Research Topics
Genomes and Genes
| Michael D HowellSummaryAffiliation: National Jewish Medical and Research Center Country: USA Publications
| Collaborators
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Detail Information
Publications
The role of human beta defensins and cathelicidins in atopic dermatitisMichael D Howell
Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Curr Opin Allergy Clin Immunol 7:413-7. 2007..The mechanisms resulting in this increased propensity for skin infections have been an area of active investigation...
Ceragenins: a class of antiviral compounds to treat orthopox infectionsMichael D Howell
Division of Allergy and Immunology, Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
J Invest Dermatol 129:2668-75. 2009..This suggests that treatment with CSA-13 may be an intervention for individuals with a disseminated VV skin infection...- Cytokine modulation of atopic dermatitis filaggrin skin expressionMichael D Howell
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 124:R7-R12. 2009..CLINICAL IMPLICATIONS: The atopic immune response contributes to the skin barrier defect in AD; therefore, neutralization of IL-4 and IL-13 could improve skin barrier integrity... - Inhibition of S100A11 gene expression impairs keratinocyte response against vaccinia virus through downregulation of the IL-10 receptor 2 chainLianghua Bin
Department of Pediatrics, National Jewish Health, Denver, Colo 80206, USA
J Allergy Clin Immunol 124:270-7, 277.e1. 2009..We have demonstrated that expression of S100A11, a calcium-binding protein involved in keratinocyte differentiation, is downregulated in AD... - Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virusMichael D Howell
Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
Immunity 24:341-8. 2006..The current study demonstrates that Th2 cytokines enhance VV replication in AD skin by subverting the innate immune response against VV in a STAT-6-dependent manner... 
The signal transducer and activator of transcription 6 gene (STAT6) increases the propensity of patients with atopic dermatitis toward disseminated viral skin infectionsMichael D Howell
Department of Pediatrics, National Jewish Health, Denver, Colo 80206, USA
J Allergy Clin Immunol 128:1006-14. 2011..Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with increased susceptibility to recurrent skin infections...- Mechanism of HBD-3 deficiency in atopic dermatitisMichael D Howell
Division of Allergy and Immunology, Department of Pediatrics, The National Jewish Medical and Research Center, Room K926, 1400 Jackson Street, Denver, CO 80206, USA
Clin Immunol 121:332-8. 2006..These studies suggest that neutralizing the Th2 cytokine milieu in AD skin may augment the innate immune response against bacterial and viral pathogens... - Cathelicidin deficiency predisposes to eczema herpeticumMichael D Howell
Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Allergy Clin Immunol 117:836-41. 2006..Eczema herpeticum (ADEH) develops in a subset of patients with atopic dermatitis (AD) because of disseminated infection with herpes simplex virus (HSV)... - Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiationMichael D Howell
Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Invest Dermatol 128:2248-58. 2008..S100/A11 and p21 gene expression was also found to be significantly lower in acute and chronic AD skin. This study demonstrates an important role for S100/A11 and p21 in regulating skin barrier integrity and the innate immune response... - IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammationSarita Sehra
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Immunol 184:3186-90. 2010..These data suggest that IL-4 plays an important role in regulating epidermal homeostasis and innate barrier function... - Specificity protein 1 is pivotal in the skin's antiviral responseLianghua Bin
Department of Pediatrics, National Jewish Health, Denver, Colo, USA
J Allergy Clin Immunol 127:430-438.e1-2. 2011..Previous studies have found specificity protein (Sp) 1 transcription factor in the viral replication machinery and postulated that Sp1 was required for viral replication in host cells... - Macrophage inflammatory protein 3alpha deficiency in atopic dermatitis skin and role in innate immune response to vaccinia virusByung Eui Kim
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 119:457-63. 2007..Macrophage inflammatory protein 3alpha (MIP-3alpha) is a C-C chemokine expressed by keratinocytes that exhibits antimicrobial activity against bacteria and fungi; however, its role in antiviral innate immunity is unknown... - Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6Byung Eui Kim
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Clin Immunol 126:332-7. 2008..This study suggests that Th2 cytokines inhibit expression of LOR and IVL through a STAT-6 dependent mechanism... - Interleukin-10 downregulates anti-microbial peptide expression in atopic dermatitisMichael D Howell
Division of Allergy and Immunology, Department of Pediatrics, The National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Invest Dermatol 125:738-45. 2005..Additionally, treatment of AD skin explants with anti-IL-10 augmented the expression of both HBD-2 and LL-37. Thus, increased levels of IL-10 may contribute to the AMP deficiency in both IAD and EAD by reducing cytokines that induce AMP... - Cytokine modulation of atopic dermatitis filaggrin skin expressionMichael D Howell
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 120:150-5. 2007..Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by a defective skin barrier function. Recent studies have reported mutations of the skin barrier gene encoding filaggrin in a subset of patients with AD... - The constitutive capacity of human keratinocytes to kill Staphylococcus aureus is dependent on beta-defensin 3Kevin O Kisich
Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Invest Dermatol 127:2368-80. 2007..aureus were exposed to human skin explants. Blocking peptide binding of HBD3 inhibited killing of the bacteria, indicating an essential role for beta-defensin 3 in the constitutive killing of bacteria by normal keratinocytes... - TNF-α downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-α antagonists to improve skin barrierByung Eui Kim
Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
J Invest Dermatol 131:1272-9. 2011..Our current study suggests that TNF inhibits barrier protein expression, and TNF-α antagonists may contribute to clinical improvement in patients with psoriasis by improving barrier protein expression... - Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammationJordan E Scott
Department of Pediatrics, Division of Allergy and Immunology, Children s Hospital, Harvard Medical School, Boston, MA, USA
J Allergy Clin Immunol 120:1382-8. 2007..Patients with atopic dermatitis (AD) exposed to the vaccinia virus (VV) smallpox vaccine have an increased risk of developing eczema vaccinatum... - Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ responseDonald Y M Leung
Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
J Allergy Clin Immunol 127:965-73.e1-5. 2011..The basis for increased susceptibility of patients with atopic dermatitis (AD) to develop disseminated viral skin infections such as eczema herpeticum (AD with a history of eczema herpeticum, ADEH(+)) is poorly understood... - Selective killing of vaccinia virus by LL-37: implications for eczema vaccinatumMichael D Howell
Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 172:1763-7. 2004..01). These data support a role for cathelicidins in the inhibition of orthopox virus (vaccinia) replication both in vitro and in vivo. Susceptibility of patients with AD to eczema vaccinatum may be due to a deficiency of cathelicidin... - New insights into atopic dermatitisDonald Y M Leung
Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
J Clin Invest 113:651-7. 2004..This review summarizes recent progress in our understanding of the pathophysiology of atopic dermatitis and the implications for new management strategies... - Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genesIchiro Nomura
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 171:3262-9. 2003..These observations could explain the increased susceptibility of AD skin to microorganisms, and suggest a new fundamental rule that may explain the mechanism for frequent infection in other Th2 cytokine-mediated diseases... - Antiviral activity of human beta-defensin 3 against vaccinia virusMichael D Howell
J Allergy Clin Immunol 119:1022-5. 2007 - IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3Cristina Albanesi
Laboratory of Immunologia and Allergology, Istituto Dermopatico dell Immacolata Instituti di Recovero e Cura a Carattere Scientifico, Roma, Italy
J Immunol 179:984-92. 2007....