K W Hunter

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Mechanisms of metastasis
    Kent W Hunter
    Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, NIH, Bethesda, Maryland 20892 4264, USA
    Breast Cancer Res 10:S2. 2008
  2. pmc Genetic background may contribute to PAM50 gene expression breast cancer subtype assignments
    Ying Hu
    Center for Biomedical Informatics and Information Technology, Bethesda, Maryland, United States of America
    PLoS ONE 8:e72287. 2013
  3. pmc Cadm1 is a metastasis susceptibility gene that suppresses metastasis by modifying tumor interaction with the cell-mediated immunity
    Farhoud Faraji
    Metastasis Susceptibility Section, Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 8:e1002926. 2012
  4. pmc Allelic variation and differential expression of the mSIN3A histone deacetylase complex gene Arid4b promote mammary tumor growth and metastasis
    Scott F Winter
    Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 8:e1002735. 2012
  5. pmc Bromodomain-Containing Protein 4: A Dynamic Regulator of Breast Cancer Metastasis through Modulation of the Extracellular Matrix
    Jude Alsarraj
    Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Breast Cancer 2012:670632. 2012
  6. doi request reprint Mouse models of cancer: does the strain matter?
    Kent W Hunter
    Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, 37 5046, 37 Convent Drive, Bethesda, Maryland 20892 4264, USA
    Nat Rev Cancer 12:144-9. 2012
  7. pmc Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer
    Nigel P S Crawford
    Laboratory of Population Genetics, National Cancer Institute National Institutes of Health, Bethesda, Maryland, USA
    Breast Cancer Res 8:R16. 2006
  8. pmc Distinct inherited metastasis susceptibility exists for different breast cancer subtypes: a prognosis study
    Szu Min Hsieh
    Laboratory of Cancer Biology and Genetics, NCI, NIH, Room 5046, 37 Convent Drive, Bethesda, Maryland 20892 4264, USA
    Breast Cancer Res 11:R75. 2009
  9. pmc Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility
    Szu Min Hsieh
    Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Cancer 9:331. 2009
  10. pmc Host genetics and tumour metastasis
    K W Hunter
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Building 41, Room D702, 41 Library Drive, Bethesda, MD 20892 5060, USA
    Br J Cancer 90:752-5. 2004

Collaborators

Detail Information

Publications40

  1. pmc Mechanisms of metastasis
    Kent W Hunter
    Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, NIH, Bethesda, Maryland 20892 4264, USA
    Breast Cancer Res 10:S2. 2008
    ..In this review we summarize some of the proposed models that were developed in attempt to understand the mechanisms of tumor dissemination and colonization as well as metastatic progression...
  2. pmc Genetic background may contribute to PAM50 gene expression breast cancer subtype assignments
    Ying Hu
    Center for Biomedical Informatics and Information Technology, Bethesda, Maryland, United States of America
    PLoS ONE 8:e72287. 2013
    ....
  3. pmc Cadm1 is a metastasis susceptibility gene that suppresses metastasis by modifying tumor interaction with the cell-mediated immunity
    Farhoud Faraji
    Metastasis Susceptibility Section, Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 8:e1002926. 2012
    ....
  4. pmc Allelic variation and differential expression of the mSIN3A histone deacetylase complex gene Arid4b promote mammary tumor growth and metastasis
    Scott F Winter
    Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 8:e1002735. 2012
    ..These studies support a causative role of ARID4B in metastatic progression of breast cancer...
  5. pmc Bromodomain-Containing Protein 4: A Dynamic Regulator of Breast Cancer Metastasis through Modulation of the Extracellular Matrix
    Jude Alsarraj
    Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Breast Cancer 2012:670632. 2012
    ..In this paper, we will discuss that host genetic background on which a tumor arises can significantly alter the biology of the subsequent metastatic disease, and we will focus on the role of Brd4 in regulating metastasis susceptibility...
  6. doi request reprint Mouse models of cancer: does the strain matter?
    Kent W Hunter
    Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, 37 5046, 37 Convent Drive, Bethesda, Maryland 20892 4264, USA
    Nat Rev Cancer 12:144-9. 2012
    ....
  7. pmc Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer
    Nigel P S Crawford
    Laboratory of Population Genetics, National Cancer Institute National Institutes of Health, Bethesda, Maryland, USA
    Breast Cancer Res 8:R16. 2006
    ..The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) within the human SIPA1 gene are associated with metastasis and other disease characteristics in breast cancer...
  8. pmc Distinct inherited metastasis susceptibility exists for different breast cancer subtypes: a prognosis study
    Szu Min Hsieh
    Laboratory of Cancer Biology and Genetics, NCI, NIH, Room 5046, 37 Convent Drive, Bethesda, Maryland 20892 4264, USA
    Breast Cancer Res 11:R75. 2009
    ..To extend these studies and gain better understanding of the function of inherited polymorphism in breast cancer progression, a validation prognosis study was performed in a large independent breast cancer patient population...
  9. pmc Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility
    Szu Min Hsieh
    Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Cancer 9:331. 2009
    ..Therefore, this study investigated the potential relationship of SIPA1 and human breast cancer incidence by a germline SNP genotype frequency association study in a case-control Caucasian cohort in Queensland, Australia...
  10. pmc Host genetics and tumour metastasis
    K W Hunter
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Building 41, Room D702, 41 Library Drive, Bethesda, MD 20892 5060, USA
    Br J Cancer 90:752-5. 2004
    ....
  11. ncbi request reprint Host genetics influence tumour metastasis
    Kent Hunter
    Laboratory of Population Genetics, Center for Cancer Research National Cancer Institute National Institutes of Health, Building 41 Room D702, 41 Library Drive, Bethesda, Maryland 20892 5060, USA
    Nat Rev Cancer 6:141-6. 2006
    ..Further investigations into the inherited components of metastasis might help resolve many of the questions that remain about tumour progression...
  12. ncbi request reprint Germ line polymorphism in metastatic progression
    Kent W Hunter
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute NIH, Building 41 Room D702, 41 Library Drive, Bethesda, MD 20892, USA
    Cancer Res 66:1251-4. 2006
    ..The identification and characterization of these polymorphisms may have significant implications for the development of tailored treatment or prevention of recurrent disease...
  13. ncbi request reprint The intersection of inheritance and metastasis: the role and implications of germline polymorphism in tumor dissemination
    Kent Hunter
    Laboratory of Population Genetics, CCR NCI NIH, Bethesda, Maryland 20892 5060, USA
    Cell Cycle 4:1719-21. 2005
    ..This implies that the existing models are likely to be too simplistic and additional factors must be considered to adequately account for existing and newly emerging data...
  14. doi request reprint The future of mouse QTL mapping to diagnose disease in mice in the age of whole-genome association studies
    Kent W Hunter
    Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Annu Rev Genet 42:131-41. 2008
    ..In this review, we focus upon recent advances that are both reducing the technical burden traditionally associated with quantitative trait locus mapping, and enhancing the applicability of these approaches to human disease...
  15. ncbi request reprint Allelic diversity in the host genetic background may be an important determinant in tumor metastatic dissemination
    Kent W Hunter
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 41, Room D702, 41 Library Drive, Bethesda, MD 20892 5060, USA
    Cancer Lett 200:97-105. 2003
    ....
  16. doi request reprint Gene expression profiles and breast cancer metastasis: a genetic perspective
    Kent W Hunter
    Laboratory of Cancer Biology and Genetics, CCR NCI NIH, Bethesda, MD 20892 4264, USA
    Clin Exp Metastasis 26:497-503. 2009
    ..Thus, genetic background might have important clinical implications in metastasis detection, management and prevention...
  17. ncbi request reprint Predisposition to efficient mammary tumor metastatic progression is linked to the breast cancer metastasis suppressor gene Brms1
    K W Hunter
    Laboratory of Population Genetics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 61:8866-72. 2001
    ..Interestingly, Mtes1 colocalizes with the murine orthologue of the human breast cancer metastasis suppressor gene Brms1, suggesting that allelic variants of Brms1 might be responsible for the metastasis suppression observed...
  18. ncbi request reprint Ezrin, a key component in tumor metastasis
    Kent W Hunter
    Laboratory of Population Genetics, CCR NCI NIH, 41 Library Drive, Bethesda, MD 20892 5060, USA
    Trends Mol Med 10:201-4. 2004
    ....
  19. ncbi request reprint Germline polymorphisms are potential metastasis risk and prognosis markers in breast cancer
    S M Hsieh
    National Cancer Institute, National Insitutes of Health, Bethesda, MD, USA
    Breast Dis 26:157-62. 2006
    ..Taken together, these data suggest that germline polymorphism is an important modulating component in metastatic progression that needs to be investigated if we are to fully understand the metastatic process...
  20. ncbi request reprint Toward the construction of integrated physical and genetic maps of the mouse genome using interspersed repetitive sequence PCR (IRS-PCR) genomics
    K W Hunter
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genome Res 6:290-9. 1996
    ..Three hundred eighty of the contigs have been anchored to the genetic map. Approximately 16% of the physical length of the mouse genome is estimated to be represented...
  21. pmc Metastasis predictive signature profiles pre-exist in normal tissues
    Haiyan Yang
    Laboratory of Population Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Clin Exp Metastasis 22:593-603. 2005
    ..The ability to identify those individuals at high risk of disseminated disease at the time of clinical manifestation of a primary cancer could have a significant impact on cancer management...
  22. ncbi request reprint Complexities of cancer research: mouse genetic models
    Kent W Hunter
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    ILAR J 43:80-8. 2002
    ..This article summarizes the current state of quantitative trait genetic analysis and the tools, both proven and theoretical, that may be used to unravel one of the great challenges in cancer genetics...
  23. ncbi request reprint Comparative sequence analysis in eight inbred strains of the metastasis modifier QTL candidate gene Brms1
    Yeong Gwan Park
    Laboratory of Population Genetics, NIH NCI DCEG, Bldg 41, Room D702, 41 Center Drive, Bethesda, Maryland 20892, USA
    Mamm Genome 13:289-92. 2002
  24. ncbi request reprint A new member of the growing family of metastasis suppressors identified in prostate cancer
    Danny R Welch
    J Natl Cancer Inst 95:839-41. 2003
  25. ncbi request reprint Global expression profiling identifies signatures of tumor virulence in MMTV-PyMT-transgenic mice: correlation to human disease
    Ting Hu Qiu
    Laboratory of Cell Regulation and Carcinogenesis, Cancer Research Center, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Res 64:5973-81. 2004
    ..These results demonstrate that the genetic analysis of mouse models of tumorigenesis may be highly relevant to human cancer and that the metastatic phenotype of a tumor may be affected by the germline genetic configuration of the host...
  26. ncbi request reprint Modifiers of mammary tumor progression and metastasis on mouse chromosomes 7, 9, and 17
    Mindy Lancaster
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 41, Room D702, 41 Library Drive, Bethesda, Maryland 20892 5060, USA
    Mamm Genome 16:120-6. 2005
    ..Identification and analysis of these loci will likely present interesting and novel information about cancer heterogeneity in the human population...
  27. ncbi request reprint Syngeneic mouse mammary carcinoma cell lines: two closely related cell lines with divergent metastatic behavior
    Alexander D Borowsky
    Department of Medical Pathology and Laboratory Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA
    Clin Exp Metastasis 22:47-59. 2005
    ..Therefore, these two cell lines provide a stable, reproducible resource for the study of metastasis modulators, AKT molecular pathway interactions, and gene target and marker discovery...
  28. pmc Bromodomain 4 activation predicts breast cancer survival
    Nigel P S Crawford
    Laboratory of Cancer Biology and Genetics and Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:6380-5. 2008
    ..Taken together, these data suggest that dysregulation of Brd4-associated pathways may play an important role in breast cancer progression and underlies multiple common prognostic signatures...
  29. pmc The Diasporin Pathway: a tumor progression-related transcriptional network that predicts breast cancer survival
    Nigel P S Crawford
    Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Exp Metastasis 25:357-69. 2008
    ..These data imply that the Diasporin Pathway may be an important nexus in tumor progression in both mice and humans...
  30. pmc Parallel analysis of transcript and translation profiles: identification of metastasis-related signal pathways differentially regulated by drug and genetic modifications
    Haiyan Yang
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Proteome Res 5:1555-67. 2006
    ....
  31. ncbi request reprint Accelerated preclinical testing using transplanted tumors from genetically engineered mouse breast cancer models
    Lyuba Varticovski
    Center for Cancer Research, National Cancer Institute, Frederick, Maryland
    Clin Cancer Res 13:2168-77. 2007
    ..Here, we describe and validate a transplantation strategy that circumvents some of these difficulties...
  32. pmc Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1
    Yeong Gwan Park
    Laboratory of Population Genetics, National Cancer Institute, Building 41, Room 702, 41 Library Drive, Bethesda, Maryland 20892, USA
    Nat Genet 37:1055-62. 2005
    ..This report is also the first demonstration, to our knowledge, of a constitutional genetic polymorphism affecting tumor metastasis...
  33. pmc Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis
    Nigel P S Crawford
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 3:e214. 2007
    ..These data suggest that RRP1B may be a novel susceptibility gene for breast cancer progression and metastasis...
  34. pmc A high-resolution multistrain haplotype analysis of laboratory mouse genome reveals three distinctive genetic variation patterns
    Jinghui Zhang
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 8302, USA
    Genome Res 15:241-9. 2005
    ..The results suggest that the controlled complexity of the laboratory inbred strains may provide a means for uncovering the biological factors that have shaped genetic variation patterns...
  35. doi request reprint Genotype X diet interactions in mice predisposed to mammary cancer. I. Body weight and fat
    Ryan R Gordon
    Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
    Mamm Genome 19:163-78. 2008
    ..QTL x diet and/or gender interactions were present at 15 of these QTL, indicating that such interactions play a significant role in defining the genetic architecture of complex traits such as body weight and obesity...
  36. pmc Multiple cross and inbred strain haplotype mapping of complex-trait candidate genes
    Yeong Gwon Park
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 13:118-21. 2003
    ....
  37. ncbi request reprint New perspectives on hereditary influences in metastatic progression
    Nigel P S Crawford
    Laboratory of Population Genetics, National Cancer Institute National Institutes of Health, Building 41, Room D702, 41 Library Drive, Bethesda, MD 20892, USA
    Trends Genet 22:555-61. 2006
    ....
  38. pmc A bioinformatics-based strategy identifies c-Myc and Cdc25A as candidates for the Apmt mammary tumor latency modifiers
    Diana Cozma
    Laboratory of Population Genetics, Medicine Branch, Center for Cancer Research, National Cancer Institute National Institutes of Health, Bethesda, MD 20892, USA
    Genome Res 12:969-75. 2002
    ..These data suggest that c-Myc and Cdc25A are Apmt1 and Apmt2, and suggest that, at least in certain instances, bioinformatics can be utilized to bypass congenic construction and subsequent mapping in conventional QTL studies...
  39. ncbi request reprint Context-dependent cancer risk
    Kent W Hunter
    Nat Genet 38:864-5. 2006
  40. doi request reprint Genotype X diet interactions in mice predisposed to mammary cancer: II. Tumors and metastasis
    Ryan R Gordon
    Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
    Mamm Genome 19:179-89. 2008
    ..These findings highlight the importance of accurately modeling not only the human cancer characteristics in mice but also the environmental exposures of human populations...