Steven X Hou

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. ncbi request reprint The Jak/STAT pathway in model organisms: emerging roles in cell movement
    Steven X Hou
    The Laboratory of Immunobiology, National Cancer Institute at Frederick, Building 560, Room 12 70, MD 21702, USA
    Dev Cell 3:765-78. 2002
  2. pmc Competitiveness for the niche and mutual dependence of the germline and somatic stem cells in the Drosophila testis are regulated by the JAK/STAT signaling
    Shree Ram Singh
    Mouse Cancer Genetics Program, National Institutes of Health, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Cell Physiol 223:500-10. 2010
  3. ncbi request reprint Cyclin D-Cdk4 and cyclin E-Cdk2 regulate the Jak/STAT signal transduction pathway in Drosophila
    Xiu Chen
    Laboratory of Immunobiology, National Institutes of Health, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Dev Cell 4:179-90. 2003
  4. pmc Tumor suppressors Sav/Scrib and oncogene Ras regulate stem-cell transformation in adult Drosophila malpighian tubules
    Xiankun Zeng
    Mouse Cancer Genetics Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Cell Physiol 224:766-74. 2010
  5. ncbi request reprint Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis
    Hong Wang
    The Laboratory of Immunobiology, National Institutes of Health National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Dev Cell 10:117-26. 2006
  6. pmc CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila
    Hua Wei Chen
    The Laboratory of Immunobiology, National Institutes of Health, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Mol Cell Biol 22:1792-803. 2002
  7. pmc JAK-STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells
    Wei Liu
    The Mouse Cancer Genetics Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Cell Biochem 109:992-9. 2010
  8. ncbi request reprint Rap-GEF/Rap signaling restricts the formation of supernumerary spermathecae in Drosophila melanogaster
    Shree R Singh
    Mouse Cancer Genetics Program, National Institutes of Health, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Dev Growth Differ 48:169-75. 2006
  9. pmc Characterization of midgut stem cell- and enteroblast-specific Gal4 lines in drosophila
    Xiankun Zeng
    Mouse Cancer Genetics Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland, USA
    Genesis 48:607-11. 2010
  10. ncbi request reprint JAK/STAT signaling regulates tissue outgrowth and male germline stem cell fate in Drosophila
    Shree Ram Singh
    The Laboratory of Immunobiology, National Institutes of Health, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Cell Res 15:1-5. 2005

Collaborators

Detail Information

Publications25

  1. ncbi request reprint The Jak/STAT pathway in model organisms: emerging roles in cell movement
    Steven X Hou
    The Laboratory of Immunobiology, National Cancer Institute at Frederick, Building 560, Room 12 70, MD 21702, USA
    Dev Cell 3:765-78. 2002
    ..In particular, we emphasize recent insights into the role that this pathway plays in the control of cell movement...
  2. pmc Competitiveness for the niche and mutual dependence of the germline and somatic stem cells in the Drosophila testis are regulated by the JAK/STAT signaling
    Shree Ram Singh
    Mouse Cancer Genetics Program, National Institutes of Health, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Cell Physiol 223:500-10. 2010
    ..These data suggest that a single JAK/STAT signal from the niche orchestrate the competitive and dependent co-existence of GSCs and CPCs in the Drosophila testis niche...
  3. ncbi request reprint Cyclin D-Cdk4 and cyclin E-Cdk2 regulate the Jak/STAT signal transduction pathway in Drosophila
    Xiu Chen
    Laboratory of Immunobiology, National Institutes of Health, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Dev Cell 4:179-90. 2003
    ..STAT92E regulates gene expression for various biological processes, including the endocycle S phase. These data suggest that Cyclin D-Cdk4 and Cyclin E-Cdk2 play more versatile roles in Drosophila development...
  4. pmc Tumor suppressors Sav/Scrib and oncogene Ras regulate stem-cell transformation in adult Drosophila malpighian tubules
    Xiankun Zeng
    Mouse Cancer Genetics Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Cell Physiol 224:766-74. 2010
    ..Therefore, we have identified a molecular mechanism that regulates stem-cell transformation, and this finding may lead to strategies for preventing tumor formation in certain organs...
  5. ncbi request reprint Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis
    Hong Wang
    The Laboratory of Immunobiology, National Institutes of Health National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Dev Cell 10:117-26. 2006
    ..Thus, the Rap signaling/E-cadherin pathway may represent one mechanism that regulates polarized niche formation and stem cell anchoring...
  6. pmc CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila
    Hua Wei Chen
    The Laboratory of Immunobiology, National Institutes of Health, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Mol Cell Biol 22:1792-803. 2002
    ..These data suggest that CKA represents a novel molecule regulating AP-1 activity by organizing a molecular complex of kinases and transcription factors, thus coordinating the spatial-temporal expression of AP-1-regulated genes...
  7. pmc JAK-STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells
    Wei Liu
    The Mouse Cancer Genetics Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Cell Biochem 109:992-9. 2010
    ..This study provides insight into how stem cells, under steady conditions, balance the processes of proliferation and differentiation to maintain the stable cellular composition of a healthy tissue...
  8. ncbi request reprint Rap-GEF/Rap signaling restricts the formation of supernumerary spermathecae in Drosophila melanogaster
    Shree R Singh
    Mouse Cancer Genetics Program, National Institutes of Health, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Dev Growth Differ 48:169-75. 2006
    ..These data suggest that the Rap-GEF/Rap signaling controls the formation of supernumerary spermathecae through modulating cell adhesion in Drosophila...
  9. pmc Characterization of midgut stem cell- and enteroblast-specific Gal4 lines in drosophila
    Xiankun Zeng
    Mouse Cancer Genetics Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland, USA
    Genesis 48:607-11. 2010
    ..These two Gal4 lines will serve as invaluable tools for navigating ISC behaviors...
  10. ncbi request reprint JAK/STAT signaling regulates tissue outgrowth and male germline stem cell fate in Drosophila
    Shree Ram Singh
    The Laboratory of Immunobiology, National Institutes of Health, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Cell Res 15:1-5. 2005
    ..In this review, we discuss the general overview of JAK/STAT signaling in Drosophila with respect to its functions in the eye development and stem cell fate determination...
  11. doi request reprint Intestinal stem cell asymmetric division in the Drosophila posterior midgut
    Steven X Hou
    National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Cell Physiol 224:581-4. 2010
    ..In this review, I will focus on the establishment of these stem cells in their niche during development and the molecular mechanisms that regulate their asymmetric division in adults...
  12. pmc The adult Drosophila malpighian tubules are maintained by multipotent stem cells
    Shree Ram Singh
    The Mouse Cancer Genetics Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Cell Stem Cell 1:191-203. 2007
    ..Identifying adult kidney stem cells in Drosophila may provide important clues for understanding mammalian kidney repair and regeneration during injury...
  13. pmc A P-element insertion screen identified mutations in 455 novel essential genes in Drosophila
    Su Wan Oh
    The Laboratory of Immunobiology, National Institutes of Health, National Cancer Institute, Frederick, Maryland 21702 1201, USA
    Genetics 163:195-201. 2003
    ..Our mutation collection represents approximately 56% of the second chromosome vital genes and approximately 24% of the total vital Drosophila genes...
  14. pmc Multipotent stem cells in the Malpighian tubules of adult Drosophila melanogaster
    Shree Ram Singh
    Mouse Cancer Genetics Program, National Institutes of Health, National Cancer Institute, MD 21702, USA
    J Exp Biol 212:413-23. 2009
    ..Identifying and understanding the cellular processes underlying the development and repair of the mammalian kidney may enable more effective, targeted therapies for acute and chronic kidney diseases in humans...
  15. pmc Broad relays hormone signals to regulate stem cell differentiation in Drosophila midgut during metamorphosis
    Xiankun Zeng
    The Mouse Cancer Genetics Program, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, MD 21702, USA
    Development 139:3917-25. 2012
    ..Our results reveal a molecular mechanism whereby Br-mediated hormone signaling directly regulates stem cells to generate adult cells during metamorphosis...
  16. pmc Spermatogonial stem cells, infertility and testicular cancer
    Shree Ram Singh
    Mouse Cancer Genetics Program, National Institutes of Health, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    J Cell Mol Med 15:468-83. 2011
    ..We believe that studying the biology of SSCs will not only provide better understanding of stem cell regulation in the testis, but eventually will also be a novel target for male infertility and testicular cancers...
  17. doi request reprint Regulation of intestinal stem cells in mammals and Drosophila
    Ping Wang
    The Mouse Cancer Genetics Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Cell Physiol 222:33-7. 2010
    ..However, it is clear that the stem cells in the two systems are regulated in different ways. In this review, we will compare cell renewal and stem cell regulation in the two systems...
  18. doi request reprint Genetic tools used for cell lineage tracing and gene manipulation in Drosophila germline stem cells
    Wei Liu
    Mouse Cancer Genetics Program, National Institutes of Health, National Cancer Institute at Frederick, Frederick, MD, USA
    Methods Mol Biol 450:61-70. 2008
    ....
  19. doi request reprint Immunohistological techniques for studying the Drosophila male germline stem cell
    Shree Ram Singh
    Mouse Cancer Genetics Program, National Institutes of Health, National Cancer Institute at Frederick, Frederick, MD, USA
    Methods Mol Biol 450:45-59. 2008
    ..We describe the detailed in vivo immunohistological protocols that mark GSCs, SSCs, and their progeny in Drosophila testes...
  20. doi request reprint Lessons learned about adult kidney stem cells from the malpighian tubules of Drosophila
    Shree Ram Singh
    Mouse Cancer Genetics Program, National Institutes of Health, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    J Am Soc Nephrol 19:660-6. 2008
    ..Furthermore, the potential application of the adult renal stem cells in kidney repair and the treatment of kidney cancers are discussed...
  21. ncbi request reprint Germline stem cells. Preface
    Steven X Hou
    Mouse Cancer Genetics Program, National Institutes of Health, National Cancer Institute at Frederick, Frederick, MD, USA
    Methods Mol Biol 450:v. 2008
  22. doi request reprint Stem cells in the Drosophila digestive system
    Xiankun Zeng
    The Mouse Cancer Genetics Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Adv Exp Med Biol 786:63-78. 2013
    ....
  23. pmc mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family
    Hua Wei Chen
    The Laboratory of Immunobiology, National Institutes of Health, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Genes Dev 16:388-98. 2002
    ..mom encodes a protein distantly related to the mammalian cytokine receptor family. These data show that mom functions as a receptor of the Drosophila JAK/STAT signal transduction pathway...
  24. pmc The Osa-containing SWI/SNF chromatin-remodeling complex regulates stem cell commitment in the adult Drosophila intestine
    Xiankun Zeng
    The Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    Development 140:3532-40. 2013
    ..Our data uncover a unique mechanism whereby the commitment of stem cells to discrete lineages is coordinately regulated by chromatin-remodeling factors. ..
  25. ncbi request reprint Kidney stem cells found in adult zebrafish
    Xiankun Zeng
    The Mouse Cancer Genetics Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Cell Stem Cell 8:247-9. 2011
    ..Clumps of progenitors give rise to functional nephrons after serial transplantation, demonstrating the ability of tissue stem cells to regenerate damaged kidney structures...