J Huff

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Aspartame bioassay findings portend human cancer hazards
    James Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27514, USA
    Int J Occup Environ Health 13:446-8. 2007
  2. ncbi request reprint Does exposure to bisphenol A represent a human health risk?
    James Huff
    Regul Toxicol Pharmacol 37:407-8; author reply 409-10. 2003
  3. pmc David Rall and the national toxicology program
    James Huff
    Environ Health Perspect 113:A152. 2005
  4. doi request reprint Long-term toxicology and carcinogenicity of 2,4,6-trichlorophenol
    James Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Chemosphere 89:521-5. 2012
  5. doi request reprint Environmental justice and primary prevention of cancer: the odyssey and legacy of lorenzo tomatis
    James Huff
    NIEHS, P O Box 12233, Research Triangle Park, NC 27709, USA
    New Solut 22:7-17. 2012
  6. pmc Lorenzo Tomatis and primary prevention of environmental cancer
    Ronald L Melnick
    Ron Melnick Consulting, LLC, 111 Roundtree Rd, Chapel Hill, NC 25514, USA
    Environ Health 10:S14. 2011
  7. ncbi request reprint Chemicals studied and evaluated in long-term carcinogenesis bioassays by both the Ramazzini Foundation and the National Toxicology Program: in tribute to Cesare Maltoni and David Rall
    James Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Ann N Y Acad Sci 982:208-30. 2002
  8. pmc Cadmium-induced cancers in animals and in humans
    James Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27514, USA
    Int J Occup Environ Health 13:202-12. 2007
  9. ncbi request reprint Industry influence on occupational and environmental public health
    James Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Occup Environ Health 13:107-17. 2007
  10. ncbi request reprint Absence of carcinogenic activity in Fischer rats and B6C3F1 mice following 103-week inhalation exposures to toluene
    James Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Occup Environ Health 9:138-46. 2003

Detail Information

Publications48

  1. ncbi request reprint Aspartame bioassay findings portend human cancer hazards
    James Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27514, USA
    Int J Occup Environ Health 13:446-8. 2007
    ..No study of long-term adverse occupational health effects on aspartame workers have been conducted. The FDA should consider sponsoring a prospective epidemiologic study of aspartame workers...
  2. ncbi request reprint Does exposure to bisphenol A represent a human health risk?
    James Huff
    Regul Toxicol Pharmacol 37:407-8; author reply 409-10. 2003
  3. pmc David Rall and the national toxicology program
    James Huff
    Environ Health Perspect 113:A152. 2005
  4. doi request reprint Long-term toxicology and carcinogenicity of 2,4,6-trichlorophenol
    James Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Chemosphere 89:521-5. 2012
    ....
  5. doi request reprint Environmental justice and primary prevention of cancer: the odyssey and legacy of lorenzo tomatis
    James Huff
    NIEHS, P O Box 12233, Research Triangle Park, NC 27709, USA
    New Solut 22:7-17. 2012
    ..Some of his achievements, with excerpts from his writings, especially on primary prevention and on social injustice, are highlighted herein...
  6. pmc Lorenzo Tomatis and primary prevention of environmental cancer
    Ronald L Melnick
    Ron Melnick Consulting, LLC, 111 Roundtree Rd, Chapel Hill, NC 25514, USA
    Environ Health 10:S14. 2011
    ..Cancer still remains a mainly lethal disease. Primary prevention remains the most relevant approach to reduce mortality through a reduction in incidence"...
  7. ncbi request reprint Chemicals studied and evaluated in long-term carcinogenesis bioassays by both the Ramazzini Foundation and the National Toxicology Program: in tribute to Cesare Maltoni and David Rall
    James Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Ann N Y Acad Sci 982:208-30. 2002
    ....
  8. pmc Cadmium-induced cancers in animals and in humans
    James Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27514, USA
    Int J Occup Environ Health 13:202-12. 2007
    ..Available information about the carcinogenicity of cadmium and cadmium compounds is reviewed, evaluated, and discussed...
  9. ncbi request reprint Industry influence on occupational and environmental public health
    James Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Occup Environ Health 13:107-17. 2007
    ..Until public health is removed from politics and the influence of corporate money, real progress will be difficult to achieve and past achievements will be lost...
  10. ncbi request reprint Absence of carcinogenic activity in Fischer rats and B6C3F1 mice following 103-week inhalation exposures to toluene
    James Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Occup Environ Health 9:138-46. 2003
    ..For mice, no biologically important increase was observed for any nonneoplastic or neoplastic lesion. Studies by others had reported carcinogenicity of toluene, especially for total malignant tumors...
  11. pmc Multicomponent criteria for predicting carcinogenicity: dataset of 30 NTP chemicals
    J Huff
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 104:1105-12. 1996
    ..Until then, and in the best interests of public health, however, we urge long term testing of chemicals in animals be continued, at increased pace...
  12. pmc Clarifying carcinogenicity of ethylbenzene
    James Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Regul Toxicol Pharmacol 58:167-9; discussion 170-2. 2010
    ....
  13. ncbi request reprint IARC monographs, industry influence, and upgrading, downgrading, and under-grading chemicals: a personal point of view. International Agency for Research on Cancer
    James Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Occup Environ Health 8:249-70. 2002
    ..To stem this tide at the IARC, new leadership, with more objectivity and public health perspective, is needed...
  14. pmc Benzene-induced cancers: abridged history and occupational health impact
    James Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27514, USA
    Int J Occup Environ Health 13:213-21. 2007
    ..This paper presents a condensed history of the benzene bioassay story with mention of benzene-associated human cancers...
  15. pmc Styrene exposure and risk of cancer
    James Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, 111 T W Alexander Drive, NC 27709, USA
    Mutagenesis 26:583-4. 2011
    ..No adequate human studies are available for styrene-7,8-oxide although this is the primary and active epoxide metabolite of styrene. Both are genotoxic and form DNA adducts in humans...
  16. ncbi request reprint Long-term chemical carcinogenesis bioassays predict human cancer hazards. Issues, controversies, and uncertainties
    J Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Ann N Y Acad Sci 895:56-79. 1999
    ..One fact remains abundantly clear: for every known human carcinogen that has been tested adequately in laboratory animals, the findings of carcinogenicity are concordant...
  17. ncbi request reprint Alleged misconceptions' distort perceptions of environmental cancer risks
    L Tomatis
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 15:195-203. 2001
    ..Dismissing animal carcinogenicity findings would lead to human cancer cases as the only means of demonstrating carcinogenicity of environmental agents. This is unacceptable public health policy...
  18. ncbi request reprint Relevance of animal carcinogenesis findings to human cancer predictions and prevention
    R R Maronpot
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:40-8. 2004
    ..Nonetheless public health considerations must take precedence when deciding human safety issues...
  19. ncbi request reprint Carcinogenesis bioassays: study duration and biological relevance
    J Haseman
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Food Chem Toxicol 39:739-44. 2001
    ..This is not prudent public health policy...
  20. ncbi request reprint Frequent p53 and H-ras mutations in benzene- and ethylene oxide-induced mammary gland carcinomas from B6C3F1 mice
    Christopher D Houle
    Laboratory of Experimental Pathology, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 34:752-62. 2006
    ..Our results demonstrate that p53 and H-ras mutations are relatively common in control and chemically induced mouse mammary carcinomas although both chemicals can alter the mutational spectra and more commonly induce concurrent mutations...
  21. pmc Fundamental flaws of hormesis for public health decisions
    Kristina A Thayer
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 113:1271-6. 2005
    ..Key words: biphasic dose response, hormesis, individual susceptibility, low-dose exposures, nonmonotonic dose response, nonlinear dose response, public health, regulation, risk assessment...
  22. ncbi request reprint High frequency of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed to 1-amino-2,4-dibromoanthraquinone for 2 years
    S Hayashi
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 29:422-9. 2001
    ..major finding of A to T transversions or A to G transitions in forestomach and lung tumors suggests that ADBAQ or its metabolites target adenine bases in the ras proto-oncogenes and that these mutations play a dominant role in multi-organ..
  23. pmc Sawmill chemicals and carcinogenesis
    J Huff
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 109:209-12. 2001
    ..A key to preventing occupationally and environmentally associated cancers, as in the wood industries, is avoiding exposures to chemicals and wood dusts and, in particular, chemicals known to cause cancer in animals or/and humans...
  24. ncbi request reprint Use of historical control data in carcinogenicity studies in rodents
    J K Haseman
    Biometry and Risk Assessment Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 12:126-35. 1984
    ..All studies in the database are of two years duration, and all neoplasms occurring with a frequency of 0.5% or more are reported...
  25. ncbi request reprint The IARC evaluation of DEHP excludes key papers demonstrating carcinogenic effects
    Ronald L Melnick
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Occup Environ Health 9:400-2. 2003
  26. pmc The limits of two-year bioassay exposure regimens for identifying chemical carcinogens
    James Huff
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 116:1439-42. 2008
    ..New findings indicate the need to extend the timing and duration of exposures used in the rodent bioassay...
  27. pmc Bioassay bashing is bad science
    Frank M Johnson
    Environ Health Perspect 110:A736-7; author reply A737-9. 2002
  28. ncbi request reprint Letter to U.S. FDA commissioner. Questions about the safety of the artificial sweetener aspartame
    Kamal M Abdo
    Int J Occup Environ Health 13:449-50. 2007
  29. ncbi request reprint Re: Regulatory Toxicology and Pharmacology
    Olav Axelson
    Int J Occup Environ Health 9:386-9; author reply 389-90. 2003
  30. ncbi request reprint Re: Implementation of WHO Guidelines on Disclosure of Interest by members of WHO Expert Panels
    Olav Axelson
    Int J Occup Environ Health 8:271-3. 2002
  31. ncbi request reprint FIOH-sponsored newsletter misrepresents asbestos hazards in Zimbabwe
    John C Bailar
    The University of Chicago, IL, USA
    Int J Occup Environ Health 12:254-8. 2006
    ..Instead, FIOH should provide the same level of scientific information in Africa that it does in Finland and other developed countries...
  32. ncbi request reprint Industry influences IARC carcinogenesis evaluations
    James Huff
    Int J Occup Environ Health 9:83-4. 2003
  33. ncbi request reprint The International Commission on Occupational Health (ICOH) and its influence on international organizations
    Nicholas A Ashford
    Massachusetts Institute of Technology, USA
    Int J Occup Environ Health 8:156-62. 2002
    ..Official recognition of the ICOH compromises the credibility of the WHO and the ILO. It is inappropriate for the ICOH to continue to receive WHO and ILO recognition unless the ICOH is recognized as an industry organization...
  34. ncbi request reprint Unrecognized or potential risk factors for childhood cancer
    Nicolas A van Larebeke
    Study Center for Carcinogenesis and Primary Prevention of Cancer, Ghent University, Ghent, Belgium
    Int J Occup Environ Health 11:199-201. 2005
    ..That environmental exposures may be important causes of childhood cancers is indicated by associations of enzyme polymorphisms with risk...
  35. ncbi request reprint IARC and the DEHP quagmire
    James Huff
    Int J Occup Environ Health 9:402-4. 2003
  36. ncbi request reprint American College of Occupational and Environmental Medicine (ACOEM): a professional association in service to industry
    Joseph LaDou
    Division of Occupational and Environmental Medicine, University of California School of Medicine, San Francisco, CA 94143 0924, USA
    Int J Occup Environ Health 13:404-26. 2007
    ..This paper chronicles the history of occupational medicine and industry physicians as influenced and even controlled by corporate leaders...
  37. ncbi request reprint Development of a multi-organ rat model for evaluating chemopreventive agents: efficacy of indole-3-carbinol-. Certain health supplements may cause both carcinogenic and anticarcinogenic effects
    Frank Johnson
    Carcinogenesis 23:1767-8; author reply 1769. 2002
  38. ncbi request reprint Carcinogenicity of bisphenol A revisited
    James Huff
    Toxicol Sci 70:281-3; author reply 283-4. 2002
  39. pmc MtBE and cancer in animals: statistical issues with poly-3 survival adjustments for lifetime studies
    Grace E Kissling
    Regul Toxicol Pharmacol 50:428-9. 2008
  40. pmc Testing toxic pesticides in humans: health risks with no health benefits
    Ronald L Melnick
    Environ Health Perspect 112:A459-61. 2004
  41. pmc Declaring chemicals "not carcinogenic to humans" requires validation, not speculation
    Ronald L Melnick
    Environ Health Perspect 111:A203-4. 2003
  42. ncbi request reprint Editorial policies on financial disclosure
    Michael F Jacobson
    Nat Neurosci 6:1001. 2003
  43. pmc Hormesis: a new religion?
    Kristina A Thayer
    Environ Health Perspect 114:A632-3. 2006
  44. ncbi request reprint Texaco and its consultants
    Jaime Breilh
    Int J Occup Environ Health 11:217-20. 2005
  45. ncbi request reprint Re: Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial
    James Huff
    J Natl Cancer Inst 96:333-4; author reply 334. 2004
  46. ncbi request reprint Trichloroethylene and cancers in humans
    James Huff
    Toxicology 197:185-7. 2004
  47. doi request reprint More toxin tests needed
    James Huff
    Science 319:725-6. 2008