Research Topics
Genomes and Genes | Jing HuSummaryAffiliation: National Cancer Institute Country: USA Publications
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Publications
Suppression of p65 phosphorylation coincides with inhibition of IkappaBalpha polyubiquitination and degradationJing Hu
Gene Regulation Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
Mol Carcinog 44:274-84. 2005..Accordingly, the nuclear translocation of phosphorylation-impaired p65 was significantly reduced. These findings suggest that p65 phosphorylation plays a key role in stimulus-induced IkappaBalpha ubiquitination...
Exploiting noise in array CGH data to improve detection of DNA copy number changeJing Hu
Department of Electrical and Computer Engineering, University of Florida Gainesville, FL 32611, USA
Nucleic Acids Res 35:e35. 2007..Finally, we propose a new concept, posteriori signal-to-noise ratio (p-SNR), to assign certain confidence level to an aberration region and boundaries detected...- Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cellsJing Hu
Gene Regulation Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702, USA
Carcinogenesis 25:1991-2003. 2004..Thus, p65 phosphorylation at S536 offers a potential molecular target for cancer prevention... - Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA bindingJing Hu
Gene Regulation Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute Frederick, Building 567, Room 188, Frederick, MD 21702, USA
Mol Cancer Res 3:100-9. 2005..NF-kappaB is therefore identified as a transcription factor target of trichostatin A treatment... - Dominant-negative c-Jun (TAM67) target genes: HMGA1 is required for tumor promoter-induced transformationArindam Dhar
Gene Regulation Section, Laboratory of Cancer Prevention, NCI at Frederick, Frederick, MD 21702 1201, USA
Oncogene 23:4466-76. 2004.... - Glucocorticoids inhibit lung cancer cell growth through both the extracellular signal-related kinase pathway and cell cycle regulatorsAlissa K Greenberg
Department of Medicine, New York University School of Medicine, New York 10016, USA
Am J Respir Cell Mol Biol 27:320-8. 2002.... - The R362A mutation at the C-terminus of CA inhibits packaging of human immunodeficiency virus type 1 RNAXiaofeng Guo
McGill AIDS Centre, Lady Davis Institute-Jewish General Hospital, 3755 Cote Ste-Catherine Road, Montreal, Quebec, Canada H3T 1E2
Virology 343:190-200. 2005..These data suggest that one potential function for the C-terminal disordered sequence of CA in HIV-1 replication is to regulate HIV-1 RNA packaging... - Downregulation of MDM2 expression by RNAi inhibits LoVo human colorectal adenocarcinoma cells growth and the treatment of LoVo cells with mdm2siRNA3 enhances the sensitivity to cisplatinYan Yu
Department of Internal Medicine, Cancer Hospital of Harbin Medical University, Harbin 150040, People s Republic of China
Biochem Biophys Res Commun 339:71-8. 2006..It also could be a therapeutic target in colorectal carcinoma. The synergistic activation of RNAi and cell toxicity agents indicated that the combination of chemotherapy and gene therapy will be a promising approach in the future... - Association of RNA helicase a with human immunodeficiency virus type 1 particlesBibhuti Bhusan Roy
McGill AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
J Biol Chem 281:12625-35. 2006..Therefore, RHA represents the first example of cellular RNA helicases that participate in HIV-1 particle production and promote viral reverse transcription... - Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1Jing Hu
Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
Cancer Res 67:3569-73. 2007..The present study also suggests that inhibition of cap-dependent translation may be an important mechanism in PEITC-induced apoptosis... - Histamine in Macaca mulatto monkey cardiac sympathetic nerve system: a morphological and functional assessmentMingkai Li
Department of Pharmacology, The Fourth Military Medical University, Xi an 710032, PR China
Auton Neurosci 137:37-43. 2007..Sympathetic histamine may act as a neurotransmitter to modulate sympathetic neurotransmission... - Expression of midkine in regenerating skeletal muscle fibers and cultured myoblasts of human skeletal muscleJing Hu
Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
Eur Neurol 47:20-5. 2002..This is the first report demonstrating the presence of midkine in skeletal muscle cells... - Spliced human immunodeficiency virus type 1 RNA is reverse transcribed into cDNA within infected cellsChen Liang
McGill University AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada H3T
AIDS Res Hum Retroviruses 20:203-11. 2004..Therefore, spliced HIV-1 RNA molecules must have been reverse transcribed along with full-length viral RNA during infection... - Selective p38 activation in human non-small cell lung cancerAlissa K Greenberg
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
Am J Respir Cell Mol Biol 26:558-64. 2002.... 
Characterization of a putative alpha-helix across the capsid-SP1 boundary that is critical for the multimerization of human immunodeficiency virus type 1 gagChen Liang
McGill AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
J Virol 76:11729-37. 2002..Therefore, these four mutations must have prevented Gag from generating large complexes...- Translation of Pr55(gag) augments packaging of human immunodeficiency virus type 1 RNA in a cis-acting mannerChen Liang
McGill AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
AIDS Res Hum Retroviruses 18:1117-26. 2002..Taken together, our data demonstrate that cis translation of Pr55(gag) is needed for efficient packaging of HIV-1 RNA... - Fibronectin receptor reduction in skin and fibroblasts of patients with Ullrich's diseaseJing Hu
Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
Muscle Nerve 26:696-701. 2002..These results suggest that collagen VI deficiency may lead to the reduction of fibronectin receptors and that an abnormality of cell adhesion may be involved in the pathogenesis of Ullrich's disease... - Expression and localization of Smad1, Smad2 and Smad4 proteins in rat testis during postnatal developmentJing Hu
Department of Histology and Embryology, Fourth Military Medical University, Xi an 710032, China
Asian J Androl 5:51-5. 2003..To study the expression and regulation of Smad1, Smad2 and Smad4 proteins (intracellular signaling molecules of transforming growth factor-b family) in rat testis during postnatal development... - Energetics and specificity of interactions within Ub.Uev.Ubc13 human ubiquitin conjugation complexesSean McKenna
Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
Biochemistry 42:7922-30. 2003..Ubc13 heterodimer described in detail in this study will allow for a more thorough rationalization of the mechanism of formation of Lys(63)-linked poly-Ub chains... - [The effects of L-NMMA on experimental temporomandibular joint osteoarthrosis in goats]Zhan-wei Gao
Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu 610041, China
Zhonghua Kou Qiang Yi Xue Za Zhi 38:295-7. 2003..There was a significant difference in osteoarthrotic changes between the L-NMMA-treated and control TMJs (P < 0.01). CONCLUSIONS: Repeated intra-articular injection of L-NMMA into TMJ may play a role in inhibiting TMJOA progression... - Effects of a single amino acid substitution within the p2 region of human immunodeficiency virus type 1 on packaging of spliced viral RNARodney S Russell
McGill AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
J Virol 77:12986-95. 2003..Taken together, our data demonstrate that selective packaging of viral genomic RNA is influenced by the MP2 mutation and that this represents a major mechanism for rescue of viruses containing the DeltaDIS deletion... - Important role for the CA-NC spacer region in the assembly of bovine immunodeficiency virus Gag proteinXiaofeng Guo
McGill AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
J Virol 78:551-60. 2004..Taken together, these data suggest a pivotal role for the CA-NC spacer region in the assembly of BIV Gag; however, the mechanism involved therein may differ from that for the HIV-1 CA-NC spacer... - Stomatin and sensory neuron mechanotransductionCarlos Martinez-Salgado
Department of Neuroscience, Max Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin, Robert Rössle Str, Berlin Buch, Germany
J Neurophysiol 98:3802-8. 2007..We conclude that stomatin is required for normal mechanotransduction in a subpopulation of vertebrate sensory neurons...