S Ikemoto

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking
    S Ikemoto
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Brain Res Brain Res Rev 31:6-41. 1999
  2. pmc Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex
    Satoshi Ikemoto
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Brain Res Rev 56:27-78. 2007
  3. pmc Primary reinforcing effects of nicotine are triggered from multiple regions both inside and outside the ventral tegmental area
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 26:723-30. 2006
  4. pmc The functional divide for primary reinforcement of D-amphetamine lies between the medial and lateral ventral striatum: is the division of the accumbens core, shell, and olfactory tubercle valid?
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 25:5061-5. 2005
  5. ncbi request reprint A five-minute, but not a fifteen-minute, conditioning trial duration induces conditioned place preference for cocaine administration into the olfactory tubercle
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Synapse 56:57-9. 2005
  6. pmc The supramammillary nucleus mediates primary reinforcement via GABA(A) receptors
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Neuropsychopharmacology 30:1088-95. 2005
  7. ncbi request reprint Mapping of chemical trigger zones for reward
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse NIDA, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropharmacology 47:190-201. 2004
  8. ncbi request reprint Rewarding effects of AMPA administration into the supramammillary or posterior hypothalamic nuclei but not the ventral tegmental area
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 24:5758-65. 2004
  9. ncbi request reprint Unconditional hyperactivity and transient reinforcing effects of NMDA administration into the ventral tegmental area in rats
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, Department of Health and Human Services, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 172:202-10. 2004
  10. ncbi request reprint Involvement of the olfactory tubercle in cocaine reward: intracranial self-administration studies
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 23:9305-11. 2003

Collaborators

Detail Information

Publications25

  1. ncbi request reprint The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking
    S Ikemoto
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Brain Res Brain Res Rev 31:6-41. 1999
    ..The present conceptual framework may be valuable in understanding the dynamic interplay of NAS DA neurochemistry and behavior, both normal and pathophysiological...
  2. pmc Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex
    Satoshi Ikemoto
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Brain Res Rev 56:27-78. 2007
    ....
  3. pmc Primary reinforcing effects of nicotine are triggered from multiple regions both inside and outside the ventral tegmental area
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 26:723-30. 2006
    ..These findings demonstrate that nicotine reinforcement involves multiple regions both inside and outside the VTA...
  4. pmc The functional divide for primary reinforcement of D-amphetamine lies between the medial and lateral ventral striatum: is the division of the accumbens core, shell, and olfactory tubercle valid?
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 25:5061-5. 2005
    ..The current core-shell-tubercle scheme should be reconsidered in light of recent anatomical data and these functional findings...
  5. ncbi request reprint A five-minute, but not a fifteen-minute, conditioning trial duration induces conditioned place preference for cocaine administration into the olfactory tubercle
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Synapse 56:57-9. 2005
    ..Effective conditioning trial durations for CPP induced by intracranial cocaine injections are apparently much shorter than those typically used for intracranial injections of other drugs of abuse...
  6. pmc The supramammillary nucleus mediates primary reinforcement via GABA(A) receptors
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Neuropsychopharmacology 30:1088-95. 2005
    ..In conclusion, the blockade of GABA(A) receptors in the SUM is reinforcing, and the brain 'reward' circuitry appears to be tonically inhibited via supramammillary GABA(A) receptors and more extensive than the meso-limbic dopamine system...
  7. ncbi request reprint Mapping of chemical trigger zones for reward
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse NIDA, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuropharmacology 47:190-201. 2004
    ..This approach has identified GABAergic, dopaminergic, glutamatergic, and cholinergic trigger zones within meso-corticolimbic circuitry important for natural reward function...
  8. ncbi request reprint Rewarding effects of AMPA administration into the supramammillary or posterior hypothalamic nuclei but not the ventral tegmental area
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 24:5758-65. 2004
    ..These findings implicate posterior hypothalamic regions in reward function and suggest that reward mechanisms localized around the ventral tegmental area are more complex than has been assumed recently...
  9. ncbi request reprint Unconditional hyperactivity and transient reinforcing effects of NMDA administration into the ventral tegmental area in rats
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, Department of Health and Human Services, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 172:202-10. 2004
    ..Administration of the excitatory amino acid NMDA (N-methyl-D-aspartate) into the VTA may likewise be positively reinforcing, because it stimulates the meso-accumbens dopamine system and locomotion...
  10. ncbi request reprint Involvement of the olfactory tubercle in cocaine reward: intracranial self-administration studies
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 23:9305-11. 2003
    ..In conclusion, the tubercle plays a critical role in mediating rewarding action of cocaine...
  11. ncbi request reprint Intermittent microinjection method in freely-moving rats and its application to neuropharmacology
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Nihon Yakurigaku Zasshi 121:264-7. 2003
    ..This injection system is reliable, easy to operate and inexpensive to construct. The application of intermittent injection systems to study reward neurochemical circuits is discussed...
  12. ncbi request reprint Rewarding injections of the cholinergic agonist carbachol into the ventral tegmental area induce locomotion and c-Fos expression in the retrosplenial area and supramammillary nucleus
    Satoshi Ikemoto
    Behavioral Neuroscience Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res 969:78-87. 2003
    ..These results suggest that the retrosplenial area supramammillary nucleus may be parts of the circuitry for the reward triggered by ventral tegmental cholinergic stimulation...
  13. ncbi request reprint Locomotor inhibition induced by procaine injections into the nucleus accumbens core, but not the medial ventral striatum: implication for cocaine-induced locomotion
    Satoshi Ikemoto
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, NIH, Baltimore, Maryland 21224, USA
    Synapse 47:117-22. 2003
    ..In other words, cocaine at the doses inducing vigorous locomotion in the medial ventral striatum induces local anesthesia when applied to the core...
  14. ncbi request reprint Rewarding effects of the cholinergic agents carbachol and neostigmine in the posterior ventral tegmental area
    Satoshi Ikemoto
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 22:9895-904. 2002
    ..These findings implicate both nicotinic and muscarinic cholinergic neurotransmission in ventral tegmental reward function and suggest special involvement of the posterior portion of the VTA in cholinergic reward function...
  15. ncbi request reprint Ventral striatal anatomy of locomotor activity induced by cocaine, D-amphetamine, dopamine and D1/D2 agonists
    S Ikemoto
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroscience 113:939-55. 2002
    ..Moreover, the differential effects of cocaine between the medial and lateral portions of the shell on locomotion and rearing suggest more than two functional units (the core vs. the shell) within the accumbens...
  16. ncbi request reprint A head-attachable device for injecting nanoliter volumes of drug solutions into brain sites of freely moving rats
    S Ikemoto
    Behavioral Neuroscience Branch, Intramural Research Program National Institute on Drug Abuse NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Neurosci Methods 110:135-40. 2001
    ..This system overcomes some of the weaknesses of currently used intracranial self-administration systems...
  17. pmc The midbrain raphe nuclei mediate primary reinforcement via GABA(A) receptors
    Zhong Hua Liu
    Behavioural Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, Maryland, USA
    Eur J Neurosci 25:735-43. 2007
    ..The midbrain raphe nuclei may be involved in a variety of reward-related phenomena including drug addiction...
  18. pmc Intracranial self-administration of MDMA into the ventral striatum of the rat: differential roles of the nucleus accumbens shell, core, and olfactory tubercle
    Rick Shin
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 198:261-70. 2008
    ..Cocaine and D: -amphetamine appear to be more rewarding when administered into the medial olfactory tubercle or medial accumbens shell than into their lateral counterparts, including the accumbens core...
  19. pmc Administration of the GABAA receptor antagonist picrotoxin into rat supramammillary nucleus induces c-Fos in reward-related brain structures. Supramammillary picrotoxin and c-Fos expression
    Rick Shin
    Department of Health and Human Services, Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    BMC Neurosci 11:101. 2010
    ..Here, we hypothesized that these brain structures are activated by picrotoxin injections into the SuM...
  20. pmc Dual role of medial A10 dopamine neurons in affective encoding
    Zhong Hua Liu
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, MD 21224, USA
    Neuropsychopharmacology 33:3010-20. 2008
    ..Together with previous findings, we propose that medial A10 neurons are an important component of the mechanism via which animals learn to avoid negative incentive stimuli...
  21. ncbi request reprint Two brain sites for cannabinoid reward
    Abraham Zangen
    National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 26:4901-7. 2006
    ..These findings link the sites of rewarding action of Delta9THC to brain regions where such drugs as amphetamines, cocaine, heroin, and nicotine are also thought to have their sites of rewarding action...
  22. ncbi request reprint Nucleus accumbens amphetamine microinjections unconditionally elicit 50-kHz ultrasonic vocalizations in rats
    J Burgdorf
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, USA
    Behav Neurosci 115:940-4. 2001
    ..These findings indicate that NAcc AMPH microinjections selectively evoke 50-kHz USVs in rats, supporting the notion that dopamine elevations in the NAcc may unconditionally elicit a state of reward anticipation...
  23. ncbi request reprint Rewarding and psychomotor stimulant effects of endomorphin-1: anteroposterior differences within the ventral tegmental area and lack of effect in nucleus accumbens
    Abraham Zangen
    National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 22:7225-33. 2002
    ..The present findings implicate the posterior VTA as a highly specific and sensitive site for opioid reward and suggest a role for EM-1-containing projections to the posterior VTA in the rewarding effects of other reinforcers...
  24. pmc Brain reward circuitry beyond the mesolimbic dopamine system: a neurobiological theory
    Satoshi Ikemoto
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, United States
    Neurosci Biobehav Rev 35:129-50. 2010
    ....
  25. pmc Amphetamine administration into the ventral striatum facilitates behavioral interaction with unconditioned visual signals in rats
    Rick Shin
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, United States Department of Health and Human Services, Baltimore, Maryland, United States of America
    PLoS ONE 5:e8741. 2010
    ..However, it is unclear whether psychomotor stimulants facilitate behavioral interaction with unconditioned distal stimuli...