Om Zack Howard

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Naturally occurring CCR5 extracellular and transmembrane domain variants affect HIV-1 Co-receptor and ligand binding function
    O M Howard
    Intramural Research Support Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Biol Chem 274:16228-34. 1999
  2. ncbi request reprint An expanding appreciation of the role chemokine receptors play in cancer progression
    O M Zack Howard
    National Cancer Institute, Center for Cancer Research, Laboratory of Molecular Immunoregulation, NCI Frederick, Frederick, MD 21702, USA
    Curr Pharm Des 10:2377-89. 2004
  3. pmc Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate
    O M Zack Howard
    National Cancer Institute Center for Cancer Research, Laboratory of Molecular Immunoregulation, Basic Research Program, Science Applications International Corporation, Frederick, MD, USA
    Blood 105:4207-14. 2005
  4. ncbi request reprint Autoantigen signalling through chemokine receptors
    Om Zack Howard
    Center for Cancer Research, Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, Maryland, USA
    Curr Opin Rheumatol 18:642-6. 2006
  5. pmc Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells
    O M Zack Howard
    National Cancer Institute, Center for Cancer Research, Laboratory of Molecular Immunoregulation, Frederick, MD 21702, USA
    J Exp Med 196:781-91. 2002
  6. ncbi request reprint Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds
    O M Howard
    Laboratory of Molecular Immunoregulation, National Cancer Istitute Frederick Cancer Research and Development Center, MD 21702, USA
    Bioorg Med Chem Lett 11:59-62. 2001
  7. ncbi request reprint LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8
    O M Howard
    Intramural Research Support Program, Laboratory of Molecular Immunoregulation, Division of Basic Science, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD, USA
    Blood 96:840-5. 2000
  8. ncbi request reprint Differential response of murine CD4+CD25+ and CD4+CD25- T cells to dexamethasone-induced cell death
    Xin Chen
    Basic Research Program, SAIC Frederick, Inc, Frederick, MD, USA
    Eur J Immunol 34:859-69. 2004
  9. ncbi request reprint Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines
    Teresa Krakauer
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Bldg 1425, Fort Detrick, Frederick, MD 21702 5011, USA
    Immunopharmacol Immunotoxicol 27:53-66. 2005
  10. ncbi request reprint Yin zi huang, an injectable multicomponent chinese herbal medicine, is a potent inhibitor of T-cell activation
    Xin Chen
    Basic Research Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    J Altern Complement Med 10:519-26. 2004

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Naturally occurring CCR5 extracellular and transmembrane domain variants affect HIV-1 Co-receptor and ligand binding function
    O M Howard
    Intramural Research Support Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Biol Chem 274:16228-34. 1999
    ....
  2. ncbi request reprint An expanding appreciation of the role chemokine receptors play in cancer progression
    O M Zack Howard
    National Cancer Institute, Center for Cancer Research, Laboratory of Molecular Immunoregulation, NCI Frederick, Frederick, MD 21702, USA
    Curr Pharm Des 10:2377-89. 2004
    ..Several therapeutic approaches have been reviewed and suggest that the most promising arise from the development of combinations of chemokine receptor antagonists...
  3. pmc Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate
    O M Zack Howard
    National Cancer Institute Center for Cancer Research, Laboratory of Molecular Immunoregulation, Basic Research Program, Science Applications International Corporation, Frederick, MD, USA
    Blood 105:4207-14. 2005
    ..These studies suggest that IRBP and S-Ag can initiate innate and, in sensitive individuals, adaptive immune response by attracting iDCs and T and B cells expressing CXCR3 and CXCR5...
  4. ncbi request reprint Autoantigen signalling through chemokine receptors
    Om Zack Howard
    Center for Cancer Research, Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, Maryland, USA
    Curr Opin Rheumatol 18:642-6. 2006
    ....
  5. pmc Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells
    O M Zack Howard
    National Cancer Institute, Center for Cancer Research, Laboratory of Molecular Immunoregulation, Frederick, MD 21702, USA
    J Exp Med 196:781-91. 2002
    ..Therefore, the selection of a self-molecule as a target for an autoantibody response may be a consequence of the proinflammatory properties of the molecule itself...
  6. ncbi request reprint Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds
    O M Howard
    Laboratory of Molecular Immunoregulation, National Cancer Istitute Frederick Cancer Research and Development Center, MD 21702, USA
    Bioorg Med Chem Lett 11:59-62. 2001
    ..Acetylation of the reactive amino groups of RANTES abrogated the inhibitory activity of cosalane. The data suggest that cosalane and its structural analogues may interfere with the RANTES/CCR1 interaction by binding to RANTES...
  7. ncbi request reprint LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8
    O M Howard
    Intramural Research Support Program, Laboratory of Molecular Immunoregulation, Division of Basic Science, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD, USA
    Blood 96:840-5. 2000
    ..This study suggests that LEC may be a more effective inducer of cell adhesion than cell migration...
  8. ncbi request reprint Differential response of murine CD4+CD25+ and CD4+CD25- T cells to dexamethasone-induced cell death
    Xin Chen
    Basic Research Program, SAIC Frederick, Inc, Frederick, MD, USA
    Eur J Immunol 34:859-69. 2004
    ..Our data also suggest that selective protection of CD4+CD25+ T cell from apoptosis may constitute a role in immune tolerance for IL-2...
  9. ncbi request reprint Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines
    Teresa Krakauer
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Bldg 1425, Fort Detrick, Frederick, MD 21702 5011, USA
    Immunopharmacol Immunotoxicol 27:53-66. 2005
    ..It also may be therapeutically useful for mitigating the pathogenic effects of these microbial products by downregulating the signaling pathways activated by both bacterial exotoxins and endotoxins...
  10. ncbi request reprint Yin zi huang, an injectable multicomponent chinese herbal medicine, is a potent inhibitor of T-cell activation
    Xin Chen
    Basic Research Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    J Altern Complement Med 10:519-26. 2004
    ..The effects of 10 ingredient components of YZH were also evaluated...
  11. ncbi request reprint Pertussis toxin by inducing IL-6 promotes the generation of IL-17-producing CD4 cells
    Xin Chen
    Basic Research Program, SAIC Frederick, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    J Immunol 178:6123-9. 2007
    ..Thus, in addition to inhibiting the development of Treg, the immunoadjuvant activity of PTx can be attributable to the generation of IL-6-dependent IL-17-producing CD4 cells...
  12. pmc Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1
    Xin Chen
    Basic Research Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, Maryland 21702 1201, USA
    Antimicrob Agents Chemother 47:2810-6. 2003
    ..Therefore, shikonin, as a naturally occurring, low-molecular-weight pan-chemokine receptor inhibitor, constitutes a basis for the development of novel anti-HIV therapeutic agents...
  13. doi request reprint Expression of costimulatory TNFR2 induces resistance of CD4+FoxP3- conventional T cells to suppression by CD4+FoxP3+ regulatory T cells
    Xin Chen
    Basic Science Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 185:174-82. 2010
    ..However, intratumoral Tregs expressing more TNFR2 are able to overcome the greater resistance to suppression of intratumoral Tconv cells, resulting in a dominant immunosuppressive tumor environment...
  14. ncbi request reprint Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis
    Carole L Galligan
    National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Arthritis Rheum 50:1806-14. 2004
    ..We undertook this study to examine CCRL2 expression in RA, cytokine regulation of expression, and the source of a putative ligand in an attempt to determine the role of this receptor during inflammation...
  15. ncbi request reprint Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells
    Xin Chen
    Laboratory of Molecular Immunoregulation, Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 179:154-61. 2007
    ..Moreover, our study suggests that the slower response of Tregs than Teffs to TNF results in delayed immunosuppressive feedback effects...
  16. pmc Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking
    Xin Chen
    Basic Research Program, Science Applications International Corporation Frederick, Inc, Laboratory of Molecular Immunoregulation, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    Blood 106:2409-16. 2005
    ..These data provide new insight into the mechanism of action of TPT and indicate that the inhibition of maturation and trafficking of DCs by TPT contributes to its immunosuppressive effects...
  17. ncbi request reprint Chemokines and chemokine receptors as novel therapeutic targets in rheumatoid arthritis (RA): inhibitory effects of traditional Chinese medicinal components
    Xin Chen
    Basic Research Program, SAIC Frederick, Inc, MD 21702 1201, USA
    Cell Mol Immunol 1:336-42. 2004
    ..Thus, this approach may lead to the discovery of new inhibitors of chemokines or chemokine receptors that can be used to treat diseases associated with inappropriately overactive chemokine mediated inflammatory reactions...
  18. pmc Pertussis toxin as an adjuvant suppresses the number and function of CD4+CD25+ T regulatory cells
    Xin Chen
    Basic Research Program, SAIC Frederick, Inc, Laboratory of Molecular Immunoregulation, National Cancer Institute Frederick Frederick, MD 21702 1201, USA
    Eur J Immunol 36:671-80. 2006
    ..This study concludes that an underlying cause for the immunological adjuvanticity of PTx is down-regulation of Treg cell number and function...
  19. pmc The scaffold protein Cybr is required for cytokine-modulated trafficking of leukocytes in vivo
    Vincenzo Coppola
    Neural Development Group, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, USA
    Mol Cell Biol 26:5249-58. 2006
    ..Taken together, these data support a role for Cybr in leukocyte trafficking, especially in response to proinflammatory cytokines in stress conditions...
  20. ncbi request reprint Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3(+)CD4(+)CD25(+) T regulatory cells in vivo and enhances their capacity to suppress EAE
    Xin Chen
    Basic Research Program, SAIC Frederick, Center for Cancer Research, National Cancer Institute Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Eur J Immunol 36:2139-49. 2006
    ..Therefore, the combination of glucocorticoid and IL-2, two currently used therapeutics, may provide a novel approach for the treatment of autoimmune diseases, transplant rejection and graft-vs.-host disease...
  21. ncbi request reprint Functional and genomic analyses of FOXP3-transduced Jurkat-T cells as regulatory T (Treg)-like cells
    Joon Young Kim
    Cancer Stem Cell Section, Laboratory of Cancer Prevention, NCI Frederick, 1050 Boyles Street, Building 560, Room 21 78, Frederick, MD 21702, USA
    Biochem Biophys Res Commun 362:44-50. 2007
    ....
  22. ncbi request reprint Autoantigens act as tissue-specific chemoattractants
    Joost J Oppenheim
    National Cancer Institute Frederick, Center for Cancer Research, Laboratory of Molecular Immunoregulation, MD 21702 1201, USA
    J Leukoc Biol 77:854-61. 2005
    ....
  23. ncbi request reprint BALB/c mice have more CD4+CD25+ T regulatory cells and show greater susceptibility to suppression of their CD4+CD25- responder T cells than C57BL/6 mice
    Xin Chen
    Basic Research Program, SAIC Frederick, Inc, MD 21702, USA
    J Leukoc Biol 78:114-21. 2005
    ..Our data also suggest that differences in the CD4(+)CD25(+) Treg cell number and the susceptibility of CD4(+)CD25(-) Tres cells may, at least in part, account for the differences in immune response between B6 and BALB/c strains of mice...
  24. ncbi request reprint Effects of Shuanghuanglian and Qingkailing, two multi-components of traditional Chinese medicinal preparations, on human leukocyte function
    Xin Chen
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute Frederick, Fort Detrick, MD, 21702 1201, USA
    Life Sci 70:2897-913. 2002
    ..Identification of the responsible components in these two herbal preparations may yield compounds suitable for structural modification into potent novel drugs...
  25. ncbi request reprint Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor
    Li Hua Wang
    Basic Research Program, SAIC Frederick, National Cancer Institute Frederick, National Institutes of Health, PO Box B, Frederick, Maryland 21702, USA
    Nat Med 10:40-7. 2004
    ..Our results provide the proof of principle for a new strategy to inhibit breast cancer at the level of DNA binding, rather than the classical antagonism of estrogen binding...
  26. pmc Chemokine receptors on dendritic cells promote autoimmune reactions
    Joost J Oppenheim
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    Arthritis Res 4:S183-8. 2002
    ..These observations suggest the hypothesis that antigens delivered to receptors on iDCs are potent immunogens capable of breaking self-tolerance to tumor antigens to induce autoimmune diseases...
  27. pmc Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation
    De Yang
    Basic Research Program, Science Applications International Corporation SAIC Frederick, MD 21702, USA
    J Immunol 173:6134-42. 2004
    ..We therefore propose these mediators be considered as endogenous multifunctional immune alarmins...
  28. pmc Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation
    Jian Huang
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Carcinogenesis 30:348-55. 2009
    ..These results indicate that increased methylation of p53 gene retains human glioblastoma cells at a more poorly differentiated phase associated with the aberrant expression of FPR as a tumor-promoting cell surface receptor...
  29. ncbi request reprint Effects of IL-7 and dexamethasone: induction of CD25, the high affinity IL-2 receptor, on human CD4+ cells
    Il Yup Chung
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, Frederick, MD 21702 1201, USA
    Cell Immunol 232:57-63. 2004
    ..This combination may provide a novel means of priming CD4 T cells to respond to IL-2 and may prove useful in up-regulation of normal immune responses in immune deficient diseases...
  30. ncbi request reprint Functional redundancy of the human CCL4 and CCL4L1 chemokine genes
    O M Zack Howard
    Laboratory of Molecular Immunoregulation, NCI Frederick, Frederick, MD 21702, USA
    Biochem Biophys Res Commun 320:927-31. 2004
    ..These data combined with the observation of individual variation in CCL4L1 gene copy number [Eur. J. Immunol. 32 (2002) 3016, Genomics 83 (2004) 735] support the contention that the CCL4 and CCL4L1 proteins have redundant functions...
  31. ncbi request reprint Formylpeptide receptor FPR and the rapid growth of malignant human gliomas
    Ye Zhou
    Laboratory of Molecular Immunoregulation, CCR, NCI Frederick, Building 560, Room 31 40, Frederick, MD 21702 1201, USA
    J Natl Cancer Inst 97:823-35. 2005
    ..We previously showed that selected human glioma cell lines also express functional FPR. We therefore investigated the relationship between FPR expression and the biologic behavior of glioma cells...
  32. pmc Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells
    Xin Chen
    Basic Research Program, SAIC Frederick Inc, National Cancer Institute NCI Frederick, Frederick, MD 21702 1201, USA
    J Immunol 180:6467-71. 2008
    ..Thus, TNFR2 identifies a unique subset of mouse Tregs with an activated/memory phenotype and maximal suppressive activity that may account for tumor-infiltrating lymphocyte-mediated immune evasion by tumors...
  33. ncbi request reprint RNase protection assay for the study of the differential effects of therapeutic agents in suppressing staphylococcal enterotoxin B-induced cytokines in human peripheral blood mononuclear cells
    Teresa Krakauer
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Methods Mol Biol 214:151-64. 2003
  34. pmc Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells
    Heather Kopf
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, NCI Frederick, Frederick, Maryland 21702 1201, USA
    Int Immunopharmacol 7:1819-24. 2007
    ....
  35. ncbi request reprint Suradista NSC 651016 inhibits the angiogenic activity of CXCL12-stromal cell-derived factor 1alpha
    Gregory P Schneider
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, Intramural Research Support Program, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    Clin Cancer Res 8:3955-60. 2002
    ..c. assay. These data indicate that suradista NSC 651016 possesses in vitro and in vivo antiangiogenic activity and has the potential to interfere with neovacularization of tumors and their metastases...
  36. pmc Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN
    Ping Gao
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute Frederick, PO Box B, Bldg 560, Rm 31 19, Frederick, MD 21702 1201, USA
    Blood 106:2619-26. 2005
    ..Our findings may account for the reported increase in metastatic activity of PTEN-null tumor cells...
  37. ncbi request reprint Selenium deficiency abrogates inflammation-dependent plasma cell tumors in mice
    Klaus Felix
    Laboratory of Genetics, Center for Cancer Research, National Cancer Institute and Veterinary Resources Program, NIH, Bethesda, Maryland, USA
    Cancer Res 64:2910-7. 2004
    ....
  38. pmc Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood
    Xin Chen
    Basic Science Program, Laboratory of Molecular Immunoregulation, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702 1201, USA
    Eur J Immunol 40:1099-106. 2010
    ..As some non-Treg express TNFR2, the combination of CD25 and TNFR2 must be used to identify a larger population of human Treg, a population that may prove to be of diagnostic and therapeutic benefit in cancer and autoimmune diseases...
  39. pmc Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15
    Ronald Wolf
    Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 181:1499-506. 2008
    ..The identified S100A7 interaction with RAGE may provide a novel therapeutic target for inflammation...
  40. ncbi request reprint Dendritic cells as a pharmacological target of traditional Chinese medicine
    Xin Chen
    Basic Research Program, SAIC Frederick, Inc, Lab of Molecular Immunoregulation, Cancer and Inflammation Program, CCR, NCI Frederick, P O Box B, Bldg 560, Rm 31 19, Maryland 21702 1201, USA
    Cell Mol Immunol 3:401-10. 2006
    ..These studies have revealed novel biological effects of TCM and documented the utility of this approach to discover novel biological modifier of DC functions derived from natural sources...
  41. ncbi request reprint Transactivation of the epidermal growth factor receptor by formylpeptide receptor exacerbates the malignant behavior of human glioblastoma cells
    Jian Huang
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Science Applications International Corporation Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702 1201, USA
    Cancer Res 67:5906-13. 2007
    ..Thus, targeting both receptors may yield antiglioblastoma agents superior to those targeting one of them...
  42. ncbi request reprint Selective inactivation of CCR5 and decreased infectivity of R5 HIV-1 strains mediated by opioid-induced heterologous desensitization
    Imre Szabo
    Department of Microbiology and Immunology, Temple University School of Medicine, 3400 N Broad Street, Philadelphia, PA 19140, USA
    J Leukoc Biol 74:1074-82. 2003
    ..The interference with HIV-1 uptake by heterologous desensitization of CCR5 suggests that HIV-1 interaction with this receptor is not passive but involves a signal transduction process...
  43. ncbi request reprint Brugia malayi asparaginyl-transfer RNA synthetase induces chemotaxis of human leukocytes and activates G-protein-coupled receptors CXCR1 and CXCR2
    Bernadette L Ramirez
    Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines, Manila, The Philippines
    J Infect Dis 193:1164-71. 2006
    ..Our findings suggest that a filarial parasite chemoattractant protein may contribute to the development of chronic inflammatory disease and that chemokine receptors may be therapeutic targets to ameliorate parasite-induced pathology...
  44. ncbi request reprint Human tumor antigen MUC1 is chemotactic for immature dendritic cells and elicits maturation but does not promote Th1 type immunity
    Casey A Carlos
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 175:1628-35. 2005
    ....
  45. ncbi request reprint Tannic acid is an inhibitor of CXCL12 (SDF-1alpha)/CXCR4 with antiangiogenic activity
    Xin Chen
    The Basic Research Program, Science Applications International Corporation Frederick, Inc Gaithersburg, Maryland 20879, USA
    Clin Cancer Res 9:3115-23. 2003
    ..The antiangiogenic effect of tannic acid was assessed by in vitro endothelial cell tube formation...