Research Topics
| K W HunterSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Mechanisms of metastasisKent W Hunter
Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, NIH, Bethesda, Maryland 20892 4264, USA
Breast Cancer Res 10:S2. 2008..In this review we summarize some of the proposed models that were developed in attempt to understand the mechanisms of tumor dissemination and colonization as well as metastatic progression...
Mouse models of cancer: does the strain matter?Kent W Hunter
Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, 37 5046, 37 Convent Drive, Bethesda, Maryland 20892 4264, USA
Nat Rev Cancer 12:144-9. 2012....- Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancerNigel P S Crawford
Laboratory of Population Genetics, National Cancer Institute National Institutes of Health, Bethesda, Maryland, USA
Breast Cancer Res 8:R16. 2006..The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) within the human SIPA1 gene are associated with metastasis and other disease characteristics in breast cancer... - Distinct inherited metastasis susceptibility exists for different breast cancer subtypes: a prognosis studySzu Min Hsieh
Laboratory of Cancer Biology and Genetics, NCI, NIH, Room 5046, 37 Convent Drive, Bethesda, Maryland 20892 4264, USA
Breast Cancer Res 11:R75. 2009..To extend these studies and gain better understanding of the function of inherited polymorphism in breast cancer progression, a validation prognosis study was performed in a large independent breast cancer patient population... - Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibilitySzu Min Hsieh
Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
BMC Cancer 9:331. 2009..Therefore, this study investigated the potential relationship of SIPA1 and human breast cancer incidence by a germline SNP genotype frequency association study in a case-control Caucasian cohort in Queensland, Australia... 
Germ line polymorphism in metastatic progressionKent W Hunter
Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute NIH, Building 41 Room D702, 41 Library Drive, Bethesda, MD 20892, USA
Cancer Res 66:1251-4. 2006..The identification and characterization of these polymorphisms may have significant implications for the development of tailored treatment or prevention of recurrent disease...- Host genetics influence tumour metastasisKent Hunter
Laboratory of Population Genetics, Center for Cancer Research National Cancer Institute National Institutes of Health, Building 41 Room D702, 41 Library Drive, Bethesda, Maryland 20892 5060, USA
Nat Rev Cancer 6:141-6. 2006..Further investigations into the inherited components of metastasis might help resolve many of the questions that remain about tumour progression... - The future of mouse QTL mapping to diagnose disease in mice in the age of whole-genome association studiesKent W Hunter
Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Annu Rev Genet 42:131-41. 2008..In this review, we focus upon recent advances that are both reducing the technical burden traditionally associated with quantitative trait locus mapping, and enhancing the applicability of these approaches to human disease... - Gene expression profiles and breast cancer metastasis: a genetic perspectiveKent W Hunter
Laboratory of Cancer Biology and Genetics, CCR NCI NIH, Bethesda, MD 20892 4264, USA
Clin Exp Metastasis 26:497-503. 2009..Thus, genetic background might have important clinical implications in metastasis detection, management and prevention... - The intersection of inheritance and metastasis: the role and implications of germline polymorphism in tumor disseminationKent Hunter
Laboratory of Population Genetics, CCR NCI NIH, Bethesda, Maryland 20892 5060, USA
Cell Cycle 4:1719-21. 2005..This implies that the existing models are likely to be too simplistic and additional factors must be considered to adequately account for existing and newly emerging data... - Host genetics and tumour metastasisK W Hunter
Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Building 41, Room D702, 41 Library Drive, Bethesda, MD 20892 5060, USA
Br J Cancer 90:752-5. 2004.... - Predisposition to efficient mammary tumor metastatic progression is linked to the breast cancer metastasis suppressor gene Brms1K W Hunter
Laboratory of Population Genetics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cancer Res 61:8866-72. 2001..Interestingly, Mtes1 colocalizes with the murine orthologue of the human breast cancer metastasis suppressor gene Brms1, suggesting that allelic variants of Brms1 might be responsible for the metastasis suppression observed... - Allelic diversity in the host genetic background may be an important determinant in tumor metastatic disseminationKent W Hunter
Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 41, Room D702, 41 Library Drive, Bethesda, MD 20892 5060, USA
Cancer Lett 200:97-105. 2003.... - Ezrin, a key component in tumor metastasisKent W Hunter
Laboratory of Population Genetics, CCR NCI NIH, 41 Library Drive, Bethesda, MD 20892 5060, USA
Trends Mol Med 10:201-4. 2004.... - Germline polymorphisms are potential metastasis risk and prognosis markers in breast cancerS M Hsieh
National Cancer Institute, National Insitutes of Health, Bethesda, MD, USA
Breast Dis 26:157-62. 2006..Taken together, these data suggest that germline polymorphism is an important modulating component in metastatic progression that needs to be investigated if we are to fully understand the metastatic process... - Toward the construction of integrated physical and genetic maps of the mouse genome using interspersed repetitive sequence PCR (IRS-PCR) genomicsK W Hunter
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA
Genome Res 6:290-9. 1996..Three hundred eighty of the contigs have been anchored to the genetic map. Approximately 16% of the physical length of the mouse genome is estimated to be represented... - Bromodomain 4 activation predicts breast cancer survivalNigel P S Crawford
Laboratory of Cancer Biology and Genetics and Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 105:6380-5. 2008..Taken together, these data suggest that dysregulation of Brd4-associated pathways may play an important role in breast cancer progression and underlies multiple common prognostic signatures... - The Diasporin Pathway: a tumor progression-related transcriptional network that predicts breast cancer survivalNigel P S Crawford
Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Clin Exp Metastasis 25:357-69. 2008..These data imply that the Diasporin Pathway may be an important nexus in tumor progression in both mice and humans... - Comparative sequence analysis in eight inbred strains of the metastasis modifier QTL candidate gene Brms1Yeong-Gwan Park
Laboratory of Population Genetics, NIH/NCI/DCEG, Bldg. 41, Room D702, 41 Center Drive, Bethesda, Maryland 20892, USA
Mamm Genome 13:289-92. 2002 - Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasisNigel P S Crawford
Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Genet 3:e214. 2007..These data suggest that RRP1B may be a novel susceptibility gene for breast cancer progression and metastasis... - Complexities of cancer research: mouse genetic modelsKent W Hunter
Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
ILAR J 43:80-8. 2002..This article summarizes the current state of quantitative trait genetic analysis and the tools, both proven and theoretical, that may be used to unravel one of the great challenges in cancer genetics... - Accelerated preclinical testing using transplanted tumors from genetically engineered mouse breast cancer modelsLyuba Varticovski
Center for Cancer Research, National Cancer Institute, Frederick, Maryland
Clin Cancer Res 13:2168-77. 2007..Here, we describe and validate a transplantation strategy that circumvents some of these difficulties... - Global expression profiling identifies signatures of tumor virulence in MMTV-PyMT-transgenic mice: correlation to human diseaseTing Hu Qiu
Laboratory of Cell Regulation and Carcinogenesis, Cancer Research Center, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer Res 64:5973-81. 2004..These results demonstrate that the genetic analysis of mouse models of tumorigenesis may be highly relevant to human cancer and that the metastatic phenotype of a tumor may be affected by the germline genetic configuration of the host... - Modifiers of mammary tumor progression and metastasis on mouse chromosomes 7, 9, and 17Mindy Lancaster
Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 41, Room D702, 41 Library Drive, Bethesda, Maryland 20892 5060, USA
Mamm Genome 16:120-6. 2005..Identification and analysis of these loci will likely present interesting and novel information about cancer heterogeneity in the human population... - Syngeneic mouse mammary carcinoma cell lines: two closely related cell lines with divergent metastatic behaviorAlexander D Borowsky
Department of Medical Pathology and Laboratory Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA
Clin Exp Metastasis 22:47-59. 2005..Therefore, these two cell lines provide a stable, reproducible resource for the study of metastasis modulators, AKT molecular pathway interactions, and gene target and marker discovery... - Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1Yeong Gwan Park
Laboratory of Population Genetics, National Cancer Institute, Building 41, Room 702, 41 Library Drive, Bethesda, Maryland 20892, USA
Nat Genet 37:1055-62. 2005..This report is also the first demonstration, to our knowledge, of a constitutional genetic polymorphism affecting tumor metastasis... - Metastasis predictive signature profiles pre-exist in normal tissuesHaiyan Yang
Laboratory of Population Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Clin Exp Metastasis 22:593-603. 2005..The ability to identify those individuals at high risk of disseminated disease at the time of clinical manifestation of a primary cancer could have a significant impact on cancer management... - A new member of the growing family of metastasis suppressors identified in prostate cancerDanny R Welch
J Natl Cancer Inst 95:839-41. 2003 - Parallel analysis of transcript and translation profiles: identification of metastasis-related signal pathways differentially regulated by drug and genetic modificationsHaiyan Yang
Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
J Proteome Res 5:1555-67. 2006.... - Genotype X diet interactions in mice predisposed to mammary cancer: II. Tumors and metastasisRyan R Gordon
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
Mamm Genome 19:179-89. 2008..These findings highlight the importance of accurately modeling not only the human cancer characteristics in mice but also the environmental exposures of human populations... - Genotype X diet interactions in mice predisposed to mammary cancer. I. Body weight and fatRyan R Gordon
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
Mamm Genome 19:163-78. 2008..QTL x diet and/or gender interactions were present at 15 of these QTL, indicating that such interactions play a significant role in defining the genetic architecture of complex traits such as body weight and obesity... - Multiple cross and inbred strain haplotype mapping of complex-trait candidate genesYeong-Gwon Park
Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Genome Res 13:118-21. 2003.... - A bioinformatics-based strategy identifies c-Myc and Cdc25A as candidates for the Apmt mammary tumor latency modifiersDiana Cozma
Laboratory of Population Genetics, Medicine Branch, Center for Cancer Research, National Cancer Institute National Institutes of Health, Bethesda, MD 20892, USA
Genome Res 12:969-75. 2002..These data suggest that c-Myc and Cdc25A are Apmt1 and Apmt2, and suggest that, at least in certain instances, bioinformatics can be utilized to bypass congenic construction and subsequent mapping in conventional QTL studies... - Context-dependent cancer riskKent W Hunter
Nat Genet 38:864-5. 2006 - A high-resolution multistrain haplotype analysis of laboratory mouse genome reveals three distinctive genetic variation patternsJinghui Zhang
Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-8302, USA
Genome Res 15:241-9. 2005..The results suggest that the controlled complexity of the laboratory inbred strains may provide a means for uncovering the biological factors that have shaped genetic variation patterns... - New perspectives on hereditary influences in metastatic progressionNigel P S Crawford
Laboratory of Population Genetics, National Cancer Institute/National Institutes of Health, Building 41, Room D702, 41 Library Drive, Bethesda, MD 20892, USA
Trends Genet 22:555-61. 2006....