Research Topics
Species | Richard D IrwinSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Predicting the hepatocarcinogenic potential of alkenylbenzene flavoring agents using toxicogenomics and machine learningScott S Auerbach
National Toxicology Program, National Institute of Environmental Health Sciences, NIH, RTP, NC 27709, USA
Toxicol Appl Pharmacol 243:300-14. 2010..Furthermore, we find that exposure duration is a critical variable in the success or failure of such an approach, particularly when evaluating chemicals with unknown carcinogenic potency...- Gene expression response in target organ and whole blood varies as a function of target organ injury phenotypeEdward K Lobenhofer
Cogenics, Division of Clinical Data, Inc, Morrisville, NC 27560, USA
Genome Biol 9:R100. 2008..The results of the study demonstrate the classification of histopathological differences, likely reflecting differences in mechanisms of cell-specific toxicity, using either liver tissue or blood transcriptomic data... - Transcriptional profiling of the left and median liver lobes of male f344/n rats following exposure to acetaminophenRichard D Irwin
Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 33:111-7. 2005.... - Application of toxicogenomics to toxicology: basic concepts in the analysis of microarray dataRichard D Irwin
Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 32:72-83. 2004..Most studies will require the input from the disciplines of toxicology, pathology, molecular biology, bioinformatics, biochemistry, and others depending on the types of questions being asked... - A review of evidence leading to the prediction that 1,4-butanediol is not a carcinogenRichard D Irwin
National Toxicology Program, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709, USA
J Appl Toxicol 26:72-80. 2006.... - Hepatic gene expression changes throughout the day in the Fischer rat: implications for toxicogenomic experimentsGary A Boorman
Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 86:185-93. 2005..The results of this study demonstrate a prominent circadian rhythm in gene expression in the rat that is a critical factor in planning toxicogenomic experiments... - Variation in the hepatic gene expression in individual male Fischer ratsGary A Boorman
Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 33:102-10. 2005..The level of hepatic gene expression under carefully controlled study conditions is less than 1.5-fold for most genes. The impact of individual animal variability on microarray data can be minimized through experimental design... - Testing an aflatoxin B1 gene signature in rat archival tissuesB Alex Merrick
Biomolecular Screening Branch, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States
Chem Res Toxicol 25:1132-44. 2012..We conclude that an evaluation of gene signatures in archival tissues can be an important toxicological tool for evaluating critical molecular events associated with chemical exposures... - Hepatic transcript levels for genes coding for enzymes associated with xenobiotic metabolism are altered with ageKazuhiko Mori
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27701, USA
Toxicol Pathol 35:242-51. 2007..Alterations that are considered crucial to the interpretation of long-term study results could then be confirmed by subsequent metabolic studies... - Gene set enrichment analysis for non-monotone association and multiple experimental categoriesRongheng Lin
Biostatistics Branch, National Institute of Environmental Health Science, Research Triangle Park, NC 27713, USA
BMC Bioinformatics 9:481. 2008..Methods applicable to continuous non-monotone relationships are needed. Furthermore, for multiple experimental categories, methods that combine multiple GSEA/SAFE analyses are needed... - Gene interaction network analysis suggests differences between high and low doses of acetaminophenHiroyoshi Toyoshiba
Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 215:306-16. 2006..The approaches shown here could provide predictive information to understand high- versus low-dose mechanisms of toxicity... - Gene expression profiling of rat livers reveals indicators of potential adverse effectsAlexandra N Heinloth
National Center for Toxicogenomics, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 80:193-202. 2004..In conclusion, this study provides evidence that supports the hypothesis that gene expression profiling may be a sensitive means of identifying indicators of potential adverse effects in the absence of the occurrence of overt toxicity... - A comparative 90-day toxicity study of allyl acetate, allyl alcohol and acroleinScott S Auerbach
National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States
Toxicology 253:79-88. 2008..Increased systemic exposure to acrolein is likely responsible for the differences in hepatic toxicological profile observed with these chemicals... - Influence of functional group substitutions on the carcinogenicity of anthraquinone in rats and mice: analysis of long-term bioassays by the National Cancer Institute and the National Toxicology ProgramAdriana M Doi
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
J Toxicol Environ Health B Crit Rev 8:109-26. 2005..Multiple amino substitutions diminished, while bromine substitutions enhanced the carcinogenicity induced by anthraquinone and extended the target organs to include forestomach and lung... - Genetic alterations in the Catnb gene but not the H-ras gene in hepatocellular neoplasms and hepatoblastomas of B6C3F(1) mice following exposure to diethanolamine for 2 yearsShim-mo Hayashi
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
Chem Biol Interact 146:251-61. 2003.... - Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular glandChangyu Zheng
Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Hum Gene Ther 17:1122-33. 2006..In aggregate, these findings show that localized delivery of AdhAQP1 to salivary glands appears to occur without significant toxicity...