Satoshi Ikemoto

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Neurocircuitry of drug reward
    Satoshi Ikemoto
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, U S Department of Health and Human Services, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA Electronic address
    Neuropharmacology 76:329-41. 2014
  2. pmc Brain reward circuitry beyond the mesolimbic dopamine system: a neurobiological theory
    Satoshi Ikemoto
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, United States
    Neurosci Biobehav Rev 35:129-50. 2010
  3. pmc The midbrain raphe nuclei mediate primary reinforcement via GABA(A) receptors
    Zhong Hua Liu
    Behavioural Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, Maryland, USA
    Eur J Neurosci 25:735-43. 2007
  4. pmc Intracranial self-administration of MDMA into the ventral striatum of the rat: differential roles of the nucleus accumbens shell, core, and olfactory tubercle
    Rick Shin
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 198:261-70. 2008
  5. pmc Rewarding and incentive motivational effects of excitatory amino acid receptor antagonists into the median raphe and adjacent regions of the rat
    Sierra M Webb
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 224:401-12. 2012
  6. pmc Synergistic interaction between baclofen administration into the median raphe nucleus and inconsequential visual stimuli on investigatory behavior of rats
    Fiori R Vollrath-Smith
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 220:15-25. 2012
  7. pmc Administration of the GABAA receptor antagonist picrotoxin into rat supramammillary nucleus induces c-Fos in reward-related brain structures. Supramammillary picrotoxin and c-Fos expression
    Rick Shin
    Department of Health and Human Services, Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    BMC Neurosci 11:101. 2010
  8. pmc Dual role of medial A10 dopamine neurons in affective encoding
    Zhong Hua Liu
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, MD 21224, USA
    Neuropsychopharmacology 33:3010-20. 2008
  9. pmc Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex
    Satoshi Ikemoto
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Brain Res Rev 56:27-78. 2007
  10. ncbi request reprint Involvement of the olfactory tubercle in cocaine reward: intracranial self-administration studies
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 23:9305-11. 2003

Collaborators

Detail Information

Publications30

  1. pmc Neurocircuitry of drug reward
    Satoshi Ikemoto
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, U S Department of Health and Human Services, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA Electronic address
    Neuropharmacology 76:329-41. 2014
    ..This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  2. pmc Brain reward circuitry beyond the mesolimbic dopamine system: a neurobiological theory
    Satoshi Ikemoto
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, United States
    Neurosci Biobehav Rev 35:129-50. 2010
    ....
  3. pmc The midbrain raphe nuclei mediate primary reinforcement via GABA(A) receptors
    Zhong Hua Liu
    Behavioural Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, Maryland, USA
    Eur J Neurosci 25:735-43. 2007
    ..The midbrain raphe nuclei may be involved in a variety of reward-related phenomena including drug addiction...
  4. pmc Intracranial self-administration of MDMA into the ventral striatum of the rat: differential roles of the nucleus accumbens shell, core, and olfactory tubercle
    Rick Shin
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 198:261-70. 2008
    ..Cocaine and D: -amphetamine appear to be more rewarding when administered into the medial olfactory tubercle or medial accumbens shell than into their lateral counterparts, including the accumbens core...
  5. pmc Rewarding and incentive motivational effects of excitatory amino acid receptor antagonists into the median raphe and adjacent regions of the rat
    Sierra M Webb
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 224:401-12. 2012
    ..This process may be mediated by many neurotransmitter systems and a network of many brain structures, including the median and dorsal raphe regions (MR and DR, respectively)...
  6. pmc Synergistic interaction between baclofen administration into the median raphe nucleus and inconsequential visual stimuli on investigatory behavior of rats
    Fiori R Vollrath-Smith
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 220:15-25. 2012
    ..When these drugs are contingently administered, rats learn to self-administer them. We recently found that rats self-administer the GABA(B) receptor agonist baclofen into the median (MR) or dorsal (DR) raphe nuclei...
  7. pmc Administration of the GABAA receptor antagonist picrotoxin into rat supramammillary nucleus induces c-Fos in reward-related brain structures. Supramammillary picrotoxin and c-Fos expression
    Rick Shin
    Department of Health and Human Services, Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    BMC Neurosci 11:101. 2010
    ..Here, we hypothesized that these brain structures are activated by picrotoxin injections into the SuM...
  8. pmc Dual role of medial A10 dopamine neurons in affective encoding
    Zhong Hua Liu
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, MD 21224, USA
    Neuropsychopharmacology 33:3010-20. 2008
    ..Together with previous findings, we propose that medial A10 neurons are an important component of the mechanism via which animals learn to avoid negative incentive stimuli...
  9. pmc Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex
    Satoshi Ikemoto
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Brain Res Rev 56:27-78. 2007
    ....
  10. ncbi request reprint Involvement of the olfactory tubercle in cocaine reward: intracranial self-administration studies
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 23:9305-11. 2003
    ..In conclusion, the tubercle plays a critical role in mediating rewarding action of cocaine...
  11. ncbi request reprint Rewarding effects of AMPA administration into the supramammillary or posterior hypothalamic nuclei but not the ventral tegmental area
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 24:5758-65. 2004
    ..These findings implicate posterior hypothalamic regions in reward function and suggest that reward mechanisms localized around the ventral tegmental area are more complex than has been assumed recently...
  12. ncbi request reprint Two brain sites for cannabinoid reward
    Abraham Zangen
    National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 26:4901-7. 2006
    ..These findings link the sites of rewarding action of Delta9THC to brain regions where such drugs as amphetamines, cocaine, heroin, and nicotine are also thought to have their sites of rewarding action...
  13. pmc The GABAB receptor agonist baclofen administered into the median and dorsal raphe nuclei is rewarding as shown by intracranial self-administration and conditioned place preference in rats
    Rick Shin
    Behavioral Neuroscience Branch, Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 208:545-54. 2010
    ..The midbrain raphe regions have long been implicated in affective processes and disorders. There is increasing evidence to suggest that the median (MR) and dorsal raphe nuclei (DR) tonically inhibit reward-related processes...
  14. pmc Primary reinforcing effects of nicotine are triggered from multiple regions both inside and outside the ventral tegmental area
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 26:723-30. 2006
    ..These findings demonstrate that nicotine reinforcement involves multiple regions both inside and outside the VTA...
  15. ncbi request reprint Rewarding injections of the cholinergic agonist carbachol into the ventral tegmental area induce locomotion and c-Fos expression in the retrosplenial area and supramammillary nucleus
    Satoshi Ikemoto
    Behavioral Neuroscience Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res 969:78-87. 2003
    ..These results suggest that the retrosplenial area supramammillary nucleus may be parts of the circuitry for the reward triggered by ventral tegmental cholinergic stimulation...
  16. ncbi request reprint Rewarding effects of the cholinergic agents carbachol and neostigmine in the posterior ventral tegmental area
    Satoshi Ikemoto
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 22:9895-904. 2002
    ..These findings implicate both nicotinic and muscarinic cholinergic neurotransmission in ventral tegmental reward function and suggest special involvement of the posterior portion of the VTA in cholinergic reward function...
  17. ncbi request reprint Mapping of chemical trigger zones for reward
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse NIDA, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropharmacology 47:190-201. 2004
    ..This approach has identified GABAergic, dopaminergic, glutamatergic, and cholinergic trigger zones within meso-corticolimbic circuitry important for natural reward function...
  18. pmc Cocaine drives aversive conditioning via delayed activation of dopamine-responsive habenular and midbrain pathways
    Thomas C Jhou
    Behavioral Neuroscience Research Branch and Electrophysiology Research Section, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 33:7501-12. 2013
    ..Together, these results indicate that LHb/RMTg pathways contribute critically to cocaine-induced avoidance behaviors, while also participating in reciprocally inhibitory interactions with dopamine neurons...
  19. pmc The supramammillary nucleus mediates primary reinforcement via GABA(A) receptors
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Neuropsychopharmacology 30:1088-95. 2005
    ..In conclusion, the blockade of GABA(A) receptors in the SUM is reinforcing, and the brain 'reward' circuitry appears to be tonically inhibited via supramammillary GABA(A) receptors and more extensive than the meso-limbic dopamine system...
  20. pmc The functional divide for primary reinforcement of D-amphetamine lies between the medial and lateral ventral striatum: is the division of the accumbens core, shell, and olfactory tubercle valid?
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 25:5061-5. 2005
    ..The current core-shell-tubercle scheme should be reconsidered in light of recent anatomical data and these functional findings...
  21. pmc Mapping of reinforcing and analgesic effects of the mu opioid agonist endomorphin-1 in the ventral midbrain of the rat
    Thomas C Jhou
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA
    Psychopharmacology (Berl) 224:303-12. 2012
    ....
  22. pmc Amphetamine administration into the ventral striatum facilitates behavioral interaction with unconditioned visual signals in rats
    Rick Shin
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, United States Department of Health and Human Services, Baltimore, Maryland, United States of America
    PLoS ONE 5:e8741. 2010
    ..However, it is unclear whether psychomotor stimulants facilitate behavioral interaction with unconditioned distal stimuli...
  23. pmc Intraventricular administration of neuropeptide S has reward-like effects
    Junran Cao
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, MD 21224, USA
    Eur J Pharmacol 658:16-21. 2011
    ..Our data suggest that intraventricular NPS injections have reward-like effects in that NPS weakly facilitates seeking and induces positive reinforcement. These effects may depend on intact dopamine and hypocretin systems...
  24. doi request reprint Similar roles of substantia nigra and ventral tegmental dopamine neurons in reward and aversion
    Anton Ilango
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, U S Department of Health and Human Services, Baltimore, Maryland 21014, and Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
    J Neurosci 34:817-22. 2014
    ..These observations suggest that the excitation and inhibition of SNc dopamine neurons elicit positive and negative affective effects, respectively, similar to those of VTA dopamine neurons. ..
  25. ncbi request reprint A five-minute, but not a fifteen-minute, conditioning trial duration induces conditioned place preference for cocaine administration into the olfactory tubercle
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Synapse 56:57-9. 2005
    ..Effective conditioning trial durations for CPP induced by intracranial cocaine injections are apparently much shorter than those typically used for intracranial injections of other drugs of abuse...
  26. ncbi request reprint Unconditional hyperactivity and transient reinforcing effects of NMDA administration into the ventral tegmental area in rats
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, Department of Health and Human Services, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 172:202-10. 2004
    ..Administration of the excitatory amino acid NMDA (N-methyl-D-aspartate) into the VTA may likewise be positively reinforcing, because it stimulates the meso-accumbens dopamine system and locomotion...
  27. ncbi request reprint Locomotor inhibition induced by procaine injections into the nucleus accumbens core, but not the medial ventral striatum: implication for cocaine-induced locomotion
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, NIH, Baltimore, Maryland 21224, USA
    Synapse 47:117-22. 2003
    ..In other words, cocaine at the doses inducing vigorous locomotion in the medial ventral striatum induces local anesthesia when applied to the core...
  28. doi request reprint Synergistic interaction between caloric restriction and amphetamine in food-unrelated approach behavior of rats
    Kristine L Keller
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, U S Department of Health and Human Services, 251 Bayview Blvd, Suite 200, Baltimore, MD, 21224, USA
    Psychopharmacology (Berl) 231:825-40. 2014
    ..Approach behavior is regulated by the brain integrating information about environment and body state. Psychoactive drugs interact with this process...
  29. ncbi request reprint Intermittent microinjection method in freely-moving rats and its application to neuropharmacology
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Nihon Yakurigaku Zasshi 121:264-7. 2003
    ..This injection system is reliable, easy to operate and inexpensive to construct. The application of intermittent injection systems to study reward neurochemical circuits is discussed...
  30. ncbi request reprint Rewarding and psychomotor stimulant effects of endomorphin-1: anteroposterior differences within the ventral tegmental area and lack of effect in nucleus accumbens
    Abraham Zangen
    National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 22:7225-33. 2002
    ..The present findings implicate the posterior VTA as a highly specific and sensitive site for opioid reward and suggest a role for EM-1-containing projections to the posterior VTA in the rewarding effects of other reinforcers...