Thomas M Hyde

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs
    Barbara K Lipska
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Hum Mol Genet 15:1245-58. 2006
  2. pmc Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia
    Thomas M Hyde
    Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:11088-95. 2011
  3. pmc Enuresis as a premorbid developmental marker of schizophrenia
    Thomas M Hyde
    Clinical Brain Disorders Branch, NIMH DIRP NIH, Bethesda, MD 20892, USA
    Brain 131:2489-98. 2008
  4. ncbi request reprint Frontal release signs and cognition in people with schizophrenia, their siblings and healthy controls
    Thomas M Hyde
    Clinical Brain Disorders Branch, Intramural Research Program, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
    Br J Psychiatry 191:120-5. 2007
  5. pmc Transcript-specific associations of SLC12A5 (KCC2) in human prefrontal cortex with development, schizophrenia, and affective disorders
    Ran Tao
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1385, USA
    J Neurosci 32:5216-22. 2012
  6. ncbi request reprint RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activity
    Barbara K Lipska
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute for Mental Health, NIH, DHHS, Bethesda, MD 20892 1385, USA
    Hum Mol Genet 15:2804-12. 2006
  7. doi request reprint Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex
    Carlo Colantuoni
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Brain Struct Funct 213:255-71. 2008
  8. ncbi request reprint Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1
    Shiny V Mathew
    Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 1385, USA
    Hum Mol Genet 16:2921-32. 2007
  9. ncbi request reprint A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain
    Mitsuyuki Matsumoto
    Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 138:58-69. 2005
  10. pmc Genetic variation in CACNA1C affects brain circuitries related to mental illness
    Kristin L Bigos
    Genes, Cognition, and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 67:939-45. 2010

Detail Information

Publications52

  1. ncbi request reprint Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs
    Barbara K Lipska
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Hum Mol Genet 15:1245-58. 2006
    ..Although, many other DISC1 binding partners still need to be investigated, these data implicate genetically linked abnormalities in the DISC1 molecular pathway in the pathophysiology of schizophrenia...
  2. pmc Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia
    Thomas M Hyde
    Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:11088-95. 2011
    ..These findings suggest that abnormalities in GABA signaling critical to brain development contribute to genetic risk for schizophrenia...
  3. pmc Enuresis as a premorbid developmental marker of schizophrenia
    Thomas M Hyde
    Clinical Brain Disorders Branch, NIMH DIRP NIH, Bethesda, MD 20892, USA
    Brain 131:2489-98. 2008
    ..These findings add to the evidence implicating prefrontal dysmaturation in this disorder, potentially related to genetic risk factors...
  4. ncbi request reprint Frontal release signs and cognition in people with schizophrenia, their siblings and healthy controls
    Thomas M Hyde
    Clinical Brain Disorders Branch, Intramural Research Program, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
    Br J Psychiatry 191:120-5. 2007
    ..Frontal release signs, a subset of neurological soft signs, are common in schizophrenia...
  5. pmc Transcript-specific associations of SLC12A5 (KCC2) in human prefrontal cortex with development, schizophrenia, and affective disorders
    Ran Tao
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1385, USA
    J Neurosci 32:5216-22. 2012
    ..Alternate transcripts from KCC2 may participate in the abnormal GABA signaling in the DLPFC associated with schizophrenia...
  6. ncbi request reprint RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activity
    Barbara K Lipska
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute for Mental Health, NIH, DHHS, Bethesda, MD 20892 1385, USA
    Hum Mol Genet 15:2804-12. 2006
    ..These data suggest that RGS4 mRNA expression is associated with cortical dopamine signaling and illustrate the importance of genetic and/or environmental background in gene expression studies in schizophrenia...
  7. doi request reprint Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex
    Carlo Colantuoni
    Clinical Brain Disorders Branch, Genes Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Brain Struct Funct 213:255-71. 2008
    ..All microarray data are available at NCBI's Gene Expression Omnibus: GEO Series accession number GSE11546 (http://www.ncbi.nlm.nih.gov/geo) [corrected]..
  8. ncbi request reprint Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1
    Shiny V Mathew
    Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 1385, USA
    Hum Mol Genet 16:2921-32. 2007
    ..Together, these results suggest that the molecular mechanism of the association between NRG1 risk alleles and schizophrenia may include down-regulation of nAChR alpha7 expression...
  9. ncbi request reprint A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain
    Mitsuyuki Matsumoto
    Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 138:58-69. 2005
    ..Together, these data suggest a possible link between SREB family and neural plasticity, which may explain its extremely high conservation throughout vertebrate evolution...
  10. pmc Genetic variation in CACNA1C affects brain circuitries related to mental illness
    Kristin L Bigos
    Genes, Cognition, and Psychosis Program, Division of Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 67:939-45. 2010
    ..The CACNA1C gene (alpha-1C subunit of the L-type voltage-gated calcium channel) has been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of association has not been explored...
  11. ncbi request reprint Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain
    Cynthia Shannon Weickert
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 61:544-55. 2004
    ..3) encodes a neuronal protein that binds to beta-dystrobrevin and may be part of the dystrophin protein complex. Little is known about dysbindin expression in normal or schizophrenic brain...
  12. pmc DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms
    Kenji Nakata
    Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1385, USA
    Proc Natl Acad Sci U S A 106:15873-8. 2009
    ..Our results implicate a molecular mechanism of genetic risk associated with DISC1 involving specific alterations in gene processing...
  13. pmc Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia
    Michael F Egan
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health NIH DHHS, Building 10, Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:12604-9. 2004
    ..These convergent data point to a specific molecular pathway by which GRM3 genotype alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia...
  14. doi request reprint Evidence of sex-modulated association of ZNF804A with schizophrenia
    Fengyu Zhang
    Genes, Cognition and Psychosis Program and Clinical, Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 69:914-7. 2011
    ..A recent candidate gene study, which replicated the positive association with rs1344706, identified another positive SNP (rs7597593) in ZNF804A associated with schizophrenia...
  15. pmc Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia
    Shruti N Mitkus
    Clinical Brain Disorders Branch, Section on Neuropathology, DIRP NIMH NIH, Bethesda, MD, 20892 1385, USA
    Schizophr Res 98:129-38. 2008
    ..These data illustrate the importance of genetic background in gene expression studies in schizophrenia...
  16. pmc Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients
    Cynthia Shannon Weickert
    MiNDS Unit of the Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Schizophr Res 98:105-10. 2008
    ..Our results indicate that previously reported dysbindin-1 protein reductions may be due in part to decreased dysbindin-1 mRNA and that reduced dysbindin-1 may contribute to hippocampal formation synaptic pathology in schizophrenia...
  17. pmc Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia
    Subroto Ghose
    Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, Maryland, USA
    Int J Neurosci 118:1609-27. 2008
    ..The expression of mGluR2, 3 in DA cells provide a mechanism for glutamate to modulate dopamine release in the human brain and this species-specific difference may be critical to understanding rodent models in schizophrenia...
  18. doi request reprint Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains
    Joel E Kleinman
    Section on Neuropathology, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Biol Psychiatry 69:140-5. 2011
    ..Moreover, the data, interpreted judiciously, can strengthen the plausibility of the association itself...
  19. pmc DNA methylation signatures in development and aging of the human prefrontal cortex
    Shusuke Numata
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 90:260-72. 2012
    ..Additional discovery is made possible with a stand-alone application, BrainCloudMethyl...
  20. pmc Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain
    Wee Tin Kao
    Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1385, USA
    Proc Natl Acad Sci U S A 107:15619-24. 2010
    ..Our observations strengthen the evidence that NRG3 is a schizophrenia susceptibility gene, provide quantitative insight into NRG3 transcription traits in the human brain, and reveal a probable mechanistic basis for disease association...
  21. ncbi request reprint Critical factors in gene expression in postmortem human brain: Focus on studies in schizophrenia
    Barbara K Lipska
    Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1385, USA
    Biol Psychiatry 60:650-8. 2006
    ..They are, however, confounded by pre- and postmortem factors. The purpose of this study was to identify sources of variation that will enable a better design of gene expression studies and higher reliability of gene expression data...
  22. pmc Genetic variation in FGF20 modulates hippocampal biology
    Herve Lemaitre
    Clinical Brain Disorder Branch, Genes, Cognition, and Psychosis Program, National Institutes of Health National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:5992-7. 2010
    ..These associations, from mRNA expression to brain morphology to cognition and an interaction with aging, confirm a role of FGF20 in human brain structure and function during development and aging...
  23. pmc Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain
    Jingshan Chen
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 75:807-21. 2004
    ....
  24. pmc Temporal dynamics and genetic control of transcription in the human prefrontal cortex
    Carlo Colantuoni
    Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA
    Nature 478:519-23. 2011
    ..v1.p1) and can also be interrogated via a biologist-friendly stand-alone application (http://www.libd.org/braincloud)...
  25. doi request reprint Expression of a GRM3 splice variant is increased in the dorsolateral prefrontal cortex of individuals carrying a schizophrenia risk SNP
    Leah J Sartorius
    Genes Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 33:2626-34. 2008
    ..Our results suggest that rs2228595, or a neighboring SNP in linkage disequilibrium with it, may contribute to risk for schizophrenia by modulating GRM3 splicing...
  26. pmc Increased lactate levels and reduced pH in postmortem brains of schizophrenics: medication confounds
    Nader D Halim
    Graduate Program in Molecular and Cell Biology, Bethesda, MD 20814, USA
    J Neurosci Methods 169:208-13. 2008
    ....
  27. ncbi request reprint Glutamate carboxypeptidase II gene expression in the human frontal and temporal lobe in schizophrenia
    Subroto Ghose
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 29:117-25. 2004
    ..Our findings support the notion that the hydrolysis of NAAG is disrupted in schizophrenia and that specific anatomical regions may show discrete abnormalities in GCP II synthesis...
  28. pmc Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy
    Amanda J Law
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:12165-70. 2012
    ....
  29. pmc A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia
    Stephen J Huffaker
    Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, Maryland, USA
    Nat Med 15:509-18. 2009
    ..These results identify a previously undescribed KCNH2 channel isoform involved in cortical physiology, cognition and psychosis, providing a potential new therapeutic drug target...
  30. pmc Functional genomics in postmortem human brain: abnormalities in a DISC1 molecular pathway in schizophrenia
    Barbara K Lipska
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Dialogues Clin Neurosci 8:353-7. 2006
    ..These data suggest involvement of genetically linked abnormalities in the DISC1 molecular pathway in the pathophysiology of schizophrenia...
  31. pmc Evaluation of tissue collection for postmortem studies of bipolar disorder
    Amy Deep-Soboslay
    Division of Intramural Research Programs, Section on Neuropathology, Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Bipolar Disord 10:822-8. 2008
    ..We set out to evaluate BPD postmortem brain collections in order to identify both successful methods as well as barriers to collection...
  32. pmc Psychiatric brain banking: three perspectives on current trends and future directions
    Amy Deep-Soboslay
    Section on Neuropathology, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 69:104-12. 2011
    ....
  33. pmc Binding of a tritiated inverse agonist to cannabinoid CB1 receptors is increased in patients with schizophrenia
    Kimberly J Jenko
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1003, USA
    Schizophr Res 141:185-8. 2012
    ..05)...
  34. ncbi request reprint Dopamine modulates the response of the human amygdala: a study in Parkinson's disease
    Alessandro Tessitore
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1384, USA
    J Neurosci 22:9099-103. 2002
    ..Furthermore, consistent with findings in experimental animal paradigms, our results provide in vivo evidence of the role of dopamine in modulating the response of the amygdala to sensory information in human subjects...
  35. pmc Postmortem diagnosis and toxicological validation of illicit substance use
    Elin Lehrmann
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse NIDA IRP, National Institutes of Health, Baltimore, MD 21224, USA
    Addict Biol 13:105-17. 2008
    ....
  36. pmc Handedness, heritability, neurocognition and brain asymmetry in schizophrenia
    Amy Deep-Soboslay
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Brain 133:3113-22. 2010
    ..Our data neither provide strong support for 'atypical' handedness as a schizophrenia risk-associated heritable phenotype nor that it is associated with poorer neurocognition or anomalous cerebral asymmetries...
  37. ncbi request reprint Catechol O-methyltransferase (COMT) mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia
    Mitsuyuki Matsumoto
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA
    Neuropsychopharmacology 28:1521-30. 2003
    ..The disease-related laminar difference of COMT expression may be involved in dysregulation of dopamine signaling circuits in the DLPFC of patients with schizophrenia...
  38. ncbi request reprint Catechol-O-methyltransferase genotype and dopamine regulation in the human brain
    Mayada Akil
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 23:2008-13. 2003
    ..This indicates that COMT genotype is a heritable aspect of dopamine regulation and it further explicates the mechanism by which the COMT valine allele increases susceptibility for psychosis...
  39. pmc Use of postmortem human dura mater and scalp for deriving human fibroblast cultures
    Lindsay A Bliss
    Section on Neuropathology, Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 7:e45282. 2012
    ..These tissues may be accessible through existing brain tissue collections, which is critical for studying disorders such as neuropsychiatric diseases...
  40. ncbi request reprint Neurotensin receptor binding abnormalities in the entorhinal cortex in schizophrenia and affective disorders
    Emad H Hamid
    Clinical Brain Disorders Branch IRP, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Building 10 Room 4S237A, MSC 1379, Bethesda, MD 20892, USA
    Biol Psychiatry 51:795-800. 2002
    ..We have previously reported decreased neurotensin receptor density in layer II of the intermediate entorhinal cortex (ERC) in schizophrenia, a finding seen elsewhere but not seen in more caudal ERC...
  41. ncbi request reprint Reliability of psychiatric diagnosis in postmortem research
    Amy Deep-Soboslay
    Section on Neuropathology, Clinical Brain Disorders Branch, National Institute of Mental Health NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Biol Psychiatry 57:96-101. 2005
    ..Finding reliable methods for assessing lifetime psychiatric diagnoses in subjects after death is extremely challenging...
  42. pmc Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse
    Elin Lehrmann
    Cellular Neurobiology Research Branch and Chemistry and Drug Metabolism Section, National Institute on Drug Abuse NIDA Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America
    PLoS ONE 1:e114. 2006
    ..These changes represent common molecular features of drug abuse, which may underlie changes in synaptic function and plasticity that could have important ramifications for decision-making capabilities in drug abusers...
  43. ncbi request reprint Dopaminergic modulation of cortical function in patients with Parkinson's disease
    Venkata S Mattay
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20982 1379, USA
    Ann Neurol 51:156-64. 2002
    ....
  44. ncbi request reprint A validated positive chemical ionization GC/MS method for the identification and quantification of amphetamine, opiates, cocaine, and metabolites in human postmortem brain
    Ross H Lowe
    Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Mass Spectrom 41:175-84. 2006
    ..This method will be employed to quantify drug concentrations in human postmortem brain in support of basic and clinical research on the physiologic, biochemical, and behavioral effects of drugs in humans...
  45. pmc A comparison of human brain dissection by drill versus saw on nucleic acid quality
    Ross C Buerlein
    National Institutes of Mental Health, Clinical Brain Disorders Branch, Bethesda, MD 20892, USA
    J Neurosci Methods 179:68-70. 2009
    ..Therefore, these results support the use of a high-speed hand-held electric dental drill as an efficient and anatomically precise means of human brain dissection without compromising tissue quality...
  46. ncbi request reprint Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines
    Amanda J Law
    University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Am J Psychiatry 161:1848-55. 2004
    ..There is reasonable neuropathological evidence for a presynaptic pathology but few studies of the postsynaptic component. This study tested the hypothesis that hippocampal dendritic pathology is also present in schizophrenia...
  47. ncbi request reprint Gene expression of metabolic enzymes and a protease inhibitor in the prefrontal cortex are decreased in schizophrenia
    Marquis P Vawter
    Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, California 92697 1675, USA
    Neurochem Res 29:1245-55. 2004
    ..These results confirm earlier reports and suggest abnormalities of specific genes related to metabolic and protease activities in the DLPFC might be considered as part of a molecular pathway in male patients with schizophrenia...
  48. ncbi request reprint Reduced density of cholinergic interneurons in the ventral striatum in schizophrenia: an in situ hybridization study
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital East, Room 2625, 149 13th Street, Charlestown, MA 02129, USA
    Biol Psychiatry 58:408-16. 2005
    ..In a previous postmortem study, we found a reduction in the density of striatal interneurons that stain immunohistochemically for choline acetyltransferase (ChAT) in schizophrenia...
  49. pmc Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease
    Amanda J Law
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom
    Proc Natl Acad Sci U S A 103:6747-52. 2006
    ..These data implicate variation in isoform expression as a molecular mechanism for the genetic association of NRG1 with schizophrenia...
  50. ncbi request reprint Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary study
    Marquis P Vawter
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Schizophr Res 58:11-20. 2002
    ..These results are subject to limitations based on variations inherent to human subjects and tissue samples, possible effects of neuroleptic treatment, and the requirement for verification using independent techniques...
  51. ncbi request reprint Characterization of KIAA0513, a novel signaling molecule that interacts with modulators of neuroplasticity, apoptosis, and the cytoskeleton
    Tara L Lauriat
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Brain Res 1121:1-11. 2006
    ..Therefore, KIAA0513 is likely to be involved in signaling pathways related to these processes...
  52. pmc Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite
    Varsha Agarwal
    Division of Molecular and Cellular Neuroscience, National Brain Research Centre, Nainwal Mode, Manesar, India
    PLoS ONE 3:e2337. 2008
    ....