Thomas R Insel

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Devising prevention and treatment strategies for the nation's diverse populations with mental illness
    Thomas R Insel
    National Institute of Mental Health, Room 8235, MSC 9669, 6001 Executive Boulevard, Bethesda, MD 20892, USA
    Psychiatr Serv 58:395. 2007
  2. doi request reprint Rethinking schizophrenia
    Thomas R Insel
    National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Nature 468:187-93. 2010
  3. pmc Twenty-five years of progress: the view from NIMH and NINDS
    Thomas R Insel
    National Institute of Mental Health, 6001 Executive Boulevard, Room 8129, MSC 9669, Bethesda, MD 20892 9669, USA Electronic address
    Neuron 80:561-7. 2013
  4. pmc Mouse maps of gene expression in the brain
    Susan E Koester
    Division of Neuroscience and Basic Behavioral Science, National Institute of Mental Health, Executive Blvd, Bethesda, MD 20892 9645, USA
    Genome Biol 8:212. 2007
  5. pmc Disruptive insights in psychiatry: transforming a clinical discipline
    Thomas R Insel
    National Institute of Mental Health, 6001 Executive Blvd, Room 8235, MSC 9669, Bethesda, Maryland 20892 9669, USA
    J Clin Invest 119:700-5. 2009
  6. pmc Psychiatry as a clinical neuroscience discipline
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 294:2221-4. 2005
  7. doi request reprint Translating scientific opportunity into public health impact: a strategic plan for research on mental illness
    Thomas R Insel
    Natrional Institute of Mental Health, 6001 Executive Blvd, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 66:128-33. 2009
  8. ncbi request reprint Research on major depression: strategies and priorities
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892, USA
    JAMA 289:3167-8. 2003
  9. pmc The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 65:768-79. 2010
  10. pmc Neuroscience. Shining light on depression
    Thomas R Insel
    National Institute for Mental Health, Bethesda, MD 20892, USA
    Science 317:757-8. 2007

Detail Information

Publications47

  1. pmc Devising prevention and treatment strategies for the nation's diverse populations with mental illness
    Thomas R Insel
    National Institute of Mental Health, Room 8235, MSC 9669, 6001 Executive Boulevard, Bethesda, MD 20892, USA
    Psychiatr Serv 58:395. 2007
  2. doi request reprint Rethinking schizophrenia
    Thomas R Insel
    National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Nature 468:187-93. 2010
    ..This 'rethinking' of schizophrenia as a neurodevelopmental disorder, which is profoundly different from the way we have seen this illness for the past century, yields new hope for prevention and cure over the next two decades...
  3. pmc Twenty-five years of progress: the view from NIMH and NINDS
    Thomas R Insel
    National Institute of Mental Health, 6001 Executive Boulevard, Room 8129, MSC 9669, Bethesda, MD 20892 9669, USA Electronic address
    Neuron 80:561-7. 2013
    ..In contrast to many other areas of medicine, we lack basic knowledge about our organ of interest. The next phase of progress on brain disorders will require a significantly deeper understanding of fundamental neurobiology. ..
  4. pmc Mouse maps of gene expression in the brain
    Susan E Koester
    Division of Neuroscience and Basic Behavioral Science, National Institute of Mental Health, Executive Blvd, Bethesda, MD 20892 9645, USA
    Genome Biol 8:212. 2007
    ..The completion of the Allen Brain Atlas generated a great deal of press interest and enthusiasm from the research community. What does it do, and what other complementary resources increase its functionality?..
  5. pmc Disruptive insights in psychiatry: transforming a clinical discipline
    Thomas R Insel
    National Institute of Mental Health, 6001 Executive Blvd, Room 8235, MSC 9669, Bethesda, Maryland 20892 9669, USA
    J Clin Invest 119:700-5. 2009
    ..Current medications are not sufficient for most patients. A new and deep understanding of the pathophysiology of these disabling disorders is our best hope for a new generation of treatments that will help patients to recover...
  6. pmc Psychiatry as a clinical neuroscience discipline
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 294:2221-4. 2005
  7. doi request reprint Translating scientific opportunity into public health impact: a strategic plan for research on mental illness
    Thomas R Insel
    Natrional Institute of Mental Health, 6001 Executive Blvd, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 66:128-33. 2009
    ..Exciting advances in neuroscience and genomics have transformed research but have not yet been translated to public health impact in psychiatry. Current treatments are necessary but not sufficient for most patients...
  8. ncbi request reprint Research on major depression: strategies and priorities
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892, USA
    JAMA 289:3167-8. 2003
  9. pmc The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 65:768-79. 2010
    ..This review describes the promises and problems of extrapolating these findings to human social cognition, with specific reference to the social deficits of autism...
  10. pmc Neuroscience. Shining light on depression
    Thomas R Insel
    National Institute for Mental Health, Bethesda, MD 20892, USA
    Science 317:757-8. 2007
  11. ncbi request reprint Limits to growth: why neuroscience needs large-scale science
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health, 6001 Executive Boulevard, Bethesda, Maryland 20892 9669, USA
    Nat Neurosci 7:426-7. 2004
  12. doi request reprint Wayne Fenton, M.D
    Ellen Stover
    NIMH, 6001 Executive Blvd, Rm 8235, MSC 9669, Bethesda, MD 20892 9669, USA
    Am J Psychiatry 165:177-8. 2008
  13. pmc The NIH toolbox: setting a standard for biomedical research
    Richard J Hodes
    National Institute on Aging, Bethesda, MD, USA
    Neurology 80:S1. 2013
    ..The NIH Toolbox achieves that end by providing psychometrically sound, cutting-edge, adaptable measures that enable uniformity of measurement, data sharing, and integration of findings in the research setting...
  14. ncbi request reprint Developmental psychobiology for public health: a bridge for translational research
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892, USA
    Dev Psychobiol 47:209-16. 2005
  15. ncbi request reprint NIH Molecular Libraries Initiative
    Christopher P Austin
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 306:1138-9. 2004
  16. pmc Eating disorders: National Institute of Mental Health's perspective
    Mark Chavez
    National Institute of Mental Health, Bethesda, MD 20892, USA
    Am Psychol 62:159-66. 2007
    ....
  17. pmc Psychiatric epidemiology: it's not just about counting anymore
    Thomas R Insel
    Arch Gen Psychiatry 62:590-2. 2005
  18. ncbi request reprint Is social attachment an addictive disorder?
    Thomas R Insel
    Center for Behavioral Neuroscience, Emory University, Altanta, GA, USA
    Physiol Behav 79:351-7. 2003
    ..The neuropeptides oxytocin (OT) and vasopressin (AVP) appear to be critical for linking social signals to the mesocorticolimbic circuit...
  19. pmc Toward the future of psychiatric diagnosis: the seven pillars of RDoC
    Bruce N Cuthbert
    National Institute of Mental Health, National Institutes of Health, 6001 Executive Boulevard, MSC 9632, Room 7121, Bethesda, MD 20892 9632, USA
    BMC Med 11:126. 2013
    ....
  20. pmc Neuroscience networks: data-sharing in an information age
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health in Bethesda, Maryland, USA
    PLoS Biol 1:E17. 2003
  21. ncbi request reprint The conundrum of co-occurring mental and substance use disorders: opportunities for research
    Junius J Gonzales
    National Institute of Mental Health, 6001 Executive Boulevard, Room 8235, Bethesda, MD 20892, USA
    Biol Psychiatry 56:723-5. 2004
  22. ncbi request reprint Psychiatry in the genomics era
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892, USA
    Am J Psychiatry 160:616-20. 2003
  23. pmc Research funding: the view from NIH
    Thomas R Insel
    National Institute of Mental Health, 6001 Executive Blvd, Room 8235, MSC 9669 Bethesda, MD 20892 9669, USA
    Am J Psychiatry 163:2043-5. 2006
  24. doi request reprint Next-generation treatments for mental disorders
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892, USA
    Sci Transl Med 4:155ps19. 2012
    ..This retreat comes just as research is identifying new molecular targets, new clinical targets, and new uses of current treatments that may serve as the basis for the next generation of treatments for mental disorders...
  25. ncbi request reprint Breaking the log-jam in treatment development for cognition in schizophrenia: NIMH perspective
    Wayne S Fenton
    National Institute of Mental Health, National Institute of Health, US Department of Health and Human Services, Room 6216, 6001 Executive Boulevard, MSC 9621, Bethesda, MD 20892 9621, USA
    Psychopharmacology (Berl) 169:365-6. 2003
  26. ncbi request reprint How the brain processes social information: searching for the social brain
    Thomas R Insel
    National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Annu Rev Neurosci 27:697-722. 2004
    ....
  27. pmc Translational research in the decade of discovery
    Thomas R Insel
    National Institute of Mental Health, 6001 Executive Blvd, Room 8235, Bethesda, MD 20892, USA
    Horm Behav 50:504-5. 2006
  28. ncbi request reprint Neuroendocrine basis of social recognition
    James T Winslow
    National Institute of Mental Health, National Institutes of Health Animal Center, Building 110, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Curr Opin Neurobiol 14:248-53. 2004
    ..Several lines of evidence have emerged that indicate that neuropeptide regulation is significantly modulated by gonadal and corticosteroid activation...
  29. pmc Pharmacogenomics and personalized medicine in neuropsychiatry
    Francis J McMahon
    National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 3719, USA
    Neuron 74:773-6. 2012
    ..Here we discuss the promise of personalized medicine in developing more efficacious and individualized pharmacotherapies that take into account genetic variation and target groups of patients who share biology, not just symptoms...
  30. doi request reprint The STAR*D trial: revealing the need for better treatments
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892 9669, USA
    Psychiatr Serv 60:1466-7. 2009
    ..However, initial and one-year remission rates (28% and 70%, respectively) suggest that important goals for treatment of this disabling disease remain out of reach and that the bar for antidepressants has been set far too low...
  31. ncbi request reprint Ensuring public trust
    Thomas R Insel
    National Institute of Mental Health, 6001 Executive Boulevard, Room 8235, MSC 9669, Bethesda, MD 20892, USA
    Biol Psychiatry 56:539. 2004
  32. pmc The knockout mouse project
    Christopher P Austin
    National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, 31 Center Drive, Bethesda, Maryland 20892, USA
    Nat Genet 36:921-4. 2004
    ..It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain...
  33. ncbi request reprint Depression and comorbid medical illness: the National Institute of Mental Health perspective
    Ellen Stover
    National Institute of Mental Health, National Institutes of Health, 6001 Executive Boulevard, Room 6217, MSC 9621 Bethesda, MD 20892 9621, USA
    Biol Psychiatry 54:184-6. 2003
  34. ncbi request reprint Epigenetic sources of behavioral differences in mice
    Darlene D Francis
    Center for Behavioral Neuroscience, Emory University, Yerkes Research Center, 954 Gatewood Rd, Atlanta, Georgia 30329, USA
    Nat Neurosci 6:445-6. 2003
  35. pmc Public health contributions
    Steven E Hyman
    Schizophr Bull 33:1151-2. 2007
  36. pmc Tribute to Wayne Fenton, MD (1953-2006)
    Thomas R Insel
    Schizophr Res 88:1-2. 2006
  37. pmc A new era in psychiatric genetics?
    Thomas R Insel
    Biol Psychiatry 61:1017-8. 2007
  38. doi request reprint Cognitive neuroscience and schizophrenia: translational research in need of a translator
    Jonathan D Cohen
    Department of Psychology and Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA
    Biol Psychiatry 64:2-3. 2008
  39. doi request reprint Assessing the economic costs of serious mental illness
    Thomas R Insel
    Am J Psychiatry 165:663-5. 2008
  40. ncbi request reprint What are the long-term effects of methylphenidate treatment?
    Nora D Volkow
    Biol Psychiatry 54:1307-9. 2003
  41. ncbi request reprint The neuroendocrine basis of social recognition
    Jennifer N Ferguson
    Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30322, USA
    Front Neuroendocrinol 23:200-24. 2002
    ..These findings support the hypothesis that vasopressin and oxytocin are essential for social memory, although they appear to influence different cognitive processes and may modulate different neural systems. (c) Elsevier Science...
  42. ncbi request reprint Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds
    Brandon J Aragona
    Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida 32306 1270, USA
    Nat Neurosci 9:133-9. 2006
    ..Thus, neuroplastic reorganization of the nucleus accumbens dopamine system is responsible for the enduring nature of monogamous pair bonding. Finally, we show that this system may also contribute to species-specific social organization...
  43. pmc The promise of extinction research for the prevention and treatment of anxiety disorders
    Kathleen C Anderson
    Biol Psychiatry 60:319-21. 2006
  44. pmc Beyond efficacy: the STAR*D trial
    Thomas R Insel
    Am J Psychiatry 163:5-7. 2006
  45. ncbi request reprint Rearing effects on cerebrospinal fluid oxytocin concentration and social buffering in rhesus monkeys
    James T Winslow
    Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30322, USA
    Neuropsychopharmacology 28:910-8. 2003
    ..These results are consistent with earlier reports from studies of rodents suggesting an important role for central OT pathways in the development of social affiliation...
  46. ncbi request reprint From animal models to model animals
    Thomas R Insel
    Biol Psychiatry 62:1337-9. 2007