Research Topics
Genomes and Genes
| Wen Yi HuangSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Prospective study of genomic hypomethylation of leukocyte DNA and colorectal cancer riskWen Yi Huang
Corresponding Author Wen Yi Huang, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8110, MSC 7240, Bethesda, MD 20892
Cancer Epidemiol Biomarkers Prev 21:2014-21. 2012..Reduced 5-mC levels in peripheral blood leukocytes have been associated with increased risk of colorectal cancer and adenoma in cross-sectional studies...
Impact of patient characteristics on the risk of influenza/ILI-related complicationsD E Irwin
Ingenix Pharmaceutical Services, Epidemiology Division, Newton Lower Falls, Massachusetts, USA
BMC Health Serv Res 1:8. 2001..We sought to quantify the impact of patient characteristics on complications and health care costs associated with influenza and influenza-like illness (ILI) in a nonelderly population...- High-throughput single nucleotide polymorphism genotyping using nanofluidic Dynamic ArraysJun Wang
Fluidigm Corporation, South San Francisco, CA, USA
BMC Genomics 10:561. 2009..This is also important for those who work on high throughput genotyping in non-model systems where off-the-shelf assays are not available and a flexible platform is needed... - Simultaneous recovery of DNA and RNA from formalin-fixed paraffin-embedded tissue and application in epidemiologic studiesWen Yi Huang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8110, MSC 7240, Bethesda, MD 20892 7240, USA
Cancer Epidemiol Biomarkers Prev 19:973-7. 2010..Here, we report the method that we used to simultaneously recover DNA and RNA from FFPE tissue specimens with appreciable quantity and quality and discuss briefly the application of tumor markers in epidemiologic studies... 
Alcohol concentration and risk of oral cancer in Puerto RicoWen Yi Huang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Am J Epidemiol 157:881-7. 2003..These results suggest that alcohol concentration is a risk factor for oral cancer independent of the total quantity of alcohol consumed...- Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related riskWen Yi Huang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, Maryland 20892, USA
Cancer Epidemiol Biomarkers Prev 15:306-11. 2006.... - Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenomaWen Yi Huang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 14:152-7. 2005..02). In conclusion, EPHX1 variants at codon 113 and 139 associated with high predicted enzymatic activity appear to increase risk for colorectal adenoma, particularly among recent and current smokers... - Sexually transmissible infections and prostate cancer riskWen Yi Huang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 17:2374-81. 2008..Sexually transmissible infections (STI) have been variably associated with increased risks of prostate cancer, largely in case-control studies... - Selected DNA repair polymorphisms and gastric cancer in PolandWen Yi Huang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Carcinogenesis 26:1354-9. 2005..These results need replication in larger epidemiological studies of gastric cancer... - Selected genetic polymorphisms in MGMT, XRCC1, XPD, and XRCC3 and risk of head and neck cancer: a pooled analysisWen Yi Huang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8113, MSC 7240, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 14:1747-53. 2005..Consistent findings from three case-control studies suggest that selected DNA repair enzymes may play a role in head and neck carcinogenesis... - Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenomaSarah E Daugherty
Divison of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, 6120 Executive Boulevard, EPS Rm 8113, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 16:1536-42. 2007..AMACR gene variants have been associated with hereditary prostate cancer, but no studies have evaluated their etiologic role in colorectal carcinogenesis... - Genetic variation in base excision repair genes and the prevalence of advanced colorectal adenomaSonja I Berndt
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cancer Res 67:1395-404. 2007..51; 95% CI, 0.33-0.78, P = 0.002 for PARP1 A284A). This study suggests that polymorphisms in APEX1, XRCC1, and PARP1 may be associated with advanced colorectal adenoma... - A case-control study of tobacco use and other non-occupational risk factors for lymphoma subtypes defined by t(14; 18) translocations and bcl-2 expressionCindy M Chang
Infections and Immunoepidemiology Branch, National Cancer Institute, Rockville, MD, USA
Cancer Causes Control 21:1147-54. 2010.... - The association between inflammation-related genes and serum androgen levels in men: the prostate, lung, colorectal, and ovarian studyTamra E Meyer
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA
Prostate 72:65-71. 2012..Androgens and inflammation have been implicated in the etiology of several cancers, including prostate cancer. Serum androgens have been shown to correlate with markers of inflammation and expression of inflammation-related genes... 
Serum vitamin D concentration and prostate cancer risk: a nested case-control studyJiyoung Ahn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Bethesda, MD 20892, USA
J Natl Cancer Inst 100:796-804. 2008....- RNASEL Arg462Gln polymorphism and prostate cancer in PLCOSarah E Daugherty
Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Prostate 67:849-54. 2007..The relationship of this variant to sporadic prostate cancer remains uncertain... - CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenomaLifang Hou
Department of Human and Health Services, Division of Cancer Epidemiology and Genetics, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
Carcinogenesis 26:1122-8. 2005..002). In summary, joint carriage of CYP1A1 Val(462) and NQO1 Ser(187) alleles, particularly in smokers, was related to colorectal adenoma risk, with a propensity for formation of multiple lesions... - Transforming growth factor beta 1 (TGFB1) gene polymorphisms and risk of advanced colorectal adenomaSonja I Berndt
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Carcinogenesis 28:1965-70. 2007..No associations were observed for polymorphisms at codons 25 and 263. In conclusion, variants that enhance TGFB1 production may be associated with an increased risk of advanced colorectal adenoma... - Genetic variants in frizzled-related protein (FRZB) and the risk of colorectal neoplasiaSonja I Berndt
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8116, MSC 7240, Bethesda, MD 20892 7240, USA
Cancer Causes Control 20:487-90. 2009..To determine if this finding could be replicated, we investigated the association between two FRZB polymorphisms (Arg324Gly and Arg200Trp) and the risk of colorectal adenoma and cancer in nested case-control studies... - GSTM1, GSTT1, and GSTP1 polymorphisms and risk of advanced colorectal adenomaLee E Moore
National Cancer Institute, 6120 Executive Boulevard, EPS 7034, Bethesda, MD 20892 7240, USA
Cancer Epidemiol Biomarkers Prev 14:1823-7. 2005..These findings only became apparent using a newly developed assay able to distinguish heterozygous from wild-type individuals. Our data provide evidence that phenotypic differences between these two groups exist... - Variant in sex hormone-binding globulin gene and the risk of prostate cancerSonja I Berndt
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7240, USA
Cancer Epidemiol Biomarkers Prev 16:165-8. 2007..34; 95% confidence interval, 1.10-1.63; P = 0.0007). This study suggests that genetic variation in SHBG may influence prostate cancer susceptibility... - Iron homeostasis and distal colorectal adenoma risk in the prostate, lung, colorectal, and ovarian cancer screening trialAmanda J Cross
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20852, USA
Cancer Prev Res (Phila) 4:1465-75. 2011.... - Association between genetic variants in the 8q24 cancer risk regions and circulating levels of androgens and sex hormone-binding globulinLisa W Chu
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
Cancer Epidemiol Biomarkers Prev 19:1848-54. 2010..Genome-wide association studies have identified multiple independent regions on chromosome 8q24 that are associated with cancers of the prostate, breast, colon, and bladder... - Genetic polymorphisms of interleukin-1B (IL-1B), IL-6, IL-8, and IL-10 and risk of prostate cancerDominique S Michaud
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer Res 66:4525-30. 2006..At least seven common polymorphisms in genes of inflammatory cytokines IL-1B, IL-6, IL-8, and IL-10 do not seem to play a role in the risk of prostate cancer... - TNF polymorphisms and prostate cancer riskKim N Danforth
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20852, USA
Prostate 68:400-7. 2008..Inflammation has been hypothesized to increase prostate cancer risk. Tumor necrosis factor (TNF) is an important mediator of the inflammatory process, but the relationship between TNF variants and prostate cancer remains unclear... - Sugarcane farming, occupational solvent exposures, and the risk of oral cancer in Puerto RicoJoseph B Coble
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
J Occup Environ Med 45:869-74. 2003.... - Tobacco smoking and colorectal hyperplastic and adenomatous polypsBu Tian Ji
National Cancer Institute, 6120 Executive Boulevard, EPS 8120, Bethesda, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 15:897-901. 2006..In conclusion, tobacco use, particularly recent use, increases risk for both adenomatous and hyperplastic polyps, but the risks are substantially greater for hyperplastic lesions... - Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancerStella Koutros
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
Cancer Res 70:2389-96. 2010..In conclusion, we observed a significant association between PIK3C2B and prostate cancer risk, especially for familial, early-onset disease, which may be attributable to IGF-dependent PI3K signaling... - DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomasYing Gao
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7236, USA
Carcinogenesis 32:882-7. 2011.... - Endogenous sex hormones and the risk of prostate cancer: a prospective studyJocelyn M Weiss
Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD, USA
Int J Cancer 122:2345-50. 2008..T:SHBG ratio was related to risk in this older population of men, but the significance of this ratio in steroidal biology is unclear. (c) 2008 Wiley-Liss, Inc... - Nitric oxide synthase gene polymorphisms and prostate cancer riskKyoung Mu Lee
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Carcinogenesis 30:621-5. 2009..61, 1.18-2.19; P(interaction) = 0.01). Our results suggest that NOS gene polymorphisms are genetic susceptibility factors for aggressive prostate cancer... - Polymorphisms in the adenomatous polyposis coli (APC) gene and advanced colorectal adenoma riskHui Lee Wong
Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
Eur J Cancer 46:2457-66. 2010..Fat intake modified the APC D1822V-adenoma association, but further studies are warranted... - IGF-1 and IGFBP-3: Risk of prostate cancer among men in the Prostate, Lung, Colorectal and Ovarian Cancer Screening TrialJocelyn M Weiss
Division of Cancer Epidemiology and Genetics, NCI NIH, Bethesda, MD, USA
Int J Cancer 121:2267-73. 2007..11-7.08). In summary, our large prospective study showed no overall association between the insulin-like growth factor axis and prostate cancer risk, however, IGFmr was related to risk for aggressive prostate cancer in obese men... - Whole blood cryopreservation in epidemiological studiesRichard B Hayes
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer Epidemiol Biomarkers Prev 11:1496-8. 2002..Whole blood cryopreservation is a cost-effective approach to large-scale storage of viable cells in epidemiological studies... - Polymorphic variants in alpha-methylacyl-CoA racemase and prostate cancerSarah E Daugherty
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Prostate 67:1487-97. 2007..Significant differences in AMACR allele frequencies have been reported for hereditary prostate cancer (HPC), but the relevance of AMACR in the context of its substrates have not been studied... - Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia riskSonja I Berndt
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
Hum Mol Genet 17:2665-72. 2008..008. This study confirms the association between colorectal neoplasia and the 8q24 polymorphisms located between 128.47 and 128.54 Mb and suggests a role for these variants in the formation of multiple adenomas... - Association of energy intake and energy balance with postmenopausal breast cancer in the prostate, lung, colorectal, and ovarian cancer screening trialShih Chen Chang
Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, National Cancer Institute, Executive Plaza South, Suite 320, MSC7232, Bethesda, Maryland 20892 7232, USA
Cancer Epidemiol Biomarkers Prev 15:334-41. 2006..In addition, these three aspects of energy balance may act jointly in determining breast cancer risk... - Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studiesKim N Danforth
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
Carcinogenesis 29:568-72. 2008.... - Methods for etiologic and early marker investigations in the PLCO trialRichard B Hayes
Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8114, Bethesda, MD 20892, USA
Mutat Res 592:147-54. 2005..g., diet), biochemical, and genetic factors. Early detection studies focus on blood-based biologic markers of early disease. Clinical epidemiology is also an important component of the PLCO trial... - Hormone replacement therapy, reproductive history, and colorectal adenomas: data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial (United States)Mark P Purdue
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, MSC 7240, Executive Plaza South 8121, Rockville, MD 20892, USA
Cancer Causes Control 16:965-73. 2005.... - Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in ChinaWen Yi Huang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Carcinogenesis 29:100-5. 2008..This study suggests that genetic variants in XRCC1 and APEX1 may alter susceptibility to biliary tract cancer and stones. Further studies are required to confirm the reported associations... - Epidemiologic considerations to assess altered DNA methylation from environmental exposures in cancerLee E Moore
Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Ann N Y Acad Sci 983:181-96. 2003..Methods for incorporating markers of DNA methylation status into etiologic investigations of the impact of environmental exposures on disease (e.g., cancer) are discussed... - Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohortsLi Jiao
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Cancer Causes Control 21:1305-14. 2010..To investigate whether the positive association of body mass index (BMI, kg/m(2)) with risk of pancreatic cancer is modified by age, sex, smoking status, physical activity, and history of diabetes... - Diabetes mellitus and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening TrialMichael F Leitzmann
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
Cancer Causes Control 19:1267-76. 2008.... - Serum levels of vitamin D metabolites and breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trialD Michal Freedman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892 7238, USA
Cancer Epidemiol Biomarkers Prev 17:889-94. 2008.... - Vitamin D-related genes, serum vitamin D concentrations and prostate cancer riskJiyoung Ahn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
Carcinogenesis 30:769-76. 2009..Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3' UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status... - The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancerLisa Mirabello
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Aging Cell 8:405-13. 2009..However, correlations of telomere length with healthy lifestyles were noted, suggesting the role of these factors in telomere biology maintenance and potentially impacting overall health status... - Xenobiotic metabolizing gene variants, dietary heterocyclic amine intake, and risk of prostate cancerStella Koutros
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland 20852, USA
Cancer Res 69:1877-84. 2009..The observed effect provides evidence to support the hypothesis that HCAs may act as promoters of malignant transformation by altering mitogenic signaling... - Prospective analysis of DNA damage and repair markers of lung cancer risk from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening TrialAlice J Sigurdson
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Carcinogenesis 32:69-73. 2011..02), supporting the notion the assay may be a measure of cancer susceptibility. The Comet and HCR assays were unrelated to lung cancer risk... - A systematic review of vitamin D receptor gene polymorphisms and prostate cancer riskSonja I Berndt
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
J Urol 175:1613-23. 2006..However, studies investigating the associations between specific vitamin D receptor polymorphisms and prostate cancer risk have yielded inconsistent results... - Non-Hodgkin lymphoma (NHL) subtypes defined by common translocations: utility of fluorescence in situ hybridization (FISH) in a case-control studyCindy M Chang
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7074, Rockville, MD 20892, USA
Leuk Res 34:190-5. 2010..FISH assays detected twice as many t(14;18)-positive follicular lymphomas as PCR assays. Overall, study findings support the use of FISH assays to detect t(14;18) in archival tumor samples for epidemiologic studies of NHL subtypes... - A prospective study of serum soluble CD30 concentration and risk of non-Hodgkin lymphomaMark P Purdue
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
Blood 114:2730-2. 2009.... - DNA repair gene polymorphisms and risk of second primary neoplasms and mortality in oral cancer patientsThomas J Gal
Department of Otolaryngology Head and Neck Surgery, School of Medicine, University of Washington, Seattle, Washington 98195, USA
Laryngoscope 115:2221-31. 2005.... - Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer studyDaehee Kang
Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
Cancer Epidemiol Biomarkers Prev 16:1581-6. 2007..These results suggest that the Ala variant of SOD2 is associated with moderately increased risk of prostate cancer, particularly among men with lower intakes of dietary and supplemental vitamin E... - Lack of association of transforming growth factor-beta1 polymorphisms and haplotypes with prostate cancer risk in the prostate, lung, colorectal, and ovarian trialDaehee Kang
Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-799, Korea
Cancer Epidemiol Biomarkers Prev 16:1303-5. 2007 - HER2 codon 655 polymorphism and risk of breast cancer in African Americans and whitesRobert Millikan
Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Breast Cancer Res Treat 79:355-64. 2003..Results of previous studies have been mixed, with most studies showing no association but some suggesting an association in younger women or women with a family history of breast cancer... - Genetic variants of DNA repair genes and prostate cancer: a population-based studyJamie D Ritchey
George Washington University School of Public Health and Health Services, Washington, District of Columbia, USA
Cancer Epidemiol Biomarkers Prev 14:1703-9. 2005..Replication in larger studies is necessary to preclude chance findings, particularly those among subgroups, and clarify the mechanisms involved... - Microsatellite polymorphisms in the epidermal growth factor receptor (EGFR) gene and the transforming growth factor-alpha (TGFA) gene and risk of oral cancer in Puerto RicoDaehee Kang
Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, SNUCM, Seoul, Korea
Pharmacogenet Genomics 15:343-7. 2005....