Ling Hou

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Cell-autonomous and cell non-autonomous signaling through endothelin receptor B during melanocyte development
    Ling Hou
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 4472, USA
    Development 131:3239-47. 2004
  2. ncbi A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy
    Ivana Matera
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 17:2118-31. 2008
  3. ncbi The secreted metalloprotease ADAMTS20 is required for melanoblast survival
    Debra L Silver
    Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America
    PLoS Genet 4:e1000003. 2008
  4. ncbi Genetic evidence does not support direct regulation of EDNRB by SOX10 in migratory neural crest and the melanocyte lineage
    Ramin Mollaaghababa Hakami
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 4472, USA
    Mech Dev 123:124-34. 2006
  5. ncbi Interspecies difference in the regulation of melanocyte development by SOX10 and MITF
    Ling Hou
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:9081-5. 2006
  6. ncbi Complementation of melanocyte development in SOX10 mutant neural crest using lineage-directed gene transfer
    Ling Hou
    Mouse Embryology Section, Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    Dev Dyn 229:54-62. 2004
  7. ncbi Spotlight on spotted mice: a review of white spotting mouse mutants and associated human pigmentation disorders
    Laura L Baxter
    Mouse Embryology Section, Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Pigment Cell Res 17:215-24. 2004
  8. ncbi The genetic regulation of pigment cell development
    Debra L Silver
    Genetic Diseases Branch, NHGRI, NIH, Room 4A51, Bldg. 49, 49 Convent Drive, Bethesda, Maryland 20892, USA
    Adv Exp Med Biol 589:155-69. 2006
  9. ncbi Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
    Proc Natl Acad Sci U S A 99:4477-82. 2002

Collaborators

  • Heinz Arnheiter
  • William J Pavan
  • Stacie K Loftus
  • Debra L Silver
  • Laura L Baxter
  • Ivana Matera
  • Arturo Incao
  • Ramin Mollaaghababa Hakami
  • Eirikur Steingrimsson
  • Eugene C Elliott
  • Suneel S Apte
  • Dawn E Watkins-Chow
  • Mary E Young
  • Robert Somerville
  • Cecelia Rivas
  • Jun Cheng
  • E Michelle Southard-Smith
  • Bhavani Pathak
  • Neal G Copeland
  • Lino Tessarollo
  • Nancy A Jenkins

Detail Information

Publications9

  1. ncbi Cell-autonomous and cell non-autonomous signaling through endothelin receptor B during melanocyte development
    Ling Hou
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 4472, USA
    Development 131:3239-47. 2004
    ..The results suggest that Ednrb plays a significant role during melanocyte differentiation and effects melanocyte development by both cell non-autonomous and cell-autonomous signaling mechanisms...
  2. ncbi A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy
    Ivana Matera
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 17:2118-31. 2008
    ..This study demonstrates the feasibility of sensitized screens to identify disease modifier loci and implicates GLI3 and other HH signaling components as modifiers of human neurocristopathies...
  3. ncbi The secreted metalloprotease ADAMTS20 is required for melanoblast survival
    Debra L Silver
    Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America
    PLoS Genet 4:e1000003. 2008
    ..Our results have implications not only for understanding mechanisms of NC-derived melanoblast development but also provide insights on novel biological functions of secreted metalloproteases...
  4. ncbi Genetic evidence does not support direct regulation of EDNRB by SOX10 in migratory neural crest and the melanocyte lineage
    Ramin Mollaaghababa Hakami
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 4472, USA
    Mech Dev 123:124-34. 2006
    ..Given that SOX10 directly activates Ednrb in the enteric nervous system, our results suggest that SOX10 may differentially activate target genes based on the particular cellular context...
  5. ncbi Interspecies difference in the regulation of melanocyte development by SOX10 and MITF
    Ling Hou
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:9081-5. 2006
    ..The results may help to explain how some embryos, such as zebrafish, can achieve rapid pigmentation after fertilization, whereas others, such as mice, become pigmented only several days after birth...
  6. ncbi Complementation of melanocyte development in SOX10 mutant neural crest using lineage-directed gene transfer
    Ling Hou
    Mouse Embryology Section, Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    Dev Dyn 229:54-62. 2004
    ..This system will be useful for assessing genetic hierarchies in NC development. Developmental Dynamics 229:54-62, 2004...
  7. ncbi Spotlight on spotted mice: a review of white spotting mouse mutants and associated human pigmentation disorders
    Laura L Baxter
    Mouse Embryology Section, Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Pigment Cell Res 17:215-24. 2004
    ..We describe our current understanding of how these genes function in development, and explore their complex roles regulating the various stages of melanocyte development...
  8. ncbi The genetic regulation of pigment cell development
    Debra L Silver
    Genetic Diseases Branch, NHGRI, NIH, Room 4A51, Bldg. 49, 49 Convent Drive, Bethesda, Maryland 20892, USA
    Adv Exp Med Biol 589:155-69. 2006
    ..These include several classes of proteins: transcription factors, transmembrane receptors, and extracellular ligands. This chapter discusses an overview of pigment cell development and the genes that regulate this important process...
  9. ncbi Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
    Proc Natl Acad Sci U S A 99:4477-82. 2002
    ..These results suggest that heterodimeric interactions are not essential for Mitf-Tfe function in contrast to other bHLH-Zip families like Myc/Max/Mad, where heterodimeric interactions seem to be essential...