D K Ingram

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Development of calorie restriction mimetics as a prolongevity strategy
    Donald K Ingram
    Laboratory of Experimental Gerontology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Ann N Y Acad Sci 1019:412-23. 2004
  2. ncbi request reprint Calorie restriction in nonhuman primates: assessing effects on brain and behavioral aging
    D K Ingram
    Laboratory of Experimental Gerontology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroscience 145:1359-64. 2007
  3. ncbi request reprint The potential for dietary restriction to increase longevity in humans: extrapolation from monkey studies
    Donald K Ingram
    Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Biogerontology 7:143-8. 2006
  4. ncbi request reprint Calorie restriction mimetics: an emerging research field
    Donald K Ingram
    Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Aging Cell 5:97-108. 2006
  5. ncbi request reprint Caloric restriction in primates and relevance to humans
    G S Roth
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 928:305-15. 2001
  6. ncbi request reprint Effects of reduced energy intake on the biology of aging: the primate model
    G S Roth
    National Institute on Aging, Baltimore, MD 21224, USA
    Eur J Clin Nutr 54:S15-20. 2000
  7. ncbi request reprint Short-term calorie restriction improves disease-related markers in older male rhesus monkeys (Macaca mulatta)
    M A Lane
    Intramural Research Program, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Mech Ageing Dev 112:185-96. 2000
  8. ncbi request reprint Stereological estimation of total microglia number in mouse hippocampus
    J M Long
    Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Neurosci Methods 84:101-8. 1998
  9. ncbi request reprint A nonhuman primate model of age-related bone loss: a longitudinal study in male and premenopausal female rhesus monkeys
    A Black
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA
    Bone 28:295-302. 2001
  10. ncbi request reprint Caloric restriction in primates
    M A Lane
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 928:287-95. 2001

Collaborators

Detail Information

Publications114 found, 100 shown here

  1. ncbi request reprint Development of calorie restriction mimetics as a prolongevity strategy
    Donald K Ingram
    Laboratory of Experimental Gerontology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Ann N Y Acad Sci 1019:412-23. 2004
    ..Further life span analyses in addition to expanded toxicity studies must be completed to assess the potential of any CR mimetic, but this strategy now appears to offer a very promising and expanding research field...
  2. ncbi request reprint Calorie restriction in nonhuman primates: assessing effects on brain and behavioral aging
    D K Ingram
    Laboratory of Experimental Gerontology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroscience 145:1359-64. 2007
    ..Increasing interest in the CR paradigm will expand its role in demonstrating how nutrition can modulate the rate of aging and the mechanisms responsible for this modulation...
  3. ncbi request reprint The potential for dietary restriction to increase longevity in humans: extrapolation from monkey studies
    Donald K Ingram
    Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Biogerontology 7:143-8. 2006
    ....
  4. ncbi request reprint Calorie restriction mimetics: an emerging research field
    Donald K Ingram
    Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Aging Cell 5:97-108. 2006
    ..Ultimately, lifespan analyses in addition to expanded toxicity studies must be accomplished to fully assess the potential of any CRM. Nonetheless, this strategy clearly offers a very promising and expanding research endeavor...
  5. ncbi request reprint Caloric restriction in primates and relevance to humans
    G S Roth
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 928:305-15. 2001
    ....
  6. ncbi request reprint Effects of reduced energy intake on the biology of aging: the primate model
    G S Roth
    National Institute on Aging, Baltimore, MD 21224, USA
    Eur J Clin Nutr 54:S15-20. 2000
    ..In summary, nearly all CR effects detected in rodents, which have thus far been examined in primates, exhibit similar phenomenology. Potential applicability of these beneficial effects to humans is discussed...
  7. ncbi request reprint Short-term calorie restriction improves disease-related markers in older male rhesus monkeys (Macaca mulatta)
    M A Lane
    Intramural Research Program, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Mech Ageing Dev 112:185-96. 2000
    ..Interestingly, the observed glucoregulatory changes emerged prior to any evidence of a change in body composition suggesting that certain effects of CR may not be wholly dependent on changes in body composition in older monkeys...
  8. ncbi request reprint Stereological estimation of total microglia number in mouse hippocampus
    J M Long
    Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Neurosci Methods 84:101-8. 1998
    ..The combination of immunocytochemistry and stereology provides a reliable means to assess microglia number that can easily be adopted for studies of transgenic and lesion-based models of aging and neurodegenerative diseases...
  9. ncbi request reprint A nonhuman primate model of age-related bone loss: a longitudinal study in male and premenopausal female rhesus monkeys
    A Black
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA
    Bone 28:295-302. 2001
    ..Changes in markers of bone turnover with age were also observed in male monkeys. The results of this longitudinal study suggest that the rhesus monkey is a potential model for age-related changes in the human skeleton...
  10. ncbi request reprint Caloric restriction in primates
    M A Lane
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 928:287-95. 2001
    ....
  11. ncbi request reprint Energy restriction does not alter bone mineral metabolism or reproductive cycling and hormones in female rhesus monkeys
    M A Lane
    Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Nutr 131:820-7. 2001
    ..02) concentrations than did younger monkeys. We conclude that ER does not negatively affect these indices of skeletal or reproductive health and does not alter age-associated changes in the same variables...
  12. ncbi request reprint Aging and caloric restriction in nonhuman primates: behavioral and in vivo brain imaging studies
    D K Ingram
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 928:316-26. 2001
    ....
  13. ncbi request reprint Nutritional modulation of aging in nonhuman primates
    M A Lane
    Intramural Research Program, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    J Nutr Health Aging 3:69-76. 1999
    ..This review summarizes the major findings from the primate CR studies after over a decade of research in this model...
  14. ncbi request reprint Calorie restriction and skeletal mass in rhesus monkeys (Macaca mulatta): evidence for an effect mediated through changes in body size
    A Black
    Molecular and Nutritional Physiology Unit, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Gerontol A Biol Sci Med Sci 56:B98-107. 2001
    ..Although osteocalcin concentrations were significantly lower in young restricted males after 1 month on 30% CR in the short-term study, they were no longer different from control values by 6 months on 30% CR...
  15. ncbi request reprint Effect of age and caloric restriction on cutaneous wound closure in rats and monkeys
    G S Roth
    Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, USA
    J Gerontol A Biol Sci Med Sci 52:B98-102. 1997
    ..Thus, impaired wound healing appears to be a generalized physiological manifestation of aging, but its possible amelioration by "anti-aging" interventions remains to be established...
  16. ncbi request reprint Calorie restriction in nonhuman primates: effects on diabetes and cardiovascular disease risk
    M A Lane
    Intramural Research Program, Gerontology Research Center, National Institute on Aging, NIH Baltimore, Maryland 21224, USA
    Toxicol Sci 52:41-8. 1999
    ..These and other findings have suggested that CR might have beneficial effects on certain disease risk factors independent of reductions in body weight or prevention of obesity...
  17. ncbi request reprint Developing mouse models of aging: a consideration of strain differences in age-related behavioral and neural parameters
    D K Ingram
    Molecular Physiology and Genetics Section, Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Neurobiol Aging 20:137-45. 1999
    ..Thus, our intention is to underscore the growing importance of mouse models of brain aging and the concomitant need for additional information about mouse aging in general...
  18. ncbi request reprint Sildenafil citrate attenuates a complex maze impairment induced by intracerebroventricular infusion of the NOS inhibitor Nomega-nitro-L-arginine methyl ester
    Bryan D Devan
    Behavioral Neuroscience Section, Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Gerontology Research Center, 5600 Nathan Shock Dr, Baltimore MD 21204, United States
    Eur J Pharmacol 563:134-40. 2007
    ..This pathway has been implicated in age-related cognitive decline and may be a useful target for pharmacological intervention of neurodegenerative disease...
  19. ncbi request reprint Dehydroepiandrosterone sulfate: a biomarker of primate aging slowed by calorie restriction
    M A Lane
    Gerontology Research Center, Nathan W Shock Laboratories, National Institutes of Health, Johns Hopkins University Bayview Campus, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 82:2093-6. 1997
    ..This represents the first evidence that this nutritional intervention has the potential to alter aspects of postmaturational aging in a long-lived species...
  20. ncbi request reprint The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics
    N H Greig
    Laboratory of Neurosciences, Intramural Research Program, National Institute of Aging, Gerontology Research Center, Baltimore, MD 21224, USA
    Acta Neurol Scand Suppl 176:74-84. 2000
    ....
  21. ncbi request reprint Biomarkers of caloric restriction may predict longevity in humans
    George S Roth
    National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Science 297:811. 2002
  22. pmc The effects of age and lipopolysaccharide (LPS)-mediated peripheral inflammation on numbers of central catecholaminergic neurons
    P R Mouton
    Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Neurobiol Aging 33:423.e27-36. 2012
    ..Thus, unknown mechanisms in the B6 mouse brain appear to protect against catecholaminergic neuron loss following an acute episode of severe inflammation, while catecholaminergic neuron loss occurs during normal aging...
  23. ncbi request reprint Stereological analysis of astrocyte and microglia in aging mouse hippocampus
    J M Long
    Molecular Physiology and Genetics Section, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Neurobiol Aging 19:497-503. 1998
    ..These findings suggest that age-related increases in the total numbers of hippocampal microglia and astrocytes is not causal for observed age-related increases in cytokine response...
  24. ncbi request reprint Behavioral assessment of the senescence-accelerated mouse (SAM P8 and R1)
    A L Markowska
    Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218, USA
    Physiol Behav 64:15-26. 1998
    ..Thus, the behavioral abnormalities that exist not only represent an accelerated aging phenomenon but may also be considered a developmental pathology...
  25. ncbi request reprint Death of PC12 cells and hippocampal neurons induced by adenoviral-mediated FAD human amyloid precursor protein gene expression
    J J Luo
    Molecular Neurobiology Unit, Laboratory of Biological Chemistry, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Neurosci Res 55:629-42. 1999
    ..These results demonstrate the usefulness of recombinant adenoviral mediated gene transfer in cell culture studies and suggest that overexpression of a familial Alzheimer's disease mutant APP may be toxic to neuronal cells...
  26. ncbi request reprint Strategy for identifying biomarkers of aging in long-lived species
    D K Ingram
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Exp Gerontol 36:1025-34. 2001
    ....
  27. ncbi request reprint What counts in brain aging? Design-based stereological analysis of cell number
    J M Long
    Molecular Physiology and Genetics Section, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Gerontol A Biol Sci Med Sci 54:B407-17. 1999
    ..Emergence of this method of morphometrics, however, can have relevance to many areas of gerontological research...
  28. ncbi request reprint Effect of long-term caloric restriction and exercise on muscle bioenergetics and force development in rats
    A Horska
    Nuclear Magnetic Resonance Unit, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Am J Physiol 276:E766-73. 1999
    ..6 +/- 5.7 micromol. min-1. g-1; P < 0.05). Our experiments thus demonstrated a synergistic effect of long-term caloric restriction and free exercise on muscle bioenergetics during electrical stimulation...
  29. ncbi request reprint Combined administration of subthreshold doses of the nitric oxide inhibitor, nitro-L-arginine, and muscarinic receptor antagonist, scopolamine, impairs complex maze learning in rats
    Paul J Pistell
    Behavioral Neuroscience Section, Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Gerontology Research Center, Baltimore, Maryland, USA
    Behav Pharmacol 18:801-5. 2007
    ..These data suggest that manipulation of learning and memory processes with multiple compounds potentially offers a clinically relevant paradigm for investigating cognitive function in normal and abnormal aging...
  30. ncbi request reprint Age-related decline in caloric intake and motivation for food in rhesus monkeys
    Julie A Mattison
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurobiol Aging 26:1117-27. 2005
    ..In addition, a positive correlation was observed between leptin and intake in males...
  31. pmc Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
    Kevin J Pearson
    Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Cell Metab 8:157-68. 2008
    ..Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife...
  32. pmc Dietary deprivation extends lifespan in Caenorhabditis elegans
    Garrick D Lee
    Laboratory of Experimental Gerontology, National Institute on Aging, Balimore, MD 21224, USA
    Aging Cell 5:515-24. 2006
    ..elegans. This study presents the first evidence that long-term DD, instead of being detrimental, can extend lifespan of a multicellular adult organism...
  33. ncbi request reprint Age-related decline in striatal volume in monkeys as measured by magnetic resonance imaging
    J A Matochik
    Brain Imaging Center, Neuroimaging Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neurobiol Aging 21:591-8. 2000
    ..The current results provide normative data to assess potential interventions (e.g. caloric restriction) in the aging process...
  34. ncbi request reprint Age-related changes in cytokine production by leukocytes in rhesus monkeys
    P Mascarucci
    Laboratories of Neurosciences, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Aging (Milano) 13:85-94. 2001
    ..We believe that such age-related alterations in cytokine production may play a role in the reduced immune responses observed in elderly human populations...
  35. ncbi request reprint Dietary caloric restriction prevents the age-related decline in plasma melatonin levels of rhesus monkeys
    G S Roth
    Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 86:3292-5. 2001
    ..Moreover, this index of age-associated physiological decrement seems to be inhibited by dietary CR...
  36. ncbi request reprint Application of gene therapy to treat age-related loss of dopamine D2 receptor
    D K Ingram
    Molecular Physiology and Genetics Section, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Exp Gerontol 33:793-804. 1998
    ..These include functional assessment of the current vector in D2R null mutant mice as well as construction of new vectors that may yield more long-term expression...
  37. ncbi request reprint Enhancement of amphetamine-induced locomotor response in rats on different regimens of diet restriction and 2-deoxy-D-glucose treatment
    J Mamczarz
    Behavioral Neuroscience Section, Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroscience 131:451-64. 2005
    ..Thus, 2DG appears to activate DA pathways in the same direction as DR does but without the necessity of reducing caloric intake...
  38. ncbi request reprint Aging in rhesus monkeys: relevance to human health interventions
    George S Roth
    Laboratory of Experimental Gerontology, Intramural Research Program, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Science 305:1423-6. 2004
    ....
  39. pmc Chronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in rats
    Robin K Minor
    Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Toxicol Appl Pharmacol 243:332-9. 2010
    ....
  40. pmc Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease
    Navin Maswood
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 101:18171-6. 2004
    ....
  41. ncbi request reprint Identification of maze learning-associated genes in rat hippocampus by cDNA microarray
    Y Luo
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Mol Neurosci 17:397-404. 2001
    ..The gene-expression profile presented here provides the groundwork for future, more focused research to elucidate the contribution of these genes in learning and memory processes...
  42. ncbi request reprint Accuracy and precision of dual-energy X-ray absorptiometry for body composition measurements in rhesus monkeys
    A Black
    Nutritional and Molecular Physiology Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Med Primatol 30:94-9. 2001
    ..DXA also accurately measured lumbar spine BMC but underestimated total body BMC as compared with carcass ash determinations...
  43. ncbi request reprint Preclinical investigation of the topical administration of phenserine: transdermal flux, cholinesterase inhibition, and cognitive efficacy
    Tadanobu Utsuki
    Drug Design and Development Section, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    J Pharmacol Exp Ther 321:353-61. 2007
    ..Particular benefits over oral therapies might include avoiding first-pass metabolic effects and improved dosing compliance...
  44. ncbi request reprint Endometriosis: clinical monitoring and treatment procedures in Rhesus Monkeys
    Julie A Mattison
    Laboratory of Experimental Gerontology, NIA, NIH Animal Center, Poolesville, MD, USA
    J Med Primatol 36:391-8. 2007
    ..Participants outlined a course of action for the effective management of this disease that would best maintain the integrity of long-term aging studies...
  45. pmc Adipogenic signaling in rat white adipose tissue: modulation by aging and calorie restriction
    Min Zhu
    Laboratory of Experimental Gerontology, National Institute on Aging, 6200 Seaforth Street, Baltimore, MD 21224, USA
    Exp Gerontol 42:733-44. 2007
    ..Overall these results suggest that CR increased the expression of adipogenic factors, and maintained the differentiated state of adipocytes, which is critically important for adiponectin biosynthesis and insulin sensitivity...
  46. pmc Prolongevity effects of an oregano and cranberry extract are diet dependent in the Mexican fruit fly (Anastrepha ludens)
    Sige Zou
    Functional Genomics Unit, Laboratory of Experimental Gerontology, National Institute on Aging, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    J Gerontol A Biol Sci Med Sci 65:41-50. 2010
    ..This study reveals the prolongevity effects of OC and supports the emerging view that benefits of botanicals on aging depend on diet composition and gender...
  47. ncbi request reprint Phosphodiesterase inhibition by sildenafil citrate attenuates a maze learning impairment in rats induced by nitric oxide synthase inhibition
    Bryan D Devan
    Behavioral Neuroscience Section, Laboratory of Experimental Gerontology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 183:439-45. 2006
    ..Recent findings suggest that inhibition of phosphodiesterase (PDE) enzymes that degrade cGMP may have memory-enhancing effects...
  48. ncbi request reprint Phosphodiesterase inhibition by sildenafil citrate attenuates the learning impairment induced by blockade of cholinergic muscarinic receptors in rats
    Bryan D Devan
    Behavioral Neuroscience Section, Laboratory of Experimental Gerontology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD, 21224, USA
    Pharmacol Biochem Behav 79:691-9. 2004
    ..These results suggest that sildenafil citrate may serve as a cognitive enhancer for therapeutic treatment of cholinergic dysfunction in age-related cognitive decline and Alzheimer's dementia (AD)...
  49. ncbi request reprint Stereological analysis of microvascular parameters in a double transgenic model of Alzheimer's disease
    Garrick D Lee
    Laboratory of Experimental Gerontology, Behavioral Neuroscience Section, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res Bull 65:317-22. 2005
    ....
  50. ncbi request reprint Impaired long-term depression in P2X3 deficient mice is not associated with a spatial learning deficit
    Yue Wang
    Laboratory of Neurosciences, National Institute on Aging, Baltimore, MD 21224, USA
    J Neurochem 99:1425-34. 2006
    ....
  51. ncbi request reprint Age and gender effects on microglia and astrocyte numbers in brains of mice
    Peter R Mouton
    Laboratory of Neurosciences, Gerontology Research Center, Room 4E05, NIA NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res 956:30-5. 2002
    ..Since astrocytes and microglia are thought to be targets of gonadal hormones, the effects of sex hormones and reproductive aging may be responsible for these findings...
  52. ncbi request reprint Calorie restriction in rhesus monkeys
    Julie A Mattison
    Intramural Research Program, Gerontology Research Center, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Exp Gerontol 38:35-46. 2003
    ..We are now preparing a battery of measures to provide a thorough and relevant analysis of the effectiveness of CR at delaying the onset of age-related disease and maintaining function later into life...
  53. ncbi request reprint Caloric restriction and aging in primates: Relevance to humans and possible CR mimetics
    Mark A Lane
    Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland 21224, USA
    Microsc Res Tech 59:335-8. 2002
    ..CR mimetics, or interventions that "mimic" certain protective effects of CR, may represent one such alternative strategy...
  54. pmc Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent
    Nigel H Greig
    Laboratory of Neurosciences and Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 102:17213-8. 2005
    ..Selective, reversible inhibition of brain BChE may represent a treatment for Alzheimer's disease, improving cognition and modulating neuropathological markers of the disease...
  55. pmc The prolongevity effect of resveratrol depends on dietary composition and calorie intake in a tephritid fruit fly
    Sige Zou
    Functional Genomics Unit, Laboratory of Experimental Gerontology, National Institute on Aging, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Exp Gerontol 44:472-6. 2009
    ..Coupled with a recent study indicating that resveratrol does not extend lifespan of mice fed the standard diet, our findings further question the ability of resveratrol to increase lifespan in organisms under normal conditions...
  56. ncbi request reprint Age-related decline in striatal volume in rhesus monkeys: assessment of long-term calorie restriction
    John A Matochik
    Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurobiol Aging 25:193-200. 2004
    ..Further study, involving sequential imaging, is warranted in order to clarify the possible effects of CR on age-related changes in striatal volume...
  57. pmc Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice
    Peter R Mouton
    Laboratory of Experimental Gerontology, Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224, United States
    Neurosci Lett 464:184-7. 2009
    ....
  58. ncbi request reprint The Roy Walford legacy: diet restriction from molecules to mice to monkeys to man and onto mimetics
    Mark A Lane
    Laboratory of Experimental Gerontology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Exp Gerontol 39:897-902. 2004
  59. ncbi request reprint Nicotine lowers the secretion of the Alzheimer's amyloid beta-protein precursor that contains amyloid beta-peptide in rat
    Tadanobu Utsuki
    Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Gerontology Research Center, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    J Alzheimers Dis 4:405-15. 2002
    ..These results suggest that within the brain, levels of total sAPP, sAPPgamma and, accordingly, Abeta are subject to cholinergic manipulation, offering therapeutic potential at the level of AbetaPP processing to decrease Abetadeposition...
  60. ncbi request reprint Effects of dietary caloric restriction and aging on thyroid hormones of rhesus monkeys
    G S Roth
    Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland 21224, USA
    Horm Metab Res 34:378-82. 2002
    ..In the light of the effects of the thyroid axis on overall metabolism, these results suggest a possible mechanism by which CR diets may elicit their well-known beneficial 'anti-aging' effects in mammals...
  61. pmc A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys
    P V Vaitkevicius
    Intramural Research Program, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 98:1171-5. 2001
    ....
  62. ncbi request reprint Vaccine development for Alzheimer's disease: a shot of good news
    D K Ingram
    Behavioral Neuroscience Section, Laboratory of Neuroscience, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Lane Drive, Baltimore, MD 21224, USA
    Trends Neurosci 24:305-7. 2001
    ....
  63. ncbi request reprint Calorie restriction attenuates age-related alterations in the plasma membrane antioxidant system in rat liver
    R de Cabo
    Laboratory of Experimental Gerontology, National Institute on Aging, NIH, Gerontology Research Center, Box 10, 5600 Nathan Shock Drive, Baltimore, MD 21224 6825, USA
    Exp Gerontol 39:297-304. 2004
    ..Thus, our results suggest that CR induces a higher capacity to oxidize NAD(P)H in the PM of old rat livers and as a result, a higher resistance to oxidative stress-induced damage...
  64. pmc Accelerated cognitive aging in diabetic rats is prevented by lowering corticosterone levels
    Alexis M Stranahan
    Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA
    Neurobiol Learn Mem 90:479-83. 2008
    ..The pattern of errors made by adrenally intact diabetic rats was similar to the pattern of errors made by aged rats, suggesting that the cognitive profiles of diabetic and aged rats share common features...
  65. ncbi request reprint Caloric restriction mimetics: a novel approach for biogerontology
    Mark A Lane
    Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Methods Mol Biol 371:143-9. 2007
    ..To date, a number of candidate CR mimetics including glycolytic inhibitors, antioxidants and specific gene-modulators have been investigated and appear to validate the potential of this approach...
  66. ncbi request reprint Dietary restriction in aging nonhuman primates
    Julie A Mattison
    Intramural Research Program, Laboratory of Experimental Gerontology, National Institute on Aging NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Interdiscip Top Gerontol 35:137-58. 2007
    ..There remains much to be learned from this model of DR including whether long-term DR will increase life span in a primate species...
  67. doi request reprint Calorie restriction alters physical performance but not cognition in two models of altered neuroendocrine signaling
    Robin K Minor
    Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Behav Brain Res 189:202-11. 2008
    ..We conclude that despite established effects of CR on ARC signaling, our results suggest a mechanistic separation between the two where behavior is concerned...
  68. ncbi request reprint A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats
    Kara B Duffy
    Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurobiol Aging 29:1680-9. 2008
    ..These findings suggest that BB supplementation may protect against neurodegeneration and cognitive impairment mediated by excitotoxicity and oxidative stress...
  69. pmc Effects of caloric restriction on inflammatory periodontal disease
    Mark A Reynolds
    Department of Periodontics, University of Maryland, Dental School, Baltimore, Maryland, USA
    Nutrition 25:88-97. 2009
    ..The purpose of this study was to examine the effects of long-term CR on naturally occurring chronic inflammatory periodontal disease in a nonhuman primate model...
  70. pmc The effects of a calorie-reduced diet on periodontal inflammation and disease in a non-human primate model
    Grishondra L Branch-Mays
    Department of Periodontics, University of Maryland Dental School, Baltimore, MD, USA
    J Periodontol 79:1184-91. 2008
    ..The purpose of this study was to evaluate the clinical effects of a long-term calorie-restriction (CR) diet on periodontitis in an animal model of periodontitis...
  71. ncbi request reprint Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy
    Garrick D Lee
    Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, Baltimore, Maryland 21224, USA
    Clin Cancer Res 12:198-205. 2006
    ..To control these factors, we conducted cognitive studies in female rats receiving cyclophosphamide or 5-fluorouracil (5FU)...
  72. pmc Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
    Kevin J Pearson
    Laboratories of Experimental Gerontology, Clinical Investigation, and Immunology and Research Resources Branch, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 105:2325-30. 2008
    ..However, CR extended lifespan and increased insulin sensitivity similarly in KO and WT mice. These findings identify a molecular pathway that dissociates the prolongevity and anticarcinogenic effects of CR...
  73. ncbi request reprint Effects of long-term diet restriction on aging and longevity in primates remain uncertain
    Mark A Lane
    Laboratory of Experimental Gerontology, Intramural Research Program, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Gerontol A Biol Sci Med Sci 59:405-7. 2004
  74. ncbi request reprint A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78
    Yongquan Luo
    Laboratory of Immunology, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA
    J Neurochem 80:354-61. 2002
    ..Interaction of NLK with gp78 and subsequent signaling may strengthen synaptic mechanisms underlying learning and memory formation...
  75. ncbi request reprint Caloric restriction modulates insulin receptor signaling in liver and skeletal muscle of rat
    Min Zhu
    Laboratory of Experimental Gerontology, Gerontology Research Center, Intramural Research Program, National Institute on Aging, Baltimore, Maryland, USA
    Nutrition 21:378-88. 2005
    ..We investigated how the insulin/insulin-like growth factor-1 signaling pathway is involved in the robust antiaging effects produced by caloric restriction...
  76. ncbi request reprint Caloric restriction modulates early events in insulin signaling in liver and skeletal muscle of rat
    Min Zhu
    Laboratory of Experimental Gerontology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Ann N Y Acad Sci 1019:448-52. 2004
    ..An altered expression of transcription of a number of genes involved in lipid metabolism may also contribute to modulation of the IS pathway by CR...
  77. ncbi request reprint Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization
    Min Zhu
    Laboratory of Experimental Gerontology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Exp Gerontol 39:1049-59. 2004
    ..Taken together, our findings suggest an important role for adiponectin in the beneficial effects of long-term CR...
  78. ncbi request reprint Age-related decline in physical activity: generalization to nonhumans
    D K Ingram
    Behavioral Neuroscience Section, Laboratory of the Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Med Sci Sports Exerc 32:1623-9. 2000
    ..Reduced dopamine release or loss of dopamine receptors appears to underlie age-related activity decline, and interventions that enhance dopamine function can increase activity levels in aged animals...
  79. pmc Acquisition of conditioned taste aversion is impaired in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer's disease
    P J Pistell
    Behavioral Neuroscience Section, Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroscience 152:594-600. 2008
    ..However, further analysis indicated a potential gender difference in both the CTA deficit and onset of plaque deposition with females showing greater conditioned aversion...
  80. pmc Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and women
    Olga Carlson
    Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging Intramural Research Program, Baltimore, MD, USA
    Metabolism 56:1729-34. 2007
    ..The impaired glucose tolerance was reversible and was not associated with alterations in the levels of adipokines or BDNF...
  81. pmc Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake
    R Michael Anson
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 100:6216-20. 2003
    ..Intermittent fasting therefore has beneficial effects on glucose regulation and neuronal resistance to injury in these mice that are independent of caloric intake...
  82. ncbi request reprint The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats
    Anne M Janas
    Laboratory of Experimental Gerontology, NIA NIH, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Life Sci 76:1073-81. 2005
    ..These findings demonstrate the ability of this drug to improve learning when cholinergic function has been impaired in a spatial memory task...
  83. pmc Involvement of Notch signaling in hippocampal synaptic plasticity
    Yue Wang
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 101:9458-62. 2004
    ..These findings suggest an important role for Notch signaling in a form of synaptic plasticity known to be associated with learning and memory processes...
  84. pmc In vitro cellular adaptations of indicators of longevity in response to treatment with serum collected from humans on calorie restricted diets
    Joanne S Allard
    Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 3:e3211. 2008
    ..The use of this in vitro technique may be helpful for predicting the potential of CR, ADF and other dietary manipulations to affect markers of longevity in humans...
  85. ncbi request reprint Cytokine responses in young and old rhesus monkeys: effect of caloric restriction
    Paolo Mascarucci
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    J Interferon Cytokine Res 22:565-71. 2002
    ..Altered regulation of IFN-gamma in old CR rhesus monkeys may be a key factor in reducing cancer incidence and other age-associated diseases...
  86. pmc Milk fat globule protein epidermal growth factor-8: a pivotal relay element within the angiotensin II and monocyte chemoattractant protein-1 signaling cascade mediating vascular smooth muscle cells invasion
    Zongming Fu
    Laboratory of Cardiovascular Science, National Institute on Aging National Institutes of Health, Baltimore, MD 21224, USA
    Circ Res 104:1337-46. 2009
    ..Thus, targeting of MFG-E8 within this signaling axis pathway is a potential novel therapy for the prevention and treatment of the age-associated vascular diseases such as atherosclerosis...
  87. ncbi request reprint Bioenergetics of aging and calorie restriction
    Nicole D Hunt
    Laboratory of Experimental Gerontology, NIA, NIH, Gerontology Research Center, Box 10, 5600 Nathan Shock Drive, Baltimore, MD 21224 6825, USA
    Ageing Res Rev 5:125-43. 2006
    ..The aim of this review is to summarize the recent findings on the effects of aging and calorie restriction on energy metabolism. The effect of calorie restriction on age-associated changes in bioenergetic parameters will be examined...
  88. ncbi request reprint Passive avoidance and complex maze learning in the senescence accelerated mouse (SAM): age and strain comparisons of SAM P8 and R1
    Edward L Spangler
    Behavior Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Gerontol A Biol Sci Med Sci 57:B61-8. 2002
    ..Although PA learning results were in agreement with other reports, results obtained in the 14-unit T-maze were not consistent with previous reports of learning impairments in the P8 senescence accelerated mouse...
  89. ncbi request reprint A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase
    N H Greig
    National Institute on Aging, Baltimore, MD, USA
    Curr Med Res Opin 17:159-65. 2001
    ..The development of specific BuChE inhibitors and the continued use of ChE inhibitors with the ability to inhibit BuChE in addition to AChE should lead to improved clinical outcomes...
  90. ncbi request reprint Effects of estrogen and raloxifene on neuroglia number and morphology in the hippocampus of aged female mice
    D L Lei
    Laboratory of Experimental Gerontology, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Neuroscience 121:659-66. 2003
    ..These findings indicate that estrogen and selective estrogen receptor modulators can influence glial-mediated inflammatory pathways and possibly protect against age- and disease-related neuropathology...
  91. pmc Survival and cardioprotective benefits of long-term blueberry enriched diet in dilated cardiomyopathy following myocardial infarction in rats
    Ismayil Ahmet
    Laboratory of Cardiovascular Science and Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 4:e7975. 2009
    ..Previously we reported that a blueberry-enriched diet (BD) attenuated necroapoptosis and inflammation in periinfarct area in a rat model of myocardial infarction (MI)...
  92. pmc Striatal lesions interfere with acquisition of a complex maze task in rats
    Paul J Pistell
    Behavioral Neuroscience Section, Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Gerontology Research Center, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    Behav Brain Res 197:138-43. 2009
    ..These results indicate that the 14-unit T-maze most likely is requires a large egocentric procedural learning component, and previously observed AAMI may involve age-related dysfunction of the striatum...
  93. pmc Blueberry-enriched diet protects rat heart from ischemic damage
    Ismayil Ahmet
    Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 4:e5954. 2009
    ..to assess the cardioprotective properties of a blueberry enriched diet (BD)...
  94. ncbi request reprint Red cell interactions with amyloid-beta(1-40) fibrils in a murine model
    Luke B Ravi
    Molecular Dynamics Section, Gerontology Research Center, National Institute on Aging Fully accredited by the American Association for the Accreditation of Laboratory Animal Care, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurobiol Dis 19:28-37. 2005
    ..Heme staining further indicates that the binding of A beta(1-40) to red blood cells enhances red cell phagocytosis by the spleen...
  95. pmc Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species
    Sige Zou
    National Institute on Aging, Intramural Research Program, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Mech Ageing Dev 128:222-6. 2007
    ..This study shows that a comparative approach, utilizing multiple invertebrate species, can increase the robustness of invertebrate-based pilot screens for prolongevity interventions...
  96. pmc Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans
    Mark A Wilson
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
    Aging Cell 5:59-68. 2006
    ..In conclusion, polyphenolic compounds in blueberries had robust and reproducible benefits during aging that were separable from antioxidant effects...
  97. doi request reprint Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8
    Toshimitsu Komatsu
    Department of Investigative Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan
    Exp Gerontol 43:339-46. 2008
    ..These results suggest restriction of calorie intake is important for the prevention of learning and memory deficits, and that the simulation of serum changes induced by CR is not sufficient to prevent the cognitive defects of SAMP8 mice...
  98. ncbi request reprint Effects of calorie restriction on reproductive and adrenal systems in Japanese quail: are responses similar to mammals, particularly primates?
    Mary Ann Ottinger
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA
    Mech Ageing Dev 126:967-75. 2005
    ..These data are discussed and compared to data collected in mammals, especially the rhesus monkey, on the effects of timing and degree of CR on reproductive and stress responses...
  99. ncbi request reprint Ovarian aging and menopause: current theories, hypotheses, and research models
    Julie M Wu
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA
    Exp Biol Med (Maywood) 230:818-28. 2005
    ..Comparisons of aging in various taxa provide insight into fundamental biological mechanisms of aging that could underlie reproductive decline...
  100. ncbi request reprint Functional recovery of the striatal cholinergic system in aged rats by adenoviral vector-mediated gene transfer of dopamine D2 receptor
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Mech Ageing Dev 127:813-5. 2006
    ..The current study suggests that age-associated functional decline with decreased gene expression of the receptor may be restored by intervention...
  101. ncbi request reprint The effect of caloric restriction on glycation and glycoxidation in skin collagen of nonhuman primates
    David R Sell
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Gerontol A Biol Sci Med Sci 58:508-16. 2003
    ..These results suggest that caloric restriction, when maintained long-term in nonhuman primates, tends to decrease glycation, but not glycoxidation...