Thomas R Insel

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Devising prevention and treatment strategies for the nation's diverse populations with mental illness
    Thomas R Insel
    National Institute of Mental Health, Room 8235, MSC 9669, 6001 Executive Boulevard, Bethesda, MD 20892, USA
    Psychiatr Serv 58:395. 2007
  2. ncbi Rethinking schizophrenia
    Thomas R Insel
    National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Nature 468:187-93. 2010
  3. ncbi Mouse maps of gene expression in the brain
    Susan E Koester
    Division of Neuroscience and Basic Behavioral Science, National Institute of Mental Health, Executive Blvd, Bethesda, MD 20892 9645, USA
    Genome Biol 8:212. 2007
  4. ncbi Psychiatry as a clinical neuroscience discipline
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 294:2221-4. 2005
  5. ncbi Neuroscience. Shining light on depression
    Thomas R Insel
    National Institute for Mental Health, Bethesda, MD 20892, USA
    Science 317:757-8. 2007
  6. ncbi Translating scientific opportunity into public health impact: a strategic plan for research on mental illness
    Thomas R Insel
    Natrional Institute of Mental Health, 6001 Executive Blvd, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 66:128-33. 2009
  7. ncbi Research on major depression: strategies and priorities
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892, USA
    JAMA 289:3167-8. 2003
  8. ncbi Disruptive insights in psychiatry: transforming a clinical discipline
    Thomas R Insel
    National Institute of Mental Health, 6001 Executive Blvd, Room 8235, MSC 9669, Bethesda, Maryland 20892 9669, USA
    J Clin Invest 119:700-5. 2009
  9. ncbi The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 65:768-79. 2010
  10. ncbi Limits to growth: why neuroscience needs large-scale science
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health, 6001 Executive Boulevard, Bethesda, Maryland 20892-9669, USA
    Nat Neurosci 7:426-7. 2004

Detail Information

Publications42

  1. ncbi Devising prevention and treatment strategies for the nation's diverse populations with mental illness
    Thomas R Insel
    National Institute of Mental Health, Room 8235, MSC 9669, 6001 Executive Boulevard, Bethesda, MD 20892, USA
    Psychiatr Serv 58:395. 2007
  2. ncbi Rethinking schizophrenia
    Thomas R Insel
    National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Nature 468:187-93. 2010
    ..This 'rethinking' of schizophrenia as a neurodevelopmental disorder, which is profoundly different from the way we have seen this illness for the past century, yields new hope for prevention and cure over the next two decades...
  3. ncbi Mouse maps of gene expression in the brain
    Susan E Koester
    Division of Neuroscience and Basic Behavioral Science, National Institute of Mental Health, Executive Blvd, Bethesda, MD 20892 9645, USA
    Genome Biol 8:212. 2007
    ..The completion of the Allen Brain Atlas generated a great deal of press interest and enthusiasm from the research community. What does it do, and what other complementary resources increase its functionality?..
  4. ncbi Psychiatry as a clinical neuroscience discipline
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 294:2221-4. 2005
  5. ncbi Neuroscience. Shining light on depression
    Thomas R Insel
    National Institute for Mental Health, Bethesda, MD 20892, USA
    Science 317:757-8. 2007
  6. ncbi Translating scientific opportunity into public health impact: a strategic plan for research on mental illness
    Thomas R Insel
    Natrional Institute of Mental Health, 6001 Executive Blvd, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 66:128-33. 2009
    ..Exciting advances in neuroscience and genomics have transformed research but have not yet been translated to public health impact in psychiatry. Current treatments are necessary but not sufficient for most patients...
  7. ncbi Research on major depression: strategies and priorities
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892, USA
    JAMA 289:3167-8. 2003
  8. ncbi Disruptive insights in psychiatry: transforming a clinical discipline
    Thomas R Insel
    National Institute of Mental Health, 6001 Executive Blvd, Room 8235, MSC 9669, Bethesda, Maryland 20892 9669, USA
    J Clin Invest 119:700-5. 2009
    ..Current medications are not sufficient for most patients. A new and deep understanding of the pathophysiology of these disabling disorders is our best hope for a new generation of treatments that will help patients to recover...
  9. ncbi The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 65:768-79. 2010
    ..This review describes the promises and problems of extrapolating these findings to human social cognition, with specific reference to the social deficits of autism...
  10. ncbi Limits to growth: why neuroscience needs large-scale science
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health, 6001 Executive Boulevard, Bethesda, Maryland 20892-9669, USA
    Nat Neurosci 7:426-7. 2004
  11. ncbi Wayne Fenton, M.D
    Ellen Stover
    NIMH, 6001 Executive Blvd, Rm. 8235, MSC 9669, Bethesda, MD 20892-9669, USA
    Am J Psychiatry 165:177-8. 2008
  12. ncbi Developmental psychobiology for public health: a bridge for translational research
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892, USA
    Dev Psychobiol 47:209-16. 2005
  13. ncbi NIH Molecular Libraries Initiative
    Christopher P Austin
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 306:1138-9. 2004
  14. ncbi Psychiatric epidemiology: it's not just about counting anymore
    Thomas R Insel
    Arch Gen Psychiatry 62:590-2. 2005
  15. ncbi Eating disorders: National Institute of Mental Health's perspective
    Mark Chavez
    National Institute of Mental Health, Bethesda, MD 20892, USA
    Am Psychol 62:159-66. 2007
    ....
  16. ncbi Is social attachment an addictive disorder?
    Thomas R Insel
    Center for Behavioral Neuroscience, Emory University, Altanta, GA, USA
    Physiol Behav 79:351-7. 2003
    ..The neuropeptides oxytocin (OT) and vasopressin (AVP) appear to be critical for linking social signals to the mesocorticolimbic circuit...
  17. ncbi The conundrum of co-occurring mental and substance use disorders: opportunities for research
    Junius J Gonzales
    National Institute of Mental Health, 6001 Executive Boulevard, Room 8235, Bethesda, MD 20892, USA
    Biol Psychiatry 56:723-5. 2004
  18. ncbi Psychiatry in the genomics era
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892, USA
    Am J Psychiatry 160:616-20. 2003
  19. ncbi Research funding: the view from NIH
    Thomas R Insel
    National Institute of Mental Health, 6001 Executive Blvd, Room 8235, MSC 9669 Bethesda, MD 20892-9669, USA
    Am J Psychiatry 163:2043-5. 2006
  20. ncbi Translational research in the decade of discovery
    Thomas R Insel
    National Institute of Mental Health, 6001 Executive Blvd, Room 8235, Bethesda, MD 20892, USA
    Horm Behav 50:504-5. 2006
  21. ncbi Neuroscience networks: data-sharing in an information age
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health in Bethesda, Maryland, USA
    PLoS Biol 1:E17. 2003
  22. ncbi Neuroendocrine basis of social recognition
    James T Winslow
    National Institute of Mental Health, National Institutes of Health Animal Center, Building 110, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Curr Opin Neurobiol 14:248-53. 2004
    ..Several lines of evidence have emerged that indicate that neuropeptide regulation is significantly modulated by gonadal and corticosteroid activation...
  23. ncbi Breaking the log-jam in treatment development for cognition in schizophrenia: NIMH perspective
    Wayne S Fenton
    National Institute of Mental Health, National Institute of Health, US Department of Health and Human Services, Room 6216, 6001 Executive Boulevard, MSC 9621, Bethesda, MD 20892-9621, USA
    Psychopharmacology (Berl) 169:365-6. 2003
  24. ncbi How the brain processes social information: searching for the social brain
    Thomas R Insel
    National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Annu Rev Neurosci 27:697-722. 2004
    ....
  25. ncbi Pharmacogenomics and personalized medicine in neuropsychiatry
    Francis J McMahon
    National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 3719, USA
    Neuron 74:773-6. 2012
    ..Here we discuss the promise of personalized medicine in developing more efficacious and individualized pharmacotherapies that take into account genetic variation and target groups of patients who share biology, not just symptoms...
  26. ncbi The knockout mouse project
    Christopher P Austin
    National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, 31 Center Drive, Bethesda, Maryland 20892, USA
    Nat Genet 36:921-4. 2004
    ..It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain...
  27. ncbi Ensuring public trust
    Thomas R Insel
    National Institute of Mental Health, 6001 Executive Boulevard, Room 8235, MSC 9669, Bethesda, MD 20892, USA
    Biol Psychiatry 56:539. 2004
  28. ncbi The STAR*D trial: revealing the need for better treatments
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892 9669, USA
    Psychiatr Serv 60:1466-7. 2009
    ..However, initial and one-year remission rates (28% and 70%, respectively) suggest that important goals for treatment of this disabling disease remain out of reach and that the bar for antidepressants has been set far too low...
  29. ncbi Depression and comorbid medical illness: the National Institute of Mental Health perspective
    Ellen Stover
    National Institute of Mental Health, National Institutes of Health, 6001 Executive Boulevard, Room 6217, MSC 9621 Bethesda, MD 20892-9621, USA
    Biol Psychiatry 54:184-6. 2003
  30. ncbi Epigenetic sources of behavioral differences in mice
    Darlene D Francis
    Center for Behavioral Neuroscience, Emory University, Yerkes Research Center, 954 Gatewood Rd, Atlanta, Georgia 30329, USA
    Nat Neurosci 6:445-6. 2003
  31. ncbi Cognitive neuroscience and schizophrenia: translational research in need of a translator
    Jonathan D Cohen
    Department of Psychology and Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA
    Biol Psychiatry 64:2-3. 2008
  32. ncbi Assessing the economic costs of serious mental illness
    Thomas R Insel
    Am J Psychiatry 165:663-5. 2008
  33. ncbi Tribute to Wayne Fenton, MD (1953-2006)
    Thomas R Insel
    Schizophr Res 88:1-2. 2006
  34. ncbi Public health contributions
    Steven E Hyman
    Schizophr Bull 33:1151-2. 2007
  35. ncbi A new era in psychiatric genetics?
    Thomas R Insel
    Biol Psychiatry 61:1017-8. 2007
  36. ncbi From animal models to model animals
    Thomas R Insel
    Biol Psychiatry 62:1337-9. 2007
  37. ncbi The promise of extinction research for the prevention and treatment of anxiety disorders
    Kathleen C Anderson
    Biol Psychiatry 60:319-21. 2006
  38. ncbi What are the long-term effects of methylphenidate treatment?
    Nora D Volkow
    Biol Psychiatry 54:1307-9. 2003
  39. ncbi Rearing effects on cerebrospinal fluid oxytocin concentration and social buffering in rhesus monkeys
    James T Winslow
    Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30322, USA
    Neuropsychopharmacology 28:910-8. 2003
    ..These results are consistent with earlier reports from studies of rodents suggesting an important role for central OT pathways in the development of social affiliation...
  40. ncbi The neuroendocrine basis of social recognition
    Jennifer N Ferguson
    Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30322, USA
    Front Neuroendocrinol 23:200-24. 2002
    ..These findings support the hypothesis that vasopressin and oxytocin are essential for social memory, although they appear to influence different cognitive processes and may modulate different neural systems. (c) Elsevier Science...
  41. ncbi Beyond efficacy: the STAR*D trial
    Thomas R Insel
    Am J Psychiatry 163:5-7. 2006
  42. ncbi Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds
    Brandon J Aragona
    Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida 32306 1270, USA
    Nat Neurosci 9:133-9. 2006
    ..Thus, neuroplastic reorganization of the nucleus accumbens dopamine system is responsible for the enduring nature of monogamous pair bonding. Finally, we show that this system may also contribute to species-specific social organization...