Peggy Hsieh

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc DNA mismatch repair: molecular mechanism, cancer, and ageing
    Peggy Hsieh
    Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mech Ageing Dev 129:391-407. 2008
  2. ncbi request reprint DNA mismatch repair: molecular mechanisms and biological function
    Mark J Schofield
    Genetics and Biochemistry Branch, National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Microbiol 57:579-608. 2003
  3. pmc ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts
    Ken Ichi Yoshioka
    Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell 22:501-10. 2006
  4. ncbi request reprint Formation of a DNA mismatch repair complex mediated by ATP
    Tassadite Selmane
    Genetics and Biochemistry Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1810, USA
    J Mol Biol 334:949-65. 2003
  5. ncbi request reprint Crystal structure and biochemical analysis of the MutS.ADP.beryllium fluoride complex suggests a conserved mechanism for ATP interactions in mismatch repair
    Eric Alani
    Department of Molecular Biology and Genetics, 459 Biotechnology Building, Cornell University, Ithaca, NY 14853 2703, USA
    J Biol Chem 278:16088-94. 2003
  6. pmc DNA bending and unbending by MutS govern mismatch recognition and specificity
    Hong Wang
    Department of Chemistry and Curriculum in Applied and Materials Sciences, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 100:14822-7. 2003
  7. pmc Determination of protein-DNA binding constants and specificities from statistical analyses of single molecules: MutS-DNA interactions
    Yong Yang
    Department of Chemistry, University of North Carolina at Chapel Hill Chapel Hill, NC 27599 3290, USA
    Nucleic Acids Res 33:4322-34. 2005

Collaborators

Detail Information

Publications7

  1. pmc DNA mismatch repair: molecular mechanism, cancer, and ageing
    Peggy Hsieh
    Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mech Ageing Dev 129:391-407. 2008
    ..This review summarizes what is known about the molecular details of the MMR pathway and the role of MMR proteins in cancer susceptibility and ageing...
  2. ncbi request reprint DNA mismatch repair: molecular mechanisms and biological function
    Mark J Schofield
    Genetics and Biochemistry Branch, National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Microbiol 57:579-608. 2003
    ..In addition to its role in postreplication repair, the MMR machinery serves to police homologous recombination events and acts as a barrier to genetic exchange between species...
  3. pmc ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts
    Ken Ichi Yoshioka
    Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell 22:501-10. 2006
    ..These results suggest that MMR proteins can act as direct sensors of methylation damage and help recruit ATR-ATRIP to sites of cytotoxic O(6)-meG adducts to initiate ATR checkpoint signaling...
  4. ncbi request reprint Formation of a DNA mismatch repair complex mediated by ATP
    Tassadite Selmane
    Genetics and Biochemistry Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1810, USA
    J Mol Biol 334:949-65. 2003
    ..However, recruitment of MutL results in the formation of a dynamic ternary complex that we propose is the intermediate that signals subsequent repair steps requiring ATP hydrolysis...
  5. ncbi request reprint Crystal structure and biochemical analysis of the MutS.ADP.beryllium fluoride complex suggests a conserved mechanism for ATP interactions in mismatch repair
    Eric Alani
    Department of Molecular Biology and Genetics, 459 Biotechnology Building, Cornell University, Ithaca, NY 14853 2703, USA
    J Biol Chem 278:16088-94. 2003
    ....
  6. pmc DNA bending and unbending by MutS govern mismatch recognition and specificity
    Hong Wang
    Department of Chemistry and Curriculum in Applied and Materials Sciences, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 100:14822-7. 2003
    ..Our results provide a structural explanation for the long-standing question of how MutS achieves mismatch repair specificity...
  7. pmc Determination of protein-DNA binding constants and specificities from statistical analyses of single molecules: MutS-DNA interactions
    Yong Yang
    Department of Chemistry, University of North Carolina at Chapel Hill Chapel Hill, NC 27599 3290, USA
    Nucleic Acids Res 33:4322-34. 2005
    ..In conclusion, from a single set of AFM experiments, it is possible to determine the binding affinity, specificity and stoichiometry, as well as the conformational properties of the protein-DNA complexes...