Wen Yi Huang

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Prospective study of genomic hypomethylation of leukocyte DNA and colorectal cancer risk
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8110, MSC 7240, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 21:2014-21. 2012
  2. pmc Impact of patient characteristics on the risk of influenza/ILI-related complications
    D E Irwin
    Ingenix Pharmaceutical Services, Epidemiology Division, Newton Lower Falls, Massachusetts, USA
    BMC Health Serv Res 1:8. 2001
  3. pmc High-throughput single nucleotide polymorphism genotyping using nanofluidic Dynamic Arrays
    Jun Wang
    Fluidigm Corporation, South San Francisco, CA, USA
    BMC Genomics 10:561. 2009
  4. ncbi request reprint Selected genetic polymorphisms in MGMT, XRCC1, XPD, and XRCC3 and risk of head and neck cancer: a pooled analysis
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:1747-53. 2005
  5. pmc Simultaneous recovery of DNA and RNA from formalin-fixed paraffin-embedded tissue and application in epidemiologic studies
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8110, MSC 7240, Bethesda, MD 20892 7240, USA
    Cancer Epidemiol Biomarkers Prev 19:973-7. 2010
  6. ncbi request reprint Selected DNA repair polymorphisms and gastric cancer in Poland
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 26:1354-9. 2005
  7. ncbi request reprint Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 15:306-11. 2006
  8. ncbi request reprint Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenoma
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:152-7. 2005
  9. pmc Sexually transmissible infections and prostate cancer risk
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 17:2374-81. 2008
  10. ncbi request reprint Alcohol concentration and risk of oral cancer in Puerto Rico
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Epidemiol 157:881-7. 2003

Detail Information

Publications65

  1. pmc Prospective study of genomic hypomethylation of leukocyte DNA and colorectal cancer risk
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8110, MSC 7240, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 21:2014-21. 2012
    ..Reduced 5-mC levels in peripheral blood leukocytes have been associated with increased risk of colorectal cancer and adenoma in cross-sectional studies...
  2. pmc Impact of patient characteristics on the risk of influenza/ILI-related complications
    D E Irwin
    Ingenix Pharmaceutical Services, Epidemiology Division, Newton Lower Falls, Massachusetts, USA
    BMC Health Serv Res 1:8. 2001
    ..We sought to quantify the impact of patient characteristics on complications and health care costs associated with influenza and influenza-like illness (ILI) in a nonelderly population...
  3. pmc High-throughput single nucleotide polymorphism genotyping using nanofluidic Dynamic Arrays
    Jun Wang
    Fluidigm Corporation, South San Francisco, CA, USA
    BMC Genomics 10:561. 2009
    ..This is also important for those who work on high throughput genotyping in non-model systems where off-the-shelf assays are not available and a flexible platform is needed...
  4. ncbi request reprint Selected genetic polymorphisms in MGMT, XRCC1, XPD, and XRCC3 and risk of head and neck cancer: a pooled analysis
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:1747-53. 2005
    ..Consistent findings from three case-control studies suggest that selected DNA repair enzymes may play a role in head and neck carcinogenesis...
  5. pmc Simultaneous recovery of DNA and RNA from formalin-fixed paraffin-embedded tissue and application in epidemiologic studies
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8110, MSC 7240, Bethesda, MD 20892 7240, USA
    Cancer Epidemiol Biomarkers Prev 19:973-7. 2010
    ..Here, we report the method that we used to simultaneously recover DNA and RNA from FFPE tissue specimens with appreciable quantity and quality and discuss briefly the application of tumor markers in epidemiologic studies...
  6. ncbi request reprint Selected DNA repair polymorphisms and gastric cancer in Poland
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 26:1354-9. 2005
    ..These results need replication in larger epidemiological studies of gastric cancer...
  7. ncbi request reprint Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 15:306-11. 2006
    ....
  8. ncbi request reprint Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenoma
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:152-7. 2005
    ..02). In conclusion, EPHX1 variants at codon 113 and 139 associated with high predicted enzymatic activity appear to increase risk for colorectal adenoma, particularly among recent and current smokers...
  9. pmc Sexually transmissible infections and prostate cancer risk
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 17:2374-81. 2008
    ..Sexually transmissible infections (STI) have been variably associated with increased risks of prostate cancer, largely in case-control studies...
  10. ncbi request reprint Alcohol concentration and risk of oral cancer in Puerto Rico
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Epidemiol 157:881-7. 2003
    ..These results suggest that alcohol concentration is a risk factor for oral cancer independent of the total quantity of alcohol consumed...
  11. ncbi request reprint Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma
    Sarah E Daugherty
    Divison of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, 6120 Executive Boulevard, EPS Rm 8113, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 16:1536-42. 2007
    ..AMACR gene variants have been associated with hereditary prostate cancer, but no studies have evaluated their etiologic role in colorectal carcinogenesis...
  12. ncbi request reprint Genetic variation in base excision repair genes and the prevalence of advanced colorectal adenoma
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Res 67:1395-404. 2007
    ..51; 95% CI, 0.33-0.78, P = 0.002 for PARP1 A284A). This study suggests that polymorphisms in APEX1, XRCC1, and PARP1 may be associated with advanced colorectal adenoma...
  13. pmc A case-control study of tobacco use and other non-occupational risk factors for lymphoma subtypes defined by t(14; 18) translocations and bcl-2 expression
    Cindy M Chang
    Infections and Immunoepidemiology Branch, National Cancer Institute, Rockville, MD, USA
    Cancer Causes Control 21:1147-54. 2010
    ....
  14. pmc The association between inflammation-related genes and serum androgen levels in men: the prostate, lung, colorectal, and ovarian study
    Tamra E Meyer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA
    Prostate 72:65-71. 2012
    ..Androgens and inflammation have been implicated in the etiology of several cancers, including prostate cancer. Serum androgens have been shown to correlate with markers of inflammation and expression of inflammation-related genes...
  15. ncbi request reprint RNASEL Arg462Gln polymorphism and prostate cancer in PLCO
    Sarah E Daugherty
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Prostate 67:849-54. 2007
    ..The relationship of this variant to sporadic prostate cancer remains uncertain...
  16. pmc Serum vitamin D concentration and prostate cancer risk: a nested case-control study
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Bethesda, MD 20892, USA
    J Natl Cancer Inst 100:796-804. 2008
    ....
  17. pmc Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasia
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8116, MSC 7240, Bethesda, MD 20892 7240, USA
    Cancer Causes Control 20:487-90. 2009
    ..To determine if this finding could be replicated, we investigated the association between two FRZB polymorphisms (Arg324Gly and Arg200Trp) and the risk of colorectal adenoma and cancer in nested case-control studies...
  18. ncbi request reprint CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenoma
    Lifang Hou
    Department of Human and Health Services, Division of Cancer Epidemiology and Genetics, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Carcinogenesis 26:1122-8. 2005
    ..002). In summary, joint carriage of CYP1A1 Val(462) and NQO1 Ser(187) alleles, particularly in smokers, was related to colorectal adenoma risk, with a propensity for formation of multiple lesions...
  19. ncbi request reprint Transforming growth factor beta 1 (TGFB1) gene polymorphisms and risk of advanced colorectal adenoma
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 28:1965-70. 2007
    ..No associations were observed for polymorphisms at codons 25 and 263. In conclusion, variants that enhance TGFB1 production may be associated with an increased risk of advanced colorectal adenoma...
  20. doi request reprint TNF polymorphisms and prostate cancer risk
    Kim N Danforth
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20852, USA
    Prostate 68:400-7. 2008
    ..Inflammation has been hypothesized to increase prostate cancer risk. Tumor necrosis factor (TNF) is an important mediator of the inflammatory process, but the relationship between TNF variants and prostate cancer remains unclear...
  21. pmc Prospective investigation of body mass index, colorectal adenoma, and colorectal cancer in the prostate, lung, colorectal, and ovarian cancer screening trial
    Cari M Kitahara
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    J Clin Oncol 31:2450-9. 2013
    ..We evaluated the associations of BMI with colorectal adenoma incidence, adenoma recurrence, and cancer in the context of a large screening trial, in which cases and controls had an equal chance for disease detection...
  22. ncbi request reprint GSTM1, GSTT1, and GSTP1 polymorphisms and risk of advanced colorectal adenoma
    Lee E Moore
    National Cancer Institute, 6120 Executive Boulevard, EPS 7034, Bethesda, MD 20892 7240, USA
    Cancer Epidemiol Biomarkers Prev 14:1823-7. 2005
    ..These findings only became apparent using a newly developed assay able to distinguish heterozygous from wild-type individuals. Our data provide evidence that phenotypic differences between these two groups exist...
  23. ncbi request reprint Variant in sex hormone-binding globulin gene and the risk of prostate cancer
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7240, USA
    Cancer Epidemiol Biomarkers Prev 16:165-8. 2007
    ..34; 95% confidence interval, 1.10-1.63; P = 0.0007). This study suggests that genetic variation in SHBG may influence prostate cancer susceptibility...
  24. pmc DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas
    Ying Gao
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7236, USA
    Carcinogenesis 32:882-7. 2011
    ....
  25. pmc Iron homeostasis and distal colorectal adenoma risk in the prostate, lung, colorectal, and ovarian cancer screening trial
    Amanda J Cross
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20852, USA
    Cancer Prev Res (Phila) 4:1465-75. 2011
    ....
  26. pmc Association between genetic variants in the 8q24 cancer risk regions and circulating levels of androgens and sex hormone-binding globulin
    Lisa W Chu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
    Cancer Epidemiol Biomarkers Prev 19:1848-54. 2010
    ..Genome-wide association studies have identified multiple independent regions on chromosome 8q24 that are associated with cancers of the prostate, breast, colon, and bladder...
  27. ncbi request reprint Genetic polymorphisms of interleukin-1B (IL-1B), IL-6, IL-8, and IL-10 and risk of prostate cancer
    Dominique S Michaud
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Res 66:4525-30. 2006
    ..At least seven common polymorphisms in genes of inflammatory cytokines IL-1B, IL-6, IL-8, and IL-10 do not seem to play a role in the risk of prostate cancer...
  28. doi request reprint Endogenous sex hormones and the risk of prostate cancer: a prospective study
    Jocelyn M Weiss
    Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD, USA
    Int J Cancer 122:2345-50. 2008
    ..T:SHBG ratio was related to risk in this older population of men, but the significance of this ratio in steroidal biology is unclear. (c) 2008 Wiley-Liss, Inc...
  29. pmc Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Cancer Res 70:2389-96. 2010
    ..In conclusion, we observed a significant association between PIK3C2B and prostate cancer risk, especially for familial, early-onset disease, which may be attributable to IGF-dependent PI3K signaling...
  30. pmc Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer
    Bríd M Ryan
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892
    Int J Cancer 134:1399-407. 2014
    ..Additional studies on the functional consequences of rs5995355 in NCF4 may help to clarify the mechanistic link between inflammation and colorectal cancer...
  31. ncbi request reprint Sugarcane farming, occupational solvent exposures, and the risk of oral cancer in Puerto Rico
    Joseph B Coble
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    J Occup Environ Med 45:869-74. 2003
    ....
  32. pmc Nitric oxide synthase gene polymorphisms and prostate cancer risk
    Kyoung Mu Lee
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Carcinogenesis 30:621-5. 2009
    ..61, 1.18-2.19; P(interaction) = 0.01). Our results suggest that NOS gene polymorphisms are genetic susceptibility factors for aggressive prostate cancer...
  33. pmc Polymorphisms in the adenomatous polyposis coli (APC) gene and advanced colorectal adenoma risk
    Hui Lee Wong
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
    Eur J Cancer 46:2457-66. 2010
    ..Fat intake modified the APC D1822V-adenoma association, but further studies are warranted...
  34. ncbi request reprint IGF-1 and IGFBP-3: Risk of prostate cancer among men in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
    Jocelyn M Weiss
    Division of Cancer Epidemiology and Genetics, NCI NIH, Bethesda, MD, USA
    Int J Cancer 121:2267-73. 2007
    ..11-7.08). In summary, our large prospective study showed no overall association between the insulin-like growth factor axis and prostate cancer risk, however, IGFmr was related to risk for aggressive prostate cancer in obese men...
  35. ncbi request reprint Tobacco smoking and colorectal hyperplastic and adenomatous polyps
    Bu Tian Ji
    National Cancer Institute, 6120 Executive Boulevard, EPS 8120, Bethesda, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 15:897-901. 2006
    ..In conclusion, tobacco use, particularly recent use, increases risk for both adenomatous and hyperplastic polyps, but the risks are substantially greater for hyperplastic lesions...
  36. pmc Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Hum Mol Genet 17:2665-72. 2008
    ..008. This study confirms the association between colorectal neoplasia and the 8q24 polymorphisms located between 128.47 and 128.54 Mb and suggests a role for these variants in the formation of multiple adenomas...
  37. ncbi request reprint Polymorphic variants in alpha-methylacyl-CoA racemase and prostate cancer
    Sarah E Daugherty
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Prostate 67:1487-97. 2007
    ..Significant differences in AMACR allele frequencies have been reported for hereditary prostate cancer (HPC), but the relevance of AMACR in the context of its substrates have not been studied...
  38. pmc Innate immunity gene polymorphisms and the risk of colorectal neoplasia
    Cindy M Chang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892, USA
    Carcinogenesis 34:2512-20. 2013
    ..Other notable findings were observed for SNPs in BPI/LBP and MYD88. Although the results need to be replicated, our findings suggest that genetic variation in inflammation-related genes may be related to the risk of colorectal neoplasia...
  39. pmc Prospective evaluation of serum sarcosine and risk of prostate cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 34:2281-5. 2013
    ..95-1.59, P-interaction = 0.01). This study found that elevated levels of serum sarcosine are associated with an increased prostate cancer risk and evidence to suggest that sarcosine may be an early biomarker for this disease. ..
  40. pmc Circulating adipokine levels and endometrial cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial
    Patricia Luhn
    Division of Cancer Epidemiology and Genetics, Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 22:1304-12. 2013
    ..Circulating adipokine levels may be associated with endometrial cancer risk, yet few studies have evaluated these markers prospectively...
  41. ncbi request reprint Whole blood cryopreservation in epidemiological studies
    Richard B Hayes
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 11:1496-8. 2002
    ..Whole blood cryopreservation is a cost-effective approach to large-scale storage of viable cells in epidemiological studies...
  42. pmc The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Aging Cell 8:405-13. 2009
    ..However, correlations of telomere length with healthy lifestyles were noted, suggesting the role of these factors in telomere biology maintenance and potentially impacting overall health status...
  43. pmc Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Carcinogenesis 30:769-76. 2009
    ..Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3' UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status...
  44. ncbi request reprint Hormone replacement therapy, reproductive history, and colorectal adenomas: data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial (United States)
    Mark P Purdue
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, MSC 7240, Executive Plaza South 8121, Rockville, MD 20892, USA
    Cancer Causes Control 16:965-73. 2005
    ....
  45. ncbi request reprint Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 29:100-5. 2008
    ..This study suggests that genetic variants in XRCC1 and APEX1 may alter susceptibility to biliary tract cancer and stones. Further studies are required to confirm the reported associations...
  46. ncbi request reprint Methods for etiologic and early marker investigations in the PLCO trial
    Richard B Hayes
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8114, Bethesda, MD 20892, USA
    Mutat Res 592:147-54. 2005
    ..g., diet), biochemical, and genetic factors. Early detection studies focus on blood-based biologic markers of early disease. Clinical epidemiology is also an important component of the PLCO trial...
  47. ncbi request reprint Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies
    Kim N Danforth
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    Carcinogenesis 29:568-72. 2008
    ....
  48. ncbi request reprint Association of energy intake and energy balance with postmenopausal breast cancer in the prostate, lung, colorectal, and ovarian cancer screening trial
    Shih Chen Chang
    Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, National Cancer Institute, Executive Plaza South, Suite 320, MSC7232, Bethesda, Maryland 20892 7232, USA
    Cancer Epidemiol Biomarkers Prev 15:334-41. 2006
    ..In addition, these three aspects of energy balance may act jointly in determining breast cancer risk...
  49. ncbi request reprint Epidemiologic considerations to assess altered DNA methylation from environmental exposures in cancer
    Lee E Moore
    Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 983:181-96. 2003
    ..Methods for incorporating markers of DNA methylation status into etiologic investigations of the impact of environmental exposures on disease (e.g., cancer) are discussed...
  50. doi request reprint Diabetes mellitus and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
    Michael F Leitzmann
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Cancer Causes Control 19:1267-76. 2008
    ....
  51. pmc Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohorts
    Li Jiao
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Cancer Causes Control 21:1305-14. 2010
    ..To investigate whether the positive association of body mass index (BMI, kg/m(2)) with risk of pancreatic cancer is modified by age, sex, smoking status, physical activity, and history of diabetes...
  52. pmc Serum levels of vitamin D metabolites and breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial
    D Michal Freedman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 17:889-94. 2008
    ....
  53. pmc Xenobiotic metabolizing gene variants, dietary heterocyclic amine intake, and risk of prostate cancer
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland 20852, USA
    Cancer Res 69:1877-84. 2009
    ..The observed effect provides evidence to support the hypothesis that HCAs may act as promoters of malignant transformation by altering mitogenic signaling...
  54. pmc Metabolites of tobacco smoking and colorectal cancer risk
    Amanda J Cross
    Nutritional Epidemiology Branch, Biostatistics Branch, Genetic Epidemiology Branch and Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20850, USA
    Carcinogenesis 35:1516-22. 2014
    ..16, 95% CI: 0.57-2.37). Biomarkers capturing smoking behavior and metabolic variation exhibit stronger associations with colorectal cancer than self-report, providing additional evidence for a role for tobacco in this malignancy. ..
  55. pmc Prospective analysis of DNA damage and repair markers of lung cancer risk from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 32:69-73. 2011
    ..02), supporting the notion the assay may be a measure of cancer susceptibility. The Comet and HCR assays were unrelated to lung cancer risk...
  56. ncbi request reprint A systematic review of vitamin D receptor gene polymorphisms and prostate cancer risk
    Sonja I Berndt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Urol 175:1613-23. 2006
    ..However, studies investigating the associations between specific vitamin D receptor polymorphisms and prostate cancer risk have yielded inconsistent results...
  57. ncbi request reprint Telomere length in white blood cell DNA and lung cancer: a pooled analysis of three prospective cohorts
    Wei Jie Seow
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland
    Cancer Res 74:4090-8. 2014
    ..Telomere length in white blood cell DNA may be a biomarker of future increased risk of lung cancer in diverse populations. Cancer Res; 74(15); 4090-8. ©2014 AACR. ..
  58. pmc Non-Hodgkin lymphoma (NHL) subtypes defined by common translocations: utility of fluorescence in situ hybridization (FISH) in a case-control study
    Cindy M Chang
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7074, Rockville, MD 20892, USA
    Leuk Res 34:190-5. 2010
    ..FISH assays detected twice as many t(14;18)-positive follicular lymphomas as PCR assays. Overall, study findings support the use of FISH assays to detect t(14;18) in archival tumor samples for epidemiologic studies of NHL subtypes...
  59. pmc A prospective study of serum soluble CD30 concentration and risk of non-Hodgkin lymphoma
    Mark P Purdue
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Blood 114:2730-2. 2009
    ....
  60. ncbi request reprint HER2 codon 655 polymorphism and risk of breast cancer in African Americans and whites
    Robert Millikan
    Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 79:355-64. 2003
    ..Results of previous studies have been mixed, with most studies showing no association but some suggesting an association in younger women or women with a family history of breast cancer...
  61. ncbi request reprint Microsatellite polymorphisms in the epidermal growth factor receptor (EGFR) gene and the transforming growth factor-alpha (TGFA) gene and risk of oral cancer in Puerto Rico
    Daehee Kang
    Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, SNUCM, Seoul, Korea
    Pharmacogenet Genomics 15:343-7. 2005
    ....
  62. ncbi request reprint Genetic variants of DNA repair genes and prostate cancer: a population-based study
    Jamie D Ritchey
    George Washington University School of Public Health and Health Services, Washington, District of Columbia, USA
    Cancer Epidemiol Biomarkers Prev 14:1703-9. 2005
    ..Replication in larger studies is necessary to preclude chance findings, particularly those among subgroups, and clarify the mechanisms involved...
  63. ncbi request reprint Lack of association of transforming growth factor-beta1 polymorphisms and haplotypes with prostate cancer risk in the prostate, lung, colorectal, and ovarian trial
    Daehee Kang
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 16:1303-5. 2007
  64. ncbi request reprint DNA repair gene polymorphisms and risk of second primary neoplasms and mortality in oral cancer patients
    Thomas J Gal
    Department of Otolaryngology Head and Neck Surgery, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    Laryngoscope 115:2221-31. 2005
    ....
  65. ncbi request reprint Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer study
    Daehee Kang
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 16:1581-6. 2007
    ..These results suggest that the Ala variant of SOD2 is associated with moderately increased risk of prostate cancer, particularly among men with lower intakes of dietary and supplemental vitamin E...