Guang Hu

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc NuRD and pluripotency: a complex balancing act
    Guang Hu
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cell Stem Cell 10:497-503. 2012
  2. pmc A primer on using pooled shRNA libraries for functional genomic screens
    Guang Hu
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Acta Biochim Biophys Sin (Shanghai) 44:103-12. 2012
  3. pmc Integrative framework for identification of key cell identity genes uncovers determinants of ES cell identity and homeostasis
    Senthilkumar Cinghu
    Systems Biology Section and Stem Cell Biology Section, Laboratory of Molecular Carcinogenesis, and Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709
    Proc Natl Acad Sci U S A 111:E1581-90. 2014
  4. pmc INO80 facilitates pluripotency gene activation in embryonic stem cell self-renewal, reprogramming, and blastocyst development
    Li Wang
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cell Stem Cell 14:575-91. 2014
  5. pmc Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity
    Johannes M Freudenberg
    Systems Biology Section, Biostatistics Branch, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 40:3364-77. 2012
  6. pmc Fip1 regulates mRNA alternative polyadenylation to promote stem cell self-renewal
    Brad Lackford
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    EMBO J 33:878-89. 2014
  7. pmc The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming
    Li Wang
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cell Stem Cell 13:676-90. 2013
  8. pmc SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation
    Shuang Tang
    Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Cell 55:843-55. 2014
  9. pmc Use of genome-wide RNAi screens to identify regulators of embryonic stem cell pluripotency and self-renewal
    Xiaofeng Zheng
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA
    Methods Mol Biol 1150:163-73. 2014
  10. pmc Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation
    Xiaofeng Zheng
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, RTP, North Carolina, USA
    Stem Cells 30:910-22. 2012

Collaborators

Detail Information

Publications10

  1. pmc NuRD and pluripotency: a complex balancing act
    Guang Hu
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cell Stem Cell 10:497-503. 2012
    ..Recent findings have implicated the NuRD chromatin remodeling complex in the sophisticated choreography of ESC regulatory pathways...
  2. pmc A primer on using pooled shRNA libraries for functional genomic screens
    Guang Hu
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Acta Biochim Biophys Sin (Shanghai) 44:103-12. 2012
    ..We provide an introduction to the technical aspects of using pooled shRNA libraries for genetic screens...
  3. pmc Integrative framework for identification of key cell identity genes uncovers determinants of ES cell identity and homeostasis
    Senthilkumar Cinghu
    Systems Biology Section and Stem Cell Biology Section, Laboratory of Molecular Carcinogenesis, and Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709
    Proc Natl Acad Sci U S A 111:E1581-90. 2014
    ..The proposed computational framework, by helping to prioritize and preselect candidate genes for tests using complex and expensive genetic screens, provides a powerful yet inexpensive means for identification of key cell identity genes. ..
  4. pmc INO80 facilitates pluripotency gene activation in embryonic stem cell self-renewal, reprogramming, and blastocyst development
    Li Wang
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cell Stem Cell 14:575-91. 2014
    ....
  5. pmc Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity
    Johannes M Freudenberg
    Systems Biology Section, Biostatistics Branch, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 40:3364-77. 2012
    ....
  6. pmc Fip1 regulates mRNA alternative polyadenylation to promote stem cell self-renewal
    Brad Lackford
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    EMBO J 33:878-89. 2014
    ..Together, our data highlight the role for post-transcriptional control in stem cell self-renewal, provide mechanistic insight on APA regulation in development, and establish an important function for APA in cell fate specification. ..
  7. pmc The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming
    Li Wang
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cell Stem Cell 13:676-90. 2013
    ..Together, our data indicate that THO regulates pluripotency gene mRNA export to control ESC self-renewal and differentiation, and therefore uncover a role for this aspect of posttranscriptional regulation in stem cell fate specification...
  8. pmc SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation
    Shuang Tang
    Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Cell 55:843-55. 2014
    ..Our findings reveal a molecular mechanism that regulates RA signaling and highlight the importance of SIRT1 in regulation of ESC pluripotency and embryogenesis...
  9. pmc Use of genome-wide RNAi screens to identify regulators of embryonic stem cell pluripotency and self-renewal
    Xiaofeng Zheng
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA
    Methods Mol Biol 1150:163-73. 2014
    ..With modifications, this method can also be adapted to study the fate specification events during ESC differentiation. ..
  10. pmc Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation
    Xiaofeng Zheng
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, RTP, North Carolina, USA
    Stem Cells 30:910-22. 2012
    ..Together, our results indicate that Cnot1, Cnot2, and Cnot3 represent a novel component of the core self-renewal and pluripotency circuitry conserved in mouse and human ESCs...