Ann W Hsing

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Hormones and prostate cancer: what's next?
    A W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS MSC 7234, 6120 Executive Boulevard, Bethesda, MD 20852 7234, USA
    Epidemiol Rev 23:42-58. 2001
  2. ncbi Hormones and prostate cancer: current perspectives and future directions
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852 7234, USA
    Prostate 52:213-35. 2002
  3. ncbi Polymorphic CAG/CAA repeat length in the AIB1/SRC-3 gene and prostate cancer risk: a population-based case-control study
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 11:337-41. 2002
  4. ncbi Polymorphic markers in the SRD5A2 gene and prostate cancer risk: a population-based case-control study
    A W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 10:1077-82. 2001
  5. ncbi Prostate cancer risk and serum levels of insulin and leptin: a population-based study
    A W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 93:783-9. 2001
  6. ncbi Body size and prostate cancer: a population-based case-control study in China
    A W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute Bethesda, Maryland 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 9:1335-41. 2000
  7. ncbi Polymorphic CAG and GGN repeat lengths in the androgen receptor gene and prostate cancer risk: a population-based case-control study in China
    A W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852 7234, USA
    Cancer Res 60:5111-6. 2000
  8. ncbi Polymorphisms of genes in the lipid metabolism pathway and risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China
    Gabriella Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 8011, MSC 7240, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 17:525-34. 2008
  9. ncbi Variants of DNA repair genes and the risk of biliary tract cancers and stones: a population-based study in China
    Mingdong Zhang
    Food and Drug Administration, Rockville, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 17:2123-7. 2008
  10. ncbi Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China
    Gabriella Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, 6120 Executive Blvd, EPS 8011, MSC 7240, Bethesda, MD, 20892, USA
    Eur J Epidemiol 24:763-74. 2009

Collaborators

Detail Information

Publications90

  1. ncbi Hormones and prostate cancer: what's next?
    A W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS MSC 7234, 6120 Executive Boulevard, Bethesda, MD 20852 7234, USA
    Epidemiol Rev 23:42-58. 2001
    ....
  2. ncbi Hormones and prostate cancer: current perspectives and future directions
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852 7234, USA
    Prostate 52:213-35. 2002
    ..Such collaboration will lead to a deeper understanding of the etiologic pathways of prostate cancer, ultimately yielding better preventive, diagnostic, and therapeutic strategies...
  3. ncbi Polymorphic CAG/CAA repeat length in the AIB1/SRC-3 gene and prostate cancer risk: a population-based case-control study
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 11:337-41. 2002
    ..Expanded studies in other populations are needed to confirm this association and the combined effect of AIB1/SRC-3 and other hormone-related genes in prostate cancer etiology...
  4. ncbi Polymorphic markers in the SRD5A2 gene and prostate cancer risk: a population-based case-control study
    A W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 10:1077-82. 2001
    ....
  5. ncbi Prostate cancer risk and serum levels of insulin and leptin: a population-based study
    A W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 93:783-9. 2001
    ..Because leptin and insulin are related to body fat distribution, we examined whether leptin and insulin were associated with prostate cancer risk...
  6. ncbi Body size and prostate cancer: a population-based case-control study in China
    A W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute Bethesda, Maryland 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 9:1335-41. 2000
    ..Additional research is needed to confirm these findings in prospective studies, especially in Western populations where abdominal obesity is much more common, and to clarify the underlying hormonal mechanisms involved...
  7. ncbi Polymorphic CAG and GGN repeat lengths in the androgen receptor gene and prostate cancer risk: a population-based case-control study in China
    A W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852 7234, USA
    Cancer Res 60:5111-6. 2000
    ..Because of the significance of AR in prostate cancer, investigation of factors that interact with the polyglutamine region of the AR gene to alter AR function and modulate prostate cancer risk is an important area for future research...
  8. ncbi Polymorphisms of genes in the lipid metabolism pathway and risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China
    Gabriella Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 8011, MSC 7240, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 17:525-34. 2008
    ..5-fold risk of bile duct cancer. Our findings suggest that gene variants in the lipid metabolism pathway contribute to the risk of biliary tract stones and cancers, particularly of the bile duct...
  9. ncbi Variants of DNA repair genes and the risk of biliary tract cancers and stones: a population-based study in China
    Mingdong Zhang
    Food and Drug Administration, Rockville, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 17:2123-7. 2008
    ..Findings from this population-based study in Shanghai suggest that MGMT gene variants may alter susceptibility to biliary tract cancer, particularly gallbladder cancer. Confirmation in future studies, however, is required...
  10. ncbi Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China
    Gabriella Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, 6120 Executive Blvd, EPS 8011, MSC 7240, Bethesda, MD, 20892, USA
    Eur J Epidemiol 24:763-74. 2009
    ..These findings provide insight into the role of lipid metabolism genes, as well as the mechanisms by which these genes may be linked with disease...
  11. ncbi Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China
    Shih Chen Chang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 29:944-8. 2008
    ..Results from this population-based study suggest that certain genetic variants involved in the regulation of obesity-related insulin sensitivity may increase susceptibility to bile duct cancer and gallstones...
  12. ncbi CYP17 MspA1 polymorphism and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, China
    Lifang Hou
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Rockville MD 20852 7236, USA
    Int J Cancer 118:2847-53. 2006
    ....
  13. ncbi Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China
    Sue K Park
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, EPS 5024, MSC 7234, Bethesda, MD 20892 7234, USA
    Carcinogenesis 30:606-14. 2009
    ..1-4.9; P-interaction = 0.05) was statistically significant. Our findings suggest that common variants in hormone-related genes contribute to the risk of biliary tract cancers and stones, possibly by modulating hormone metabolism...
  14. ncbi Association between genetic variants in the 8q24 cancer risk regions and circulating levels of androgens and sex hormone-binding globulin
    Lisa W Chu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
    Cancer Epidemiol Biomarkers Prev 19:1848-54. 2010
    ..Genome-wide association studies have identified multiple independent regions on chromosome 8q24 that are associated with cancers of the prostate, breast, colon, and bladder...
  15. ncbi The association between inflammation-related genes and serum androgen levels in men: the prostate, lung, colorectal, and ovarian study
    Tamra E Meyer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA
    Prostate 72:65-71. 2012
    ..Androgens and inflammation have been implicated in the etiology of several cancers, including prostate cancer. Serum androgens have been shown to correlate with markers of inflammation and expression of inflammation-related genes...
  16. ncbi Correlation between circadian gene variants and serum levels of sex steroids and insulin-like growth factor-I
    Lisa W Chu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, MSC 7234, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 17:3268-73. 2008
    ..Our findings, although in need of confirmation, suggest that variations in circadian genes are associated with serum hormone levels, providing biological support for the role of circadian genes in hormone-related cancers...
  17. ncbi Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 29:100-5. 2008
    ..This study suggests that genetic variants in XRCC1 and APEX1 may alter susceptibility to biliary tract cancer and stones. Further studies are required to confirm the reported associations...
  18. ncbi Hepatitis B and C virus infection and the risk of biliary tract cancer: a population-based study in China
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 5024, MSC 7234, 6120 Executive Blvd, Bethesda, MD 20852 7234, USA
    Int J Cancer 122:1849-53. 2008
    ..In Shanghai, an HBV endemic area, chronic HBV infection was associated with a 2.4-fold risk of extrahepatic bile duct cancer. These results should be confirmed in other populations with varying risks of HBV and HCV infection...
  19. ncbi Polymorphisms of estrogen receptors and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, China
    Sue K Park
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, EPS MSC 7234, 6120 Executive Boulevard, Bethesda, MD 20892 7234, USA
    Carcinogenesis 31:842-6. 2010
    ..1). No association was found for ESR1 haplotype based on four SNPs. These preliminary results suggest that variants in ESR genes could play a role in the etiology of biliary tract cancers, especially bile duct cancer in men...
  20. ncbi Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics and Office of Preventive Oncology, National Cancer Institute, NIH, Bethesda, Maryland 20892 7234, USA
    Cancer Res 68:6442-52. 2008
    ....
  21. ncbi MSR1 variants and the risks of prostate cancer and benign prostatic hyperplasia: a population-based study in China
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 28:2530-6. 2007
    ..The role of MSR1 warrants further investigation in larger studies and other populations...
  22. ncbi Prostaglandin-endoperoxide synthase 2 (PTGS2) gene polymorphisms and risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China
    Lori C Sakoda
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7234, USA
    Carcinogenesis 27:1251-6. 2006
    ..Further investigation is needed to confirm and extend our findings in studies of biliary tract cancer that more comprehensively examine PTGS2 and other inflammation-related genes...
  23. ncbi Medical history and the risk of biliary tract cancers in Shanghai, China: implications for a role of inflammation
    Gabriella Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8011, MSC 7240, Bethesda, MD 20892, USA
    Cancer Causes Control 22:1289-96. 2011
    ..2-15.0) or duodenal ulcers (OR = 3.7, 1.2-12.0) was associated with an excess risk of gallbladder cancer. Although the mechanisms are unclear, our results further support the role for inflammation in the etiology of biliary tract cancers...
  24. ncbi Endogenous sex hormones and the risk of prostate cancer: a prospective study
    Jocelyn M Weiss
    Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD, USA
    Int J Cancer 122:2345-50. 2008
    ..T:SHBG ratio was related to risk in this older population of men, but the significance of this ratio in steroidal biology is unclear. (c) 2008 Wiley-Liss, Inc...
  25. ncbi TNF polymorphisms and prostate cancer risk
    Kim N Danforth
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20852, USA
    Prostate 68:400-7. 2008
    ..Inflammation has been hypothesized to increase prostate cancer risk. Tumor necrosis factor (TNF) is an important mediator of the inflammatory process, but the relationship between TNF variants and prostate cancer remains unclear...
  26. ncbi Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population-based study in China
    Gabriella Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA
    Int J Cancer 122:2322-9. 2008
    ..Our findings support a role for serum lipids in gallstone development and biliary carcinogenesis...
  27. ncbi CYP17 polymorphisms in relation to risks of prostate cancer and benign prostatic hyperplasia: a population-based study in China
    M Patricia Madigan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852 7234, USA
    Int J Cancer 107:271-5. 2003
    ..Large population-based studies are needed to clarify whether CYP17 plays a role in prostate cancer risk and whether genotype effects vary in different racial/ethnic and other subgroups...
  28. ncbi Insulin resistance and prostate cancer risk
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    J Natl Cancer Inst 95:67-71. 2003
    ..Because of the retrospective design of this study, the role of insulin resistance in prostate cancer needs to be confirmed in prospective studies...
  29. ncbi Androgen receptor CAG repeat length and risk of biliary tract cancer and stones
    Tamra E Meyer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS Room 5032, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 19:787-93. 2010
    ..Further studies are needed to confirm these findings and clarify the mechanisms involved...
  30. ncbi Diabetes mellitus and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
    Michael F Leitzmann
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Cancer Causes Control 19:1267-76. 2008
    ....
  31. ncbi Insulin-like growth factors and prostate cancer: a population-based case-control study in China
    A P Chokkalingam
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Cancer Epidemiol Biomarkers Prev 10:421-7. 2001
    ....
  32. ncbi Family history of gallstones and the risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20852, USA
    Int J Cancer 121:832-8. 2007
    ....
  33. ncbi Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies
    Kim N Danforth
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
    Carcinogenesis 29:568-72. 2008
    ....
  34. ncbi Risk factors for intrahepatic cholangiocarcinoma in a low-risk population: a nationwide case-control study
    Tania M Welzel
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7234, USA
    Int J Cancer 120:638-41. 2007
    ..02, 95% CI = 1.05-8.69). Obesity was unrelated to risk. These results confirm that prior bile duct diseases increase risk of ICC and suggest that alcoholic liver disease and diabetes may also increase risk...
  35. ncbi Biliary tract cancer and stones in relation to chronic liver conditions: A population-based study in Shanghai, China
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Int J Cancer 120:1981-5. 2007
    ..Given that chronic infection with hepatitis B virus (HBV) is the most common cause of liver disease in China, serologic markers of HBV need to be measured in future studies to examine the link between HBV and bile duct cancer...
  36. ncbi Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: a population-based case-control study
    Tania M Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Clin Gastroenterol Hepatol 5:1221-8. 2007
    ..Because the etiology of both tumors is poorly understood, a population-based case-control study was conducted to examine the association of ECC and ICC with preexisting medical conditions...
  37. ncbi Allium vegetables and risk of prostate cancer: a population-based study
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7234, USA
    J Natl Cancer Inst 94:1648-51. 2002
    ..001). The reduced risk of prostate cancer associated with allium vegetables was independent of body size, intake of other foods, and total calorie intake and was more pronounced for men with localized than with advanced prostate cancer...
  38. ncbi Prostate cancer epidemiology
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852 7234, USA
    Front Biosci 11:1388-413. 2006
    ..Results of these studies may lead to better detection, treatment, and, ultimately, prevention of prostate cancer...
  39. ncbi Insulin-like growth factors and risk of benign prostatic hyperplasia
    Anand P Chokkalingam
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Prostate 52:98-105. 2002
    ..The IGF axis has been implicated in prostate cancer risk, but its role in benign prostatic hyperplasia (BPH) is unclear...
  40. ncbi Association between adult height, genetic susceptibility and risk of glioma
    Cari M Kitahara
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Int J Epidemiol 41:1075-85. 2012
    ..In a pooled analysis of observational studies, we investigated the strength and consistency of this association, overall and for major sub-types, and investigated effect modification by genetic susceptibility to the disease...
  41. ncbi Measuring serum melatonin in epidemiologic studies
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 5024, MSC 7234, Bethesda, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 19:932-7. 2010
    ....
  42. ncbi Androgen and prostate cancer: is the hypothesis dead?
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South 5024, MSC 7234, 6120 Executive Boulevard, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 17:2525-30. 2008
    ....
  43. ncbi Obesity, metabolic syndrome, and prostate cancer
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852 7234, USA
    Am J Clin Nutr 86:s843-57. 2007
    ..Given that the prevalence of obesity and metabolic syndrome is increasing worldwide and that the world population is aging, the roles of obesity and metabolic syndrome in prostate carcinogenesis warrant further clarification...
  44. ncbi Resampling-based multiple hypothesis testing procedures for genetic case-control association studies
    Bingshu E Chen
    Biostatistics Branch, Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852 7244, USA
    Genet Epidemiol 30:495-507. 2006
    ....
  45. ncbi Prostate cancer, benign prostatic hyperplasia and physical activity in Shanghai, China
    J V Lacey
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Int J Epidemiol 30:341-9. 2001
    ....
  46. ncbi Inflammatory gene variants and the risk of biliary tract cancers and stones: a population-based study in China
    Felipe A Castro
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Rockville, MD 20892, USA
    BMC Cancer 12:468. 2012
    ..Genetic variants in inflammation-related genes have been associated with biliary stones and biliary tract cancers in previous studies...
  47. ncbi Chronic typhoid infection and the risk of biliary tract cancer and stones in Shanghai, China
    Mahboobeh Safaeian
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Infect Agent Cancer 6:6. 2011
    ..The low seroprevalence of S. Typhi in Shanghai is unlikely to explain the high incidence of biliary cancers in this population...
  48. ncbi Androgens and the molecular epidemiology of prostate cancer
    Lisa W Chu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Opin Endocrinol Diabetes Obes 15:261-70. 2008
    ..In this review, we summarize the current state of the literature and provide insights and direction for epidemiologic research on androgens and prostate cancer...
  49. ncbi Rising prostate cancer rates in South Korea
    Sue Kyung Park
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
    Prostate 66:1285-91. 2006
    ..Prostate cancer incidence and mortality rates in South Korea are relatively low, but rising steadily...
  50. ncbi Androgen receptor CAG repeat length and association with prostate cancer risk: results from the prostate cancer prevention trial
    Douglas K Price
    Medical Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Urol 184:2297-302. 2010
    ..We investigated the association between the length of the polymorphic trinucleotide CAG microsatellite repeats in exon 1 of the AR gene and the risk of prostate cancer...
  51. ncbi Aspirin use and risk of biliary tract cancer: a population-based study in Shanghai, China
    Enju Liu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7058, Bethesda, MD 20892-7234, USA
    Cancer Epidemiol Biomarkers Prev 14:1315-8. 2005
    ....
  52. ncbi Reproducibility of serum sex steroid assays in men by RIA and mass spectrometry
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 5024, MSC 7234, 6120 Executive Boulevard, Bethesda, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 16:1004-8. 2007
    ....
  53. ncbi Evaluation of multiplexed cytokine and inflammation marker measurements: a methodologic study
    Anil K Chaturvedi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 7072, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 20:1902-11. 2011
    ....
  54. ncbi Prevalence of monoclonal gammopathy of undetermined significance among men in Ghana
    Ola Landgren
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Bldg EPS Room 7110, Bethesda, MD 20892 7236, USA
    Mayo Clin Proc 82:1468-73. 2007
    ....
  55. ncbi Simultaneous recovery of DNA and RNA from formalin-fixed paraffin-embedded tissue and application in epidemiologic studies
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8110, MSC 7240, Bethesda, MD 20892 7240, USA
    Cancer Epidemiol Biomarkers Prev 19:973-7. 2010
    ..Here, we report the method that we used to simultaneously recover DNA and RNA from FFPE tissue specimens with appreciable quantity and quality and discuss briefly the application of tumor markers in epidemiologic studies...
  56. ncbi Prostate carcinoma risk subsequent to diagnosis of benign prostatic hyperplasia: a population-based cohort study in Sweden
    Anand P Chokkalingam
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
    Cancer 98:1727-34. 2003
    ..Further studies are needed to confirm the minimal excess risk of prostate carcinoma among BPH patients overall and the possible impact of BPH treatment methods on subsequent prostate carcinoma risk...
  57. ncbi Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China
    G Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    Br J Cancer 102:1185-9. 2010
    ..Parity has been linked to gallbladder cancer and gallstones, but the effects of other reproductive factors are less clear...
  58. ncbi Risk of prostate cancer and family history of cancer: a population-based study in China
    Y Bai
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Blvd, Room 7106, MSC 7236 Bethesda, MD 20892, USA
    Prostate Cancer Prostatic Dis 8:60-5. 2005
    ..Larger studies are needed to confirm these findings, and to clarify the genetic and lifestyle factors that may be involved...
  59. ncbi Diabetes in relation to biliary tract cancer and stones: a population-based study in Shanghai, China
    F M Shebl
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD, USA
    Br J Cancer 103:115-9. 2010
    ..Biliary tract cancers are rare but fatal malignancies. Diabetes has been related to biliary stones, but its association with biliary tract cancers is less conclusive...
  60. ncbi Body size and the risk of biliary tract cancer: a population-based study in China
    A W Hsing
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, Bethesda, MD 20892 7324, USA
    Br J Cancer 99:811-5. 2008
    ..The increasing prevalence of obesity and cholesterol stones in Shanghai seems at least partly responsible for the rising incidence of gall bladder cancer in Shanghai...
  61. ncbi Risk factors for colorectal cancer in a prospective study among U.S. white men
    A W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Int J Cancer 77:549-53. 1998
    ..Our findings support previous reports that a high intake of red meat and a sedentary life-style may increase the risk of colon cancer...
  62. ncbi Vitamin D receptor gene polymorphisms, insulin-like growth factors, and prostate cancer risk: a population-based case-control study in China
    A P Chokkalingam
    Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, MD 21201, USA
    Cancer Res 61:4333-6. 2001
    ..Our findings in a low-risk population suggest that the IGF and vitamin D regulatory systems may interact to affect prostate cancer risk. Larger studies are needed to confirm these findings and clarify the underlying mechanisms...
  63. ncbi Gallstones and the risk of biliary tract cancer: a population-based study in China
    A W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852 7234, USA
    Br J Cancer 97:1577-82. 2007
    ..9 vs 2.8 grams; P=0.001). We estimate that in Shanghai 80% (95% CI 75-84%), 59% (56-61%), and 41% (29-59%) of gallbladder, bile duct, and ampulla of Vater cancers, respectively, could be attributed to gallstones...
  64. ncbi Variants in circadian genes and prostate cancer risk: a population-based study in China
    L W Chu
    Cancer Prevention Fellowship Program, Office of Preventive Oncology, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Prostate Cancer Prostatic Dis 11:342-8. 2008
    ..5, 95% CI, 0.3-1.0) as compared to the GG genotype. Our findings, although in need of confirmation, suggest that variations in circadian genes may alter prostate cancer risk and some biological processes may modify this effect...
  65. ncbi Risk of stomach cancer in relation to consumption of cigarettes, alcohol, tea and coffee in Warsaw, Poland
    W H Chow
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Int J Cancer 81:871-6. 1999
    ..Our findings confirm an association with cigarette smoking, which is estimated to account for approximately 20% of stomach cancers diagnosed among Warsaw residents during the study period...
  66. ncbi Rising incidence of biliary tract cancers in Shanghai, China
    A W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7368, USA
    Int J Cancer 75:368-70. 1998
    ..The increase in incidence was seen for all 3 subsites, both sexes, and all age groups. Future studies are needed to identify reasons for the large increases in these rates...
  67. ncbi Cigarette and alcohol consumption and the risk of colorectal cancer in Shanghai, China
    B T Ji
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8120, Bethesda, MD 20852, USA
    Eur J Cancer Prev 11:237-44. 2002
    ..Although cigarette smoking and alcohol drinking in general were not risk factors for colorectal cancers in Shanghai, there were small excess risks for rectal cancer among heavy smokers and colon cancer among heavy drinkers...
  68. ncbi Genome-wide association study of circulating retinol levels
    Alison M Mondul
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Hum Mol Genet 20:4724-31. 2011
    ..31× 10(-5)). Discovery of common genetic variants associated with serum retinol levels may provide further insight into the contribution of retinol and other vitamin A compounds to the development of cancer and other complex diseases...
  69. ncbi Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence of intra- and extrahepatic cholangiocarcinoma in the United States
    Tania M Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 7084, MSC 7234 6120 Executive Blvd, Bethesda, MD 20892, USA
    J Natl Cancer Inst 98:873-5. 2006
    ..001)...
  70. ncbi Obesity and thyroid cancer risk among U.S. men and women: a pooled analysis of five prospective studies
    Cari M Kitahara
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 20:464-72. 2011
    ..Thyroid cancer incidence has risen dramatically in the United States since the early 1980s. Although the prevalence of obesity has doubled during this time period, the relationship between obesity and thyroid cancer is uncertain...
  71. ncbi International trends and patterns of prostate cancer incidence and mortality
    A W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852 7234, USA
    Int J Cancer 85:60-7. 2000
    ....
  72. ncbi A reproducible and high-throughput HPLC/MS method to separate sarcosine from α- and β-alanine and to quantify sarcosine in human serum and urine
    Tamra E Meyer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Anal Chem 83:5735-40. 2011
    ..7% and ICC = 98.2% and interassay CV = 12.3% and ICC = 94.2%). In conclusion, this high-throughput LC-MS method is able to resolve sarcosine from α- and β-alanine and is useful for quantifying sarcosine in serum and urine samples...
  73. ncbi Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, USA
    Nat Genet 43:60-5. 2011
    ..31 for rs4765623, which maps to SCARB1, the scavenger receptor class B, member 1 gene (P = 2.6 × 10⁻⁸). Our study reports previously unidentified genomic regions associated with RCC risk that may lead to new etiological insights...
  74. ncbi Prostate cancer incidence rates in Africa
    Lisa W Chu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20852 7234, USA
    Prostate Cancer 2011:947870. 2011
    ..Incidence rates in Africa will likely continue to rise with improving economies and increasing Westernization, warranting the need for more high-quality population-based registration to monitor cancer incidence in Africa...
  75. ncbi Detectable clonal mosaicism and its relationship to aging and cancer
    Kevin B Jacobs
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
    Nat Genet 44:651-8. 2012
    ..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases...
  76. ncbi International trends and patterns of primary liver cancer
    K A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. mcglynnkmail.nih.gov
    Int J Cancer 94:290-6. 2001
    ..Further progress against PLC may be seen in the developing world once the HBV-vaccinated segment of the population reaches adulthood. Published 2001 Wiley-Liss, Inc...
  77. ncbi Benign prostatic hyperplasia and subsequent risk of bladder cancer
    D Kang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7234, USA
    Br J Cancer 96:1475-9. 2007
    ..74, respectively. These findings suggest that BPH overall is not associated with bladder cancer risk. However, among men treated with TURP, particularly those with other comorbid GU tract conditions, risk of bladder cancer was elevated...
  78. ncbi Tea drinking and the risk of biliary tract cancers and biliary stones: a population-based case-control study in Shanghai, China
    Xue-Hong Zhang
    Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
    Int J Cancer 118:3089-94. 2006
    ..0, but were not statistically significant. Further studies are needed to confirm these results in other populations and clarify the hormonal and other mechanisms that may be involved...
  79. ncbi [Tea consumption and risk of biliary tract cancers and gallstone disease: a population-based case-control study in Shanghai, China]
    Xue-Hong Zhang
    Department of Epidemiology, Shanghai Cancer Institute, Shanghai 200032, China
    Zhonghua Zhong Liu Za Zhi 27:667-71. 2005
    ..CONCLUSION: Tea consumption may decrease the risk of cancers of the gallbladder and extrahepatic bile duct among females. The protective effect appears to be independent of gallstone disease...
  80. ncbi Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial
    Zhihong Gong
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 15:1977-83. 2006
    ..Obesity increases the risk of high-grade but decreases the risk of low-grade prostate cancer, and this relationship is independent of the lower risk for prostate cancer among men with diabetes...
  81. ncbi Alterations of p16 and prognosis in biliary tract cancers from a population-based study in China
    Takashi Ueki
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 10:1717-25. 2004
    ..Biliary tract cancer is an uncommon malignancy with a poor survival rate. We evaluated p16 gene alteration as a prognostic marker for this disease...
  82. ncbi Molecular epidemiology of prostate cancer: hormone-related genetic loci
    Anand P Chokkalingam
    Division of Epidemiology, School of Public Health, University of California, Berkeley, CA 94707, USA
    Front Biosci 12:3436-60. 2007
    ..Such collaboration will lead to a deeper understanding of the etiologic pathways of prostate cancer, ultimately yielding better preventive, diagnostic, and therapeutic strategies...
  83. ncbi Polymorphisms in angiogenesis-related genes and prostate cancer
    Eric J Jacobs
    Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, GA 30303 1002, USA
    Cancer Epidemiol Biomarkers Prev 17:972-7. 2008
    ..Potentially functional single nucleotide polymorphisms (SNP) in genes important in prostate angiogenesis (VEGF, HIF1A, and NOS3) have previously been associated with risk or severity of prostate cancer...
  84. ncbi Soy and isoflavone consumption in relation to prostate cancer risk in China
    Marion M Lee
    Department of Epidemiology and Biostatistics, University of California at San Francisco, 94143 0560, USA
    Cancer Epidemiol Biomarkers Prev 12:665-8. 2003
    ..Our results indicate a reduced risk of prostate cancer associated with consumption of soy foods and isoflavones. These findings should be confirmed in longitudinal follow-up studies in populations with varying risk of prostate cancer...
  85. ncbi K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China
    Asif Rashid
    Department of Pathology and Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Cancer Res 8:3156-63. 2002
    ..These genetic alterations were compared with patient demographics and clinicopathological characteristics of the tumors...
  86. ncbi Body size and serum levels of insulin and leptin in relation to the risk of benign prostatic hyperplasia
    Sara E Dahle
    Department of Epidemiology and Biostatistics, School of Public Health and Health Sciences, George Washington University, Washington, DC, USA
    J Urol 168:599-604. 2002
    ..Further prospective and laboratory studies are needed to confirm these results and elucidate the underlying mechanisms...
  87. ncbi Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk
    Victoria L Stevens
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA 30303 1002, USA
    Int J Cancer 123:2644-50. 2008
    ..55, 95% CI: 0.33, 0.90). Our study suggest that a common haplotype in the TLR10-TLR1-TLR6 gene cluster influences prostate cancer risk and clearly supports the need for further investigation of TLR genes in other populations...
  88. ncbi Insulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studies
    Andrew W Roddam
    Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, United Kingdom
    Ann Intern Med 149:461-71, W83-8. 2008
    ..Some, but not all, published results have shown an association between circulating blood levels of some insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) and the subsequent risk for prostate cancer...
  89. ncbi Genetic variants of DNA repair genes and prostate cancer: a population-based study
    Jamie D Ritchey
    George Washington University School of Public Health and Health Services, Washington, District of Columbia, USA
    Cancer Epidemiol Biomarkers Prev 14:1703-9. 2005
    ..Replication in larger studies is necessary to preclude chance findings, particularly those among subgroups, and clarify the mechanisms involved...
  90. ncbi [A survey on the diagnosis and treatment of biliary tract cancers in Shanghai]
    Bing Sheng Wang
    Department of Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Zhonghua Wai Ke Za Zhi 43:455-9. 2005
    ..To survey the status of diagnosis and treatment of biliary tract cancer in Shanghai...