Li Yueh Hsu

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Nonlinear myocardial signal intensity correction improves quantification of contrast-enhanced first-pass MR perfusion in humans
    Li Yueh Hsu
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1061, USA
    J Magn Reson Imaging 27:793-801. 2008
  2. pmc Myocardial edema as detected by pre-contrast T1 and T2 CMR delineates area at risk associated with acute myocardial infarction
    Martin Ugander
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    JACC Cardiovasc Imaging 5:596-603. 2012
  3. pmc Motion-corrected free-breathing delayed enhancement imaging of myocardial infarction
    Peter Kellman
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, DHHS, 10 Center Drive, MSC 1061, Building 10, Room B1D416, Bethesda, MD 20892, USA
    Magn Reson Med 53:194-200. 2005
  4. ncbi request reprint Quantitative myocardial infarction on delayed enhancement MRI. Part I: Animal validation of an automated feature analysis and combined thresholding infarct sizing algorithm
    Li Yueh Hsu
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    J Magn Reson Imaging 23:298-308. 2006
  5. pmc Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology
    Martin Ugander
    Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services, 10 Center Drive, Bethesda, MD 20892 1061, USA
    Eur Heart J 33:1268-78. 2012
  6. ncbi request reprint Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging: histopathological and displacement encoding with stimulated echoes (DENSE) functional validations
    Anthony H Aletras
    National Heart, Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 1061, USA
    Circulation 113:1865-70. 2006
  7. pmc T2* measurement during first-pass contrast-enhanced cardiac perfusion imaging
    Peter Kellman
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 56:1132-4. 2006
  8. pmc Late gadolinium-enhancement cardiac magnetic resonance identifies postinfarction myocardial fibrosis and the border zone at the near cellular level in ex vivo rat heart
    Erik B Schelbert
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1061, USA
    Circ Cardiovasc Imaging 3:743-52. 2010
  9. pmc Regadenoson and adenosine are equivalent vasodilators and are superior than dipyridamole- a study of first pass quantitative perfusion cardiovascular magnetic resonance
    Sujethra Vasu
    Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, 10 Center Drive, Building 10, Room B1D416, 20892 1061 Bethesda, MD, USA
    J Cardiovasc Magn Reson 15:85. 2013
  10. ncbi request reprint Quantitative myocardial infarction on delayed enhancement MRI. Part II: Clinical application of an automated feature analysis and combined thresholding infarct sizing algorithm
    Li Yueh Hsu
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    J Magn Reson Imaging 23:309-14. 2006

Collaborators

Detail Information

Publications27

  1. doi request reprint Nonlinear myocardial signal intensity correction improves quantification of contrast-enhanced first-pass MR perfusion in humans
    Li Yueh Hsu
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1061, USA
    J Magn Reson Imaging 27:793-801. 2008
    ..To study the nonlinearity of myocardial signal intensity and gadolinium contrast concentration during first-pass perfusion MRI, and to compare quantitative perfusion estimates using nonlinear myocardial signal intensity correction...
  2. pmc Myocardial edema as detected by pre-contrast T1 and T2 CMR delineates area at risk associated with acute myocardial infarction
    Martin Ugander
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    JACC Cardiovasc Imaging 5:596-603. 2012
    ..The aim of this study was to determine whether cardiac magnetic resonance (CMR) in vivo T1 mapping can measure myocardial area at risk (AAR) compared with microspheres or T2 mapping CMR...
  3. pmc Motion-corrected free-breathing delayed enhancement imaging of myocardial infarction
    Peter Kellman
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, DHHS, 10 Center Drive, MSC 1061, Building 10, Room B1D416, Bethesda, MD 20892, USA
    Magn Reson Med 53:194-200. 2005
    ..In this study, motion correction was implemented using image registration postprocessing rather than navigator correction of individual frames. Navigator techniques may be incorporated as well...
  4. ncbi request reprint Quantitative myocardial infarction on delayed enhancement MRI. Part I: Animal validation of an automated feature analysis and combined thresholding infarct sizing algorithm
    Li Yueh Hsu
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    J Magn Reson Imaging 23:298-308. 2006
    ..To develop a computer algorithm to measure myocardial infarct size in gadolinium-enhanced magnetic resonance (MR) imaging and to validate this method using a canine histopathological reference...
  5. pmc Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology
    Martin Ugander
    Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services, 10 Center Drive, Bethesda, MD 20892 1061, USA
    Eur Heart J 33:1268-78. 2012
    ....
  6. ncbi request reprint Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging: histopathological and displacement encoding with stimulated echoes (DENSE) functional validations
    Anthony H Aletras
    National Heart, Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 1061, USA
    Circulation 113:1865-70. 2006
    ....
  7. pmc T2* measurement during first-pass contrast-enhanced cardiac perfusion imaging
    Peter Kellman
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 56:1132-4. 2006
    ..For single-dose Gd-DTPA (0.1 mmol/kg at 5 ml/s), the LV blood pool T(2) (*) had a mean value of 9 ms (N = 10) at peak enhancement. Distortion of the AIF due to T(2) (*) signal intensity loss will be less than 10% using TE = 0.6 ms...
  8. pmc Late gadolinium-enhancement cardiac magnetic resonance identifies postinfarction myocardial fibrosis and the border zone at the near cellular level in ex vivo rat heart
    Erik B Schelbert
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1061, USA
    Circ Cardiovasc Imaging 3:743-52. 2010
    ....
  9. pmc Regadenoson and adenosine are equivalent vasodilators and are superior than dipyridamole- a study of first pass quantitative perfusion cardiovascular magnetic resonance
    Sujethra Vasu
    Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, 10 Center Drive, Building 10, Room B1D416, 20892 1061 Bethesda, MD, USA
    J Cardiovasc Magn Reson 15:85. 2013
    ..The specific aim of this study was to determine the relative potency of these three vasodilators by quantifying stress and rest myocardial perfusion in humans using cardiovascular magnetic resonance (CMR)...
  10. ncbi request reprint Quantitative myocardial infarction on delayed enhancement MRI. Part II: Clinical application of an automated feature analysis and combined thresholding infarct sizing algorithm
    Li Yueh Hsu
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    J Magn Reson Imaging 23:309-14. 2006
    ....
  11. pmc Magnetic resonance imaging delineates the ischemic area at risk and myocardial salvage in patients with acute myocardial infarction
    Colin Berry
    Department of Health and Human Services, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1061, USA
    Circ Cardiovasc Imaging 3:527-35. 2010
    ..The area at risk (AAR) is a key determinant of myocardial infarction (MI) size. We investigated whether magnetic resonance imaging (MRI) measurement of AAR would be correlated with an angiographic AAR risk score in patients with acute MI...
  12. ncbi request reprint Quantitative myocardial perfusion analysis with a dual-bolus contrast-enhanced first-pass MRI technique in humans
    Li Yueh Hsu
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    J Magn Reson Imaging 23:315-22. 2006
    ..To compare fully quantitative and semiquantitative analysis of rest and stress myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) using a dual-bolus first-pass perfusion MRI method in humans...
  13. pmc A quantitative pixel-wise measurement of myocardial blood flow by contrast-enhanced first-pass CMR perfusion imaging: microsphere validation in dogs and feasibility study in humans
    Li Yueh Hsu
    Advanced Cardiovascular Imaging Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1061, USA
    JACC Cardiovasc Imaging 5:154-66. 2012
    ..The aim of this study was to evaluate fully quantitative myocardial blood flow (MBF) at a pixel level based on contrast-enhanced first-pass cardiac magnetic resonance (CMR) imaging in dogs and in patients...
  14. ncbi request reprint Determining canine myocardial area at risk with manganese-enhanced MR imaging
    Alex Natanzon
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, U S Department of Health and Human Services, 10 Center Dr, MSC 1061, Bldg 10, Room B1D 416, Bethesda, MD 20892 1061, USA
    Radiology 236:859-66. 2005
    ..To test whether manganese-enhanced magnetic resonance (MR) imaging can safely depict the myocardial area at risk both during coronary artery occlusion and for at least 2 hours after reperfusion in dogs...
  15. pmc Bright-blood T(2)-weighted MRI has high diagnostic accuracy for myocardial hemorrhage in myocardial infarction: a preclinical validation study in swine
    Alexander R Payne
    National Heart, Lung, and Blood Institute, National Institutes of Health, DHHS, Bethesda, MD 20892 1061, USA
    Circ Cardiovasc Imaging 4:738-45. 2011
    ..Myocardial hemorrhage after myocardial infarction (MI) usually goes undetected. We investigated the diagnostic accuracy of bright-blood T(2)-weighted cardiac MRI for myocardial hemorrhage in experimental MI...
  16. doi request reprint Mechanisms for overestimating acute myocardial infarct size with gadolinium-enhanced cardiovascular magnetic resonance imaging in humans: a quantitative and kinetic study †
    Sophia Hammer-Hansen
    Laboratory for Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute, Department of Health and Human Services, National Institutes of Health, Building 10, Room B1D416, MSC 1061, 10 Center Drive, Bethesda, MD 20892 1061, USA Department of Medicine B, The Heart Center, Rigshospitalet, Copenhagen, Denmark
    Eur Heart J Cardiovasc Imaging 17:76-84. 2016
    ..If so, these mechanisms could contribute to overestimation of acute myocardial infarction (AMI) size...
  17. pmc Heterogeneity of intramural function in hypertrophic cardiomyopathy: mechanistic insights from MRI late gadolinium enhancement and high-resolution displacement encoding with stimulated echoes strain maps
    Anthony H Aletras
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1061, USA
    Circ Cardiovasc Imaging 4:425-34. 2011
    ..The aim of this study was to determine whether excess collagen or myocardial scarring, as determined by LGE MRI, are the primary mechanisms leading to heterogeneous regional contractile function in patients with HCM...
  18. doi request reprint Temporal and spatial characteristics of the area at risk investigated using computed tomography and T1-weighted magnetic resonance imaging
    Jesper Van der Pals
    National Heart, Lung and Blood Institute NHLBI, National Institutes of Health NIH, Building 10, Room B1D416, MSC 1061, 10 Center Drive, Bethesda, MD 20892 1061, USA
    Eur Heart J Cardiovasc Imaging 16:1232-40. 2015
    ..We investigated the presence of a lateral perfusion gradient within the AAR and validated CMR measures of AAR against three independent reference standards of high quality...
  19. ncbi request reprint Motion corrected free-breathing delayed-enhancement imaging of myocardial infarction using nonrigid registration
    Maria J Ledesma-Carbayo
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland 20892 1061, USA
    J Magn Reson Imaging 26:184-90. 2007
    ..To develop and test an automatic free-breathing, delayed enhancement imaging method with improved image signal-to-noise ratio (SNR)...
  20. pmc Diagnostic accuracy of stress perfusion CMR in comparison with quantitative coronary angiography: fully quantitative, semiquantitative, and qualitative assessment
    Federico E Mordini
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland Department of Cardiology, Veterans Affairs Medical Center, Washington, DC
    JACC Cardiovasc Imaging 7:14-22. 2014
    ....
  21. pmc Distinction of salvaged and infarcted myocardium within the ischaemic area-at-risk with T2 mapping
    Sophia Hammer-Hansen
    Department of Health and Human Services, Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Bldg 10, Rm B1D416, Bethesda, MD 20892 1061, USA Department of Medicine B, The Heart Center, Rigshospitalet, Copenhagen, Denmark
    Eur Heart J Cardiovasc Imaging 15:1048-53. 2014
    ..To determine the differences in oedema between salvaged and infarcted myocardium, we performed quantitative T2 mapping of the AAR. We also aimed to determine the impact of reperfusion time on T2 in the AAR...
  22. ncbi request reprint In vivo T2-weighted magnetic resonance imaging can accurately determine the ischemic area at risk for 2-day-old nonreperfused myocardial infarction
    Gauri S Tilak
    National Heart, Lung and Blood Institute, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland 20892 1061, USA
    Invest Radiol 43:7-15. 2008
    ..AAR was defined as the size of the perfusion defect on day 0. MI and the residual ischemic viable border zone comprise the AAR...
  23. doi request reprint A Model-based approach for microvasculature structure distortion correction in two-photon fluorescence microscopy images
    Lam Dao
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, U S A
    J Microsc 260:180-93. 2015
    ..The proposed method will help in qualitative interpretation and quantitative analysis of vascular structures from fluorescence microscopy images. ..
  24. doi request reprint Quantitative assessment of myocardial fibrosis in an age-related rat model by ex vivo late gadolinium enhancement magnetic resonance imaging with histopathological correlation
    Pascale Beliveau
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA Institute of Biomedical Engineering, Ecole Polytechnique of Montreal, Montreal, Canada
    Comput Biol Med 65:103-13. 2015
    ..High resolution ex-vivo LGE CMR can detect the presence of diffuse fibrosis that naturally developed in elderly rat hearts. Our results suggest that texture analysis may improve the assessment of myocardial fibrosis in LGE CMR images. ..
  25. ncbi request reprint Automatic assessment of dynamic contrast-enhanced MRI in an ischemic rat hindlimb model: an exploratory study of transplanted multipotent progenitor cells
    Li Yueh Hsu
    National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1061, USA
    NMR Biomed 21:111-9. 2008
    ..The differences were primarily determined by late contrast enhancement of PBS-treated limbs. These computerized methods appear promising for assessing perfusion and late enhancement in dynamic contrast-enhanced MRI...
  26. doi request reprint Study of the development of the mouse thoracic aorta three-dimensional macromolecular structure using two-photon microscopy
    Leah M Zadrozny
    Laboratory of Cardiac Energetics LMZ, EBN, BML, LD, LYH, RSB, NIH Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USAElectron Microscopy Core Facility PSC, NIH Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USAPathology Core ZXY, NIH Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Histochem Cytochem 63:8-21. 2015
    ..Coupling this approach with the intrinsic optical properties of the macromolecules may provide unique vascular wall 3D structure in many pathological conditions, including aortic atherosclerosis, dissections and aneurysms. ..
  27. pmc Nitrite anion provides potent cytoprotective and antiapoptotic effects as adjunctive therapy to reperfusion for acute myocardial infarction
    Felix M Gonzalez
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1061, USA
    Circulation 117:2986-94. 2008
    ....