Jing Hu

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Suppression of p65 phosphorylation coincides with inhibition of IkappaBalpha polyubiquitination and degradation
    Jing Hu
    Gene Regulation Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Mol Carcinog 44:274-84. 2005
  2. pmc Exploiting noise in array CGH data to improve detection of DNA copy number change
    Jing Hu
    Department of Electrical and Computer Engineering, University of Florida Gainesville, FL 32611, USA
    Nucleic Acids Res 35:e35. 2007
  3. ncbi request reprint Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells
    Jing Hu
    Gene Regulation Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702, USA
    Carcinogenesis 25:1991-2003. 2004
  4. ncbi request reprint Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA binding
    Jing Hu
    Gene Regulation Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute Frederick, Building 567, Room 188, Frederick, MD 21702, USA
    Mol Cancer Res 3:100-9. 2005
  5. ncbi request reprint Dominant-negative c-Jun (TAM67) target genes: HMGA1 is required for tumor promoter-induced transformation
    Arindam Dhar
    Gene Regulation Section, Laboratory of Cancer Prevention, NCI at Frederick, Frederick, MD 21702 1201, USA
    Oncogene 23:4466-76. 2004
  6. ncbi request reprint Glucocorticoids inhibit lung cancer cell growth through both the extracellular signal-related kinase pathway and cell cycle regulators
    Alissa K Greenberg
    Department of Medicine, New York University School of Medicine, New York 10016, USA
    Am J Respir Cell Mol Biol 27:320-8. 2002
  7. ncbi request reprint The R362A mutation at the C-terminus of CA inhibits packaging of human immunodeficiency virus type 1 RNA
    Xiaofeng Guo
    McGill AIDS Centre, Lady Davis Institute Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, Quebec, Canada H3T 1E2
    Virology 343:190-200. 2005
  8. ncbi request reprint Downregulation of MDM2 expression by RNAi inhibits LoVo human colorectal adenocarcinoma cells growth and the treatment of LoVo cells with mdm2siRNA3 enhances the sensitivity to cisplatin
    Yan Yu
    Department of Internal Medicine, Cancer Hospital of Harbin Medical University, Harbin 150040, People s Republic of China
    Biochem Biophys Res Commun 339:71-8. 2006
  9. ncbi request reprint Association of RNA helicase a with human immunodeficiency virus type 1 particles
    Bibhuti Bhusan Roy
    McGill AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Biol Chem 281:12625-35. 2006
  10. ncbi request reprint Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1
    Jing Hu
    Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Cancer Res 67:3569-73. 2007

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Suppression of p65 phosphorylation coincides with inhibition of IkappaBalpha polyubiquitination and degradation
    Jing Hu
    Gene Regulation Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Mol Carcinog 44:274-84. 2005
    ..Accordingly, the nuclear translocation of phosphorylation-impaired p65 was significantly reduced. These findings suggest that p65 phosphorylation plays a key role in stimulus-induced IkappaBalpha ubiquitination...
  2. pmc Exploiting noise in array CGH data to improve detection of DNA copy number change
    Jing Hu
    Department of Electrical and Computer Engineering, University of Florida Gainesville, FL 32611, USA
    Nucleic Acids Res 35:e35. 2007
    ..Finally, we propose a new concept, posteriori signal-to-noise ratio (p-SNR), to assign certain confidence level to an aberration region and boundaries detected...
  3. ncbi request reprint Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells
    Jing Hu
    Gene Regulation Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702, USA
    Carcinogenesis 25:1991-2003. 2004
    ..Thus, p65 phosphorylation at S536 offers a potential molecular target for cancer prevention...
  4. ncbi request reprint Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA binding
    Jing Hu
    Gene Regulation Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute Frederick, Building 567, Room 188, Frederick, MD 21702, USA
    Mol Cancer Res 3:100-9. 2005
    ..NF-kappaB is therefore identified as a transcription factor target of trichostatin A treatment...
  5. ncbi request reprint Dominant-negative c-Jun (TAM67) target genes: HMGA1 is required for tumor promoter-induced transformation
    Arindam Dhar
    Gene Regulation Section, Laboratory of Cancer Prevention, NCI at Frederick, Frederick, MD 21702 1201, USA
    Oncogene 23:4466-76. 2004
    ....
  6. ncbi request reprint Glucocorticoids inhibit lung cancer cell growth through both the extracellular signal-related kinase pathway and cell cycle regulators
    Alissa K Greenberg
    Department of Medicine, New York University School of Medicine, New York 10016, USA
    Am J Respir Cell Mol Biol 27:320-8. 2002
    ....
  7. ncbi request reprint The R362A mutation at the C-terminus of CA inhibits packaging of human immunodeficiency virus type 1 RNA
    Xiaofeng Guo
    McGill AIDS Centre, Lady Davis Institute Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, Quebec, Canada H3T 1E2
    Virology 343:190-200. 2005
    ..These data suggest that one potential function for the C-terminal disordered sequence of CA in HIV-1 replication is to regulate HIV-1 RNA packaging...
  8. ncbi request reprint Downregulation of MDM2 expression by RNAi inhibits LoVo human colorectal adenocarcinoma cells growth and the treatment of LoVo cells with mdm2siRNA3 enhances the sensitivity to cisplatin
    Yan Yu
    Department of Internal Medicine, Cancer Hospital of Harbin Medical University, Harbin 150040, People s Republic of China
    Biochem Biophys Res Commun 339:71-8. 2006
    ..It also could be a therapeutic target in colorectal carcinoma. The synergistic activation of RNAi and cell toxicity agents indicated that the combination of chemotherapy and gene therapy will be a promising approach in the future...
  9. ncbi request reprint Association of RNA helicase a with human immunodeficiency virus type 1 particles
    Bibhuti Bhusan Roy
    McGill AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Biol Chem 281:12625-35. 2006
    ..Therefore, RHA represents the first example of cellular RNA helicases that participate in HIV-1 particle production and promote viral reverse transcription...
  10. ncbi request reprint Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1
    Jing Hu
    Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Cancer Res 67:3569-73. 2007
    ..The present study also suggests that inhibition of cap-dependent translation may be an important mechanism in PEITC-induced apoptosis...
  11. ncbi request reprint Histamine in Macaca mulatto monkey cardiac sympathetic nerve system: a morphological and functional assessment
    Mingkai Li
    Department of Pharmacology, The Fourth Military Medical University, Xi an 710032, PR China
    Auton Neurosci 137:37-43. 2007
    ..Sympathetic histamine may act as a neurotransmitter to modulate sympathetic neurotransmission...
  12. ncbi request reprint Expression of midkine in regenerating skeletal muscle fibers and cultured myoblasts of human skeletal muscle
    Jing Hu
    Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
    Eur Neurol 47:20-5. 2002
    ..This is the first report demonstrating the presence of midkine in skeletal muscle cells...
  13. ncbi request reprint Spliced human immunodeficiency virus type 1 RNA is reverse transcribed into cDNA within infected cells
    Chen Liang
    McGill University AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada H3T
    AIDS Res Hum Retroviruses 20:203-11. 2004
    ..Therefore, spliced HIV-1 RNA molecules must have been reverse transcribed along with full-length viral RNA during infection...
  14. ncbi request reprint Selective p38 activation in human non-small cell lung cancer
    Alissa K Greenberg
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    Am J Respir Cell Mol Biol 26:558-64. 2002
    ....
  15. pmc Characterization of a putative alpha-helix across the capsid-SP1 boundary that is critical for the multimerization of human immunodeficiency virus type 1 gag
    Chen Liang
    McGill AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Virol 76:11729-37. 2002
    ..Therefore, these four mutations must have prevented Gag from generating large complexes...
  16. ncbi request reprint Translation of Pr55(gag) augments packaging of human immunodeficiency virus type 1 RNA in a cis-acting manner
    Chen Liang
    McGill AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    AIDS Res Hum Retroviruses 18:1117-26. 2002
    ..Taken together, our data demonstrate that cis translation of Pr55(gag) is needed for efficient packaging of HIV-1 RNA...
  17. ncbi request reprint Fibronectin receptor reduction in skin and fibroblasts of patients with Ullrich's disease
    Jing Hu
    Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Muscle Nerve 26:696-701. 2002
    ..These results suggest that collagen VI deficiency may lead to the reduction of fibronectin receptors and that an abnormality of cell adhesion may be involved in the pathogenesis of Ullrich's disease...
  18. ncbi request reprint Expression and localization of Smad1, Smad2 and Smad4 proteins in rat testis during postnatal development
    Jing Hu
    Department of Histology and Embryology, Fourth Military Medical University, Xi an 710032, China
    Asian J Androl 5:51-5. 2003
    ..To study the expression and regulation of Smad1, Smad2 and Smad4 proteins (intracellular signaling molecules of transforming growth factor-b family) in rat testis during postnatal development...
  19. ncbi request reprint Energetics and specificity of interactions within Ub.Uev.Ubc13 human ubiquitin conjugation complexes
    Sean McKenna
    Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    Biochemistry 42:7922-30. 2003
    ..Ubc13 heterodimer described in detail in this study will allow for a more thorough rationalization of the mechanism of formation of Lys(63)-linked poly-Ub chains...
  20. ncbi request reprint [The effects of L-NMMA on experimental temporomandibular joint osteoarthrosis in goats]
    Zhan Wei Gao
    Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu 610041, China
    Zhonghua Kou Qiang Yi Xue Za Zhi 38:295-7. 2003
    ..To investigate the effects of repeated injections of L-NMMA on a goat model with osteoarthrotic temporomandibular joint (TMJ) disease...
  21. pmc Effects of a single amino acid substitution within the p2 region of human immunodeficiency virus type 1 on packaging of spliced viral RNA
    Rodney S Russell
    McGill AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Virol 77:12986-95. 2003
    ..Taken together, our data demonstrate that selective packaging of viral genomic RNA is influenced by the MP2 mutation and that this represents a major mechanism for rescue of viruses containing the DeltaDIS deletion...
  22. pmc Important role for the CA-NC spacer region in the assembly of bovine immunodeficiency virus Gag protein
    Xiaofeng Guo
    McGill AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Virol 78:551-60. 2004
    ..Taken together, these data suggest a pivotal role for the CA-NC spacer region in the assembly of BIV Gag; however, the mechanism involved therein may differ from that for the HIV-1 CA-NC spacer...
  23. ncbi request reprint Stomatin and sensory neuron mechanotransduction
    Carlos Martinez-Salgado
    Department of Neuroscience, Max Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin, Robert Rössle Str, Berlin Buch, Germany
    J Neurophysiol 98:3802-8. 2007
    ..We conclude that stomatin is required for normal mechanotransduction in a subpopulation of vertebrate sensory neurons...