M A Huestis

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Intravenous buprenorphine and norbuprenorphine pharmacokinetics in humans
    M A Huestis
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Drug Alcohol Depend 131:258-62. 2013
  2. pmc Human cannabinoid pharmacokinetics
    Marilyn A Huestis
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21146, USA
    Chem Biodivers 4:1770-804. 2007
  3. pmc Methamphetamine disposition in oral fluid, plasma, and urine
    Marilyn A Huestis
    Chemistry and Drug Metabolism Section, IRP, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, MD, USA
    Ann N Y Acad Sci 1098:104-21. 2007
  4. pmc Cocaine and metabolites urinary excretion after controlled smoked administration
    Marilyn A Huestis
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Anal Toxicol 31:462-8. 2007
  5. ncbi request reprint Drug abuse's smallest victims: in utero drug exposure
    Marilyn A Huestis
    Intramural Research Program, Chemistry and Drug Metabolism Section, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Forensic Sci Int 128:20-30. 2002
  6. ncbi request reprint Estimating time of last oral ingestion of cannabis from plasma THC and THCCOOH concentrations
    Marilyn A Huestis
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Ther Drug Monit 28:540-4. 2006
  7. ncbi request reprint Estimating the time of last cannabis use from plasma delta9-tetrahydrocannabinol and 11-nor-9-carboxy-delta9-tetrahydrocannabinol concentrations
    Marilyn A Huestis
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Clin Chem 51:2289-95. 2005
  8. pmc Single and multiple doses of rimonabant antagonize acute effects of smoked cannabis in male cannabis users
    Marilyn A Huestis
    Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 194:505-15. 2007
  9. ncbi request reprint Blockade of effects of smoked marijuana by the CB1-selective cannabinoid receptor antagonist SR141716
    M A Huestis
    National Institute on Drug Abuse Intramural Research Program, 5500 Nathan Shock Dr, Baltimore, MD 21224, USA
    Arch Gen Psychiatry 58:322-8. 2001
  10. pmc Cannabis in sport: anti-doping perspective
    Marilyn A Huestis
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Sports Med 41:949-66. 2011

Detail Information

Publications93

  1. pmc Intravenous buprenorphine and norbuprenorphine pharmacokinetics in humans
    M A Huestis
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Drug Alcohol Depend 131:258-62. 2013
    ..Prescribed sublingual (SL) buprenorphine is sometimes diverted for intravenous (IV) abuse, but no human pharmacokinetic data are available following high-dose IV buprenorphine...
  2. pmc Human cannabinoid pharmacokinetics
    Marilyn A Huestis
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21146, USA
    Chem Biodivers 4:1770-804. 2007
  3. pmc Methamphetamine disposition in oral fluid, plasma, and urine
    Marilyn A Huestis
    Chemistry and Drug Metabolism Section, IRP, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, MD, USA
    Ann N Y Acad Sci 1098:104-21. 2007
    ..When contemplating selection of oral fluid as a test matrix, the advantages of oral fluid collection should be weighed against its shorter time of detection compared to that of urine...
  4. pmc Cocaine and metabolites urinary excretion after controlled smoked administration
    Marilyn A Huestis
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Anal Toxicol 31:462-8. 2007
    ..T(max) was not dose-dependent. All metabolites were detected in some subjects within 2 h. EC concentrations were significantly higher after smoked cocaine in a precise delivery coil compared to a glass "crack" pipe...
  5. ncbi request reprint Drug abuse's smallest victims: in utero drug exposure
    Marilyn A Huestis
    Intramural Research Program, Chemistry and Drug Metabolism Section, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Forensic Sci Int 128:20-30. 2002
    ....
  6. ncbi request reprint Estimating time of last oral ingestion of cannabis from plasma THC and THCCOOH concentrations
    Marilyn A Huestis
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Ther Drug Monit 28:540-4. 2006
    ..These results provide further evidence of the usefulness of the predictive models in estimating the time of last oral THC ingestion after single or multiple doses...
  7. ncbi request reprint Estimating the time of last cannabis use from plasma delta9-tetrahydrocannabinol and 11-nor-9-carboxy-delta9-tetrahydrocannabinol concentrations
    Marilyn A Huestis
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Clin Chem 51:2289-95. 2005
    ....
  8. pmc Single and multiple doses of rimonabant antagonize acute effects of smoked cannabis in male cannabis users
    Marilyn A Huestis
    Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 194:505-15. 2007
    ..A single 90-mg dose of the cannabinoid CB1 receptor antagonist rimonabant attenuates effects of smoked cannabis in humans...
  9. ncbi request reprint Blockade of effects of smoked marijuana by the CB1-selective cannabinoid receptor antagonist SR141716
    M A Huestis
    National Institute on Drug Abuse Intramural Research Program, 5500 Nathan Shock Dr, Baltimore, MD 21224, USA
    Arch Gen Psychiatry 58:322-8. 2001
    ..These findings suggest that CB1 receptors mediate many of the effects of marijuana, but this has not been evaluated in humans...
  10. pmc Cannabis in sport: anti-doping perspective
    Marilyn A Huestis
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Sports Med 41:949-66. 2011
    ....
  11. pmc Excretion of Delta9-tetrahydrocannabinol in sweat
    Marilyn A Huestis
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Forensic Sci Int 174:173-7. 2008
    ..Oral ingestion of up to 14.8 mg THC daily does not produce a THC positive sweat patch test...
  12. ncbi request reprint Monitoring opiate use in substance abuse treatment patients with sweat and urine drug testing
    M A Huestis
    Chemistry and Drug Metabolism Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA
    J Anal Toxicol 24:509-21. 2000
    ..However, the percentage of false-negative results, at least in this treatment population, indicates that weekly sweat testing may be less sensitive than thrice weekly urine testing in detecting opiate use...
  13. ncbi request reprint Delta(9)-tetrahydrocannabinol, 11-hydroxy-delta(9)-tetrahydrocannabinol and 11-nor-9-carboxy-delta(9)-tetrahydrocannabinol in human plasma after controlled oral administration of cannabinoids
    Robert S Goodwin
    Chemistry and Drug Metabolism Section, IRP, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Ther Drug Monit 28:545-51. 2006
    ..There was a significant correlation between body mass index and Cmax and body mass index and number of specimens positive for THC and 11-OH-THC...
  14. ncbi request reprint Sensitivity and specificity of the Cozart microplate EIA cocaine oral fluid at proposed screening and confirmation cutoffs
    Insook Kim
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Dr, Baltimore, MD 21224, USA
    Clin Chem 49:1498-503. 2003
    ....
  15. ncbi request reprint Urinary cannabinoid detection times after controlled oral administration of delta9-tetrahydrocannabinol to humans
    Richard A Gustafson
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Clin Chem 49:1114-24. 2003
    ....
  16. pmc Simultaneous liquid chromatography-mass spectrometry quantification of urinary opiates, cocaine, and metabolites in opiate-dependent pregnant women in methadone-maintenance treatment
    Diaa M Shakleya
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, Maryland 21224, USA
    J Anal Toxicol 34:17-25. 2010
    ..Of interest is the differential pattern of opiate and cocaine biomarkers observed after LC-MS as compared to gas chromatography-mass spectrometry analysis...
  17. pmc Excretion of methamphetamine and amphetamine in human sweat following controlled oral methamphetamine administration
    Allan J Barnes
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Clin Chem 54:172-80. 2008
    ..Understanding methamphetamine (MAMP) and amphetamine (AMP) excretion in sweat is important for interpreting sweat and hair testing results in judicial, workplace, and drug treatment settings...
  18. pmc A liquid chromatography tandem mass spectrometry method for the simultaneous quantification of 20 drugs of abuse and metabolites in human meconium
    Teresa R Gray
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Anal Bioanal Chem 393:1977-90. 2009
    ..Method applicability was demonstrated by analyzing meconium from drug-exposed neonates...
  19. pmc Validation of an enzyme immunoassay for detection and semiquantification of cannabinoids in oral fluid
    David M Schwope
    Chemistry and Drug Metabolism, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
    Clin Chem 56:1007-14. 2010
    ..It is important to characterize assay performance and limitations of screening techniques for Delta(9)-tetrahydrocannabinol (THC) in OF...
  20. pmc Excretion of methadone in sweat of pregnant women throughout gestation after controlled methadone administration
    Allan J Barnes
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Ther Drug Monit 32:497-503. 2010
    ....
  21. ncbi request reprint Relationship of Delta 9-tetrahydrocannabinol concentrations in oral fluid and plasma after controlled administration of smoked cannabis
    Marilyn A Huestis
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Anal Toxicol 28:394-9. 2004
    ..Consequently, when very recent passive exposure to cannabis smoke can be ruled out, it is concluded that a positive oral fluid test provides credible evidence of active cannabis use...
  22. ncbi request reprint Cozart RapiScan Oral Fluid Drug Testing System: an evaluation of sensitivity, specificity, and efficiency for cocaine detection compared with ELISA and GC-MS following controlled cocaine administration
    Erin A Kolbrich
    Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Anal Toxicol 27:407-11. 2003
    ..4%, 92.2%, and 90.7%, respectively. Cozart RapiScan had performance similar to the COC ELISA assay for the detection of cocaine exposure and suitable sensitivity and specificity at the proposed SAMHSA cutoffs...
  23. ncbi request reprint Sensitivity, specificity, and efficiency in detecting opiates in oral fluid with the Cozart Opiate Microplate EIA and GC-MS following controlled codeine administration
    Allan J Barnes
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21124, USA
    J Anal Toxicol 27:402-7. 2003
    ..In addition, the data, collected following controlled oral codeine administration, may aid in the interpretation of opiate oral fluid test results and in the selection of appropriate oral fluid screening and confirmation cutoffs...
  24. ncbi request reprint Plasma and oral fluid pharmacokinetics and pharmacodynamics after oral codeine administration
    Insook Kim
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Clin Chem 48:1486-96. 2002
    ....
  25. ncbi request reprint Detection of opiate use in a methadone maintenance treatment population with the CEDIA 6-acetylmorphine and CEDIA DAU opiate assays
    A C Spanbauer
    IRP, NIDA, NIH, Baltimore, Maryland 21224, USA
    J Anal Toxicol 25:515-9. 2001
    ..Increasing the opiate screening and confirmation cutoffs for the federal workplace drug-testing program resulted in 8% fewer opiate-positive tests; however, recent heroin use was not affected by this change...
  26. ncbi request reprint A study of peptide--peptide interaction by matrix-assisted laser desorption/ionization
    A S Woods
    Chemistry and Drug Metabolism, NIDA Intramural Research Program, NIDA, NIH, Baltimore, Maryland 21224, USA
    J Am Soc Mass Spectrom 12:88-96. 2001
    ..These findings strongly suggest that peptide-peptide interaction does occur, and can be studied by MALDI if near physiologic pH is maintained...
  27. pmc Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse
    E Lehrmann
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
    Pharmacogenomics J 3:27-40. 2003
    ..These data suggest that cocaine abuse targets a distinct subset of genes in the dlPFC, resulting in either a state of acute activation in which increased gene expression predominates, or a relatively destimulated, refractory phase...
  28. pmc Meconium nicotine and metabolites by liquid chromatography-tandem mass spectrometry: differentiation of passive and nonexposure and correlation with neonatal outcome measures
    Teresa R Gray
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Clin Chem 54:2018-27. 2008
    ....
  29. pmc Implications of plasma Delta9-tetrahydrocannabinol, 11-hydroxy-THC, and 11-nor-9-carboxy-THC concentrations in chronic cannabis smokers
    Erin L Karschner
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Anal Toxicol 33:469-77. 2009
    ..THC's presence in plasma for seven days of abstinence suggests its detection may not indicate recent use in daily cannabis users...
  30. pmc Identification of prenatal amphetamines exposure by maternal interview and meconium toxicology in the Infant Development, Environment and Lifestyle (IDEAL) study
    Teresa R Gray
    Chemistry and Drug Metabolism, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Ther Drug Monit 31:769-75. 2009
    ..Low confirmation rates in meconium reinforce the need for confirmatory testing following positive screening results and additional research to identify alternative biomarkers...
  31. pmc Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse
    Elin Lehrmann
    Cellular Neurobiology Research Branch and Chemistry and Drug Metabolism Section, National Institute on Drug Abuse NIDA Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America
    PLoS ONE 1:e114. 2006
    ..These changes represent common molecular features of drug abuse, which may underlie changes in synaptic function and plasticity that could have important ramifications for decision-making capabilities in drug abusers...
  32. ncbi request reprint Major and minor metabolites of cocaine in human plasma following controlled subcutaneous cocaine administration
    Erin A Kolbrich
    Chemistry and Drug Metabolism, IRP, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Anal Toxicol 30:501-10. 2006
    ..7 ng/mL). These data improve our knowledge of the pharmacokinetics of cocaine and its major and minor metabolites in plasma following controlled subcutaneous cocaine administration...
  33. pmc Nicotine enhances visuospatial attention by deactivating areas of the resting brain default network
    Britta Hahn
    Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 27:3477-89. 2007
    ..Together with the selectivity of effects for INT(high), this suggests a nicotine-induced potentiation of the alerting properties of external stimuli...
  34. pmc Cannabinoid concentrations in hair from documented cannabis users
    Marilyn A Huestis
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, United States
    Forensic Sci Int 169:129-36. 2007
    ..01, Pearson's product moment correlation). Using an immunoassay cutoff concentration of 5 pg THC equiv./mg hair, 83% of specimens that screened positive were confirmed by GCMSMS at a cutoff concentration of 0.1 pg THCCOOH/mg hair...
  35. ncbi request reprint Methamphetamine and amphetamine pharmacokinetics in oral fluid and plasma after controlled oral methamphetamine administration to human volunteers
    Raf J F Schepers
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, 5500 Nathan Shock Dr, Baltimore, MD 21224, USA
    Clin Chem 49:121-32. 2003
    ..Methamphetamine (METH) and amphetamine (AMP) concentrations in 200 plasma and 590 oral fluid specimens were used to evaluate METH pharmacokinetics and pharmacodynamics after oral administration of sustained-release METH...
  36. ncbi request reprint Urinary elimination of cocaine metabolites in chronic cocaine users during cessation
    Kenzie L Preston
    Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Anal Toxicol 26:393-400. 2002
    ....
  37. ncbi request reprint Duration of detectable methamphetamine and amphetamine excretion in urine after controlled oral administration of methamphetamine to humans
    Jonathan M Oyler
    Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Dr, Baltimore, MD 21224, USA
    Clin Chem 48:1703-14. 2002
    ..We determined the urinary excretion of MAMP after oral ingestion and examined the effect of using lower cutoffs on detection of exposure...
  38. pmc Extended urinary Delta9-tetrahydrocannabinol excretion in chronic cannabis users precludes use as a biomarker of new drug exposure
    Ross H Lowe
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Suite 05A721, Baltimore, MD 21224, USA
    Drug Alcohol Depend 105:24-32. 2009
    ..Delta9-Tetrahydrocannabinol (THC) and 11-hydroxy-THC (11-OH-THC) concentrations in urine following Escherichia coli beta-glucuronidase hydrolysis were proposed as biomarkers of recent (within 8h) cannabis use...
  39. pmc Effects of dose and route of administration on pharmacokinetics of (+ or -)-3,4-methylenedioxymethamphetamine in the rat
    Michael H Baumann
    Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Dr, Suite 4500, Baltimore, MD 21224, USA
    Drug Metab Dispos 37:2163-70. 2009
    ..Finally, given key similarities between MDMA pharmacokinetics in rats and humans, data from rats may be clinically relevant when appropriate dosing conditions are used...
  40. pmc Postmortem diagnosis and toxicological validation of illicit substance use
    Elin Lehrmann
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse NIDA IRP, National Institutes of Health, Baltimore, MD 21224, USA
    Addict Biol 13:105-17. 2008
    ....
  41. pmc Optimization and validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of nicotine, cotinine, trans-3'-hydroxycotinine and norcotinine in human oral fluid
    Diaa M Shakleya
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard Suite 200, Room 05A 721, Baltimore, MD 21224, USA
    Anal Bioanal Chem 395:2349-57. 2009
    ....
  42. pmc Plasma pharmacokinetics of 3,4-methylenedioxymethamphetamine after controlled oral administration to young adults
    Erin A Kolbrich
    Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ther Drug Monit 30:320-32. 2008
    ....
  43. pmc A mechanism for the inhibition of neural progenitor cell proliferation by cocaine
    Chun Ting Lee
    Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America
    PLoS Med 5:e117. 2008
    ..To understand the molecular mechanism through which cocaine inhibits cell proliferation in neural progenitors, we sought to identify the molecules that are responsible for mediating the effect of cocaine on cell cycle regulation...
  44. pmc Do Delta9-tetrahydrocannabinol concentrations indicate recent use in chronic cannabis users?
    Erin L Karschner
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Addiction 104:2041-8. 2009
    ..To quantify blood Delta(9)-tetrahydrocannabinol (THC) concentrations in chronic cannabis users over 7 days of continuous monitored abstinence...
  45. pmc Simultaneous GC-EI-MS determination of Delta9-tetrahydrocannabinol, 11-hydroxy-Delta9-tetrahydrocannabinol, and 11-nor-9-carboxy-Delta9-tetrahydrocannabinol in human urine following tandem enzyme-alkaline hydrolysis
    Tsadik T Abraham
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, Maryland, 21224, USA
    J Anal Toxicol 31:477-85. 2007
    ....
  46. ncbi request reprint Methadone and metabolite urine concentrations in patients maintained on methadone
    Kenzie L Preston
    Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Anal Toxicol 27:332-41. 2003
    ..Nevertheless, variability was too great to permit estimation of methadone dose (or detect a single missed administration) from any single specimen...
  47. pmc Nicotine and metabolites in meconium as evidence of maternal cigarette smoking during pregnancy and predictors of neonatal growth deficits
    Teresa R Gray
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Nicotine Tob Res 12:658-64. 2010
    ..However, relationships between the amount, frequency, and timing of cigarette smoking during gestation and tobacco biomarker meconium concentrations and neonatal outcomes are unclear...
  48. ncbi request reprint Matrix effect in bio-analysis of illicit drugs with LC-MS/MS: influence of ionization type, sample preparation, and biofluid
    Riet Dams
    Chemistry and Drug Metabolism, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA
    J Am Soc Mass Spectrom 14:1290-4. 2003
    ..Acetonitrile protein precipitation provided both sample clean up and concentration for oral fluid analysis, while SPE was necessary for extensive clean up of plasma prior to LC-APCI-MS/MS...
  49. ncbi request reprint Simultaneous determination of nicotine, cotinine, norcotinine, and trans-3'-hydroxycotinine in human oral fluid using solid phase extraction and gas chromatography-mass spectrometry
    Insook Kim
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 814:233-40. 2005
    ..3-Hydroxycotinine requires additional investigation to determine its usefulness as a biomarker for tobacco smoke exposure...
  50. pmc Chronic smoking, but not acute nicotine administration, modulates neural correlates of working memory
    Matthew T Sutherland
    Neuroimaging Research Branch, National Institute on Drug Abuse Intramural Research Program, NIH DHHS, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 213:29-42. 2011
    ..Beyond the amelioration of deprivation-induced impairments, and in contrast to effects on attentional processes, the cognitive-enhancing properties of nicotine on working memory (WM) operations remain unclear...
  51. ncbi request reprint Effects of high-dose intravenous buprenorphine in experienced opioid abusers
    Annie Umbricht
    National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA
    J Clin Psychopharmacol 24:479-87. 2004
    ..v. dose. Buprenorphine appears to have a ceiling for cardiorespiratory and subjective effects and a high safety margin even when taken by the i.v. route...
  52. ncbi request reprint Validated gas chromatographic-negative ion chemical ionization mass spectrometric method for delta(9)-tetrahydrocannabinol in sweat patches
    Takeshi Saito
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
    Clin Chem 50:2083-90. 2004
    ..A sensitive gas chromatography-negative ion chemical ionization mass spectrometry (GC/MS-NICI) method was developed and validated for the measurement of Delta(9)-tetrahydrocannabinol (THC) in human sweat patches...
  53. ncbi request reprint The cannabinoid CB1 receptor antagonist rimonabant attenuates the hypotensive effect of smoked marijuana in male smokers
    David A Gorelick
    Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Am Heart J 151:754.e1-754.e5. 2006
    ..In human studies, activation of CB1 receptors by cannabis or its active ingredient, Delta9-tetrahydrocannabinol (THC), has modest and inconsistent effects on BP...
  54. ncbi request reprint Opioid disposition in human sweat after controlled oral codeine administration
    Eugene W Schwilke
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
    Clin Chem 52:1539-45. 2006
    ..Characterization of opioid excretion in sweat is important for accurate interpretation of sweat tests in drug treatment, criminal justice, and workplace drug testing programs...
  55. ncbi request reprint Urinary pharmacokinetics of 11-nor-9-carboxy-delta9-tetrahydrocannabinol after controlled oral delta9-tetrahydrocannabinol administration
    Richard A Gustafson
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Anal Toxicol 28:160-7. 2004
    ..These controlled drug administration data should assist in the interpretation of urine cannabinoid results and provide clinicians with valuable information for future pharmacological studies...
  56. ncbi request reprint Recent marijuana blunt smoking impacts carbon monoxide as a measure of adolescent tobacco abstinence
    Eric T Moolchan
    Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224, USA
    Subst Use Misuse 40:231-40. 2005
    ..013). Blunt occasions also tended to be associated with the more youth-appropriate cutoff CO > or = 6 ppm, compared to non-MJ occasions (p =0.054). Blunt smoking impacted the interpretation of measures of exhaled CO for tobacco cessation...
  57. ncbi request reprint Amphetamine-induced toxicity in dopamine terminals in CD-1 and C57BL/6J mice: complex roles for oxygen-based species and temperature regulation
    I N Krasnova
    Molecular Neuropsychiatry Section, NIH/NIDA Intramural Research Program, Baltimore, MD 21224, USA
    Neuroscience 107:265-74. 2001
    ..Thus, these observations provide evidence for possible complex interactions between thermoregulation and free radical load in the long-term neurotoxic effects of this illicit drug of abuse...
  58. doi request reprint Subjective and physiological effects after controlled Sativex and oral THC administration
    E L Karschner
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA
    Clin Pharmacol Ther 89:400-7. 2011
    ..These results indicate that Sativex has a pharmacodynamic safety profile comparable to that of oral THC at low, therapeutic doses...
  59. pmc Physiological and subjective responses to controlled oral 3,4-methylenedioxymethamphetamine administration
    Erin A Kolbrich
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    J Clin Psychopharmacol 28:432-40. 2008
    ....
  60. pmc Effect of hydrolysis on identifying prenatal cannabis exposure
    Teresa R Gray
    Chemistry and Drug Metabolism, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd Suite 200, Room 05A721A, Baltimore, MD, USA
    Anal Bioanal Chem 397:2335-47. 2010
    ..Maximal identification of cannabis-exposed neonates and the widest range of cannabis biomarkers are achieved with enzyme-alkaline tandem hydrolysis...
  61. pmc Urinary MDMA, MDA, HMMA, and HMA excretion following controlled MDMA administration to humans
    Tsadik T Abraham
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, Maryland 21224, USA
    J Anal Toxicol 33:439-46. 2009
    ..Measurement of urinary HMMA provides the longest detection of MDMA exposure yet is not included in routine monitoring procedures...
  62. ncbi request reprint Usefulness of salivary trans-3'-hydroxycotinine concentration and trans-3'-hydroxycotinine/cotinine ratio as biomarkers of cigarette smoke in pregnant women
    Insook Kim
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Anal Toxicol 29:689-95. 2005
    ..Determining the hydroxycotinine/cotinine ratio may differentiate light from heavy tobacco use and help predict increased fetal tobacco exposure...
  63. ncbi request reprint Sensitive gas chromatography-mass spectrometry method for simultaneous measurement of MDEA, MDMA, and metabolites HMA, MDA, and HMMA in human urine
    Stephane O Pirnay
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Clin Chem 52:1728-34. 2006
    ....
  64. ncbi request reprint Performance characteristics of the Cozart RapiScan Oral Fluid Drug Testing System for opiates in comparison to ELISA and GC/MS following controlled codeine administration
    Sherri L Kacinko
    Chemistry and Drug Metabolism Section, Intramural Research Program, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Forensic Sci Int 141:41-8. 2004
    ....
  65. pmc Simultaneous quantification of cannabinoids and metabolites in oral fluid by two-dimensional gas chromatography mass spectrometry
    Garry Milman
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA
    J Chromatogr A 1217:1513-21. 2010
    ..This method will be applied to quantification of cannabinoids in oral fluid specimens from individuals participating in controlled cannabis and Sativex (50% THC and 50% CBD) administration studies, and during cannabis withdrawal...
  66. pmc Disposition of cannabinoids in oral fluid after controlled around-the-clock oral THC administration
    Garry Milman
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
    Clin Chem 56:1261-9. 2010
    ..Cannabinoid distribution into oral fluid is complex and incompletely characterized due to the lack of controlled drug administration studies...
  67. pmc Oral fluid as an alternative matrix to monitor opiate and cocaine use in substance-abuse treatment patients
    Riet Dams
    Chemistry and Drug Metabolism, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 87:258-67. 2007
    ..Oral fluid is a promising alternative matrix to monitor opiate and cocaine use in drug testing programs. These data guide interpretation of oral fluid test results and evaluate currently proposed SAMHSA oral fluid testing cutoffs...
  68. pmc A validated liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometric method for the quantification of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), and 2-Ethyl-5-methyl-3,3-diphenylpyroline (EMDP) in
    Robin E Choo
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Baltimore, Maryland 21224, USA
    J Anal Toxicol 31:265-9. 2007
    ..The method proved suitable for quantification of methadone and metabolites in breast milk of methadone-maintained opiate-dependent women...
  69. ncbi request reprint A validated positive chemical ionization GC/MS method for the identification and quantification of amphetamine, opiates, cocaine, and metabolites in human postmortem brain
    Ross H Lowe
    Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Mass Spectrom 41:175-84. 2006
    ..This method will be employed to quantify drug concentrations in human postmortem brain in support of basic and clinical research on the physiologic, biochemical, and behavioral effects of drugs in humans...
  70. pmc Identifying prenatal cannabis exposure and effects of concurrent tobacco exposure on neonatal growth
    Teresa R Gray
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Clin Chem 56:1442-50. 2010
    ..Testing of meconium, the first neonatal feces, offers objective evidence of prenatal cannabis exposure, but the relative ability of meconium testing and maternal self-report to identify affected neonates remains unclear...
  71. ncbi request reprint Two-dimensional gas chromatography/electron-impact mass spectrometry with cryofocusing for simultaneous quantification of MDMA, MDA, HMMA, HMA, and MDEA in human plasma
    Erin A Kolbrich
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Clin Chem 54:379-87. 2008
    ..Two-dimensional GC/MS with cryofocusing is a chromatographic technique recognized for its increased selectivity and resolution...
  72. pmc Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers
    J Hirvonen
    Molecular Imaging Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892 1026, USA
    Mol Psychiatry 17:642-9. 2012
    ..This is the first direct demonstration of cortical cannabinoid CB(1) receptor downregulation as a neuroadaptation that may promote cannabis dependence in human brain...
  73. pmc Correlations of maternal buprenorphine dose, buprenorphine, and metabolite concentrations in meconium with neonatal outcomes
    S L Kacinko
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA
    Clin Pharmacol Ther 84:604-12. 2008
    ..The results suggest that buprenorphine and metabolite concentrations in the meconium may predict the onset and frequency of NAS...
  74. ncbi request reprint Simultaneous determination of buprenorphine, norbuprenorphine, and buprenorphine-glucuronide in plasma by liquid chromatography-tandem mass spectrometry
    A Polettini
    Chemistry and Drug Metabolism Section, IRP, NIDA, NIH, Baltimore, MD 21224, USA
    J Chromatogr B Biomed Sci Appl 754:447-59. 2001
    ..Norbuprenorphine-glucuronide was also tentatively detected in plasma by monitoring the m/z 590-->m/z 414 transition...
  75. ncbi request reprint Oral fluid as a diagnostic tool
    Robin E Choo
    Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute of Drug Abuse, National Institute of Health, Baltimore, MD, USA
    Clin Chem Lab Med 42:1273-87. 2004
    ..This review describes advances over the past 5 years in the area of oral fluid as a diagnostic tool, its use in therapeutic and illicit drug monitoring, including proposed guidelines for cut-off values, and methods of collection...
  76. pmc Development and validation of a solid-phase extraction gas chromatography-mass spectrometry method for the simultaneous quantification of methadone, heroin, cocaine and metabolites in sweat
    Bertrand R Brunet
    INSERM E 0324, Universite de Poitiers, Faculte de Medecine et Pharmacie, CHU de Poitiers, rue de la Miletrie, BP 577, 86021, Poitiers, France
    Anal Bioanal Chem 392:115-27. 2008
    ..9% of target. Heroin hydrolysis during specimen processing was <11%. This novel assay offers effective monitoring of drug exposure during drug treatment, workplace and criminal justice monitoring programs...
  77. ncbi request reprint Neonatal abstinence syndrome in methadone-exposed infants is altered by level of prenatal tobacco exposure
    Robin E Choo
    Chemistry and Drug Metabolism Section, Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Drug Alcohol Depend 75:253-60. 2004
    ..0 h versus 37.8 h), than light smokers of 10 or fewer cigarettes per day. We concluded that tobacco use in conjunction with methadone plays an important role in the timing and severity of NAS in prenatally exposed infants...
  78. ncbi request reprint Urinary pharmacokinetics of methamphetamine and its metabolite, amphetamine following controlled oral administration to humans
    Insook Kim
    Chemistry and Drug Metabolism Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
    Ther Drug Monit 26:664-72. 2004
    ..4 +/- 6.5% to 35.7 +/- 26.6%. Slow urinary excretion results in drug accumulation and increases in detection time windows. Our findings also support the presence of an active renal excretion mechanism for methamphetamine...
  79. ncbi request reprint Dose-related distribution of codeine, cocaine, and metabolites into human hair following controlled oral codeine and subcutaneous cocaine administration
    Karl B Scheidweiler
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 313:909-15. 2005
    ..These data are the first demonstrating melanin-related incorporation of cocaine and metabolites into human hair following controlled cocaine administration...
  80. ncbi request reprint Urine testing for cocaine abuse: metabolic and excretion patterns following different routes of administration and methods for detection of false-negative results
    Edward J Cone
    ConeChem Research, LLC, Severna Park, Maryland 21146, USA
    J Anal Toxicol 27:386-401. 2003
    ....
  81. ncbi request reprint Eclipse can deliver crack cocaine
    Stacey L Steckley
    Nicotine Tob Res 4:S189-90. 2002
  82. ncbi request reprint Cannabis withdrawal among non-treatment-seeking adult cannabis users
    Marc L Copersino
    Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224 6823, USA
    Am J Addict 15:8-14. 2006
    ....
  83. ncbi request reprint Simultaneous quantification of methamphetamine, cocaine, codeine, and metabolites in skin by positive chemical ionization gas chromatography-mass spectrometry
    Wonkyung Yang
    National Institute of Scientific Investigation, 331 1 Shinwol 7 dong, Yangcheon Gu, Seoul 158 707, Republic of Korea
    J Chromatogr B Analyt Technol Biomed Life Sci 833:210-8. 2006
    ..999 and concentrations +/-20% of target. Intra- and inter-run precisions were <10%. This procedure should be useful for postmortem analysis; data are included on drug concentrations in skin after controlled drug administration...
  84. ncbi request reprint Quitting among non-treatment-seeking marijuana users: reasons and changes in other substance use
    Marc L Copersino
    Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    Am J Addict 15:297-302. 2006
    ..These findings suggest areas for further research on spontaneous recovery from marijuana use...
  85. ncbi request reprint Urine drug testing for opioids, cocaine, and metabolites by direct injection liquid chromatography/tandem mass spectrometry
    Riet Dams
    Chemistry and Drug Metabolism, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Rapid Commun Mass Spectrom 17:1665-70. 2003
    ..The method proved to be simple and time efficient, and was applicable for illicit drug use monitoring and methadone treatment compliance in clinical research projects at the National Institute on Drug Abuse (NIDA)...
  86. ncbi request reprint Selection and optimization of hydrolysis conditions for the quantification of urinary metabolites of MDMA
    Stephane O Pirnay
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Anal Toxicol 30:563-9. 2006
    ..Therefore, based on HMMA, HMA, and MDA recoveries, time efficiency, availability of instrumentation, and cost, acid hydrolysis was preferred to enzyme hydrolysis...
  87. pmc Interpretation of oral fluid tests for drugs of abuse
    Edward J Cone
    Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Ann N Y Acad Sci 1098:51-103. 2007
    ..Chemical, metabolic, kinetic, and analytic parameters are summarized for selected drugs of abuse, and general guidelines are offered for understanding the significance of oral fluid tests...
  88. ncbi request reprint LC-atmospheric pressure chemical ionization-MS/ MS analysis of multiple illicit drugs, methadone, and their metabolites in oral fluid following protein precipitation
    Riet Dams
    Chemistry and Drug Metabolism, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Anal Chem 75:798-804. 2003
    ..The method proved to be suitable for the evaluation of oral fluid as an alternative matrix to urine for monitoring illicit drug use and for determining oral fluid methadone concentrations in pregnant opiate and/or cocaine addicts...
  89. ncbi request reprint Disposition of cocaine and its metabolites in human sweat after controlled cocaine administration
    Sherri L Kacinko
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Clin Chem 51:2085-94. 2005
    ..Sweat testing is a noninvasive technique for monitoring drug exposure in treatment, criminal justice, and employment settings...
  90. doi request reprint Methadone maintenance and breastfeeding in the neonatal period
    Lauren M Jansson
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Pediatrics 121:106-14. 2008
    ....
  91. ncbi request reprint Simultaneous quantification of opiates, cocaine, and metabolites in hair by LC-APCI-MS/MS
    Karl B Scheidweiler
    Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Anal Chem 76:4358-63. 2004
    ..0% for all analytes. Methanolic sonication produced less than 5% hydrolysis of cocaine and 6-acetylmorphine. The method should be useful for studying cocaine and opiate distribution into hair...
  92. ncbi request reprint Buprenorphine versus methadone in the treatment of pregnant opioid-dependent patients: effects on the neonatal abstinence syndrome
    Hendree E Jones
    The Department of Psychiatry and Behavioral Sciences, Johns Hopkins Bayview Medical Campus, Johns Hopkins University School of Medicine, D 3 East, 4940 Eastern Avenue, Baltimore, MD 21224, USA
    Drug Alcohol Depend 79:1-10. 2005
    ..25). Results suggest that buprenorphine is not inferior to methadone on outcome measures assessing NAS and maternal and neonatal safety when administered starting in the second trimester of pregnancy...
  93. pmc Quantification of nicotine, cotinine, trans-3'-hydroxycotinine, nornicotine and norcotinine in human meconium by liquid chromatography/tandem mass spectrometry
    Teresa R Gray
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 863:107-14. 2008
    ..Specimen preparation included homogenization, enzyme hydrolysis and solid phase extraction. The linear range was 1.25 or 5-500ng/g. Method applicability was evaluated with meconium collected from an in utero tobacco exposed infant...