms to regulate neuronal kainate receptor function... - Casein kinase 2 regulates the NR2 subunit composition of synaptic NMDA receptorsAntonio Sanz-Clemente
Receptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Neuron 67:984-96. 2010..Thus, CK2 plays a central role in determining the NR2 subunit content of synaptic NMDARs... - mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switchJOSE A MATTA
Developmental Synaptic Plasticity Section, National Institutes of Health, Bethesda, MD 20892, USA
Neuron 70:339-51. 2011..Thus, we establish that mGluR5 and NMDARs are required for the activity-dependent NR2B-NR2A switch and play a critical role in experience-dependent regulation of NMDAR subunit composition in vivo... - Maturation of a recurrent excitatory neocortical circuit by experience-dependent unsilencing of newly formed dendritic spinesMichael C Ashby
Developmental Synaptic Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Neuron 70:510-21. 2011..Thus we describe a approach for quantitative circuit mapping and show that sensory experience sculpts an intrinsically developing template network, which is based on NMDAR-only synapses, by driving AMPARs into newly formed silent spines... - A neuronal role for SNAP-23 in postsynaptic glutamate receptor traffickingYoung Ho Suh
Receptor Biology Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
Nat Neurosci 13:338-43. 2010..SNAP-23 is therefore important for the functional regulation of postsynaptic glutamate receptors... - Differential regulation of kainate receptor trafficking by phosphorylation of distinct sites on GluR6Yukiko Nasu-Nishimura
NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 285:2847-56. 2010.... - Emergence of cortical inhibition by coordinated sensory-driven plasticity at distinct synaptic lociRamesh Chittajallu
Developmental Synaptic Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Nat Neurosci 13:1240-8. 2010.... - An essential role for PICK1 in NMDA receptor-dependent bidirectional synaptic plasticityAkira Terashima
Developmental Synaptic Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
Neuron 57:872-82. 2008..In addition, deletion of PICK1 or blockade of PICK1 PDZ binding prevented NMDAR-dependent LTD. Thus, PICK1 plays a critical role in bidirectional NMDAR-dependent long-term synaptic plasticity in the hippocampus... - Mechanisms of bi-directional modulation of thalamocortical transmission in barrel cortex by presynaptic kainate receptorsJean Sébastien Jouhanneau
Developmental Synaptic Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892 3701, USA
Neuropharmacology 60:832-41. 2011..Such presynaptic regulation provides a potentially powerful mechanism to influence sensory processing during development of barrel cortex... - Developmental synaptic plasticity at the thalamocortical input to barrel cortex: mechanisms and rolesMichael I Daw
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University Walk, Bristol BS8 1TD, UK
Mol Cell Neurosci 34:493-502. 2007..The expression mechanisms of some of the forms of neonatal synaptic plasticity are novel and, in combination with other mechanisms, produce a layer IV circuit that exhibits functional properties necessary for mature sensory processing... - Identification of an endoplasmic reticulum-retention motif in an intracellular loop of the kainate receptor subunit KA2Yukiko Nasu-Nishimura
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 26:7014-21. 2006..The combination of these mechanisms likely prevents surface expression of nonfunctional KA2 homomers and ensures a high level of GluR6/KA2 heteromeric kainate receptors... - Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiationKaren Plant
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, UK
Nat Neurosci 9:602-4. 2006..Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation... - Functional maturation of CA1 synapses involves activity-dependent loss of tonic kainate receptor-mediated inhibition of glutamate releaseSari E Lauri
Neuroscience Center and Department of Bio- and Environmental Sciences, P.O. Box 65 (Viikinkaari 1, 00014 University of Helsinki, Finland
Neuron 50:415-29. 2006..Early development of the glutamatergic connectivity thus involves an activity-dependent loss of presynaptic KAR function producing maturation in the mode of excitatory transmission from CA3 to CA1... - Synaptic strength at the thalamocortical input to layer IV neonatal barrel cortex is regulated by protein kinase CHelen L Scott
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University Walk, Bristol BS8 1TD, UK
Neuropharmacology 52:185-92. 2007..Therefore, the requirement for PKC in LTP suggests an important role for this kinase in the development of the barrel cortex sensory map... - Two differential frequency-dependent mechanisms regulating tonic firing of thalamic reticular neuronsRajen B Mistry
Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
Eur J Neurosci 27:2643-56. 2008..Thus, our data indicate that two intrinsic mechanisms play a role in controlling the tonic spike output of TRN neurons and these mechanisms are differentially related to two physiologically meaningful stimulus frequency ranges... - Long-term depression of kainate receptor-mediated synaptic transmissionYunkyung Park
Biomedical Science, School of Medicine and Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
Neuron 49:95-106. 2006..Thus, we describe the induction and expression mechanism of a form of synaptic plasticity, EPSC(KA) LTD... - Hippocalcin functions as a calcium sensor in hippocampal LTDClaire L Palmer
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, United Kingdom
Neuron 47:487-94. 2005..These data indicate that the AP2-hippocalcin complex acts as a Ca(2+) sensor that couples NMDAR-dependent activation to regulated endocytosis of AMPARs during LTD... - Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depressionMichael I Daw
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University Walk, Bristol BS8 1TD, UK
Nat Neurosci 5:835-6. 2002..These findings suggest that the synapse specificity of hippocampal LTD may not be an intrinsic property of this form of homosynaptic plasticity, but rather that it can be regulated by PI3 kinase... - Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIPHélène Hirbec
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom
Neuron 37:625-38. 2003.... - Developmental and activity dependent regulation of ionotropic glutamate receptors at synapsesElek Molnar
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
ScientificWorldJournal 2:27-47. 2002..Here we discuss the evidence that these basic mechanisms are used during developmental synaptic plasticity... - A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampusSari E Lauri
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
Neuron 39:327-41. 2003..These findings suggest that presynaptic kainate receptors at mossy fiber synapses can initiate a cascade involving Ca2+ release from intracellular stores that is important in both short-term and long-term plasticity... - Functional roles of protein interactions with AMPA and kainate receptorsGraham L Collingridge
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
Neurosci Res 47:3-15. 2003..In this article we reflect upon this work, which has led to some new ideas about how AMPA and kainate receptors are regulated at synapses... - Multiple, developmentally regulated expression mechanisms of long-term potentiation at CA1 synapsesMary J Palmer
The Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, BS8 1TD, United Kingdom
J Neurosci 24:4903-11. 2004..These findings suggest that a single class of synapse uses a number of different molecular mechanisms to produce long-term changes in synaptic strength... - Regulation of synaptic strength and AMPA receptor subunit composition by PICK1Akira Terashima
Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
J Neurosci 24:5381-90. 2004..These findings suggest that PICK1 acts to downregulate the GluR2 content of AMPARs at hippocampal CA1 synapses, thereby increasing synaptic strength at resting membrane potentials... - A presynaptic kainate receptor is involved in regulating the dynamic properties of thalamocortical synapses during developmentFleur L Kidd
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, BS8 1TD, United Kingdom
Neuron 34:635-46. 2002..This receptor may, therefore, limit the transfer of high-frequency activity to the developing cortex, the loss of which mechanism may be important for the maturation of sensory processing... - Developmental changes in AMPA and kainate receptor-mediated quantal transmission at thalamocortical synapses in the barrel cortexNeil J Bannister
Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
J Neurosci 25:5259-71. 2005..Thus, the developmental switch in transmission will dramatically alter information transfer at thalamocortical inputs to layer IV... - ATP hydrolysis is required for the rapid regulation of AMPA receptors during basal synaptic transmission and long-term synaptic plasticityWonil Lim
Department of Anatomy, MRC Centre for Synaptic Plasticity, University of Bristol, Bristol BS8 1TD, UK
Neuropharmacology 48:949-55. 2005..Our data are consistent with the idea that such a mechanism that can acutely bi-directionally regulate AMPAR function at synapses and requires ATP hydrolysis is necessary for rapid activity-dependent changes in synaptic strength... - Postsynaptic silent synapses: evidence and mechanismsJohn T R Isaac
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK
Neuropharmacology 45:450-60. 2003..This review is not intended to provide a full discussion of possible presynaptic mechanisms for silent synapses; these are covered in the accompanying recent article [Voronin and Cherubini (this issue)]... - Endogenous activation of kainate receptors regulates glutamate release and network activity in the developing hippocampusSari E Lauri
Neuroscience Center and Department of Biological and Environmental Sciences, University of Helsinki, 00014 Helsinki, Finland
J Neurosci 25:4473-84. 2005..By virtue of this, KARs are likely to play a central role in the development of hippocampal synaptic circuits... - Receptor trafficking and synaptic plasticityGraham L Collingridge
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
Nat Rev Neurosci 5:952-62. 2004..Recent insights into how these receptors are rapidly moved into and out of synaptic membranes has profound implications for our understanding of the mechanisms of long-term potentiation and long-term depression... - Kainate receptors and the induction of mossy fibre long-term potentiationZuner A Bortolotto
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
Philos Trans R Soc Lond B Biol Sci 358:657-66. 2003..We conclude that activation of presynaptic GLU(K5)-containing kainate receptors is an important trigger for the induction of mossy fibre LTP in the hippocampus... - Rapid, activity-dependent plasticity in timing precision in neonatal barrel cortexMichael I Daw
Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
J Neurosci 26:4178-87. 2006..Therefore, neonatal thalamocortical LTP may be a critical prerequisite for the maturation of information processing in the barrel cortex... - New intrathalamic pathways allowing modality-related and cross-modality switching in the dorsal thalamusJohn W Crabtree
Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
J Neurosci 22:8754-61. 2002..Moreover, TRN-mediated switching between dorsal thalamic nuclei could provide a mechanism for the selection of competing transmissions of sensory and/or motor information through the dorsal thalamus... - Coordinated developmental recruitment of latent fast spiking interneurons in layer IV barrel cortexMichael I Daw
Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK
Nat Neurosci 10:453-61. 2007.... - LTP inhibits LTD in the hippocampus via regulation of GSK3betaStephane Peineau
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol, BS8 1TD, United Kingdom
Neuron 53:703-17. 2007..We conclude that the regulation of GSK3beta activity provides a powerful mechanism to preserve information encoded during LTP from erasure by subsequent LTD, perhaps thereby permitting the initial consolidation of learnt information...