Lewis L Hsu
Affiliation: National Institutes of Health
- Positive expiratory pressure device acceptance by hospitalized children with sickle cell disease is comparable to incentive spirometryLewis L Hsu
Pediatric Hematology, St Christopher s Hospital For Children, Drexel University College of Medicine, Erie Avenue at Front Street, Philadelphia PA 19134, USA
Respir Care 50:624-7. 2005..Intermittent positive expiratory pressure (PEP) therapy may be easier for a child's coordination and more comfortable than IS for a child with chest wall pain...
- Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailabilityLewis L Hsu
Marian Anderson Sickle Cell Center at St Christopher s Hospital for Children, Drexel University College of Medicine, Philadelphia, PA 19134, USA
Blood 109:3088-98. 2007..Although the time course is shorter than typical pulmonary hypertension in human sickle cell disease, these results demonstrate that hemolytic anemia is sufficient to produce endothelial dysfunction and global dysregulation of NO...
- Peripheral arterial tonometry in assessing endothelial dysfunction in pediatric sickle cell diseaseKrupa M Sivamurthy
Hematology Oncology, St Christopher s Hospital For Children, Philadelphia, Pennsylvania 19141, USA
Pediatr Hematol Oncol 26:589-96. 2009..Peripheral arterial tonometry (PAT), a noninvasive technology for measuring EDF, utilizes reactive hyperemia following mini-ischemic stress (reactive hyperemia index or RHI)...
- The proverbial chicken or the egg? Dissection of the role of cell-free hemoglobin versus reactive oxygen species in sickle cell pathophysiologyMegan L Krajewski
Am J Physiol Heart Circ Physiol 295:H4-7. 2008
- Chimerism and cure: hematologic and pathologic correction of murine sickle cell diseaseLeslie S Kean
Division of Hem Onc BMT, Department of Pediatrics, Emory University School of Medicine, 2040 Ridgewood Dr NE, Atlanta, GA 30322, USA
Blood 102:4582-93. 2003..As the critical hematopoietic organs were not corrected without full RBC replacement, 100% peripheral blood RBC chimerism becomes the most important benchmark for cure after nonmyeloablative BMT...
- Enhanced pulmonary and systemic response to endotoxin in transgenic sickle miceJ David Holtzclaw
Division of Hematology Oncology and Bone Marrow Transplantation, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
Am J Respir Crit Care Med 169:687-95. 2004..quot; This enhanced response to inflammatory insult, particularly by adhesion molecules such as sVCAM-1, could play a role in the increased susceptibility to pulmonary dysfunction that has been observed clinically in SCD...
- C-reactive protein and interleukin-6 are decreased in transgenic sickle cell mice fed a high protein dietDavid R Archer
Emory University School of Medicine and the Aflac Cancer Center and Blood Disorders Service, Atlanta, GA 30322, USA
J Nutr 138:1148-52. 2008..Dietary L-arginine availability was investigated as a possible mechanism for increased nitric oxide production and consequent reduced inflammation...
- Sickle cell disease vasculopathy: a state of nitric oxide resistanceKatherine C Wood
Vascular Medicine Branch, National Heart Lung Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 44:1506-28. 2008..New therapeutic strategies to limit intravascular hemolysis and ROS generation and increase NO bioavailability are discussed...
- Comparison of mechanisms of anemia in mice with sickle cell disease and beta-thalassemia: peripheral destruction, ineffective erythropoiesis, and phospholipid scramblase-mediated phosphatidylserine exposureLeslie S Kean
Division of Hematology, Oncology, Blood and Marrow Transplantation, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30303, USA
Exp Hematol 30:394-402. 2002....
- Sickle erythrocyte adherence to endothelium at low shear: role of shear stress in propagation of vaso-occlusionRichard A O Montes
School of Chemical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 0100, USA
Am J Hematol 70:216-27. 2002..This suggests that in vivo, erythrostasis is an important determinant of adhesion that can act either independently or concurrently with ongoing acute events to induce adhesive interactions and vaso-occlusion...
- Risk of recurrent stroke in children with sickle cell disease receiving blood transfusion therapy for at least five years after initial strokeDouglas J Scothorn
University of Texas Southwestern Medical Center, Dallas, TX, USA
J Pediatr 140:348-54. 2002....
- Erythropoiesis and myocardial energy requirements contribute to the hypermetabolism of childhood sickle cell anemiaJacqueline M Hibbert
Department of Biochemistry, Morehouse School of Medicine, Atlanta, GA, USA
J Pediatr Gastroenterol Nutr 43:680-7. 2006..We hypothesized that an elevated hemoglobin synthesis rate (SynHb) and myocardial oxygen consumption (MVO2) contribute to the excess protein and energy metabolism reported in children with sickle cell anemia...
- Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: a retrospective cohort study of 137 children with sickle cell anemiaMonica L Hulbert
Washington University School of Medicine, St Louis, MO 63108, USA
J Pediatr 149:710-2. 2006..Children receiving simple transfusion had a 5-fold greater relative risk (95% confidence interval = 1.3 to 18.6) of second stroke than those receiving exchange transfusion...
- Parents' assessment of risk in sickle cell disease treatment with hydroxyureaJanaki D Meyappan
Emory University, Atlanta, Georgia, USA
J Pediatr Hematol Oncol 27:644-50. 2005..04). The study's mixed findings highlight the complexities of risk perception and suggest that future studies of risks and benefits from the parental viewpoint are needed as candidate therapies are developed for SCD...
- Murine and math models for the level of stable mixed chimerism to cure beta-thalassemia by nonmyeloablative bone marrow transplantationCarla Roberts
Palmetto Health Systems, Columbia, South Carolina 29203, USA
Ann N Y Acad Sci 1054:423-8. 2005..Murine and human transplant results were compared with a math model for survival advantage of donor peripheral blood cells produced by steady-state chimeric marrow...
- Erythrocytes are the major intravascular storage sites of nitrite in human bloodAndre Dejam
Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD 20892, USA
Blood 106:734-9. 2005..These studies suggest a dynamic intravascular NO metabolism in which endothelial NOS-derived NO is stabilized as nitrite, transported by erythrocytes, and consumed during arterial-to-venous transit...
- Proinflammatory cytokines and the hypermetabolism of children with sickle cell diseaseJacqueline M Hibbert
Microbiology Biochemistry Immunology Pediatrics, Morehouse School of Medicine, 720 Westview Drive, S W, Atlanta, Georgia 30310 1495, USA
Exp Biol Med (Maywood) 230:68-74. 2005....
- Alpha Thalassemia is associated with decreased risk of abnormal transcranial Doppler ultrasonography in children with sickle cell anemiaLewis L Hsu
Emory University School of Medicine and Georgia Comprehensive Sickle Cell Center, Atlanta, Georgia 30303, USA
J Pediatr Hematol Oncol 25:622-8. 2003..The authors hypothesized that children with abnormal TCD are less likely to have alpha thalassemia-2, and an increased hemoglobin level accounts for this protective effect...
- A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantationLeslie S Kean
Division of Hematology, Oncology Blood and Marrow Transplantation, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
Blood 99:1840-9. 2002..They suggest a future treatment strategy for human SCD patients that reduces the toxicity of conventional BMT and expands the use of allotransplantation to non-HLA-matched donors...