T R Insel

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Translational research in the decade of discovery
    Thomas R Insel
    National Institute of Mental Health, 6001 Executive Blvd, Room 8235, Bethesda, MD 20892, USA
    Horm Behav 50:504-5. 2006
  2. doi request reprint Next-generation treatments for mental disorders
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892, USA
    Sci Transl Med 4:155ps19. 2012
  3. ncbi request reprint Psychiatry in the genomics era
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892, USA
    Am J Psychiatry 160:616-20. 2003
  4. pmc Psychiatric epidemiology: it's not just about counting anymore
    Thomas R Insel
    Arch Gen Psychiatry 62:590-2. 2005
  5. ncbi request reprint Is social attachment an addictive disorder?
    Thomas R Insel
    Center for Behavioral Neuroscience, Emory University, Altanta, GA, USA
    Physiol Behav 79:351-7. 2003
  6. pmc Neuroscience networks: data-sharing in an information age
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health in Bethesda, Maryland, USA
    PLoS Biol 1:E17. 2003
  7. ncbi request reprint Limits to growth: why neuroscience needs large-scale science
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health, 6001 Executive Boulevard, Bethesda, Maryland 20892 9669, USA
    Nat Neurosci 7:426-7. 2004
  8. ncbi request reprint How the brain processes social information: searching for the social brain
    Thomas R Insel
    National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Annu Rev Neurosci 27:697-722. 2004
  9. ncbi request reprint Ensuring public trust
    Thomas R Insel
    National Institute of Mental Health, 6001 Executive Boulevard, Room 8235, MSC 9669, Bethesda, MD 20892, USA
    Biol Psychiatry 56:539. 2004
  10. doi request reprint The STAR*D trial: revealing the need for better treatments
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892 9669, USA
    Psychiatr Serv 60:1466-7. 2009

Detail Information

Publications56

  1. pmc Translational research in the decade of discovery
    Thomas R Insel
    National Institute of Mental Health, 6001 Executive Blvd, Room 8235, Bethesda, MD 20892, USA
    Horm Behav 50:504-5. 2006
  2. doi request reprint Next-generation treatments for mental disorders
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892, USA
    Sci Transl Med 4:155ps19. 2012
    ..This retreat comes just as research is identifying new molecular targets, new clinical targets, and new uses of current treatments that may serve as the basis for the next generation of treatments for mental disorders...
  3. ncbi request reprint Psychiatry in the genomics era
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892, USA
    Am J Psychiatry 160:616-20. 2003
  4. pmc Psychiatric epidemiology: it's not just about counting anymore
    Thomas R Insel
    Arch Gen Psychiatry 62:590-2. 2005
  5. ncbi request reprint Is social attachment an addictive disorder?
    Thomas R Insel
    Center for Behavioral Neuroscience, Emory University, Altanta, GA, USA
    Physiol Behav 79:351-7. 2003
    ..The neuropeptides oxytocin (OT) and vasopressin (AVP) appear to be critical for linking social signals to the mesocorticolimbic circuit...
  6. pmc Neuroscience networks: data-sharing in an information age
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health in Bethesda, Maryland, USA
    PLoS Biol 1:E17. 2003
  7. ncbi request reprint Limits to growth: why neuroscience needs large-scale science
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health, 6001 Executive Boulevard, Bethesda, Maryland 20892 9669, USA
    Nat Neurosci 7:426-7. 2004
  8. ncbi request reprint How the brain processes social information: searching for the social brain
    Thomas R Insel
    National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Annu Rev Neurosci 27:697-722. 2004
    ....
  9. ncbi request reprint Ensuring public trust
    Thomas R Insel
    National Institute of Mental Health, 6001 Executive Boulevard, Room 8235, MSC 9669, Bethesda, MD 20892, USA
    Biol Psychiatry 56:539. 2004
  10. doi request reprint The STAR*D trial: revealing the need for better treatments
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892 9669, USA
    Psychiatr Serv 60:1466-7. 2009
    ..However, initial and one-year remission rates (28% and 70%, respectively) suggest that important goals for treatment of this disabling disease remain out of reach and that the bar for antidepressants has been set far too low...
  11. ncbi request reprint Developmental psychobiology for public health: a bridge for translational research
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892, USA
    Dev Psychobiol 47:209-16. 2005
  12. pmc Devising prevention and treatment strategies for the nation's diverse populations with mental illness
    Thomas R Insel
    National Institute of Mental Health, Room 8235, MSC 9669, 6001 Executive Boulevard, Bethesda, MD 20892, USA
    Psychiatr Serv 58:395. 2007
  13. pmc Cure therapeutics and strategic prevention: raising the bar for mental health research
    T R Insel
    National Institute of Mental Health NIH, Rm 8235, 6001 Executive Boulevard, Bethesda, MD 20892, USA
    Mol Psychiatry 11:11-7. 2006
    ..This essay argues for approaches that can lead to cures and strategies for prevention of schizophrenia and mood disorders...
  14. pmc Research funding: the view from NIH
    Thomas R Insel
    National Institute of Mental Health, 6001 Executive Blvd, Room 8235, MSC 9669 Bethesda, MD 20892 9669, USA
    Am J Psychiatry 163:2043-5. 2006
  15. ncbi request reprint Molecular aspects of monogamy
    T R Insel
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 807:302-16. 1997
    ..Acad. Sci USA 93: 12501). The correct sequence shows greater homology with the vole oxytocin receptor gene sequences, but the remaining differences support the argument made herein for species differences in regional receptor expression...
  16. ncbi request reprint A neurobiological basis of social attachment
    T R Insel
    Yerkes Primate Center, Emory University, Atlanta, GA 30322, USA
    Am J Psychiatry 154:726-35. 1997
    ..The primary purpose of this article is to describe a novel approach to the neurobiology of attachment...
  17. ncbi request reprint Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole
    L J Young
    Department of Psychiatry and Behavioural Sciences, Emory University, Atlanta, Georgia 30322, USA
    Nature 400:766-8. 1999
    ..These data indicate that the pattern of V1a-receptor gene expression in the brain may be functionally associated with species-typical social behaviours in male vertebrates...
  18. ncbi request reprint Autoradiographic and in situ hybridization localization of corticotropin-releasing factor 1 and 2 receptors in nonhuman primate brain
    M M Sanchez
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 408:365-77. 1999
    ....
  19. pmc Psychiatry as a clinical neuroscience discipline
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 294:2221-4. 2005
  20. pmc The knockout mouse project
    Christopher P Austin
    National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, 31 Center Drive, Bethesda, Maryland 20892, USA
    Nat Genet 36:921-4. 2004
    ..It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain...
  21. doi request reprint Rethinking schizophrenia
    Thomas R Insel
    National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Nature 468:187-93. 2010
    ..This 'rethinking' of schizophrenia as a neurodevelopmental disorder, which is profoundly different from the way we have seen this illness for the past century, yields new hope for prevention and cure over the next two decades...
  22. pmc Eating disorders: National Institute of Mental Health's perspective
    Mark Chavez
    National Institute of Mental Health, Bethesda, MD 20892, USA
    Am Psychol 62:159-66. 2007
    ....
  23. pmc Neuroscience. Shining light on depression
    Thomas R Insel
    National Institute for Mental Health, Bethesda, MD 20892, USA
    Science 317:757-8. 2007
  24. pmc Disruptive insights in psychiatry: transforming a clinical discipline
    Thomas R Insel
    National Institute of Mental Health, 6001 Executive Blvd, Room 8235, MSC 9669, Bethesda, Maryland 20892 9669, USA
    J Clin Invest 119:700-5. 2009
    ..Current medications are not sufficient for most patients. A new and deep understanding of the pathophysiology of these disabling disorders is our best hope for a new generation of treatments that will help patients to recover...
  25. ncbi request reprint Breaking the log-jam in treatment development for cognition in schizophrenia: NIMH perspective
    Wayne S Fenton
    National Institute of Mental Health, National Institute of Health, US Department of Health and Human Services, Room 6216, 6001 Executive Boulevard, MSC 9621, Bethesda, MD 20892 9621, USA
    Psychopharmacology (Berl) 169:365-6. 2003
  26. ncbi request reprint NIH Molecular Libraries Initiative
    Christopher P Austin
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 306:1138-9. 2004
  27. ncbi request reprint Research on major depression: strategies and priorities
    Thomas R Insel
    National Institute of Mental Health, Bethesda, MD 20892, USA
    JAMA 289:3167-8. 2003
  28. doi request reprint Translating scientific opportunity into public health impact: a strategic plan for research on mental illness
    Thomas R Insel
    Natrional Institute of Mental Health, 6001 Executive Blvd, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 66:128-33. 2009
    ..Exciting advances in neuroscience and genomics have transformed research but have not yet been translated to public health impact in psychiatry. Current treatments are necessary but not sufficient for most patients...
  29. pmc The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 65:768-79. 2010
    ..This review describes the promises and problems of extrapolating these findings to human social cognition, with specific reference to the social deficits of autism...
  30. ncbi request reprint Neuropeptides and the evolution of social behavior
    T R Insel
    954 Gatewood Road NE, Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30329, USA
    Curr Opin Neurobiol 10:784-9. 2000
    ..Second, species variations in receptor gene structure can alter neuropeptide receptor distribution and thereby contribute to species differences in social behavior...
  31. ncbi request reprint Oxytocin: who needs it?
    T R Insel
    Center for Behavioral Neuroscience, Emory University, Atlanta, GA 30322, USA
    Prog Brain Res 133:59-66. 2001
    ..Most important, in considering the behavioral or cognitive functions of oxytocin, one cannot accurately extrapolate across species unless one knows the species have the same neuroanatomical location of oxytocin receptors...
  32. ncbi request reprint The neurobiology of attachment
    T R Insel
    Center for Behavioral Neuroscience, 954 Gatewood Road Northeast, Emory University, Atlanta, Georgia 30329, USA
    Nat Rev Neurosci 2:129-36. 2001
    ..This review describes some of the important insights from this work...
  33. ncbi request reprint Dopamine D2 receptor-mediated regulation of partner preferences in female prairie voles (Microtus ochrogaster): a mechanism for pair bonding?
    Z Wang
    Department of Psychiatry and Behavioral Sciences and Graduate Program in Neuroscience, Emory University, USA
    Behav Neurosci 113:602-11. 1999
    ..Together, these data suggest that mating-induced PP requires activation of D2 receptors and that social experience may activate dopaminergic pathways, with enduring effects on behavior...
  34. ncbi request reprint The primate neocortex in comparative perspective using magnetic resonance imaging
    J K Rilling
    Department of Anthropology and Yerkes Regional Primate Research Center, Emory University, Atlanta, GA 30322, USA
    J Hum Evol 37:191-223. 1999
    ..These modifications may constitute part of the neurobiological substrate that supports some of our species most distinctive cognitive abilities...
  35. doi request reprint Wayne Fenton, M.D
    Ellen Stover
    NIMH, 6001 Executive Blvd, Rm 8235, MSC 9669, Bethesda, MD 20892 9669, USA
    Am J Psychiatry 165:177-8. 2008
  36. ncbi request reprint Depression and comorbid medical illness: the National Institute of Mental Health perspective
    Ellen Stover
    National Institute of Mental Health, National Institutes of Health, 6001 Executive Boulevard, Room 6217, MSC 9621 Bethesda, MD 20892 9621, USA
    Biol Psychiatry 54:184-6. 2003
  37. ncbi request reprint Epigenetic sources of behavioral differences in mice
    Darlene D Francis
    Center for Behavioral Neuroscience, Emory University, Yerkes Research Center, 954 Gatewood Rd, Atlanta, Georgia 30329, USA
    Nat Neurosci 6:445-6. 2003
  38. ncbi request reprint The conundrum of co-occurring mental and substance use disorders: opportunities for research
    Junius J Gonzales
    National Institute of Mental Health, 6001 Executive Boulevard, Room 8235, Bethesda, MD 20892, USA
    Biol Psychiatry 56:723-5. 2004
  39. ncbi request reprint Facilitation of affiliation and pair-bond formation by vasopressin receptor gene transfer into the ventral forebrain of a monogamous vole
    L J Pitkow
    Center for Behavioral Neuroscience and Department of Psychiatry, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 21:7392-6. 2001
    ..These data demonstrate a role for ventral pallidal V1aR in affiliation and social attachment and provide a potential molecular mechanism for species differences in social organization...
  40. ncbi request reprint Cellular mechanisms of social attachment
    L J Young
    Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30322, USA
    Horm Behav 40:133-8. 2001
    ..Therefore, we hypothesize that oxytocin and vasopressin may be facilitating affiliation and social attachment in monogamous species by modulating these reward pathways...
  41. ncbi request reprint The social deficits of the oxytocin knockout mouse
    J T Winslow
    Center for Behavioral Neuroscience, Yerkes Regional Primate Center, Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    Neuropeptides 36:221-9. 2002
    ..These studies may provide valuable new perspectives on diseases characterized by social deficits, such as autism or reactive attachment disorder...
  42. ncbi request reprint Serotonergic responsivity in obsessive-compulsive disorder. Comparison of patients and healthy controls
    J Zohar
    Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892
    Arch Gen Psychiatry 44:946-51. 1987
    ..These findings are consistent with a special role for the neurotransmitter serotonin in OCD psychopathology...
  43. ncbi request reprint The neuroendocrine basis of social recognition
    Jennifer N Ferguson
    Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30322, USA
    Front Neuroendocrinol 23:200-24. 2002
    ..These findings support the hypothesis that vasopressin and oxytocin are essential for social memory, although they appear to influence different cognitive processes and may modulate different neural systems. (c) Elsevier Science...
  44. ncbi request reprint Neuroendocrine basis of social recognition
    James T Winslow
    National Institute of Mental Health, National Institutes of Health Animal Center, Building 110, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Curr Opin Neurobiol 14:248-53. 2004
    ..Several lines of evidence have emerged that indicate that neuropeptide regulation is significantly modulated by gonadal and corticosteroid activation...
  45. ncbi request reprint Rearing effects on cerebrospinal fluid oxytocin concentration and social buffering in rhesus monkeys
    James T Winslow
    Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30322, USA
    Neuropsychopharmacology 28:910-8. 2003
    ..These results are consistent with earlier reports from studies of rodents suggesting an important role for central OT pathways in the development of social affiliation...
  46. doi request reprint Cognitive neuroscience and schizophrenia: translational research in need of a translator
    Jonathan D Cohen
    Department of Psychology and Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA
    Biol Psychiatry 64:2-3. 2008
  47. doi request reprint Assessing the economic costs of serious mental illness
    Thomas R Insel
    Am J Psychiatry 165:663-5. 2008
  48. pmc A new era in psychiatric genetics?
    Thomas R Insel
    Biol Psychiatry 61:1017-8. 2007
  49. pmc Public health contributions
    Steven E Hyman
    Schizophr Bull 33:1151-2. 2007
  50. pmc Tribute to Wayne Fenton, MD (1953-2006)
    Thomas R Insel
    Schizophr Res 88:1-2. 2006
  51. ncbi request reprint From animal models to model animals
    Thomas R Insel
    Biol Psychiatry 62:1337-9. 2007
  52. ncbi request reprint What are the long-term effects of methylphenidate treatment?
    Nora D Volkow
    Biol Psychiatry 54:1307-9. 2003
  53. ncbi request reprint Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds
    Brandon J Aragona
    Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida 32306 1270, USA
    Nat Neurosci 9:133-9. 2006
    ..Thus, neuroplastic reorganization of the nucleus accumbens dopamine system is responsible for the enduring nature of monogamous pair bonding. Finally, we show that this system may also contribute to species-specific social organization...
  54. pmc The promise of extinction research for the prevention and treatment of anxiety disorders
    Kathleen C Anderson
    Biol Psychiatry 60:319-21. 2006
  55. pmc Beyond efficacy: the STAR*D trial
    Thomas R Insel
    Am J Psychiatry 163:5-7. 2006