Research Topics
| S IkemotoSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seekingS Ikemoto
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Brain Res Brain Res Rev 31:6-41. 1999..The present conceptual framework may be valuable in understanding the dynamic interplay of NAS DA neurochemistry and behavior, both normal and pathophysiological...- Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complexSatoshi Ikemoto
Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, Maryland 21224, USA
Brain Res Rev 56:27-78. 2007.... - Primary reinforcing effects of nicotine are triggered from multiple regions both inside and outside the ventral tegmental areaSatoshi Ikemoto
Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci 26:723-30. 2006..These findings demonstrate that nicotine reinforcement involves multiple regions both inside and outside the VTA... - The functional divide for primary reinforcement of D-amphetamine lies between the medial and lateral ventral striatum: is the division of the accumbens core, shell, and olfactory tubercle valid?Satoshi Ikemoto
Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci 25:5061-5. 2005..The current core-shell-tubercle scheme should be reconsidered in light of recent anatomical data and these functional findings... - A five-minute, but not a fifteen-minute, conditioning trial duration induces conditioned place preference for cocaine administration into the olfactory tubercleSatoshi Ikemoto
Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
Synapse 56:57-9. 2005..Effective conditioning trial durations for CPP induced by intracranial cocaine injections are apparently much shorter than those typically used for intracranial injections of other drugs of abuse... - The supramammillary nucleus mediates primary reinforcement via GABA(A) receptorsSatoshi Ikemoto
Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
Neuropsychopharmacology 30:1088-95. 2005..In conclusion, the blockade of GABA(A) receptors in the SUM is reinforcing, and the brain 'reward' circuitry appears to be tonically inhibited via supramammillary GABA(A) receptors and more extensive than the meso-limbic dopamine system... - Mapping of chemical trigger zones for rewardSatoshi Ikemoto
Behavioral Neuroscience Branch, National Institute on Drug Abuse NIDA, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Neuropharmacology 47:190-201. 2004..This approach has identified GABAergic, dopaminergic, glutamatergic, and cholinergic trigger zones within meso-corticolimbic circuitry important for natural reward function... - Rewarding effects of AMPA administration into the supramammillary or posterior hypothalamic nuclei but not the ventral tegmental areaSatoshi Ikemoto
Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci 24:5758-65. 2004..These findings implicate posterior hypothalamic regions in reward function and suggest that reward mechanisms localized around the ventral tegmental area are more complex than has been assumed recently... - Unconditional hyperactivity and transient reinforcing effects of NMDA administration into the ventral tegmental area in ratsSatoshi Ikemoto
Behavioral Neuroscience Branch, National Institute on Drug Abuse, Department of Health and Human Services, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 172:202-10. 2004..Administration of the excitatory amino acid NMDA (N-methyl-D-aspartate) into the VTA may likewise be positively reinforcing, because it stimulates the meso-accumbens dopamine system and locomotion... - Involvement of the olfactory tubercle in cocaine reward: intracranial self-administration studiesSatoshi Ikemoto
Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci 23:9305-11. 2003..In conclusion, the tubercle plays a critical role in mediating rewarding action of cocaine... - Intermittent microinjection method in freely-moving rats and its application to neuropharmacologySatoshi Ikemoto
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
Nihon Yakurigaku Zasshi 121:264-7. 2003..This injection system is reliable, easy to operate and inexpensive to construct. The application of intermittent injection systems to study reward neurochemical circuits is discussed... - Rewarding injections of the cholinergic agonist carbachol into the ventral tegmental area induce locomotion and c-Fos expression in the retrosplenial area and supramammillary nucleusSatoshi Ikemoto
Behavioral Neuroscience Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Brain Res 969:78-87. 2003..These results suggest that the retrosplenial area supramammillary nucleus may be parts of the circuitry for the reward triggered by ventral tegmental cholinergic stimulation... - Locomotor inhibition induced by procaine injections into the nucleus accumbens core, but not the medial ventral striatum: implication for cocaine-induced locomotionSatoshi Ikemoto
Behavioral Neuroscience Branch, National Institute on Drug Abuse, NIH, Baltimore, Maryland 21224, USA
Synapse 47:117-22. 2003..In other words, cocaine at the doses inducing vigorous locomotion in the medial ventral striatum induces local anesthesia when applied to the core... - Rewarding effects of the cholinergic agents carbachol and neostigmine in the posterior ventral tegmental areaSatoshi Ikemoto
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
J Neurosci 22:9895-904. 2002..These findings implicate both nicotinic and muscarinic cholinergic neurotransmission in ventral tegmental reward function and suggest special involvement of the posterior portion of the VTA in cholinergic reward function... - Ventral striatal anatomy of locomotor activity induced by cocaine, D-amphetamine, dopamine and D1/D2 agonistsS Ikemoto
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Neuroscience 113:939-55. 2002..Moreover, the differential effects of cocaine between the medial and lateral portions of the shell on locomotion and rearing suggest more than two functional units (the core vs. the shell) within the accumbens... - A head-attachable device for injecting nanoliter volumes of drug solutions into brain sites of freely moving ratsS Ikemoto
Behavioral Neuroscience Branch, Intramural Research Program National Institute on Drug Abuse NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
J Neurosci Methods 110:135-40. 2001..This system overcomes some of the weaknesses of currently used intracranial self-administration systems... - The midbrain raphe nuclei mediate primary reinforcement via GABA(A) receptorsZhong Hua Liu
Behavioural Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, Maryland, USA
Eur J Neurosci 25:735-43. 2007..The midbrain raphe nuclei may be involved in a variety of reward-related phenomena including drug addiction... - Intracranial self-administration of MDMA into the ventral striatum of the rat: differential roles of the nucleus accumbens shell, core, and olfactory tubercleRick Shin
Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 198:261-70. 2008..Cocaine and D: -amphetamine appear to be more rewarding when administered into the medial olfactory tubercle or medial accumbens shell than into their lateral counterparts, including the accumbens core... - Administration of the GABAA receptor antagonist picrotoxin into rat supramammillary nucleus induces c-Fos in reward-related brain structures. Supramammillary picrotoxin and c-Fos expressionRick Shin
Department of Health and Human Services, Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
BMC Neurosci 11:101. 2010..Here, we hypothesized that these brain structures are activated by picrotoxin injections into the SuM... - Dual role of medial A10 dopamine neurons in affective encodingZhong Hua Liu
Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, MD 21224, USA
Neuropsychopharmacology 33:3010-20. 2008..Together with previous findings, we propose that medial A10 neurons are an important component of the mechanism via which animals learn to avoid negative incentive stimuli... - Two brain sites for cannabinoid rewardAbraham Zangen
National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci 26:4901-7. 2006..These findings link the sites of rewarding action of Delta9THC to brain regions where such drugs as amphetamines, cocaine, heroin, and nicotine are also thought to have their sites of rewarding action... - Nucleus accumbens amphetamine microinjections unconditionally elicit 50-kHz ultrasonic vocalizations in ratsJ Burgdorf
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, USA
Behav Neurosci 115:940-4. 2001..These findings indicate that NAcc AMPH microinjections selectively evoke 50-kHz USVs in rats, supporting the notion that dopamine elevations in the NAcc may unconditionally elicit a state of reward anticipation... - Rewarding and psychomotor stimulant effects of endomorphin-1: anteroposterior differences within the ventral tegmental area and lack of effect in nucleus accumbensAbraham Zangen
National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
J Neurosci 22:7225-33. 2002..The present findings implicate the posterior VTA as a highly specific and sensitive site for opioid reward and suggest a role for EM-1-containing projections to the posterior VTA in the rewarding effects of other reinforcers... - Brain reward circuitry beyond the mesolimbic dopamine system: a neurobiological theorySatoshi Ikemoto
Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, 251 Bayview Blvd, Suite 200, Baltimore, MD 21224, United States
Neurosci Biobehav Rev 35:129-50. 2010.... - Amphetamine administration into the ventral striatum facilitates behavioral interaction with unconditioned visual signals in ratsRick Shin
Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, United States Department of Health and Human Services, Baltimore, Maryland, United States of America
PLoS ONE 5:e8741. 2010..However, it is unclear whether psychomotor stimulants facilitate behavioral interaction with unconditioned distal stimuli...