Michael D Howell

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. ncbi request reprint The role of human beta defensins and cathelicidins in atopic dermatitis
    Michael D Howell
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Curr Opin Allergy Clin Immunol 7:413-7. 2007
  2. doi request reprint Ceragenins: a class of antiviral compounds to treat orthopox infections
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
    J Invest Dermatol 129:2668-75. 2009
  3. ncbi request reprint Cytokine modulation of atopic dermatitis filaggrin skin expression
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 124:R7-R12. 2009
  4. doi request reprint Inhibition of S100A11 gene expression impairs keratinocyte response against vaccinia virus through downregulation of the IL-10 receptor 2 chain
    Lianghua Bin
    Department of Pediatrics, National Jewish Health, Denver, Colo 80206, USA
    J Allergy Clin Immunol 124:270-7, 277.e1. 2009
  5. ncbi request reprint Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Immunity 24:341-8. 2006
  6. pmc The signal transducer and activator of transcription 6 gene (STAT6) increases the propensity of patients with atopic dermatitis toward disseminated viral skin infections
    Michael D Howell
    Department of Pediatrics, National Jewish Health, Denver, Colo 80206, USA
    J Allergy Clin Immunol 128:1006-14. 2011
  7. ncbi request reprint Mechanism of HBD-3 deficiency in atopic dermatitis
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, The National Jewish Medical and Research Center, Room K926, 1400 Jackson Street, Denver, CO 80206, USA
    Clin Immunol 121:332-8. 2006
  8. pmc Cathelicidin deficiency predisposes to eczema herpeticum
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Allergy Clin Immunol 117:836-41. 2006
  9. doi request reprint Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Invest Dermatol 128:2248-58. 2008
  10. pmc IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation
    Sarita Sehra
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 184:3186-90. 2010

Collaborators

Detail Information

Publications24

  1. ncbi request reprint The role of human beta defensins and cathelicidins in atopic dermatitis
    Michael D Howell
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Curr Opin Allergy Clin Immunol 7:413-7. 2007
    ..The mechanisms resulting in this increased propensity for skin infections have been an area of active investigation...
  2. doi request reprint Ceragenins: a class of antiviral compounds to treat orthopox infections
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
    J Invest Dermatol 129:2668-75. 2009
    ..This suggests that treatment with CSA-13 may be an intervention for individuals with a disseminated VV skin infection...
  3. ncbi request reprint Cytokine modulation of atopic dermatitis filaggrin skin expression
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 124:R7-R12. 2009
    ..CLINICAL IMPLICATIONS: The atopic immune response contributes to the skin barrier defect in AD; therefore, neutralization of IL-4 and IL-13 could improve skin barrier integrity...
  4. doi request reprint Inhibition of S100A11 gene expression impairs keratinocyte response against vaccinia virus through downregulation of the IL-10 receptor 2 chain
    Lianghua Bin
    Department of Pediatrics, National Jewish Health, Denver, Colo 80206, USA
    J Allergy Clin Immunol 124:270-7, 277.e1. 2009
    ..We have demonstrated that expression of S100A11, a calcium-binding protein involved in keratinocyte differentiation, is downregulated in AD...
  5. ncbi request reprint Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Immunity 24:341-8. 2006
    ..The current study demonstrates that Th2 cytokines enhance VV replication in AD skin by subverting the innate immune response against VV in a STAT-6-dependent manner...
  6. pmc The signal transducer and activator of transcription 6 gene (STAT6) increases the propensity of patients with atopic dermatitis toward disseminated viral skin infections
    Michael D Howell
    Department of Pediatrics, National Jewish Health, Denver, Colo 80206, USA
    J Allergy Clin Immunol 128:1006-14. 2011
    ..Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with increased susceptibility to recurrent skin infections...
  7. ncbi request reprint Mechanism of HBD-3 deficiency in atopic dermatitis
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, The National Jewish Medical and Research Center, Room K926, 1400 Jackson Street, Denver, CO 80206, USA
    Clin Immunol 121:332-8. 2006
    ..These studies suggest that neutralizing the Th2 cytokine milieu in AD skin may augment the innate immune response against bacterial and viral pathogens...
  8. pmc Cathelicidin deficiency predisposes to eczema herpeticum
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Allergy Clin Immunol 117:836-41. 2006
    ..Eczema herpeticum (ADEH) develops in a subset of patients with atopic dermatitis (AD) because of disseminated infection with herpes simplex virus (HSV)...
  9. doi request reprint Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Invest Dermatol 128:2248-58. 2008
    ..S100/A11 and p21 gene expression was also found to be significantly lower in acute and chronic AD skin. This study demonstrates an important role for S100/A11 and p21 in regulating skin barrier integrity and the innate immune response...
  10. pmc IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation
    Sarita Sehra
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 184:3186-90. 2010
    ..These data suggest that IL-4 plays an important role in regulating epidermal homeostasis and innate barrier function...
  11. pmc Specificity protein 1 is pivotal in the skin's antiviral response
    Lianghua Bin
    Department of Pediatrics, National Jewish Health, Denver, Colo, USA
    J Allergy Clin Immunol 127:430-438.e1-2. 2011
    ..Previous studies have found specificity protein (Sp) 1 transcription factor in the viral replication machinery and postulated that Sp1 was required for viral replication in host cells...
  12. pmc Macrophage inflammatory protein 3alpha deficiency in atopic dermatitis skin and role in innate immune response to vaccinia virus
    Byung Eui Kim
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 119:457-63. 2007
    ..Macrophage inflammatory protein 3alpha (MIP-3alpha) is a C-C chemokine expressed by keratinocytes that exhibits antimicrobial activity against bacteria and fungi; however, its role in antiviral innate immunity is unknown...
  13. pmc Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6
    Byung Eui Kim
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Clin Immunol 126:332-7. 2008
    ..This study suggests that Th2 cytokines inhibit expression of LOR and IVL through a STAT-6 dependent mechanism...
  14. ncbi request reprint Interleukin-10 downregulates anti-microbial peptide expression in atopic dermatitis
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, The National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Invest Dermatol 125:738-45. 2005
    ..Additionally, treatment of AD skin explants with anti-IL-10 augmented the expression of both HBD-2 and LL-37. Thus, increased levels of IL-10 may contribute to the AMP deficiency in both IAD and EAD by reducing cytokines that induce AMP...
  15. pmc Cytokine modulation of atopic dermatitis filaggrin skin expression
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 120:150-5. 2007
    ..Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by a defective skin barrier function. Recent studies have reported mutations of the skin barrier gene encoding filaggrin in a subset of patients with AD...
  16. ncbi request reprint The constitutive capacity of human keratinocytes to kill Staphylococcus aureus is dependent on beta-defensin 3
    Kevin O Kisich
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Invest Dermatol 127:2368-80. 2007
    ..aureus were exposed to human skin explants. Blocking peptide binding of HBD3 inhibited killing of the bacteria, indicating an essential role for beta-defensin 3 in the constitutive killing of bacteria by normal keratinocytes...
  17. doi request reprint TNF-α downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-α antagonists to improve skin barrier
    Byung Eui Kim
    Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
    J Invest Dermatol 131:1272-9. 2011
    ..Our current study suggests that TNF inhibits barrier protein expression, and TNF-α antagonists may contribute to clinical improvement in patients with psoriasis by improving barrier protein expression...
  18. ncbi request reprint Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammation
    Jordan E Scott
    Department of Pediatrics, Division of Allergy and Immunology, Children s Hospital, Harvard Medical School, Boston, MA, USA
    J Allergy Clin Immunol 120:1382-8. 2007
    ..Patients with atopic dermatitis (AD) exposed to the vaccinia virus (VV) smallpox vaccine have an increased risk of developing eczema vaccinatum...
  19. pmc Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response
    Donald Y M Leung
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 127:965-73.e1-5. 2011
    ..The basis for increased susceptibility of patients with atopic dermatitis (AD) to develop disseminated viral skin infections such as eczema herpeticum (AD with a history of eczema herpeticum, ADEH(+)) is poorly understood...
  20. ncbi request reprint Selective killing of vaccinia virus by LL-37: implications for eczema vaccinatum
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 172:1763-7. 2004
    ..01). These data support a role for cathelicidins in the inhibition of orthopox virus (vaccinia) replication both in vitro and in vivo. Susceptibility of patients with AD to eczema vaccinatum may be due to a deficiency of cathelicidin...
  21. pmc New insights into atopic dermatitis
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Clin Invest 113:651-7. 2004
    ..This review summarizes recent progress in our understanding of the pathophysiology of atopic dermatitis and the implications for new management strategies...
  22. ncbi request reprint Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes
    Ichiro Nomura
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 171:3262-9. 2003
    ..These observations could explain the increased susceptibility of AD skin to microorganisms, and suggest a new fundamental rule that may explain the mechanism for frequent infection in other Th2 cytokine-mediated diseases...
  23. pmc Antiviral activity of human beta-defensin 3 against vaccinia virus
    Michael D Howell
    J Allergy Clin Immunol 119:1022-5. 2007
  24. ncbi request reprint IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3
    Cristina Albanesi
    Laboratory of Immunologia and Allergology, Istituto Dermopatico dell Immacolata Instituti di Recovero e Cura a Carattere Scientifico, Roma, Italy
    J Immunol 179:984-92. 2007
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