J Huff

..No study of long-term adverse occupational health effects on aspartame workers have been conducted. The FDA should consider sponsoring a prospective epidemiologic study of aspartame workers...

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..Some of his achievements, with excerpts from his writings, especially on primary prevention and on social injustice, are highlighted herein...

..quot;Cancer still remains a mainly lethal disease. Primary prevention remains the most relevant approach to reduce mortality through a reduction in incidence"...

..Until then, and in the best interests of public health, however, we urge long term testing of chemicals in animals be continued, at increased pace...

..This paper presents a condensed history of the benzene bioassay story with mention of benzene-associated human cancers...

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..Available information about the carcinogenicity of cadmium and cadmium compounds is reviewed, evaluated, and discussed...

..Until public health is removed from politics and the influence of corporate money, real progress will be difficult to achieve and past achievements will be lost...

..For mice, no biologically important increase was observed for any nonneoplastic or neoplastic lesion. Studies by others had reported carcinogenicity of toluene, especially for total malignant tumors...

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..To stem this tide at the IARC, new leadership, with more objectivity and public health perspective, is needed...

..No adequate human studies are available for styrene-7,8-oxide although this is the primary and active epoxide metabolite of styrene. Both are genotoxic and form DNA adducts in humans...

..One fact remains abundantly clear: for every known human carcinogen that has been tested adequately in laboratory animals, the findings of carcinogenicity are concordant...

..Dismissing animal carcinogenicity findings would lead to human cancer cases as the only means of demonstrating carcinogenicity of environmental agents. This is unacceptable public health policy...

..Nonetheless public health considerations must take precedence when deciding human safety issues...

..This is not prudent public health policy...

..Key words: biphasic dose response, hormesis, individual susceptibility, low-dose exposures, nonmonotonic dose response, nonlinear dose response, public health, regulation, risk assessment...

..Our results demonstrate that p53 and H-ras mutations are relatively common in control and chemically induced mouse mammary carcinomas although both chemicals can alter the mutational spectra and more commonly induce concurrent mutations...

..All studies in the database are of two years duration, and all neoplasms occurring with a frequency of 0.5% or more are reported...

..A key to preventing occupationally and environmentally associated cancers, as in the wood industries, is avoiding exposures to chemicals and wood dusts and, in particular, chemicals known to cause cancer in animals or/and humans...

..major finding of A to T transversions or A to G transitions in forestomach and lung tumors suggests that ADBAQ or its metabolites target adenine bases in the ras proto-oncogenes and that these mutations play a dominant role in multi-organ..

..New findings indicate the need to extend the timing and duration of exposures used in the rodent bioassay...

..Instead, FIOH should provide the same level of scientific information in Africa that it does in Finland and other developed countries...

..Official recognition of the ICOH compromises the credibility of the WHO and the ILO. It is inappropriate for the ICOH to continue to receive WHO and ILO recognition unless the ICOH is recognized as an industry organization...

..That environmental exposures may be important causes of childhood cancers is indicated by associations of enzyme polymorphisms with risk...

..This paper chronicles the history of occupational medicine and industry physicians as influenced and even controlled by corporate leaders...