S T Hwang

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Immune evasion by murine melanoma mediated through CC chemokine receptor-10
    Takashi Murakami
    Dermatology Branch, CCR, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1337-47. 2003
  2. ncbi request reprint Aberrant expression of adhesion molecules by Sézary cells: functional consequences under physiologic shear stress conditions
    S T Hwang
    Dermatology Branch, National Cancer Institute, Bethesda, Maryland 20892 1908, USA
    J Invest Dermatol 116:466-70. 2001
  3. doi request reprint Mycosis fungoides and Sézary syndrome
    Sam T Hwang
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, USA
    Lancet 371:945-57. 2008
  4. ncbi request reprint Mast cells migrate, but do not degranulate, in response to fractalkine, a membrane-bound chemokine expressed constitutively in diverse cells of the skin
    E J Papadopoulos
    Dermatology Branch, National Cancer Institute, Bethesda, MD 20892 1908, USA
    Eur J Immunol 30:2355-61. 2000
  5. ncbi request reprint Mechanisms of T-cell homing to skin
    S T Hwang
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Adv Dermatol 17:211-41. 2001
  6. ncbi request reprint Cutting edge: CCR4 mediates antigen-primed T cell binding to activated dendritic cells
    M Wu
    Dermatology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 167:4791-5. 2001
  7. ncbi request reprint Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation
    E J Papadopoulos
    Dermatology Branch, National Cancer Institute, Bethesda, USA
    Eur J Immunol 29:2551-9. 1999
  8. ncbi request reprint Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma
    H E Wiley
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 93:1638-43. 2001
  9. ncbi request reprint Differentiation of tumour-stage mycosis fungoides, psoriasis vulgaris and normal controls in a pilot study using serum proteomic analysis
    E W Cowen
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Br J Dermatol 157:946-53. 2007
  10. ncbi request reprint Small numbers of residual tumor cells at the site of primary inoculation are critical for anti-tumor immunity following challenge at a secondary location
    Takashi Kakinuma
    Dermatology Branch, Center for Cancer Research, NCI, Bldg 10 Rm12N246, 10 Center Dr, Bethesda, MD 20892 1908, USA
    Cancer Immunol Immunother 56:1119-31. 2007

Collaborators

Detail Information

Publications19

  1. pmc Immune evasion by murine melanoma mediated through CC chemokine receptor-10
    Takashi Murakami
    Dermatology Branch, CCR, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1337-47. 2003
    ..We propose that CCR10 engagement by locally produced CCL27 allows melanoma cells to escape host immune antitumor killing mechanisms (possibly through activation of PI3K/Akt), thereby providing a means for tumor progression...
  2. ncbi request reprint Aberrant expression of adhesion molecules by Sézary cells: functional consequences under physiologic shear stress conditions
    S T Hwang
    Dermatology Branch, National Cancer Institute, Bethesda, Maryland 20892 1908, USA
    J Invest Dermatol 116:466-70. 2001
    ..We propose a mechanism by which the upregulated expression of L-selectin and L-selectin ligands may partially compensate for altered LFA-1 function...
  3. doi request reprint Mycosis fungoides and Sézary syndrome
    Sam T Hwang
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, USA
    Lancet 371:945-57. 2008
    ....
  4. ncbi request reprint Mast cells migrate, but do not degranulate, in response to fractalkine, a membrane-bound chemokine expressed constitutively in diverse cells of the skin
    E J Papadopoulos
    Dermatology Branch, National Cancer Institute, Bethesda, MD 20892 1908, USA
    Eur J Immunol 30:2355-61. 2000
    ..Thus, CX3CR1 is expressed by MC and effectively mediates chemotaxis without inducing degranulation. We propose that the constitutive expression of FK on certain cells in the skin may be a factor in the tissue-specific homing of MC...
  5. ncbi request reprint Mechanisms of T-cell homing to skin
    S T Hwang
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Adv Dermatol 17:211-41. 2001
    ..Close cooperation between the pharmaceutical industry and basic scientists will hopefully lead to the evolution of such compounds and toward more effective treatment of inflammatory skin diseases...
  6. ncbi request reprint Cutting edge: CCR4 mediates antigen-primed T cell binding to activated dendritic cells
    M Wu
    Dermatology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 167:4791-5. 2001
    ..Our results demonstrate that DC-derived CCL22 induces rapid binding of activated T cells under dynamic conditions and that Ag-primed and naive T cells fundamentally differ with respect to chemokine-dependent binding to DC...
  7. ncbi request reprint Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation
    E J Papadopoulos
    Dermatology Branch, National Cancer Institute, Bethesda, USA
    Eur J Immunol 29:2551-9. 1999
    ....
  8. ncbi request reprint Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma
    H E Wiley
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 93:1638-43. 2001
    ..CONCLUSION: Expression of a single chemokine receptor gene, CCR7, increased B16 cell metastasis to draining lymph nodes, suggesting that cancer cells may co-opt normal mechanisms of lymph node homing during metastasis...
  9. ncbi request reprint Differentiation of tumour-stage mycosis fungoides, psoriasis vulgaris and normal controls in a pilot study using serum proteomic analysis
    E W Cowen
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Br J Dermatol 157:946-53. 2007
    ..The resultant 'proteomic signature' has been used to differentiate benign and malignant diseases, enable disease prognosis, and monitor response to therapy...
  10. ncbi request reprint Small numbers of residual tumor cells at the site of primary inoculation are critical for anti-tumor immunity following challenge at a secondary location
    Takashi Kakinuma
    Dermatology Branch, Center for Cancer Research, NCI, Bldg 10 Rm12N246, 10 Center Dr, Bethesda, MD 20892 1908, USA
    Cancer Immunol Immunother 56:1119-31. 2007
    ..These studies suggest that small numbers of tumor cells (possibly regulated by CD4(+)CD25(+) regulatory T cells expressing Foxp3) are required for effective host anti-tumor responses at alternate inoculation sites...
  11. pmc CCR7 regulates B16 murine melanoma cell tumorigenesis in skin
    Lei Fang
    Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    J Leukoc Biol 84:965-72. 2008
    ..IFN- and CXCL10 were reduced 35- and sixfold, respectively, in CCR7-B16 cell tumors (vs. control tumors). Thus, CCR7 expression enhances tumorigenesis in addition to facilitating LN metastasis...
  12. pmc Intralymphatic dendritic cell vaccination induces tumor antigen-specific, skin-homing T lymphocytes
    Amelia Grover
    Surgery Branch and Dermatology Branch, National Cancer Institute NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Clin Cancer Res 12:5801-8. 2006
    ..Accumulating evidence from animal models suggests that route of immunization can have a substantial influence on the subsequent migration of primed, activated T cells in vivo...
  13. ncbi request reprint Skin reactions in a subset of patients with stage IV melanoma treated with anti-cytotoxic T-lymphocyte antigen 4 monoclonal antibody as a single agent
    Samer H Jaber
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 1908, USA
    Arch Dermatol 142:166-72. 2006
    ....
  14. pmc Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells
    Christopher A Klebanoff
    Howard Hughes Medical Institute, National Institutes of Health Research Scholars Program, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 102:9571-6. 2005
    ..Thus, tumor-reactive CD8+ T cell populations with the phenotypic and functional attributes of T(CM) may be superior to T(EM)/effector T cells for adoptive immunotherapies using concomitant tumor-antigen vaccination...
  15. ncbi request reprint Chemokine receptors and melanoma metastasis
    Takashi Murakami
    Division of Organ Replacement Research, Center for Molecular Medicine, Jichi Medical School, Tochigi 329 0498, Japan
    J Dermatol Sci 36:71-8. 2004
    ..Therefore, manipulation of the chemokine network could have therapeutic potential in human malignancies...
  16. ncbi request reprint Disruption of Id1 reveals major differences in angiogenesis between transplanted and autochthonous tumors
    Hashmat Sikder
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Cell 4:291-9. 2003
    ....
  17. ncbi request reprint Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesis
    Lei Yao
    Experimental Transplantation and Immunology Branch, CCR, National Cancer Institute, National Institutes of Health, Bldg 10, Rm 12N226, MSC 1907, Bethesda, MD 20892, USA
    Blood 102:3900-5. 2003
    ....
  18. ncbi request reprint Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells
    Takashi Murakami
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Res 62:7328-34. 2002
    ..Thus, CXCR4 plays a potentially important role in promoting organ-selective metastasis, possibly by stimulating tumor adhesion to microvascular endothelial cells and by enhancing the growth of tumor cells under stress...
  19. doi request reprint Immunotherapy for advanced melanoma
    Lei Fang
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1908, USA
    J Invest Dermatol 128:2596-605. 2008
    ..Balancing antitumor efficacy, autoimmunity, and reconstitution of a functioning immune system remain challenging and potentially life-threatening issues...