Research Topics
Genomes and Genes
| Thomas M HydeSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPsBarbara K Lipska
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
Hum Mol Genet 15:1245-58. 2006..Although, many other DISC1 binding partners still need to be investigated, these data implicate genetically linked abnormalities in the DISC1 molecular pathway in the pathophysiology of schizophrenia...
Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophreniaThomas M Hyde
Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 31:11088-95. 2011..These findings suggest that abnormalities in GABA signaling critical to brain development contribute to genetic risk for schizophrenia...
Enuresis as a premorbid developmental marker of schizophreniaThomas M Hyde
Clinical Brain Disorders Branch, NIMH DIRP NIH, Bethesda, MD 20892, USA
Brain 131:2489-98. 2008..These findings add to the evidence implicating prefrontal dysmaturation in this disorder, potentially related to genetic risk factors...- Frontal release signs and cognition in people with schizophrenia, their siblings and healthy controlsThomas M Hyde
Clinical Brain Disorders Branch, Intramural Research Program, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
Br J Psychiatry 191:120-5. 2007..Frontal release signs, a subset of neurological soft signs, are common in schizophrenia... - Transcript-specific associations of SLC12A5 (KCC2) in human prefrontal cortex with development, schizophrenia, and affective disordersRan Tao
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1385, USA
J Neurosci 32:5216-22. 2012..Alternate transcripts from KCC2 may participate in the abnormal GABA signaling in the DLPFC associated with schizophrenia... - RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activityBarbara K Lipska
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute for Mental Health, NIH, DHHS, Bethesda, MD 20892 1385, USA
Hum Mol Genet 15:2804-12. 2006..These data suggest that RGS4 mRNA expression is associated with cortical dopamine signaling and illustrate the importance of genetic and/or environmental background in gene expression studies in schizophrenia... - Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortexCarlo Colantuoni
Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, MD 20892, USA
Brain Struct Funct 213:255-71. 2008..All microarray data are available at NCBI's Gene Expression Omnibus: GEO Series accession number GSE11546 (http://www.ncbi.nlm.nih.gov/geo) [corrected].. - A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrainMitsuyuki Matsumoto
Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, MD 20892, USA
Brain Res Mol Brain Res 138:58-69. 2005..Together, these data suggest a possible link between SREB family and neural plasticity, which may explain its extremely high conservation throughout vertebrate evolution... - Genetic variation in CACNA1C affects brain circuitries related to mental illnessKristin L Bigos
Genes, Cognition, and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 67:939-45. 2010..The CACNA1C gene (alpha-1C subunit of the L-type voltage-gated calcium channel) has been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of association has not been explored... - Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrainCynthia Shannon Weickert
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Arch Gen Psychiatry 61:544-55. 2004..3) encodes a neuronal protein that binds to beta-dystrobrevin and may be part of the dystrophin protein complex. Little is known about dysbindin expression in normal or schizophrenic brain... - Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1Shiny V Mathew
Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 1385, USA
Hum Mol Genet 16:2921-32. 2007..Together, these results suggest that the molecular mechanism of the association between NRG1 risk alleles and schizophrenia may include down-regulation of nAChR alpha7 expression... - DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphismsKenji Nakata
Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1385, USA
Proc Natl Acad Sci U S A 106:15873-8. 2009..Our results implicate a molecular mechanism of genetic risk associated with DISC1 involving specific alterations in gene processing... - Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophreniaMichael F Egan
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health NIH DHHS, Building 10, Center Drive, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:12604-9. 2004..These convergent data point to a specific molecular pathway by which GRM3 genotype alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia... - Evidence of sex-modulated association of ZNF804A with schizophreniaFengyu Zhang
Genes, Cognition and Psychosis Program and Clinical, Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 69:914-7. 2011..A recent candidate gene study, which replicated the positive association with rs1344706, identified another positive SNP (rs7597593) in ZNF804A associated with schizophrenia... - Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophreniaShruti N Mitkus
Clinical Brain Disorders Branch, Section on Neuropathology, DIRP NIMH NIH, Bethesda, MD, 20892 1385, USA
Schizophr Res 98:129-38. 2008..These data illustrate the importance of genetic background in gene expression studies in schizophrenia... - Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patientsCynthia Shannon Weickert
MiNDS Unit of the Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
Schizophr Res 98:105-10. 2008..Our results indicate that previously reported dysbindin-1 protein reductions may be due in part to decreased dysbindin-1 mRNA and that reduced dysbindin-1 may contribute to hippocampal formation synaptic pathology in schizophrenia... - Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophreniaSubroto Ghose
Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, Maryland, USA
Int J Neurosci 118:1609-27. 2008..The expression of mGluR2, 3 in DA cells provide a mechanism for glutamate to modulate dopamine release in the human brain and this species-specific difference may be critical to understanding rodent models in schizophrenia... - Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brainsJoel E Kleinman
Section on Neuropathology, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Biol Psychiatry 69:140-5. 2011..Moreover, the data, interpreted judiciously, can strengthen the plausibility of the association itself... - DNA methylation signatures in development and aging of the human prefrontal cortexShusuke Numata
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Am J Hum Genet 90:260-72. 2012..Additional discovery is made possible with a stand-alone application, BrainCloudMethyl... - Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brainWee Tin Kao
Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1385, USA
Proc Natl Acad Sci U S A 107:15619-24. 2010..Our observations strengthen the evidence that NRG3 is a schizophrenia susceptibility gene, provide quantitative insight into NRG3 transcription traits in the human brain, and reveal a probable mechanistic basis for disease association... - Critical factors in gene expression in postmortem human brain: Focus on studies in schizophreniaBarbara K Lipska
Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1385, USA
Biol Psychiatry 60:650-8. 2006..They are, however, confounded by pre- and postmortem factors. The purpose of this study was to identify sources of variation that will enable a better design of gene expression studies and higher reliability of gene expression data... - Genetic variation in FGF20 modulates hippocampal biologyHerve Lemaitre
Clinical Brain Disorder Branch, Genes, Cognition, and Psychosis Program, National Institutes of Health National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurosci 30:5992-7. 2010..These associations, from mRNA expression to brain morphology to cognition and an interaction with aging, confirm a role of FGF20 in human brain structure and function during development and aging... - Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brainJingshan Chen
Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Am J Hum Genet 75:807-21. 2004.... - Temporal dynamics and genetic control of transcription in the human prefrontal cortexCarlo Colantuoni
Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA
Nature 478:519-23. 2011..v1.p1) and can also be interrogated via a biologist-friendly stand-alone application (http://www.libd.org/braincloud)... - Expression of a GRM3 splice variant is increased in the dorsolateral prefrontal cortex of individuals carrying a schizophrenia risk SNPLeah J Sartorius
Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Neuropsychopharmacology 33:2626-34. 2008..Our results suggest that rs2228595, or a neighboring SNP in linkage disequilibrium with it, may contribute to risk for schizophrenia by modulating GRM3 splicing... - Increased lactate levels and reduced pH in postmortem brains of schizophrenics: medication confoundsNader D Halim
Graduate Program in Molecular and Cell Biology, Bethesda, MD 20814, USA
J Neurosci Methods 169:208-13. 2008.... - Glutamate carboxypeptidase II gene expression in the human frontal and temporal lobe in schizophreniaSubroto Ghose
Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
Neuropsychopharmacology 29:117-25. 2004..Our findings support the notion that the hydrolysis of NAAG is disrupted in schizophrenia and that specific anatomical regions may show discrete abnormalities in GCP II synthesis... - Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategyAmanda J Law
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 109:12165-70. 2012.... - A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophreniaStephen J Huffaker
Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, Maryland, USA
Nat Med 15:509-18. 2009..These results identify a previously undescribed KCNH2 channel isoform involved in cortical physiology, cognition and psychosis, providing a potential new therapeutic drug target... - Functional genomics in postmortem human brain: abnormalities in a DISC1 molecular pathway in schizophreniaBarbara K Lipska
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Dialogues Clin Neurosci 8:353-7. 2006..These data suggest involvement of genetically linked abnormalities in the DISC1 molecular pathway in the pathophysiology of schizophrenia... - Evaluation of tissue collection for postmortem studies of bipolar disorderAmy Deep-Soboslay
Division of Intramural Research Programs, Section on Neuropathology, Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, MD 20892, USA
Bipolar Disord 10:822-8. 2008..We set out to evaluate BPD postmortem brain collections in order to identify both successful methods as well as barriers to collection... - Psychiatric brain banking: three perspectives on current trends and future directionsAmy Deep-Soboslay
Section on Neuropathology, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 69:104-12. 2011.... - Binding of a tritiated inverse agonist to cannabinoid CB1 receptors is increased in patients with schizophreniaKimberly J Jenko
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1003, USA
Schizophr Res 141:185-8. 2012..05)... - Dopamine modulates the response of the human amygdala: a study in Parkinson's diseaseAlessandro Tessitore
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-1384, USA
J Neurosci 22:9099-103. 2002..Furthermore, consistent with findings in experimental animal paradigms, our results provide in vivo evidence of the role of dopamine in modulating the response of the amygdala to sensory information in human subjects... - Postmortem diagnosis and toxicological validation of illicit substance useElin Lehrmann
Cellular Neurobiology Research Branch, National Institute on Drug Abuse NIDA IRP, National Institutes of Health, Baltimore, MD 21224, USA
Addict Biol 13:105-17. 2008.... - Handedness, heritability, neurocognition and brain asymmetry in schizophreniaAmy Deep-Soboslay
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
Brain 133:3113-22. 2010..Our data neither provide strong support for 'atypical' handedness as a schizophrenia risk-associated heritable phenotype nor that it is associated with poorer neurocognition or anomalous cerebral asymmetries... - Catechol O-methyltransferase (COMT) mRNA expression in the dorsolateral prefrontal cortex of patients with schizophreniaMitsuyuki Matsumoto
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA
Neuropsychopharmacology 28:1521-30. 2003..The disease-related laminar difference of COMT expression may be involved in dysregulation of dopamine signaling circuits in the DLPFC of patients with schizophrenia... - Catechol-O-methyltransferase genotype and dopamine regulation in the human brainMayada Akil
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 23:2008-13. 2003..This indicates that COMT genotype is a heritable aspect of dopamine regulation and it further explicates the mechanism by which the COMT valine allele increases susceptibility for psychosis... - Use of postmortem human dura mater and scalp for deriving human fibroblast culturesLindsay A Bliss
Section on Neuropathology, Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
PLoS ONE 7:e45282. 2012..These tissues may be accessible through existing brain tissue collections, which is critical for studying disorders such as neuropsychiatric diseases... - Neurotensin receptor binding abnormalities in the entorhinal cortex in schizophrenia and affective disordersEmad H Hamid
Clinical Brain Disorders Branch-IRP, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Building 10 Room 4S237A, MSC 1379, Bethesda, MD 20892, USA
Biol Psychiatry 51:795-800. 2002.... - Reliability of psychiatric diagnosis in postmortem researchAmy Deep-Soboslay
Section on Neuropathology, Clinical Brain Disorders Branch, National Institute of Mental Health/NIH, 10 Center Drive, Bethesda, MD 20892, USA
Biol Psychiatry 57:96-101. 2005.... - Transcriptional changes common to human cocaine, cannabis and phencyclidine abuseElin Lehrmann
Cellular Neurobiology Research Branch and Chemistry and Drug Metabolism Section, National Institute on Drug Abuse NIDA Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America
PLoS ONE 1:e114. 2006..These changes represent common molecular features of drug abuse, which may underlie changes in synaptic function and plasticity that could have important ramifications for decision-making capabilities in drug abusers... - Dopaminergic modulation of cortical function in patients with Parkinson's diseaseVenkata S Mattay
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20982 1379, USA
Ann Neurol 51:156-64. 2002.... - A validated positive chemical ionization GC/MS method for the identification and quantification of amphetamine, opiates, cocaine, and metabolites in human postmortem brainRoss H Lowe
Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
J Mass Spectrom 41:175-84. 2006..This method will be employed to quantify drug concentrations in human postmortem brain in support of basic and clinical research on the physiologic, biochemical, and behavioral effects of drugs in humans... - A comparison of human brain dissection by drill versus saw on nucleic acid qualityRoss C Buerlein
National Institutes of Mental Health, Clinical Brain Disorders Branch, Bethesda, MD 20892, USA
J Neurosci Methods 179:68-70. 2009..Therefore, these results support the use of a high-speed hand-held electric dental drill as an efficient and anatomically precise means of human brain dissection without compromising tissue quality... - Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spinesAmanda J Law
University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
Am J Psychiatry 161:1848-55. 2004..There is reasonable neuropathological evidence for a presynaptic pathology but few studies of the postsynaptic component. This study tested the hypothesis that hippocampal dendritic pathology is also present in schizophrenia... - Gene expression of metabolic enzymes and a protease inhibitor in the prefrontal cortex are decreased in schizophreniaMarquis P Vawter
Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, California 92697 1675, USA
Neurochem Res 29:1245-55. 2004..These results confirm earlier reports and suggest abnormalities of specific genes related to metabolic and protease activities in the DLPFC might be considered as part of a molecular pathway in male patients with schizophrenia... - Reduced density of cholinergic interneurons in the ventral striatum in schizophrenia: an in situ hybridization studyDaphne J Holt
Department of Psychiatry, Massachusetts General Hospital East, Room 2625, 149 13th Street, Charlestown, MA 02129, USA
Biol Psychiatry 58:408-16. 2005..In a previous postmortem study, we found a reduction in the density of striatal interneurons that stain immunohistochemically for choline acetyltransferase (ChAT) in schizophrenia... - Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the diseaseAmanda J Law
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom
Proc Natl Acad Sci U S A 103:6747-52. 2006..These data implicate variation in isoform expression as a molecular mechanism for the genetic association of NRG1 with schizophrenia... - Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary studyMarquis P Vawter
Cellular Neurobiology Research Branch, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Schizophr Res 58:11-20. 2002..These results are subject to limitations based on variations inherent to human subjects and tissue samples, possible effects of neuroleptic treatment, and the requirement for verification using independent techniques... - Characterization of KIAA0513, a novel signaling molecule that interacts with modulators of neuroplasticity, apoptosis, and the cytoskeletonTara L Lauriat
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Brain Res 1121:1-11. 2006..Therefore, KIAA0513 is likely to be involved in signaling pathways related to these processes... - Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metaboliteVarsha Agarwal
Division of Molecular and Cellular Neuroscience, National Brain Research Centre, Nainwal Mode, Manesar, India
PLoS ONE 3:e2337. 2008....