D K Ingram

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Application of gene therapy to treat age-related loss of dopamine D2 receptor
    D K Ingram
    Molecular Physiology and Genetics Section, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Exp Gerontol 33:793-804. 1998
  2. ncbi request reprint Age-related decline in physical activity: generalization to nonhumans
    D K Ingram
    Behavioral Neuroscience Section, Laboratory of the Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Med Sci Sports Exerc 32:1623-9. 2000
  3. ncbi request reprint Vaccine development for Alzheimer's disease: a shot of good news
    D K Ingram
    Behavioral Neuroscience Section, Laboratory of Neuroscience, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Lane Drive, Baltimore, MD 21224, USA
    Trends Neurosci 24:305-7. 2001
  4. ncbi request reprint Developing mouse models of aging: a consideration of strain differences in age-related behavioral and neural parameters
    D K Ingram
    Molecular Physiology and Genetics Section, Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Neurobiol Aging 20:137-45. 1999
  5. ncbi request reprint Strategy for identifying biomarkers of aging in long-lived species
    D K Ingram
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Exp Gerontol 36:1025-34. 2001
  6. ncbi request reprint Aging and caloric restriction in nonhuman primates: behavioral and in vivo brain imaging studies
    D K Ingram
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 928:316-26. 2001
  7. ncbi request reprint Effects of reduced energy intake on the biology of aging: the primate model
    G S Roth
    National Institute on Aging, Baltimore, MD 21224, USA
    Eur J Clin Nutr 54:S15-20. 2000
  8. ncbi request reprint Short-term calorie restriction improves disease-related markers in older male rhesus monkeys (Macaca mulatta)
    M A Lane
    Intramural Research Program, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Mech Ageing Dev 112:185-96. 2000
  9. ncbi request reprint Caloric restriction in primates and relevance to humans
    G S Roth
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 928:305-15. 2001
  10. ncbi request reprint Caloric restriction in primates
    M A Lane
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 928:287-95. 2001

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Application of gene therapy to treat age-related loss of dopamine D2 receptor
    D K Ingram
    Molecular Physiology and Genetics Section, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Exp Gerontol 33:793-804. 1998
    ..These include functional assessment of the current vector in D2R null mutant mice as well as construction of new vectors that may yield more long-term expression...
  2. ncbi request reprint Age-related decline in physical activity: generalization to nonhumans
    D K Ingram
    Behavioral Neuroscience Section, Laboratory of the Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Med Sci Sports Exerc 32:1623-9. 2000
    ..Reduced dopamine release or loss of dopamine receptors appears to underlie age-related activity decline, and interventions that enhance dopamine function can increase activity levels in aged animals...
  3. ncbi request reprint Vaccine development for Alzheimer's disease: a shot of good news
    D K Ingram
    Behavioral Neuroscience Section, Laboratory of Neuroscience, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Lane Drive, Baltimore, MD 21224, USA
    Trends Neurosci 24:305-7. 2001
    ....
  4. ncbi request reprint Developing mouse models of aging: a consideration of strain differences in age-related behavioral and neural parameters
    D K Ingram
    Molecular Physiology and Genetics Section, Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Neurobiol Aging 20:137-45. 1999
    ..Thus, our intention is to underscore the growing importance of mouse models of brain aging and the concomitant need for additional information about mouse aging in general...
  5. ncbi request reprint Strategy for identifying biomarkers of aging in long-lived species
    D K Ingram
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Exp Gerontol 36:1025-34. 2001
    ....
  6. ncbi request reprint Aging and caloric restriction in nonhuman primates: behavioral and in vivo brain imaging studies
    D K Ingram
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 928:316-26. 2001
    ....
  7. ncbi request reprint Effects of reduced energy intake on the biology of aging: the primate model
    G S Roth
    National Institute on Aging, Baltimore, MD 21224, USA
    Eur J Clin Nutr 54:S15-20. 2000
    ..In summary, nearly all CR effects detected in rodents, which have thus far been examined in primates, exhibit similar phenomenology. Potential applicability of these beneficial effects to humans is discussed...
  8. ncbi request reprint Short-term calorie restriction improves disease-related markers in older male rhesus monkeys (Macaca mulatta)
    M A Lane
    Intramural Research Program, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Mech Ageing Dev 112:185-96. 2000
    ..Interestingly, the observed glucoregulatory changes emerged prior to any evidence of a change in body composition suggesting that certain effects of CR may not be wholly dependent on changes in body composition in older monkeys...
  9. ncbi request reprint Caloric restriction in primates and relevance to humans
    G S Roth
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 928:305-15. 2001
    ....
  10. ncbi request reprint Caloric restriction in primates
    M A Lane
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 928:287-95. 2001
    ....
  11. ncbi request reprint Stereological estimation of total microglia number in mouse hippocampus
    J M Long
    Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Neurosci Methods 84:101-8. 1998
    ..The combination of immunocytochemistry and stereology provides a reliable means to assess microglia number that can easily be adopted for studies of transgenic and lesion-based models of aging and neurodegenerative diseases...
  12. ncbi request reprint A nonhuman primate model of age-related bone loss: a longitudinal study in male and premenopausal female rhesus monkeys
    A Black
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA
    Bone 28:295-302. 2001
    ..Changes in markers of bone turnover with age were also observed in male monkeys. The results of this longitudinal study suggest that the rhesus monkey is a potential model for age-related changes in the human skeleton...
  13. ncbi request reprint Energy restriction does not alter bone mineral metabolism or reproductive cycling and hormones in female rhesus monkeys
    M A Lane
    Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Nutr 131:820-7. 2001
    ..02) concentrations than did younger monkeys. We conclude that ER does not negatively affect these indices of skeletal or reproductive health and does not alter age-associated changes in the same variables...
  14. ncbi request reprint Nutritional modulation of aging in nonhuman primates
    M A Lane
    Intramural Research Program, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    J Nutr Health Aging 3:69-76. 1999
    ..This review summarizes the major findings from the primate CR studies after over a decade of research in this model...
  15. ncbi request reprint Effect of age and caloric restriction on cutaneous wound closure in rats and monkeys
    G S Roth
    Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, USA
    J Gerontol A Biol Sci Med Sci 52:B98-102. 1997
    ..Thus, impaired wound healing appears to be a generalized physiological manifestation of aging, but its possible amelioration by "anti-aging" interventions remains to be established...
  16. ncbi request reprint Calorie restriction in nonhuman primates: assessing effects on brain and behavioral aging
    D K Ingram
    Laboratory of Experimental Gerontology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroscience 145:1359-64. 2007
    ..Increasing interest in the CR paradigm will expand its role in demonstrating how nutrition can modulate the rate of aging and the mechanisms responsible for this modulation...
  17. ncbi request reprint Calorie restriction and skeletal mass in rhesus monkeys (Macaca mulatta): evidence for an effect mediated through changes in body size
    A Black
    Molecular and Nutritional Physiology Unit, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Gerontol A Biol Sci Med Sci 56:B98-107. 2001
    ..Although osteocalcin concentrations were significantly lower in young restricted males after 1 month on 30% CR in the short-term study, they were no longer different from control values by 6 months on 30% CR...
  18. ncbi request reprint Calorie restriction in nonhuman primates: effects on diabetes and cardiovascular disease risk
    M A Lane
    Intramural Research Program, Gerontology Research Center, National Institute on Aging, NIH Baltimore, Maryland 21224, USA
    Toxicol Sci 52:41-8. 1999
    ..These and other findings have suggested that CR might have beneficial effects on certain disease risk factors independent of reductions in body weight or prevention of obesity...
  19. ncbi request reprint The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics
    N H Greig
    Laboratory of Neurosciences, Intramural Research Program, National Institute of Aging, Gerontology Research Center, Baltimore, MD 21224, USA
    Acta Neurol Scand Suppl 176:74-84. 2000
    ....
  20. ncbi request reprint What counts in brain aging? Design-based stereological analysis of cell number
    J M Long
    Molecular Physiology and Genetics Section, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Gerontol A Biol Sci Med Sci 54:B407-17. 1999
    ..Emergence of this method of morphometrics, however, can have relevance to many areas of gerontological research...
  21. ncbi request reprint Death of PC12 cells and hippocampal neurons induced by adenoviral-mediated FAD human amyloid precursor protein gene expression
    J J Luo
    Molecular Neurobiology Unit, Laboratory of Biological Chemistry, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Neurosci Res 55:629-42. 1999
    ..These results demonstrate the usefulness of recombinant adenoviral mediated gene transfer in cell culture studies and suggest that overexpression of a familial Alzheimer's disease mutant APP may be toxic to neuronal cells...
  22. ncbi request reprint Dehydroepiandrosterone sulfate: a biomarker of primate aging slowed by calorie restriction
    M A Lane
    Gerontology Research Center, Nathan W Shock Laboratories, National Institutes of Health, Johns Hopkins University Bayview Campus, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 82:2093-6. 1997
    ..This represents the first evidence that this nutritional intervention has the potential to alter aspects of postmaturational aging in a long-lived species...
  23. pmc The effects of age and lipopolysaccharide (LPS)-mediated peripheral inflammation on numbers of central catecholaminergic neurons
    P R Mouton
    Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Neurobiol Aging 33:423.e27-36. 2012
    ..Thus, unknown mechanisms in the B6 mouse brain appear to protect against catecholaminergic neuron loss following an acute episode of severe inflammation, while catecholaminergic neuron loss occurs during normal aging...
  24. ncbi request reprint Behavioral assessment of the senescence-accelerated mouse (SAM P8 and R1)
    A L Markowska
    Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218, USA
    Physiol Behav 64:15-26. 1998
    ..Thus, the behavioral abnormalities that exist not only represent an accelerated aging phenomenon but may also be considered a developmental pathology...
  25. ncbi request reprint Stereological analysis of astrocyte and microglia in aging mouse hippocampus
    J M Long
    Molecular Physiology and Genetics Section, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Neurobiol Aging 19:497-503. 1998
    ..These findings suggest that age-related increases in the total numbers of hippocampal microglia and astrocytes is not causal for observed age-related increases in cytokine response...
  26. pmc Acquisition of conditioned taste aversion is impaired in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer's disease
    P J Pistell
    Behavioral Neuroscience Section, Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroscience 152:594-600. 2008
    ..However, further analysis indicated a potential gender difference in both the CTA deficit and onset of plaque deposition with females showing greater conditioned aversion...
  27. ncbi request reprint Dietary caloric restriction prevents the age-related decline in plasma melatonin levels of rhesus monkeys
    G S Roth
    Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 86:3292-5. 2001
    ..Moreover, this index of age-associated physiological decrement seems to be inhibited by dietary CR...
  28. ncbi request reprint Effect of long-term caloric restriction and exercise on muscle bioenergetics and force development in rats
    A Horska
    Nuclear Magnetic Resonance Unit, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Am J Physiol 276:E766-73. 1999
    ..6 +/- 5.7 micromol. min-1. g-1; P < 0.05). Our experiments thus demonstrated a synergistic effect of long-term caloric restriction and free exercise on muscle bioenergetics during electrical stimulation...
  29. ncbi request reprint Age-related changes in cytokine production by leukocytes in rhesus monkeys
    P Mascarucci
    Laboratories of Neurosciences, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Aging (Milano) 13:85-94. 2001
    ..We believe that such age-related alterations in cytokine production may play a role in the reduced immune responses observed in elderly human populations...
  30. ncbi request reprint Age-related decline in striatal volume in monkeys as measured by magnetic resonance imaging
    J A Matochik
    Brain Imaging Center, Neuroimaging Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neurobiol Aging 21:591-8. 2000
    ..The current results provide normative data to assess potential interventions (e.g. caloric restriction) in the aging process...
  31. ncbi request reprint Accuracy and precision of dual-energy X-ray absorptiometry for body composition measurements in rhesus monkeys
    A Black
    Nutritional and Molecular Physiology Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Med Primatol 30:94-9. 2001
    ..DXA also accurately measured lumbar spine BMC but underestimated total body BMC as compared with carcass ash determinations...
  32. ncbi request reprint Calorie restriction attenuates age-related alterations in the plasma membrane antioxidant system in rat liver
    R de Cabo
    Laboratory of Experimental Gerontology, National Institute on Aging, NIH, Gerontology Research Center, Box 10, 5600 Nathan Shock Drive, Baltimore, MD 21224 6825, USA
    Exp Gerontol 39:297-304. 2004
    ..Thus, our results suggest that CR induces a higher capacity to oxidize NAD(P)H in the PM of old rat livers and as a result, a higher resistance to oxidative stress-induced damage...
  33. ncbi request reprint Enhancement of amphetamine-induced locomotor response in rats on different regimens of diet restriction and 2-deoxy-D-glucose treatment
    J Mamczarz
    Behavioral Neuroscience Section, Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroscience 131:451-64. 2005
    ..Thus, 2DG appears to activate DA pathways in the same direction as DR does but without the necessity of reducing caloric intake...
  34. ncbi request reprint Effects of dietary caloric restriction and aging on thyroid hormones of rhesus monkeys
    G S Roth
    Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland 21224, USA
    Horm Metab Res 34:378-82. 2002
    ..In the light of the effects of the thyroid axis on overall metabolism, these results suggest a possible mechanism by which CR diets may elicit their well-known beneficial 'anti-aging' effects in mammals...
  35. pmc A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys
    P V Vaitkevicius
    Intramural Research Program, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 98:1171-5. 2001
    ....
  36. ncbi request reprint Identification of maze learning-associated genes in rat hippocampus by cDNA microarray
    Y Luo
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Mol Neurosci 17:397-404. 2001
    ..The gene-expression profile presented here provides the groundwork for future, more focused research to elucidate the contribution of these genes in learning and memory processes...
  37. ncbi request reprint Effects of estrogen and raloxifene on neuroglia number and morphology in the hippocampus of aged female mice
    D L Lei
    Laboratory of Experimental Gerontology, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Neuroscience 121:659-66. 2003
    ..These findings indicate that estrogen and selective estrogen receptor modulators can influence glial-mediated inflammatory pathways and possibly protect against age- and disease-related neuropathology...
  38. ncbi request reprint A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase
    N H Greig
    National Institute on Aging, Baltimore, MD, USA
    Curr Med Res Opin 17:159-65. 2001
    ..The development of specific BuChE inhibitors and the continued use of ChE inhibitors with the ability to inhibit BuChE in addition to AChE should lead to improved clinical outcomes...
  39. ncbi request reprint Longitudinal follow-up study of adenoviral vector-mediated gene transfer of dopamine D2 receptors in the striatum in young, middle-aged, and aged rats: a positron emission tomography study
    H Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Neuroscience 121:479-86. 2003
    ....
  40. ncbi request reprint Effect of caloric restriction on the 24-hour plasma DHEAS and cortisol profiles of young and old male rhesus macaques
    H F Urbanski
    Division of Neuroscience, Oregon National Primate Research Center, 505 N W 185 th Avenue, Beaverton, OR 97006, USA
    Ann N Y Acad Sci 1019:443-7. 2004
    ..These data fail to support the hypothesis that CR can attenuate the aging-related decline in plasma DHEAS concentrations, at least not when initiated after puberty...
  41. ncbi request reprint Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta). J Med Primatol 30:161-173, 2001
    D A Smucny
    Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    J Med Primatol 33:48-54. 2004
    ..These data were collected from several research colonies and have been submitted to rigorous statistical analyses to identify relationships with chronological age...
  42. ncbi request reprint Nicotine reduces the secretion of Alzheimer's beta-amyloid precursor protein containing beta-amyloid peptide in the rat without altering synaptic proteins
    D K Lahiri
    Laboratory of Molecular Neurogenetics, Department of Psychiatry and Neurology, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Ann N Y Acad Sci 965:364-72. 2002
    ....
  43. pmc Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency
    G Lopez-Lluch
    Centro Andaluz de Biologia del Desarrollo, Universidad Pablo de Olavide, 41013 Sevilla, Spain
    Proc Natl Acad Sci U S A 103:1768-73. 2006
    ....
  44. ncbi request reprint Extending the lifespan of long-lived mice
    A Bartke
    Department of Physiology, School of Medicine, Southern Illinois University, Carbondale, Illinois 62901, USA
    Nature 414:412. 2001
  45. ncbi request reprint Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta)
    D A Smucny
    Wisconsin Regional Primate Research Center, Madison, USA
    J Med Primatol 30:161-73. 2001
    ..Here we present the first phase of a project that will: a) identify changes with age in physiological variables among adult captive rhesus macaques; and b) characterize normative values for the aging rhesus population...