Salik Hussain

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts
    Salik Hussain
    Clinical Research Unit, National Institute of Environmental Health Sciences NIEHS National Institute of Health NIH, Research Triangle Park, Durham, NC, USA
    Part Fibre Toxicol 11:28. 2014
  2. ncbi request reprint Intracellular signal modulation by nanomaterials
    Salik Hussain
    Clinical Research Program, National Institute of Environmental Health Sciences NIEHS, National Institute of Health NIH, Research Triangle Park, NC, USA
    Adv Exp Med Biol 811:111-34. 2014
  3. pmc Nano-titanium dioxide modulates the dermal sensitization potency of DNCB
    Salik Hussain
    Unit of Functional and Adaptive Biology CNRS EAC 4413, Laboratory of Molecular and Cellular Responses to Xenobiotics, Univ Paris Diderot, Sorbonne Paris Cité, France
    Part Fibre Toxicol 9:15. 2012
  4. pmc Cerium dioxide nanoparticles do not modulate the lipopolysaccharide-induced inflammatory response in human monocytes
    Salik Hussain
    Clinical Research Unit, National Institute of Environmental Health Sciences National Institute of Health, Research Triangle Park, Durham, NC 27709, USA
    Int J Nanomedicine 7:1387-97. 2012
  5. doi request reprint Cerium dioxide nanoparticles induce apoptosis and autophagy in human peripheral blood monocytes
    Salik Hussain
    Clinical Research Unit, National Institute of Environmental Health Sciences National Institute of Health, Research Triangle Park 27709, North Carolina, United States
    ACS Nano 6:5820-9. 2012
  6. pmc Interplay between apoptotic and autophagy pathways after exposure to cerium dioxide nanoparticles in human monocytes
    Salik Hussain
    Clinical Research Program, National Institute of Environmental Health Sciences NIEHS, National Institute of Health NIH, Research Triangle Park, NC, USA
    Autophagy 9:101-3. 2013
  7. doi request reprint Nanoparticles: molecular targets and cell signalling
    Francelyne Marano
    Unit of Functional and Adaptive Biology CNRS EAC, Laboratory of Molecular and Cellular Responses to Xenobiotics, Universite Paris Diderot, Paris, France
    Arch Toxicol 85:733-41. 2011
  8. pmc Carbon black and titanium dioxide nanoparticles elicit distinct apoptotic pathways in bronchial epithelial cells
    Salik Hussain
    Universite Paris Diderot Paris 7, Unit of Functional and Adaptive Biology BFA CNRS EAC 4413, Laboratory of Molecular and Cellular Responses to Xenobiotics, 75205 Paris, France
    Part Fibre Toxicol 7:10. 2010
  9. pmc Prior lung inflammation impacts on body distribution of gold nanoparticles
    Salik Hussain
    Laboratory of Molecular and Cellular Responses to Xenobiotics, CNRS EAC 7059, Unit of Functional and Adaptive Biology BFA, Sorbonne Paris Cité, University of Paris Diderot, 75 013 Paris, France
    Biomed Res Int 2013:923475. 2013
  10. ncbi request reprint Carbon black and titanium dioxide nanoparticles induce pro-inflammatory responses in bronchial epithelial cells: need for multiparametric evaluation due to adsorption artifacts
    Stéphanie Val
    University Paris Diderot Paris 7, Unit of Functional and Adaptive Biology BFA EAC CNRS 7059, Laboratory of Molecular and Cellular Responses to Xenobiotics, Paris, France
    Inhal Toxicol 21:115-22. 2009

Detail Information

Publications12

  1. pmc Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts
    Salik Hussain
    Clinical Research Unit, National Institute of Environmental Health Sciences NIEHS National Institute of Health NIH, Research Triangle Park, Durham, NC, USA
    Part Fibre Toxicol 11:28. 2014
    ..However, the mechanism leading to remodeling is poorly understood. Particularly, there is limited insight about the role of airway epithelial injury in these changes...
  2. ncbi request reprint Intracellular signal modulation by nanomaterials
    Salik Hussain
    Clinical Research Program, National Institute of Environmental Health Sciences NIEHS, National Institute of Health NIH, Research Triangle Park, NC, USA
    Adv Exp Med Biol 811:111-34. 2014
    ..Several biomedical applications based on the different signaling pathways induced by nanomaterials are already proposed and will certainly gain a great deal of attraction in the near future. ..
  3. pmc Nano-titanium dioxide modulates the dermal sensitization potency of DNCB
    Salik Hussain
    Unit of Functional and Adaptive Biology CNRS EAC 4413, Laboratory of Molecular and Cellular Responses to Xenobiotics, Univ Paris Diderot, Sorbonne Paris Cité, France
    Part Fibre Toxicol 9:15. 2012
    ..In conclusion, our study demonstrates that administration of nano-TiO(2) increases the dermal sensitization potency of DNCB, by augmenting a Th(2) response, showing the immunomodulatory abilities of NPs...
  4. pmc Cerium dioxide nanoparticles do not modulate the lipopolysaccharide-induced inflammatory response in human monocytes
    Salik Hussain
    Clinical Research Unit, National Institute of Environmental Health Sciences National Institute of Health, Research Triangle Park, Durham, NC 27709, USA
    Int J Nanomedicine 7:1387-97. 2012
    ..We investigated the inflammation-modulating effects of CeO(2) nanoparticles at noncytotoxic concentrations in human peripheral blood monocytes...
  5. doi request reprint Cerium dioxide nanoparticles induce apoptosis and autophagy in human peripheral blood monocytes
    Salik Hussain
    Clinical Research Unit, National Institute of Environmental Health Sciences National Institute of Health, Research Triangle Park 27709, North Carolina, United States
    ACS Nano 6:5820-9. 2012
    ..Inhibition of autophagy partially reverses cell death by CeO(2) NPs. It is concluded that CeO(2) NPs are toxic to primary human monocytes at relatively low doses...
  6. pmc Interplay between apoptotic and autophagy pathways after exposure to cerium dioxide nanoparticles in human monocytes
    Salik Hussain
    Clinical Research Program, National Institute of Environmental Health Sciences NIEHS, National Institute of Health NIH, Research Triangle Park, NC, USA
    Autophagy 9:101-3. 2013
    ..A better understanding of the implication and biological significance of CeO 2 NPs-induced autophagy and apoptosis will help us understand the risks associated with its uses and develop safer nanomedicine...
  7. doi request reprint Nanoparticles: molecular targets and cell signalling
    Francelyne Marano
    Unit of Functional and Adaptive Biology CNRS EAC, Laboratory of Molecular and Cellular Responses to Xenobiotics, Universite Paris Diderot, Paris, France
    Arch Toxicol 85:733-41. 2011
    ..However, oxidative stress is not sufficient to explain specific mechanisms which could be induced by NPs, and these new findings emphasize the need to revise the paradigm of oxidative stress to explain the effects of NPs...
  8. pmc Carbon black and titanium dioxide nanoparticles elicit distinct apoptotic pathways in bronchial epithelial cells
    Salik Hussain
    Universite Paris Diderot Paris 7, Unit of Functional and Adaptive Biology BFA CNRS EAC 4413, Laboratory of Molecular and Cellular Responses to Xenobiotics, 75205 Paris, France
    Part Fibre Toxicol 7:10. 2010
    ....
  9. pmc Prior lung inflammation impacts on body distribution of gold nanoparticles
    Salik Hussain
    Laboratory of Molecular and Cellular Responses to Xenobiotics, CNRS EAC 7059, Unit of Functional and Adaptive Biology BFA, Sorbonne Paris Cité, University of Paris Diderot, 75 013 Paris, France
    Biomed Res Int 2013:923475. 2013
    ..The individual health status is an important determinant of the response to injury/exposure. It is, therefore, critical to evaluate exposure to Au-nanomaterials with varied preexisting health status...
  10. ncbi request reprint Carbon black and titanium dioxide nanoparticles induce pro-inflammatory responses in bronchial epithelial cells: need for multiparametric evaluation due to adsorption artifacts
    Stéphanie Val
    University Paris Diderot Paris 7, Unit of Functional and Adaptive Biology BFA EAC CNRS 7059, Laboratory of Molecular and Cellular Responses to Xenobiotics, Paris, France
    Inhal Toxicol 21:115-22. 2009
    ..Thus, this study demonstrated the pro-inflammatory potential for CB and TiO(2) NP but underlines the methodological artifacts faced during the in vitro evaluation of cytokine release that necessitates a multiparametric evaluation...
  11. doi request reprint Carbon black nanoparticles impair acetylation of aromatic amine carcinogens through inactivation of arylamine N-acetyltransferase enzymes
    Elodie Sanfins
    Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, CNRS EAC4413, 75013, Paris, France
    ACS Nano 5:4504-11. 2011
    ..Our results add to recent data suggesting that major xenobiotic detoxification pathways may be altered by certain NPs and that this can result in potentially harmful pharmacological and toxicological effects...
  12. doi request reprint Interactions of nanomaterials with the immune system
    Salik Hussain
    Unit of Functional and Adaptive Biology, Laboratory of Molecular and Cellular Responses to Xenobiotics, Universite Paris Diderot, Paris, France
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 4:169-83. 2012
    ..Particular emphases include key factors that shape such interactions, cell-specific responses, allergy and immune-sensitive respiratory disorders...